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arXiv 2018年

作者： Malik, R. Luong, T. Cao, X. Han, B. Shah, N. Han, L. Shenoy, V.B. Lelkes, P.I. Cukierman, E. Cancer Biology Program Fox Chase Cancer Center Dept. Bioengineering Temple University Materials Science and Engineering University of Pennsylvania School of Biomedical Engineering Science and Health Systems Drexel University

Pancreatic ductal adenocarcinoma (PDAC) encompasses a fibrous-like tumor-associated stroma, desmoplasia, produced by cancer-associated fibroblasts (CAFs). As desmoplasia plays dual pro- and anti-tumor roles, efforts are being made to induce its anti-tumor functions for therapeutic gain. We conducted biomechanical manipulations, using variations of pathological and physiological substrates in vitro, to culture patient-harvested CAFs and generate desmoplastic CAF-derived extracellular matrices (CDMs) that can restrict PDAC growth and invasion. We posited that extrinsic modulation of the environment, via substrate rigidity, influences CAF's cell-intrinsic forces affecting CDM production. Substrates used were polyacrylamide gels of physiological (~1.5 kPa) or pathological (~7.5 kPa) stiffnesses. Results showed that physiological substrates influenced CAFs to generate CDMs similar to normal/control fibroblasts. We found CDMs to be softer than the corresponding underlying substrates, and CDM fiber anisotropy (i.e., alignment) to be biphasic and informed via substrate-imparted morphological CAF aspect ratios. Further, the biphasic nature of CDM fiber anisotropy was mathematically modeled and postulated a correlation between CAF aspect ratios and CDM alignment;regulated by extrinsic and intrinsic forces to conserve minimal free energy. Biomechanical manipulation of CDMs, generated on physiological stiffness substrates, lead to reduction in nuclear translocation of pERK1/2 in KRAS-driven PDAC. Specifically, ERK2 was essential for CDM-regulated tumor cell invasion. In vitro findings were validated in vivo, where nuclear pERK1/2 was found significantly higher in human PDAC samples compared to matching normal pancreata. The study suggests that altering underlying substrates enables CAFs to remodel CDMs and restricts KRAS-driven PDAC invasion in an ERK2 dependent manner. Copyright © 2018, The Authors. All rights reserved.

关键词： Diseases

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Localization of a Crack in Moving Cylindrical Ferromagnetic Rods by Measuring the Fourier Coefficients of the Leakage Magnetic Flux

Localization of a Crack in Moving Cylindrical Ferromagnetic ...

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Magnetic Conference - Short Papers (INTERMAG Short Papers), IEEE International

作者： Kanta Shiku Masafumi Kuromizu Yuji Gotoh Takaaki Nara Graduate School of Information Science and Technology The University of Tokyo bunkyo-ku Japan Division of Materials Science and Production Engineering Graduate School of Engineering Oita University Oita Japan Intelligent Mechanical Systems Program Faculty of Science and Technology Oita University Oita Japan

ISBN: (数字)9798350362213

ISBN: (纸本)9798350362220

Electromagnetic nondestructive inspection for high-speed moving ferromagnetic materials is necessary for manufacturing efficiency. In this paper, we present a novel leakage magnetic flux (LMF) method to estimate the crack position in a moving cylindrical ferromagnetic rod. The method directly measures the first-order Fourier coefficients of the LMF moving with the crack by using only two coils with DC excitation. The location of a crack is estimated by the proposed method, as demonstrated for an S45C cylindrical rod.

关键词： Location awareness Coils Magnetic flux Inspection Ferromagnetic materials Manufacturing Electromagnetics

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A Local Control Network Autopilot for an Unmanned Surface Vehicle

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IFAC Proceedings Volumes 2012年第27期45卷 374-379页

作者： SK Sharma R Sutton GN Roberts Marine and Industrial Dynamic Analysis Group Advanced Materials and Engineering Systems School of Marine Science and Engineering Plymouth University Plymouth PL4 8AA UK Faculty of Mathematics Computing and Technology The Open University in the South West Bristol BS1 6ND UK

