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Transferrin-Mediated Nanophotosensitizer to Enhance Phototherapy with Photoacoustic Imaging Under Hypoxia

CCS Chemistry 2025年第4期7卷 1127-1141页

作者： Mengyao Yang Yunyoung Nah Donghyeon Oh Xingshu Li Heejeong Kim Sinyoung Park Junha Lim Aibing Chen Chulhong Kim Won Jong Kim Juyoung Yoon College of Chemical and Pharmaceutical Engineering Hebei University of Science and TechnologyShijiazhuang 050018 Department of Chemistry and Nanoscience Ewha Womans UniversitySeoul 03760 Department of Chemistry POSTECH-Catholic Biomedical Engineering InstitutePOSTECHPohang 37673 Department of Electrical Engineering Convergence IT EngineeringMechanical Engineeringand Medical Science and EngineeringMedical Device Innovation CenterPOSTECHPohang 37673 Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy College of ChemistryFuzhou UniversityFuzhou 350108 School of Interdisciplinary Bioscience and Bioengineering POSTECHPohang 37673 Graduate Program in Innovative Biomaterials Convergence Ewha Womans UniversitySeoul 03760

Various obstacles[poor tissue penetration,hypoxic tumor microenvironment,and reactive oxygen species(ROS)production quenching due to aggregation]obstruct imaging-guided high-efficiency phototherapy targeting ***,nanophthalocyanine(ZnPcN4-TF)is elaborately designed based on a synthetic phthalocyanine derivative(ZnPcN4)and nonimmunogenic transferrin(TF)through multiple noncovalent interactions for photoacoustic(PA)imaging-guided *** conjugating electron-rich amino groups effectively suppressed fluorescence and ROS generation due to the strong photoinduced electron transfer effect,ZnPcN4 became an ideal photothermal and PA imaging ***4-TF not only effectively targeted tumor sites and accumulated there,but also,surprisingly,facilitated the enhancement of ROS production via a type I process in an aggregate compared to ZnPcN4 itself,potentially due to accelerated electron ***,ZnPcN4-TF had a substantially more powerful photothermal effect than ZnPcN4 ***,this design effectively overcomes the obstacles to photodynamic therapy(aggregation-related ROS generation quenching in a hypoxic environment).Furthermore,PA imaging solves the tissue penetration challenge in optical *** study provides a broader base for designing novel photosensitizers to improve phototherapy under hypoxia.

关键词： photoacoustic imaging type I reactive oxygen species photothermal effect tumor accumulation self-assembly

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Vectorial liquid‑crystal holography

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eLight 2024年第1期4卷 251-261页

作者： Ze‑Yu Wang Zhou Zhou Han Zhang Yang Wei Hong‑Guan Yu Wei Hu Wei Chen Hai‑Tao Dai Ling‑Ling Ma Cheng‑Wei Qiu Yan‑Qing Lu National Laboratory of Solid State Microstructures Key Laboratory of Intelligent Optical Sensing and ManipulationCollaborative Innovation Center of Advanced MicrostructuresCollege of Engineering and Applied SciencesNanjing UniversityNanjing 210023China Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology School of ScienceTianjin UniversityTianjin 300072China

Vectorial optics with fine inhomogeneous polarization control are highly *** have been captivated a promising candidate,but their static post-fabrication geometry largely limits the dynamic *** crystal(LC)is usually employed as an additional index-changing layer together with ***,most of the reported LCs only impart a varying but uniform phase on top of that from the metasurface,which we term“scalar”LC ***,we pixelate a single-layer LC to display versatile and tunable vectorial holography,in which the polarization and amplitude could be arbitrarily and independently controlled at varying spatial ***,the subtle and vectorial LC-holography highlights the broadband and electrically-switchable *** vectorial LC holography reveals significant opportunities for advanced cryptography,super-resolution imaging,and many other applications.

关键词： Liquid crystals Vectorial optics Holography

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Predicting Compound-Protein Interaction by Deepening the Systemic Background via Molecular Network Feature Embedding

Predicting Compound-Protein Interaction by Deepening the Sys...

