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A protocol for a randomised double-blind placebo-controlled feasibility study to determine whether the daily consumption of flavonoid-rich pure cocoa has the potential to reduce fatigue in people with relapsing and remitting multiple sclerosis (RRMS)

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Pilot and Feasibility Studies 2018年第1期4卷 1-11页

作者： Coe, S. Collett, J. Izadi, H. Wade, D.T. Clegg, M. Harrison, J.M. Buckingham, E. Cavey, A. DeLuca, G.C. Palace, J. Dawes, H. Oxford Brookes University Centre for Movement and Occupational Rehabilitation Sciences Oxford Institute of Midwifery Nursing and Allied Health Research and Oxford Brookes Centre for Nutrition and Health Oxford OX30BP United Kingdom University of Oxford Department of Neurology Nuffield Department of Clinical Neuroscienes Oxford OX3 9DU United Kingdom Oxford Brookes University School of Engineering Computing and Mathematics Faculty of Technology Design and Environment Wheatley Campus Oxford OX33 1HX United Kingdom

Background: Dietary interventions including consumption of flavonoids, plant compounds found in certain foods, may have the ability to improve fatigue. However, to date, no well-designed intervention studies assessing the role of flavonoid consumption for fatigue management in people with MS (pwMS) have been performed. The hypothesis is that the consumption of a flavonoid-rich pure cocoa beverage will reduce fatigue in pwMS. The aim of this study is to determine the feasibility and potential outcome of running a trial to evaluate this hypothesis. Methods: Using a randomised (1:1) double-blind placebo-controlled feasibility study, 40 men and women (20 in each trial arm) with a recent diagnosis (< 10 years) of relapsing and remitting MS (RRMS) and who are over 18 years of age will be recruited from neurology clinics and throughout the Thames Valley community. During a 6-week nutrition intervention period, participants will consume the cocoa beverage, high flavonoid or low flavonoid content, at breakfast daily. At baseline, demographic factors and disease-related factors will be assessed. Fatigue, activity and quality of life, in addition to other measures, will be taken at three visits (baseline, week 3 and week 6) in a university setting by a researcher blinded to group membership. Feasibility and fidelity will be assessed through recruitment and retention, adherence and a quantitative process evaluation at the end of the trial. We will describe demographic factors (age, gender, level of education) as well as disease-related factors (disease burden scores, length of time diagnosed with MS) and cognitive assessment, depression and quality of life and general physical activity in order to characterise participants and determine possible mediators to identify the processes by which the intervention may bring about change. Feasibility (recruitment, safety, feasibility of implementation of the intervention and evaluation, protocol adherence and data completion) and potent

关键词： Cocoa Diet Fatigue Flavonoids Multiple sclerosis

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MELD: A multimodal multi-party dataset for emotion recognition in conversations

arXiv

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arXiv 2018年

作者： Poria, Soujanya Hazarika, Devamanyu Majumder, Navonil Naik, Gautam Cambria, Erik Mihalcea, Rada Information Systems Technology and Design SUTD Singapore School of Computing National University of Singapore Singapore Centro de Investigación en Computación Instituto Politécnico Nacional Mexico Computer Science and Engineering Nanyang Technological University Singapore Computer Science and Engineering University of Michigan United States

Emotion recognition in conversations (ERC) is a challenging task that has recently gained popularity due to its potential applications. Until now, however, there has been no largescale multimodal multi-party emotional conversational database containing more than two speakers per dialogue. To address this gap, we propose the Multimodal EmotionLines Dataset (MELD), an extension and enhancement of EmotionLines. MELD contains about 13,000 utterances from 1,433 dialogues from the TV-series Friends. Each utterance is annotated with emotion and sentiment labels, and encompasses audio, visual, and textual modalities. We propose several strong multimodal baselines and show the importance of contextual and multimodal information for emotion recognition in conversations. The full dataset is available for use at http:// ***. Copyright © 2018, The Authors. All rights reserved.

关键词： Speech recognition

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On epistemology of construction engineering and management 25

On epistemology of construction engineering and management

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25th Annual Conference of the International Group for Lean Construction, IGLC 2017

作者： Koskela, Lauri Pikas, Ergo Niiranen, Jarkko Ferrantelli, Andrea Dave, Bhargav University of Huddersfield School of Art Design and Architecture United Kingdom Aalto University Department of Civil Engineering Tallinn University of Technology Faculty of Engineering Estonia Aalto University Department of Civil Engineering Finland Tallinn University of Technology Faculty of Engineering Estonia Aalto University Department of Computing Finland

In philosophy of science, there have been two different starting points for epistemology: Platonism and Aristotelianism. These two alternative starting points have played a major role also in the formation of fundamental ideas of engineering and management generally as well as in relation to construction. It is contended that an overly Platonic influence on engineering and management has created a number of problems. For solving these problems, beyond mere patching, a more balanced take on Platonism and Aristotelianism is needed.

关键词： Project management

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Validating CRRM for aeronautical communications using a formal description technique 35

Validating CRRM for aeronautical communications using a form...