Although marine craft are renowned for their nonlinear dynamic behaviour, autopilot system designs are still being developed based on linear control methodologies. Thus to overcome any limitations in the performance capabilities of such systems, it is appropriate to consider designing nonlinear autopilots. This paper reports an investigation into a novel approach to marine control systems design based on local control network (LCN) techniques. The approach is used to design an autopilot for controlling the nonlinear yaw dynamics of an unmanned surface vehicle and is benchmarked against another based on a standard proportional-integral-derivative controller. Simulation results are presented and the performances of the autopilots are compared using standard system performance criteria. From the results it can be observed that the LCN is more efficient compared to the PID controller. Also it out performs its PID counterpart in terms of the selected criteria. Copyright © 2012 IFAC

关键词： Unmanned surface vehicle autopilot design proportional-integral-derivative control local control network genetic algorithm

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Structure and magnetic properties characterization of electrodeposited Co37Fe63 alloys containing oxygen for magnetic recording applications

Structure and magnetic properties characterization of electr...

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作者： Elhalawaty, S. Carpenter, R.W. George, J. Brankovic, S.R. Materials Science and Engineering Graduate Program School for Engineering of Matter Transport and Energy Arizona State University 85287-6106 United States LeRoy Eyring Center for Solid State Science Arizona State University AZ 85287-9506 United States Center for Nanomagnetic Systems University of Houston TX 77204-4005 United States Electrical and Computer Engineering Department University of Houston TX 77204-4005 United States

ISBN: (纸本)9781118029473

Soft and high magnetic moment Co37Fe63 films were electro-deposited with variable additives on Cu/Ti/Si substrates. The correlation between structure and magnetic properties has been investigated. TEM showed the crystal structure of the films to be BCC with a 〈111〉 texture, and a grain size in the range of 10-20 nm. Oxygen in the deposited films has been identified by EDS and EELS using HAADF STEM. SIMS analysis revealed the presence of hydrogen and oxygen in the deposited CoFe films. Electron microscopy results showed that the oxygen was mainly distributed along the grain boundaries in the CoFe film. In regions where oxygen was present in the films, the Fe content was enhanced relative to Co. The magnetic properties of the deposits have been measured by Vibrating Sample Magnetometer (VSM), quantifying the impact of incorporated oxygen in the film on the saturation magnetization and the coercivity.

关键词： Magnetic properties

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Terahertz Magnetospectroscopy of Gadolinium Gallium Garnet in Fields up to 25 T

Terahertz Magnetospectroscopy of Gadolinium Gallium Garnet i...

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JSAP-OSA Joint Symposia, JSAP 2021

作者： Bao, J. Peraca, N. Marquez Tay, F. Kritzell, T.E. Li, X. Noe, G.T. Katayama, I. Takeda, J. Nojiri, H. Yamahara, H. Tabata, H. Baydin, A. Kono, J. Department of Physics and Astronomy Rice University HoustonTX United States Department of Electrical and Computer Engineering Rice University HoustonTX United States Applied Physics Graduate Program Smalley-Curl Institute Rice University HoustonTX United States Department of Physics Graduate School of Engineering Science Yokohama National University Yokohama Japan Institute for Materials Research Tohoku University Sendai Japan Department of Electrical Engineering and Information Systems Graduate School of Engineering University of Tokyo Japan Smalley-Curl Institute Rice University HoustonTX United States Department of Materials Science and NanoEngineering Rice University HoustonTX United States

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An ultra thin,bright,and sensitive interactive tactile display based on organic mechanoluminescence for dual-mode handwriting identification

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InfoMat 2024年第6期6卷 76-87页

作者： Tingting Hou Wenlang Li Haoyu Wang Yuantian Zheng Chaojie Chen Haoran Zhang Kai Chen Huilin Xie Xin Li Shaoshuai He Siwei Zhang Dengfeng Peng Cheng Yang Jacky W.Y.Lam Ben Zhong Tang Yunlong Zi Department of Mechanical and Automation Engineering The Chinese University of Hong KongHong Kongthe People's Republic of China Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction and Institute for Advanced StudyThe Hong Kong University of Science and TechnologyHong Kongthe People's Republic of China Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhenthe People's Republic of China Thrust of Sustainable Energy and Environment The Hong Kong University of Science and Technology(Guangzhou)Guangzhouthe People's Republic of China The Hong Kong University of Science and Technology Interdisciplinary Program Office Hong Kong SARthe People's Republic of China Institute of Materials Research Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhenthe People's Republic of China School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhenthe People's Republic of China HKUST Shenzhen-Hong Kong Collaborative Innovation Research Institute Shenzhenthe People's Republic of China Guangzhou HKUST Fok Ying Tung Research Institute Guangzhouthe People's Republic of China

