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Clinical "MUTATOME" Of Myelodysplastic Syndrome;Comparison To Primary Acute Myelogenous Leukemia

BLOOD 2013年第21期122卷 518-518页

作者： Makishima, Hideki LaFramboise, Thomas Przychodzen, Bartlomiej P. Yoshida, Kenichi Ruffalo, Matthew Gomez-Segui, Ines Husseinzadeh, Holleh D. Shiraishi, Yuichi Sanada, Masashi Nagata, Yasunobu Sato, Yusuke Sato-Otsubo, Aiko Chiba, Kenichi Tanaka, Hiroko Nakamaki, Tsuyoshi Hofmann, Wolf-Karsten Miyawaki, Shuichi Shih, Lee-Yung Chiba, Shigeru Miyano, Satoru Hosono, Naoko Polprasert, Chantana Thota, Swapna Dienes, Brittney Guinta, Kathryn M. Sauntharatajah, Yogen Sekeres, Mikkael A. Ogawa, Seishi Maciejewski, Jaroslaw P. Translational Hematology and Oncology Research Cleveland Clinic Taussig Cancer Institute Cleveland OH USA Department of Electrical Engineering and Computer Science Case Western Reserve University Cleveland OH USA Department of Pathology and Tumor biology Kyoto University Kyoto Japan Electrical Engineering and Computer Science Case Western Reserve University Cleveland OH USA Hematology Department University Hospital La Fe Valencia Spain Laboratory of DNA Information Analysis Human Genome Center Institute of Medical Science The University of Tokyo Tokyo Japan Department of Pathology and Tumor Biology Graduate School of Medicine Kyoto University Kyoto Japan Cancer Genomics Project Graduate School of Medicine The University of Tokyo Tokyo Japan Laboratory of Sequence Data Analysis Human Genome Center Institute of Medical Science The University of Tokyo Tokyo Japan Division of Hematology Department of Medicine Showa University School of Medicine Tokyo Japan Department of Hematology and Oncology University Hospital Mannheim Mannheim Germany Division of Hematology Department of Internal Medicine Tokyo Metropolitan Ohtsuka Hospital Tokyo Japan Chang Gung Memorial Hospital Taoyuan Taiwan Department of Hematology Faculty of Medicine University of Tsukuba Tsukuba Japan

Chromosomal aberrations and somatic mutations constitute key elements of the pathogenesis of myelodysplastic syndromes (MDS), a clonal hematologic malignancy characterized by cytopenias, a dysplastic bone marrow and propensity to clonal evolution. Next generation sequencing (NGS) enables definition of somatic mutational patterns and clonal architecture as a discovery platform, and for clinical applications. We systematically applied NGS to 707 cases of MDS and MDS-related disorders. 205 cases (low-risk MDS: N=78, high-risk MDS: N=42, MDS/MPN: N=48 and sAML: N=37) were tested by whole exome sequencing (WES). For validation in an additional 502 patients (low-risk MDS: N=192, high-risk MDS: N=104, MDS/MPN: N=111 and sAML: N=95), targeted deep NGS was applied for 60 index genes which were most commonly affected in the cohort analyzed by WES. For NGS data analysis a statistical pipeline was developed to focus on: i) identification of the most relevant somatic mutations, and ii) minimization of false positive results. We studied serial samples from 21 exemplary informative patients. We also compared somatic mutational patterns to those seen in primary AML TCGA cohort (N=201). Given the size of the cohort, there was, for example, a 87% chance of seeing mutations at a frequency of 1% and a 98% of seeing those with a frequency of 2%. While focusing on the most common events, we observed 1117 somatic mutations in 199 genes. The 88 genes mutated mutated in >1% of cases with MDS carried 388 mutations in MDS+sAML (2.5/case), 128 in MDS/MPN (2.7/case) and 398 in pAML (2.0/case). The average number of mutations per case increased during progression (2.2 in lower-risk, 2.8 in higher-risk MDS, 3.4 in sAML). In MDS, the 30 most frequently affected genes were present at least once in 70% of patients. The 30 most frequently mutated genes in MDS/MPN were mutated in 82% of patients. Individual mutations were also sub-grouped according to their function. When we compared three MDS subcate

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Application of PID retuning method for laboratory feedback control system incorporating FO dynamics

Application of PID retuning method for laboratory feedback c...