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35th AIAA International Communications Satellite Systems Conference, ICSSC 2017

作者： Hu, Yim Fun Pillai, Prashant Li, Jiangping Ayo, Babatope Samuel Faculty of Engineering and Informatics University of Bradford School of Electrical Engineering and Computer Science Richmond Road Bradford West Yorkshire United Kingdom Department of Computing and Communication Technologies Faculty of Technology Design and Environment Oxford Brookes University Wheatley Oxford United Kingdom

ISBN: (数字)9781624105180

ISBN: (纸本)9781624105180

This paper presents a Collaborative Radio Resource Management (CRRM) scheme to support seamless aeronautical networking. The CRRM exploits the IEEE 802.21 Media Independent Handover (MIH) framework and the ETSI Broadband Satellite Multimedia (BSM) SI-SAP concept to split the CRRM functions between the upper layers (layer 3 and above) and the lower layer (link layer and physical layer) of an aircraft terminal. Upper layer functions are managed by an Integrated Router (IR) on-board the aircraft and lower layer functions are provided by an on-board Integrated Modular Radio (IMR) consisting of heterogeneous radio access technologies. A Joint Radio Resource Manager (JRRM) provides the abstraction layer between the IR and IMR for mapping higher layer functions into lower layer functions to enable collaboration. The specification and design of the CRRM scheme is used to maintain a close collaboration to perform connection establishment functions and to support seamless handovers between different radio technologies. A detailed description of the CRRM mechanisms is presented. Message procedure charts are presented by combining MIH primitives and BSM primitives for session establishment and handover management. The design of this CRRM model is based on the Specification and Description Language (SDL) which is the most widely accepted formal description technique that enables model design validation and testing. The dynamic behavior and functionality of this CRRM scheme is validated using simulation in conjunction with the Message Sequence Chart (MSC). A set of validation scenarios have been simulated to show that the SDL model guarantees a good consistency with the designed target. © 2017, American Institute of Aeronautics and Astronautics Inc, AIAA. All rights reserved.

关键词： Specifications

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Front Cover: Automated Bonding Analysis with Crystal Orbital Hamilton Populations (ChemPlusChem 11/2022)

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ChemPlusChem 2022年第11期87卷

作者： Dr. Janine George Dr. Guido Petretto Aakash Naik Dr. Marco Esters Dr. Adam J. Jackson Dr. Ryky Nelson Prof. Dr. Richard Dronskowski Prof. Dr. Gian-Marco Rignanese Prof. Dr. Geoffroy Hautier Federal Institute for Materials Research and Testing Department Materials Chemistry Unter den Eichen 87 12205 Berlin Germany Friedrich Schiller University Jena Institute of Condensed Matter Theory and Solid-State Optics Max-Wien-Platz 1 07743 Jena Germany Université Catholique de Louvain Institute of Condensed Matter and Nanosciences Chemin des Étoiles 8 1348 Louvain-la-Neuve Belgium former address: Department of Chemistry University of Oregon Eugene OR 97403 USA Department of Mechanical Engineering and Materials Science and Center for Autonomous Materials Design Duke University Durham NC 27708 USA Scientific Computing Department Science & Technology Facilities Council Rutherford Appleton Laboratory Didcot 0X11 0QX UK RWTH Aachen University Institute of Inorganic Chemistry 52056 Aachen Germany RWTH Aachen University Jülich-Aachen Research Alliance (JARA-CSD) 52056 Aachen Germany Shenzhen Polytechnic Hoffmann Institute of Advanced Materials 7098 Liuxian Blvd Nanshan District Shenzhen 518055 P. R. China Dartmouth College Thayer School of Engineering Hanover NH 03755 USA

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A Comparative Life Cycle Assessment of Recycling the Platinum Group Metals from Automobile Catalytic Converter: An Australian Perspective

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Metallurgical and Materials Transactions E 2017年第2期4卷 77-88页

作者： Maryam Ghodrat M. Akbar Rhamdhani Pezhman Sharafi Bijan Samali School of Computing Engineering and Mathematics Centre for Infrastructure Engineering Western Sydney University Sydney Australia Department of Mechanical Engineering and Product Design Swinburne University of Technology Melbourne Australia

This study provides a comparison between environmental impacts of the recovery of platinum group metals (PGMs) from the end-of-life catalytic converters by hydrometallurgical and pyrometallurgical methods. A gate to grave life cycle assessment of a typical three-way catalytic converter manufactured for an Australian passenger car was carried out using GaBi professional environmental package. Recovery rates, as well as qualities, quantities, losses, and fugitive emissions for all materials and elements used in both methods were calculated based on the developed flowsheets. A life cycle impact assessment was then made by carrying out a mass balance calculation. Inventory data show that the hydrometallurgical route for recycling of the platinum group metals out of catalytic converter scrap has lower impacts on the environment compared with the pyrometallurgical method. In terms of emission effects, the hydrometallurgical process was found to be highly advantageous since it causes insignificant emissions to air, sea water, and fresh water. It is also found that the hydrometallurgical route performs comparatively superior in terms of acidification, eutrophication, fossil depletion, and human toxicity. The obtained results are applicable only to the Australian setting.