Visible light-based human–machine interactive media is capable of transmitting electrical readouts to machines and providing intuitive feedback to users ***,many inorganic mechanoluminescent(ML)materials-based interactive media,typically ZnS-loaded phosphors(ZLPs),have been successfully ***,organic ML materials-based solutions were rarely exploited despite their huge merits of strong structural modification,abundant luminescence property,low cost,easy preparation,and so ***,we propose a novel interactive tactile display(ITD)based on organic ML materials(Cz-A6-dye)and triboelectric nanogenerator,with ultra-brightness(130%enhancement)and ultra-low threshold pressure(57%reduction)as compared to *** proposed ITD achieves the conversion of weak mechanical stimuli into visible light and electrical signals simultaneously,without extra power ***,the relationship between the luminous performance of organic ML materials and mechanical force is quantified,benefiting from the uniform ML layer *** by convolutional neural networks,the high-accuracy recognition(97.1%)for handwriting and identity of users is realized at the same ***,the ITD has great potential for intelligent wearable electronics and classified military applications.

关键词： interactive media organic mechanoluminescence triboelectric nanogenerators

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Band gap and band alignment prediction of nitride based semiconductors using machine learning

arXiv

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arXiv 2018年

作者： Huang, Yang Yu, Changyou Chen, Weiguang Liu, Yuhuai Li, Chong Niu, Chunyao Wang, Fei Jia, Yu International Laboratory for Quantum Functional Materials of Henan School of Physics and Engineering Zhengzhou University Zhengzhou450001 China Materials Science and Engineering Program University of California San Diego La JollaCA92093 United States National Center for International Joint Research of Electronic Materials and Systems School of Information Engineering Zhengzhou University Zhengzhou450001 China Quantum Materials Research Center College of Physics and Electronic Engineering Zhengzhou Normal University Zhengzhou450044 China Institute of Materials and Systems for Sustainability Nagoya University Nagoya464-8603 Japan Key Laboratory for Special Functional Material of Ministry of Education School of Materials Science Henan University Kaifeng475004 China

Nitride has been drawing much attention due to its wide range of applications in optoelectronics and remains plenty of room for materials design and discovery. Here, a large set of nitrides have been designed, with their band gap and alignment being studied by first-principles calculations combined with machine learning. Band gap and band offset against wurtzite GaN accurately calculated by the combination of screened hybrid functional of HSE and DFT-PBE were used to train and test machine learning models. After comparison among different techniques of machine learning, when elemental properties are taken as features, support vector regression (SVR) with radial kernel performs best for predicting both band gap and band offset with prediction root mean square error (RMSE) of 0.298 eV and 0.183 eV, respectively. The former is within HSE calculation uncertainty and the latter is small enough to provide reliable predictions. Additionally, when band gap calculated by DFT-PBE was added into the feature space, band gap prediction RMSE decreases to 0.099 eV. Through a feature engineering algorithm, elemental feature space based band gap prediction RMSE further drops by around 0.005 eV and the relative importance of elemental properties for band gap prediction was revealed. Finally, band gap and band offset of all designed nitrides were predicted and two trends were noticed that as the number of cation types increases, band gap tends to narrow down while band offset tends to go up. The predicted results will be a useful guidance for precise investigation on nitride engineering. Copyright © 2018, The Authors. All rights reserved.