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International Carpathian control Conference (ICCC)

作者： L'ubomír Dorčák Emmanuel Gonzalez Ján Terpák Ivo Petráš Juraj Valsa Monika Žecová Institute of Control and Informatization of Production Processes Faculty BERG Technical University of Košice Kosice Slovakia Center for Automation Research College of Computer Studies De La Salle University Manila Philippines Faculty of Electrical Engineering and Computer Science Brno University of Technology Brno Czech Republic

Real objects in general are fractional-order (FO) systems, although in some types of systems the order is very close to integer order (IO). Since major advances have been made in the theory and practice of the identification of FO controlled objects and in the design of FO controllers, it is possible to consider also the real order of the dynamical systems and consider more quality criterion while designing the FO controllers with more degrees of freedom compared to their IO counterparts. In this paper, we present an application of the retuning method to design and apply new FO controller for the existing laboratory feedback control system with no modifications in the internal architecture of the original feedback control system. Along with the mathematical description, presented are also simulation results.

关键词： Closed loop systems Feedback control Mathematical model Laboratories Educational institutions PD control

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Fuzzy Filter Design for Discrete-Time Delayed Systems with Distributed Probabilistic Sensor Faults

Fuzzy Filter Design for Discrete-Time Delayed Systems with D...

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American control Conference

作者： Xiaojie Su Peng Shi Ligang Wu Hamid Reza Karimi Space Control and Iner-tial Technology Research Center Harbin Institute of Technology Harbin 150001 China School of Electrical and Electronic Engineering University of Adelaide SA 5005 Australia and the College of Engineering and Science Victoria University Melbourne VIC 8001 Australia Department of Engineering Faculty of Engineering and Science University of Agder N-4898 Grimstad Norway

ISBN: (纸本)9781479901777

In this paper, the problem of distributed fuzzy filter design has been solved for T-S fuzzy systems with time-varying delays and multiple probabilistic packet losses. Our attention is paid to designing the distributed fuzzy filters to guarantee the filtering error dynamic system to be meansquare asymptotically stable with an average H_∞ performance. Sufficient conditions for the obtained filtering error dynamic system are proposed by applying a comparison model and the scaled small gain theorem. Based on the measurements and estimates of the system states for each sensor and its neighbors, the solution of the parameters of the distributed fuzzy filters is characterized in terms of the feasibility of a convex optimization problem.

关键词： Distributed Probabilistic Sensor Faults filtering error dynamic system convex optimization problem fuzzy filter small gain theorem Distribute Convex function Dynamic systems Sensors Packet loss Fuzzy systems discrete-time

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Enhanced fluorescence emission of helium atoms by seeded optically driven impact excitation

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Physical Review A 2013年第1期88卷 013418-013418页

作者： Liping Shi Wenxue Li Dongbi Bai Hui Zhou Di Wang Liang'en Ding Heping Zeng State Key Laboratory of Precision Spectroscopy East China Normal University Shanghai 200062 People's Republic of China Shanghai Key Laboratory of Modern Optical System Engineering Research Center of Optical Instrument and System Ministry of Education School of Optical-Electrical and Computer Engineering University of Shanghai for Science and Technology Shanghai 200093 People's Republic of China

We demonstrated enhancement of fluorescence emission from helium atoms in terms of ultraviolet and infrared filaments nonlinear interaction in a mixture of argon and helium atomic gases. The seed electrons produced by ultraviolet pulses were accelerated by infrared filaments to kick a significant amount of helium atoms into high-lying excited states. This provided a method to efficiently excite helium atoms through electron collisions for further investigation on electron-ion collisions and their effects on atomic coherence behavior.

关键词： Fluorescence

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Thermal and optical characterization for POLARBEAR-2 optical system 7

Thermal and optical characterization for POLARBEAR-2 optical...

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Millimeter, Submillimeter, and Far-Infrared Detectors and Instrumentation for Astronomy VII