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2022 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2022

作者： Wang, Han Zhu, Hangxu Li, Wenhao Liu, Ming Zhang, Li Xu, Dong Institute of Computational Biology Northeast Normal University School of Information Science and Technology Changchun China Changchun University of Technology School of Mathematics and Statistics School of Computer Science and Engineering Changchun China University of Missouri Bond Life Sciences Center Department of Electrical Engineering and Computer Science Columbia United States

ISBN: (纸本)9781665468190

Identifying compound-protein interactions (CPI) is crucial for drug screening, drug repurposing, and combination therapy studies. The performance of CPI prediction depends heavily on the features extracted from compounds and target proteins. The existing prediction methods use different feature combinations, but both molecular-based and network-based models have the problem of incomplete feature representations. Therefore, completely integrating the relevant features of CPI would be an effective way to solve the existing problem. This study proposed a novel model named MCPI, which integrated the PPI (protein-protein interaction) network, CCI (compound-compound interaction) network, and structure features of CPI to improve prediction performance. We compared our model with other existing methods for predicting CPI on public datasets. The experimental results showed that MCPI outperformed the peer methods. In addition, in response to the SARS-CoV-2 pandemic, we applied the model to search for potential inhibitors among FDA-approved drugs and validated the prediction results through the literature. This work may also provide potential guidance for drug development. © 2022 IEEE.

关键词： Coronavirus

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Topological Landau–Zener nanophotonic circuits

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Advanced Photonics 2023年第3期5卷 127-134页

作者： Bing-Cong Xu Bi-Ye Xie Li-Hua Xu Ming Deng Weijin Chen Heng Wei Fengliang Dong Jian Wang Cheng-Wei Qiu Shuang Zhang Lin Chen Huazhong University of Science and Technology School of Optical and Electronic InformationWuhan National Laboratory for OptoelectronicsWuhanChina The Chinese University of Hong Kong School of Science and EngineeringShenzhenChina CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of ChinaNanofabrication LaboratoryCAS Key Laboratory for Nanosystems and Hierarchical FabricationCAS Key Laboratory for Nanophotonic Materials and DevicesBeijingChina National University of Singapore Department of Electrical and Computer EngineeringSingapore University of Chinese Academy of Sciences Center of Materials Science and Optoelectronics EngineeringBeijingChina The University of Hong Kong Department of PhysicsHong KongChina Peking University School of PhysicsState Key Laboratory for Mesoscopic PhysicsBeijingChina

Topological edge states(TESs),arising from topologically nontrivial phases,provide a powerful toolkit for the architecture design of photonic integrated circuits,since they are highly robust and strongly localized at the boundaries of topological *** is highly desirable to be able to control TES transport in photonic *** the coupling between the TESs in a finite-size optical lattice is capable of exchanging light energy between the boundaries of a topological lattice,hence facilitating the flexible control of TES ***,existing strategies have paid little attention to enhancing the coupling effects between the TESs through the finite-size ***,we establish a bridge linking the interaction between the TESs in a finite-size optical lattice using the Landau–Zener model so as to provide an alternative way to modulate/control the transport of topological *** experimentally demonstrate an edge-to-edge topological transport with high efficiency at telecommunication wavelengths in silicon waveguide *** results may power up various potential applications for integrated topological photonics.

关键词： topological edge states finite-size effect Landau-Zener model edge-to-edge topological transport nanophotonic integrated circuits

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Quality of Control based Resource Dimensioning for Collaborative Edge Robotics

arXiv

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arXiv 2024年

作者： Roy, Neelabhro Dhullipalla, Mani H. Sharma, Gourav Prateek Dimarogonas, Dimos V. Gross, James School of Electrical Engineering and Computer Science Digital Futures Research Center KTH Royal Institute of Technology Stockholm Sweden

With the increasing focus on flexible automation, which emphasizes systems capable of adapting to varied tasks and conditions, exploring future deployments of cloud and edge-based network infrastructures in robotic systems becomes crucial. This work, examines how wireless solutions could support the shift from rigid, wired setups toward more adaptive, flexible automation in industrial environments. We provide a quality of control (QoC) based abstraction for robotic workloads, parameterized on loop latency and reliability, and jointly optimize system performance. The setup involves collaborative robots working on distributed tasks, underscoring how wireless communication can enable more dynamic coordination in flexible automation systems. We use our abstraction to optimally maximize the QoC ensuring efficient operation even under varying network conditions. Additionally, our solution allocates the communication resources in time slots, optimizing the balance between communication and control costs. Our simulation results highlight that minimizing the delay in the system may not always ensure the best QoC but can lead to substantial gains in QoC if delays are sometimes relaxed, allowing more packets to be delivered reliably. © 2024, CC BY-NC-SA.