关键词： Energy gap

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Enhancing tetraphenylethene cyclization as photoswitch

Smart Molecules

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Smart Molecules 2023年第2期1卷 30-38页

作者： Yue Wu Yiran Ren Xiaoxuan Zeng Honglong Hu Mengqi Li Junzi Li Tingchao He Xin-Shun Li Zhen-Qiang Yu Wei-Hong Zhu College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhenChina Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Feringa Nobel Prize Scientist Joint Research CenterShanghai Key Laboratory of Functional Materials ChemistryInstitute of Fine ChemicalsFrontiers Science Center for Materiobiology and Dynamic ChemistrySchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghaiChina Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhenChina

Tetraphenylethene(TPE),a star building block with promising aggregationinduced emission,has received much *** that its intramolecular Woodward-Hoffmann cyclic intermediate instantaneously converts back to the original state within several picoseconds,the essentially photochromic characteristic of TPE is little *** a visible photocyclization of TPE is still an unsolved issue and considered as the bottleneck in the further advancement of *** report a strategy of attaching carbonate ester onto the TPE skeleton(TPE-4C)to enhance TPE photocyclization *** demonstrated,the incorporated cholesteryloxycarbonyloxy substituents in TPE-4C can increase the energy barrier for cycloreversion,thereby exhibiting extremely thermal stability of photocyclic intermediate upon UV irradiation,prolonging its lifetime from 63 picoseconds to 46 s by 7.2×10^(11)-*** photoinduced cyclization of TPE-4C could be monitored with naked eyes,and the photocyclization/cycloreversion is achieved by turning on/off UV light along with a relative fatigue *** of TPE-4C into the liquid crystal can induce a striking phase transformation(achiral↔chiral),which can be applicable to encode optical *** carbonate ester into the TPE unit plays a vital role in enhancing the unprecedented TPE photocyclization stability,providing a toolbox to allow TPE-based photocyclization to be visually monitored.

关键词： aggregation-induced emission diarylethene photocyclization photoswitch tetraphenylethene

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Erratum to: Influence of Cyclic Straining on Fatigue, Deformation, and Fracture Behavior of High-Strength Alloy Steel

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Journal of materials engineering and Performance 2015年第1期25卷 151-151页

作者： K. Manigandan T. S. Srivatsan V. K. Vasudevan D. Tammana B. Poorganji Department of Mechanical Engineering The University of Akron Akron USA School of Dynamic Systems Materials Science and Engineering Program University of Cincinnati Cincinnati USA

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Reliable operation of Cr2O3:Mg/β-Ga2O3 p-n heterojunction diodes at 600◦C

arXiv

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arXiv 2024年

作者： Callahan, William A. Egbo, Kingsley Lee, Cheng-Wei Ginley, David O'Hayre, Ryan Zakutayev, Andriy Materials Science Center National Renewable Energy Laboratory GoldenCO80401 United States Advanced Energy Systems Graduate Program Colorado School of Mines GoldenCO80401 United States Department of Metallurgical and Materials Engineering Colorado School of Mines GoldenCO80401 United States

β-Ga2O3-based semiconductor heterojunctions have recently demonstrated improved performance at high voltages and elevated temperatures and are thus promising for applications in power electronic devices and harsh-environment sensors. However, the long-term reliability of these ultra-wide band gap (UWBG) semiconductor devices remains barely addressed and may be strongly influenced by chemical reactions at the p-n heterojunction interface. Here, we experimentally demonstrate operation and evaluate the reliability of Cr2O3:Mg/β-Ga2O3 p-n heterojunction diodes at during extended operation at 600◦C, as well as after 30 repeated cycles between 25-550◦C. The calculated pO3-temperature phase stability diagram of the Ga-Cr-O material system predicts that Ga2O3 and Cr2O3 should remain thermodynamically stable in contact with each other over a wide range of oxygen pressures and operating temperatures. The fabricated Cr2O3:Mg/β-Ga2O3 p-n heterojunction diodes show room-temperature on/off ratios >104 at ±5V and a breakdown voltage (VBr) of -390V. The leakage current increases with increasing temperature up to 600◦C, which is attributed to Poole-Frenkel emission with a trap barrier height of 0.19 eV. Over the course of a 140-hour thermal soak at 600◦C, both the device turn-on voltage and on-state resistance increase from 1.08V and 5.34 mΩ-cm2 to 1.59V and 7.1 mΩ-cm2 respectively. This increase is attributed to the accumulation of Mg and MgO at the Cr2O3/Ga2O3 interface as observed from TOF-SIMS analysis. These findings inform future design strategies of UWBG semiconductor devices for harsh environment operation and underscore the need for further reliability assessments for β-Ga2O3 based devices. © 2024, CC BY.

关键词： Gallium compounds

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