作者： Inoue, Y. Stebor, N. Ade, P.A.R. Akiba, Y. Arnold, K. Anthony, A.E. Atlas, M. Barron, D. Bender, A. Boettger, D. Borrilll, J. Chapman, S. Chinone, Y. Cukierman, A. Dobbs, M. Elleflot, T. Errard, J. Fabbian, G. Feng, C. Gilbert, A. Halverson, N.W. Hasegawa, M. Hattori, K. Hazumi, M. Holzapfel, W.L. Hori, Y. Jaehnig, G.C. Jaffe, A.H. Katayama, N. Keating, B. Kermish, Z. Keskitalo, Reijo Kisner, T. Le Jeune, M. Lee, A.T. Leitch, E.M. Linder, E. Matsuda, F. Matsumura, T. Meng, X. Morii, H. Myers, M.J. Navaroli, M. Nishino, H. Okamura, T. Paar, H. Peloton, J. Poletti, D. Rebeiz, G. Reichardt, C.L. Richards, P.L. Ross, C. Schenck, D.E. Sherwin, B.D. Siritanasak, P. Smecher, G. Sholl, M. Steinbach, B. Stompor, R. Suzuki, A. Suzuki, J. Takada, S. Takakura, S. Tomaru, T. Wilson, B. Yadav, A. Yamaguchi, H. Zahn, O. Astro Particule et Cosmologie Univ Paris Diderot CNRS Sorbonne Paris Cite France Center for Astrophysics and Space Astronomy University of Colorado BoulderCO80309 United States Computational Cosmology Center Lawrence Berkeley National Laboratory BerkeleyCA94720 United States Department of Astronomy and Astrophysics University of Chicago ChicagoIL60637 United States Department of Astrophysical and Planetary Sciences University of Colorado BoulderCO80309 United States Department of Electrical and Computer Engineering University of California San DiegoCA92093 United States Department of Physics and Atmospheric Science Dalhousie University HalifaxNSB3H4R2 Canada Department of Physics Imperial College London LondonSW72AZ United Kingdom Department of Physics Princeton University PrincetonNJ08544 United States Department of Physics University of California BerkeleyCA94720 United States Department of Physics University of California San DiegoCA92093-0424 United States Department of Physics University of Colorado BoulderCO80309 United States High Energy Accelerator Research Organization Tsukuba Ibaraki305-0801 Japan Institute of Space and Astronautical Science Japan Aerospace Exploration Agency 3-1-1 Yoshinodai Sagamihara Kanagawa252-5210 Japan International School for Advanced Studies Trieste34014 Italy Kavli Institute for Cosmological Physics University of Chicago ChicagoIL60637 United States Kavli Institute for the Physics Todai Institutes for Advanced Study University of Tokyo Kashiwa Chiba277-8583 Japan Miller Institute for Basic Research in Science University of California BerkeleyCA94720 United States National Institute for Fusion Science Toki Japan Osaka University Toyonaka Osaka560-0043 Japan Physics Department McGill University MontrealQCH3A0G4 Canada Physics Division Lawrence Berkeley National Laboratory BerkeleyCA94720 United States School of Physics and Astronomy Cardiff University CardiffCF103XQ United King

ISBN: (纸本)9780819496218

POLARBEAR-2 (PB-2) is a cosmic microwave background (CMB) polarization experiment for B-mode detection. The PB-2 receiver has a large focal plane and aperture that consists of 7588 transition edge sensor (TES) bolometers at 250 mK. The receiver consists of the optical cryostat housing reimaging lenses and infrared filters, and the detector cryostat housing TES bolometers. The large focal plane places substantial requirements on the thermal design of the optical elements at the 4K, 50K, and 300K stages. Infrared filters and lenses inside the optical cryostat are made of alumina for this purpose. We measure basic properties of alumina, such as the index of refraction, loss tangent and thermal conductivity. All results meet our requirements. We also optically characterize filters and lenses made of alumina. Finally, we perform a cooling test of the entire optical cryostat. All measured temperature values satisfy our requirements. In particular, the temperature rise between the center and edge of the alumina infrared filter at 50 K is only 2:0 ± 1:4 K. Based on the measurements, we estimate the incident power to each thermal stage. © 2014 SPIE.

关键词： Bolometers

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Subcranial magnetic stimulation: a novel method of focal, non-invasive deep brain neuromodulation for the treatment of post-traumatic stress disorder.

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Brain Stimulation 2014年第2期7卷 e15-e16页

作者： Jonathan R. Young Artem Rozkov Zhao Li Oliver Young Tim Barber Pascal Wallisch Stony Brook University School of Medicine Stony Brook NY 11790 USA Cognitive Neurophysiology Research Group Department of Neurology New York University School of Medicine New York NY 10016 USA NeuTx Research Group Stony Brook NY 11790 USA Department of Electrical and Computer Engineering Polytechnic Institute of New York University Brooklyn NY 11201 USA Computational Neuroimaging Laboratory Center for Neural Science Department of Psychology New York University New York NY 10003 USA

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Corrigendum to “An analytical approach to calculate effective channel length in graphene nanoribbon field effect transistors” [Microelectron. Reliab. 53 (4) (2013) 540–543]

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Microelectronics Reliability 2014年第3期54卷 662-662页

作者： M. Ghadiry M. Nadi M. Bahadoran Asrulnizam ABD Manaf H. Karimi Hatef Sadeghi School of Electrical and Electronic Engineering Engineering Campus Universiti Sains Malaysia Penang Malaysia Department of Computer Engineering Ashtian Branch IAU Ashtian Iran Institute of Advanced Photonics Science Nanotechnology Research Alliance Universiti Teknologi Malaysia 81310 Johor Bahru Malaysia Japan International Institute of Technology (MJIIT) Universiti Teknologi Malaysia 54100 Kuala Lumpur Malaysia Lancaster Quantum Technology Center Physics Department Lancaster University LA1 4YB Lancaster UK

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Investigation of conduction mechanism in Ti/Si3N4/p-Si stacked RRAM

Investigation of conduction mechanism in Ti/Si3N4/p-Si stack...