关键词： Collaborative robots

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Emergence of composite many-body exciton states in WS2 and MoSe2 monolayers

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Physical Review B 2024年第4期109卷 L041304-L041304页

作者： J. Choi J. Li D. Van Tuan H. Dery S. A. Crooker National High Magnetic Field Laboratory Los Alamos New Mexico 87545 USA Advanced Instrumentation Institute Korea Research Institute of Standards and Science Daejeon 34113 Korea Wuhan National High Magnetic Field Center and School of Physics Huazhong University of Science and Technology Hubei 430074 China Department of Electrical and Computer Engineering University of Rochester Rochester New York 14627 USA Department of Physics and Astronomy University of Rochester Rochester New York 14627 USA

When doped with a high density of mobile charge carriers, monolayer transition-metal dichalcogenide (TMD) semiconductors can host new types of composite many-particle exciton states that do not exist in conventional semiconductors. Such multiparticle bound states arise when a photoexcited electron-hole pair couples not to just a single Fermi sea that is quantum-mechanically distinguishable (as in the case of conventional charged excitons or trions), but rather couples simultaneously to multiple Fermi seas, each having distinct spin and valley quantum numbers. Composite six-particle “hexciton” states were recently identified in electron-doped WSe2 monolayers, but under suitable conditions they should also form in all other members of the monolayer TMD family. Here we present spectroscopic evidence demonstrating the emergence of many-body hexcitons in charge-tunable WS2 monolayers (at the A-exciton) and MoSe2 monolayers (at the B-exciton). The roles of distinguishability and carrier screening on the stability of hexcitons are discussed.

关键词： Excitons Trions Transition metal dichalcogenides Two-dimensional electron system

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LanCOPE: Language-Guided Category-Level Object Pose Estimation from a Single RGB Image

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IEEE Robotics and Automation Letters 2025年第7期10卷 7555-7562页

作者： Yang, Hui Sun, Wei Liu, Jian Zheng, Jin Dai, Zhenqi Mian, Ajmal Hunan University National Engineering Research Center for Robot Visual Perception and Control Technology College of Electrical and Information Engineering State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body Changsha 410082 China Central South University School of Architecture and Art Changsha 410082 China The University of Western Australia Department of Computer Science and Software Engineering 6009 WA Australia

Monocular RGB-based category-level object pose estimation is more practical and cost-effective for robotics. However, existing methods do not fully exploit the rich semantic and contextual information in multimodal data (e.g. language) that provides additional object attributes to guide the model in extracting category features more reliably. We propose a language-guided category-level object pose estimation method (LanCOPE), taking a single RGB image as input. Our method uses DINOv2 to recover depth from a single RGB image and converts it into point cloud to perceive the object's geometry. We then introduce language descriptions for the RGB image, estimated point cloud and overall scene to better guide the point cloud encoder and image encoder in learning category features. We develop a cross-modal differential perception feature fusion network to fuse multimodal features. This network employs a differential perception module to eliminate redundant information across different modalities, highlighting signifcant semantic differences and similarities. Furthermore, it uses a cross-attention mechanism to fuse the semantic information of the language and vision features, improving the overall perception. Finally, we design a denoising network based on the skip fusion transformer to recover the object pose accurately. Extensive experiments on REAL275 and Wild6D datasets show that LanCOPE achieves state-of-the-art performance. Our code is available at LanCOPE. © 2016 IEEE.

关键词： category-level object pose estimation languag RGB image

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On the Outage of Far-Reach Communications via RIS-Empowered Satellites

On the Outage of Far-Reach Communications via RIS-Empowered ...