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Topology and material optimization of architectural components

Topology and material optimization of architectural componen...

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International Conference on Sustainable Smart Manufacturing, S2M 2016

作者： Craveiro, F. Almeida, H. Bártolo, H. Bártolo, P.J. Duarte, J.P. CIAUD Faculty of Architecture University of Lisbon Lisbon Portugal School of Technology and Management Polytechnic Institute of Leiria Portugal School of Mechanical Aerospace and Civil Engineering The University of Manchester United Kingdom Stuckeman Center for Design Computing Stuckeman School of Architecture and Landscape Architecture Penn State University United States

ISBN: (纸本)9781138713741

In today’s global economy, the construction industry is increasingly challenged to optimize its performance reducing costs and minimizing the impact on the environment. The industry is currently evolving towards a full digital-based design system through a better integration of structure, materials and form through new fabrication technologies, which can create new opportunities, respond to global challenges, and maintain competitiveness. This paper presents two possible distinct design schemes in order to produce a lightweight architectural structure. One scheme is based on topological optimization resulting in a shape design and the second one is based on material and porosity optimization resulting in a material gradient design. Both techniques can be used to optimize architectural structures. © 2017 Taylor & Francis Group, London.

关键词： Construction industry

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designing cork-based functionally-graded concrete walls

Designing cork-based functionally-graded concrete walls

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International Conference on Sustainable Smart Manufacturing, S2M 2016

作者： Craveiro, F. Bártolo, H. Duarte, J.P. Bártolo, P.J. CIAUD Faculty of Architecture University of Lisbon Lisbon Portugal School of Technology and Management Polytechnic Institute of Leiria Portugal Stuckeman School of Architecture and Landscape Architecture Stuckeman Center for Design Computing Penn State University United States School of Mechanical Aerospace and Civil Engineering The University of Manchester United Kingdom

ISBN: (纸本)9781138713741

Natural systems are optimized for the loading conditions they are subjected to and its geometry and material properties change according to stress or strain requirements. Current Additive manufacturing technologies consider the design and fabrication of physical elements with homogeneous material properties, not heterogeneous composite materials with varying material distribution, called Functionally-Graded Materials (FGM). With FGMs it is possible to take into account different functional requirements in the design, simulation and fabrication of construction elements, optimized for specific thermo-mechanical conditions. In this work, we present a new strategy developed to optimize material composition, using a graphical algorithm editor together with FEM software. The proposed algorithm adjusts the multi-material ratio locally, according to the stress map, simulating nature’s structural behavior. © 2017 Taylor & Francis Group, London.

关键词： Functionally graded materials

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Ethical by design - A manifesto 17

Ethical by design - A manifesto

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35th Annual Conference of the European Association of Cognitive Ergonomics, ECCE 2017

作者： Mulvenna, Maurice Boger, Jennifer Bond, Raymond School of Computing and Mathematics Ulster University NewtownabbeyBT37 0QB United Kingdom Systems Design Engineering University of Waterloo WaterlooONN2L 3G1 Canada

ISBN: (纸本)9781450352567

This paper presents a collection of 'ethical by design' principles for considering ethical aspects in the design and implementation of technology-based products and services. It is a work-in-progress describing the need for new, innovative concepts and approaches in ethical design-based thinking. The paper argues that design thinking should and can be 'ethical by design';that designs should strive to go beyond the ethical guidelines that are set by regulatory bodies and other such governance. This manifesto of 'ethical by design' principles is intended to support developers, providers, and users in the collaborative process of inherently and explicitly including ethics into product and service design. © 2017 Association for computing Machinery.

关键词： Product design

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Cost implications for certified Green Building Index buildings

Cost implications for certified Green Building Index buildin...

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作者： Chong, Heap-Yih Tam, Vivian W.Y. Lai, Wei Chian Sutrisna, Monty Wang, Xiangyu Illankoon, Illankoon Mudiyanselage Chethana Sanathani School of Built Environment Curtin University Perth Australia School of Computing Engineering and Mathematics Western Sydney University Penrith NSW Australia College of Civil Engineering Shenzhen University Shenzhen China Faculty of Engineering and Science Universiti Tunku Abdul Rahman Petaling Jaya Malaysia Department of Housing and Interior Design Kyung Hee University Seoul Korea Republic of

The impact of worsening global weather conditions has led to a growing awareness of the importance of sustainability in the global context, including in Malaysia. As a consequence, the Green Building Index rating tool was adopted in Malaysia from 2009 as a yardstick to guide the green buildings. The research aims to identify the initial cost premium for a residential green building to achieve certified green status with the use of basic green options. The primary data were mainly collected from bills of quantities, semi-structured discussions with project personnel, cost experts and suppliers. Finally, a sensitivity analysis is also carried out to analyse the impact of incremental costs to the changes in prices of green material. The findings show an incremental cost of 2·2% of the contract sum to develop a certified residential green building with basic green options. The research provides cost guidelines about the actual premium needed to embark on green building projects. The outcomes of this research can support the decisions of the developer to promote a greener-built environment.

关键词： Cost benefit analysis

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