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IEEE International Nanoelectronics Conference (INEC)

作者： Sunghun Jung Sungjun Kim Jeong-Hoon Oh Kyung-Chang Ryoo Jong-Ho Lee Hyungcheol Shin Byung-Gook Park Inter-university Semiconductor Research Center (ISRC) and School of Electrical Engineering and Computer Science Seoul National University Seoul South Korea DRAM Process Architecture Team Memory Division Semiconductor Business Samsung Electronics Company Limited Yongin Gyeonggi South Korea

The conduction mechanism in Ti/Si 3 N 4 /p-Si memory stack is described. In order to analyze the conduction mechanism, we measured the I-V characteristics in voltage sweep mode and conducted I-V curve fitting. And the temperature dependence in Ti/Si 3 N 4 /p-Si stacked cell is also investigated because we cannot claim the conduction mechanism just based on the I-V curve fitting. From I-V curve fitting and temperature measurement data, we found that space charge limited conduction (SCLC) model is well fitted in both high resistance state (HRS) and low resistance state (LRS).

关键词： Decision support systems Nanoelectronics Conferences

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Nanoindentation investigation of the reactive pulsed laser deposited superconducting niobium nitride thin films

Nanoindentation investigation of the reactive pulsed laser d...

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142nd Annual Meeting and Exhibition: Linking science and Technology for Global Solutions, TMS 2013

作者： Mamun, M.A. Farha, A.H. Ufuktepe, Y. Kimura, S.I. Hajiri, T. Imura, K. Karadag, F. Elsayed-Ali, H.E. Elmustafa, A.A. Department of Mechanical and Aerospace Engineering Old Dominion University Norfolk VA 23529 United States Department of Electrical and Computer Engineering Old Dominion University Norfolk VA 23529 United States Department of Physics Cukurova University Adana 01330 Turkey UVSOR Facility Institute for Molecular Science Okazaki 444-8585 Japan Okazaki 444-8585 Japan Graduate School of Engineering Nagoya University Nagoya 464-8601 Japan Department of Physics Nagoya University Nagoya 464-8601 Japan Applied Research Center Thomas Jefferson National Accelerator Facility Newport News VA 23606 United States

ISBN: (纸本)9781118605813

Nanomechanical properties were investigated for the reactive pulsed laser deposited (PLD) superconducting NbNx thin films grown on Si(100) at constant substrate temperature of 800°C using three different background nitrogen gas pressures (200, 400 and 500 mTorr). The Cross-sectional transmission electron microscopy (TEM), X-ray diffraction (XRD), and atomic force microscopy (AFM) were employed to characterize the films' surface structure and morphology. Superconductivity was determined by performing resistance measurements. Nanoindentation technique was used to evaluate the hardness and modulus of the films. The results indicate that the background pressure impacted the crystalline quality, morphology, superconductivity and the hardness of the films. As the background pressure increases to 500 mTorr, improved superconducting properties and higher hardness (17.5±1.5 GPa at 20 nm depth) values were reported as compared to the other two samples.

关键词： Atomic force microscopy

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Robust experiment design for system identification via semi-infinite programming techniques

Robust experiment design for system identification via semi-...

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Universite Libre de Bruxelles

作者： Katselis, Dimitrios Rojas, Cristian R. Welsh, James S. Hjalmarsson, Hakan Automatic Control Lab. and ACCESS Linnaeus Center Electrical Engineering KTE Royal Institute of Technology S-100 44 Stockholm Sweden School of Electrical Engineering and Computer Science University of Newcastle NSW 2308 Australia

ISBN: (纸本)9783902823069

Robust optimal experiment design for dynamic system identification is cast as a minmax optimization problem, which is infinite-dimensional. If the input spectrum is discretized (either by considering a Riemmann approximation, or by restricting it to the span of a finite dimensional linear space), this problem falls within the class of semi-infinite convex programs. One approach to this optimization problem of infinite constraints is the so called "scenario approach", which is based on a probabilistic description of the uncertainty to deliver a finite program that attempts to approximate the optimal solution with a prescribed probability. In this paper, we propose as an alternative an exchange algorithm based on some recent advances in the field of semi-infinite programming to tackle the same problem. This method is compared with the scenario approach both from the aspects of accuracy and computational efficiency. Furthermore, the comparison includes the MATLAB semi-infinite solver fseminf to provide a general palette of methods approximating the robust optimal design problem. © 2012 IFAC.

关键词： Computational efficiency

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