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2024 IEEE Pacific Rim Conference on Communications, computers and Signal Processing, PACRIM 2024

作者： Wang, Fan Jiang, Ruihong Liu, Yuan Bao, Tingnan Peng, Mugen Beijing University of Posts and Telecommunications State Key Laboratory of Networking and Switching Technology Beijing100876 China Research Center for Space Computing System Zhejiang Laboratory Hangzhou311100 China School of Electrical Engineering and Computer Science University of Ottawa OttawaON Canada

ISBN: (纸本)9798350362312

The rising demand for reliable, high-bandwidth satellite communications in far-reach areas drives the integration of low earth orbit (LEO) satellites into future 6G networks. In this paper, we investigate the deployment of reconfigurable intelligent surface (RIS) technology and rate splitting multiple access (RSMA) within LEO satellite systems to improve communication quality and system capacity. We derive closed-form expressions for outage probability (OP) and reliable throughput that validate the theoretical advantages of these technologies under various signal-to-noise ratio conditions. Numerical results demonstrate that, compared with traditional space division multiple access (SDMA) and non-orthogonal multiple access (NOMA) approaches, our RSMA and RIS-integrated framework significantly can reduce OP and enhance reliable throughput with an appropriate power-splitting factor, showcasing its superiority in RIS-enabled satellite communication scenarios. © 2024 IEEE.

关键词： Satellite communication systems

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Performance Evaluation of Coherent MIMO Radar Assisted with Space-Time Coding 9

Performance Evaluation of Coherent MIMO Radar Assisted with ...

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9th International Conference on computer and Communication engineering, ICCCE 2023

作者： Barakat, Mohammed Elmogtaba Saeed, Rashid A. Barakat, Mohammed Edam, Salaheldin Khalifa, Othman O. Sudan University of Science and Technology School of Electronics Engineering Khartoum Sudan Taif University College of Computers and Information Technology Department of Computer Engineering P.O. Box 11099 Taif21944 Saudi Arabia International Islamic University Malaysia Dept. of Electrical and Computer Engineering Malaysia Libyan Center for Engineering Research and Information Technology Bani Waleed Libya

ISBN: (纸本)9798350325218

Using multiple-input multiple-output (MIMO) technology has revolutionized the radar field by providing higher resolution, improved target detection, and reduced interference. However, interrupting signals can significantly degrade the Performance of MIMO radar systems to transmit and receive signals simultaneously;MIMO radar systems employ multiple antennas at the transmitter and receiver. This allows for improved spatial resolution and increased target detection capabilities. However, MIMO radar systems are susceptible to fading and interference, degrading performance. STC is a technique to mitigate these effects by transmitting multiple signals simultaneously from different antennas. This article evaluates the performance of space-time coding (STC) with coherent multiple-input multiple-output (MIMO) radar. The paper investigates the impact of STC on the radar system's detection and estimation capabilities in various scenarios, including target detection in cluttered environments and target tracking in the presence of interference. The simulation results demonstrate that STC can significantly improve the radar system's performance by reducing interference effects and increasing the signal-to-noise ratio. Furthermore, the study shows that different STC schemes have varying degrees of effectiveness depending on the specific scenario. Overall, this research provides valuable insights into the potential benefits of using STC with coherent MIMO radar for various applications. © 2023 IEEE.

关键词： Target tracking

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Trajectory tracking method of UAV based on discrete-time terminal sliding mode 41

Trajectory tracking method of UAV based on discrete-time ter...

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第41届中国控制会议

作者： Hao Guo Shuai Yue Bo Yu Haibo Du Shaoyu Lyu Xiaozheng Jin School of Electrical Engineering and Automation Hefei University of TechnologyHefeiAnhui 230009P.R.ChinaAnhui Province Engineering Research Center for Industrial AutomationHefei University of Technology College of Computer Science and Technology Qilu University of Technology

ISBN: (数字)9789887581536

ISBN: (纸本)9781665482561

Aiming at the problem of parameter uncertainty and external interference in the trajectory tracking of quadrotor unmanned aerial vehicle(UAV),a discrete-time fast terminal sliding mode control(FTSMC) scheme is proposed in this ***,the position model of the UAV is derived based on the dynamic equation,and the discrete-time model of the UAV is obtained and analyzed by Euler discretization ***,by introducing a new discrete-time fast terminal sliding mode surface,and designing the fast sliding mode terminal control rate based on equivalent control,the UAV can track the desired trajectory with small steady-state ***,in the experimental part,the feasibility and superiority of this scheme are verified by comparing with the traditional PID position control method.

关键词： quadrotor UAV track tracking discrete-time terminal sliding mode fast terminal sliding mode

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