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Respiratory syncytial virus vaccine effectiveness among US veterans, September, 2023 to March, 2024: a target trial emulation study

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The Lancet Infectious Diseases 2025年第6期25卷 625-633页

作者： Bajema, Kristina L Yan, Lei Li, Yuli Argraves, Stephanie Rajeevan, Nallakkandi Fox, Alexandra Vergun, Robert Berry, Kristin Bui, David Huang, Yuan Lin, Hung-Mo Hynes, Denise M Lucero-Obusan, Cynthia Schirmer, Patricia Cunningham, Francesca Huang, Grant D Aslan, Mihaela Ioannou, George N Veterans Affairs Portland Health Care System Portland OR United States Division of Infectious Diseases Department of Medicine Oregon Health & Science University Portland OR United States Veterans Affairs Cooperative Studies Program Clinical Epidemiology Research Center Veterans Affairs Connecticut Health Care System West Haven CT United States Department of Biostatistics Yale School of Public Health New Haven CT United States Biomedical Informatics & Data Science Yale School of Medicine New Haven CT United States Department of Internal Medicine Yale School of Medicine New Haven CT United States Seattle Epidemiologic Research and Information Center Veterans Affairs Puget Sound Health Care System Seattle WA United States Research and Development Veterans Affairs Puget Sound Health Care System Seattle WA United States Center of Innovation to Improve Veteran Involvement in Care Veterans Affairs Portland Health Care System Portland OR United States Health Management and Policy College of Health Oregon State University Corvallis OR United States Health Data and Informatics Program Center for Quantitative Life Sciences Oregon State University Corvallis OR United States Public Health National Program Office Veterans Health Administration Palo Alto CA United States Public Health National Program Office Veterans Health Administration Washington DC United States Veterans Affairs Center for Medication Safety—Pharmacy Benefit Management Services Hines IL United States Office of Research and Development Veterans Health Administration Washington DC United States Division of Gastroenterology Veterans Affairs Puget Sound Health Care System and University of Washington Seattle WA United States

Background: New respiratory syncytial virus (RSV) vaccines have been approved in the USA for the prevention of RSV-associated lower respiratory tract disease in adults aged 60 years and older. information on the real-world effectiveness of these vaccines is needed. Methods: We used electronic health records in the Veterans Health Administration to emulate a target trial comparing a single dose of a recombinant stabilised prefusion F protein RSV vaccine versus no vaccination among veterans aged 60 years and older. We matched eligible vaccine recipients with up to four unvaccinated individuals in four monthly nested sequential trials from Sept 1 to Dec 31, 2023. Outcomes were ascertained up to March 31, 2024. The primary outcome was any positive RSV test from day 14 following the matched index date. Secondary outcomes included hospitalisation and emergency department or urgent care encounter occurring within 1 day before or after a positive RSV test. We estimated vaccine effectiveness as 100 × (1 – risk ratio). Findings: We included 146 852 vaccinated individuals matched to 582 936 unique control individuals, weighted equally to represent 146 852 individuals. Across the two groups, 276 039 (94·0%) of 293 704 veterans were male, 17 665 (6·0%) were female, and median age was 75·9 years (IQR 71·7–79·7). Over a median follow-up of 124 days (IQR 102–150), the incidence rate of documented RSV infection was 1·7 (95% CI 1·4–2·1) events per 1000 person-years (88 total events) in the vaccinated group and 7·3 (6·6–8·1) per 1000 person-years in the unvaccinated group (372 total events), and vaccine effectiveness was estimated as 78·1% (72·6–83·5). Among the secondary outcomes, vaccine effectiveness was estimated at 78·7% (72·2–84·8) against RSV-associated emergency department or urgent care encounters, and 80·3% (65·8–90·1) against RSV-associated hospitalisation. Interpretation: RSV vaccination was effective in preventing RSV-related illness, including associated health-care use,

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Evaluation of Cuffless Blood Pressure Estimation Accuracy at Each Heartbeat During Exercise 6th

Evaluation of Cuffless Blood Pressure Estimation Accuracy a...

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6th International Conference on Biomedical and Health Informatics, ICBHI 2024

作者： Ono, Kouki Maeda, Yuka Yoshimura, Takumi Huang, Ming Tamura, Toshiyo Master’s Program in Intelligent and Mechanical Interaction Systems University of Tsukuba Tsukuba305-8577 Japan Institute of Systems and Information Engineering University of Tsukuba Tsukuba305-8577 Japan Medical and Welfare Engineering Tokyo Metropolitan College of Industrial Technology Tokyo116-8523 Japan School of Data Science Nagoya City University Nagoya467-8501 Japan Future Robotics Organization Waseda University Tokyo169-8050 Japan

ISBN: (纸本)9783031863226

Continuous blood pressure monitoring is crucial because of its dynamic nature, influenced by factors such as physical activity and mental stress. Although cuffless blood pressure estimation is a promising technique for continuous monitoring, its accuracy during drastic fluctuations, especially during exercise, remains insufficiently validated. In this study, we evaluated a simple Pulse Arrival Time based blood pressure estimation method and several improved methods for sharp fluctuations induced by exercise. Sixteen subjects in the experiment, with data from 13 valid for analysis. The proposed method achieved an average correlation of 0.527 in systolic blood pressure, suggesting that cuffless blood pressure estimation could be applied to estimate continuous blood pressure variability during exercise. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2025.

关键词： Blood pressure

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DDPS: Dynamic Differential Pricing-Based Edge Offloading system With Energy Harvesting Devices

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IEEE Transactions on Network science and Engineering 2025年

作者： Xue, Hai Xia, Yun Xiong, Neal N. Zhang, Di Pei, Songwen University of Shanghai for Science and Technology School of Optical-Electrical and Computer Engineering Shanghai200093 China Sul Ross State University Department of Computer Science and Mathematics AlpineTX79830 United States Zhengzhou University School of Electrical and Information Engineering Zhengzhou450001 China Zhengzhou University Henan International Joint Laboratory of Intelligent Health Information System Zhengzhou450001 China Zhengzhou University National Engineering Laboratory for Internet Medical Systems and Applications Zhengzhou450001 China

Mobile edge computing (MEC) mitigates the energy and computation burdens on mobile users (MUs) by offloading tasks to the network edge. To optimize MEC server utilization through effective resource allocation, a well-designed pricing strategy is indispensable. In this paper, we propose a dynamic differential pricing scheme (DDPS) for an edge offloading scenario with energy harvesting devices, which determines prices based on computing resource usage to enhance edge server (ES) utilization. First, an offloading decision algorithm is proposed to balance harvested and consumed energy, determining whether and how much data to offload. Second, a Stackelberg game-based differential pricing algorithm is proposed to optimize computing resource allocation for MUs and reallocate surplus resources to delay-sensitive devices. Extensive simulations are conducted to demonstrate the effectiveness of the proposed DDPS scheme. Specifically, in comparison to the existing best-performing pricing scheme, for different task arrival rates, DDPS can achieve a 5.3% decrease in average execution delay, a 1.7% increase in ES utility (Userver, which represents the payment from MUs minus penalties for discarded tasks), and a 2.1% increase in the average ratio of service for MUs. In addition, DDPS also improves 2.8% Userver on average with different ES computation capacities. © 2025 IEEE. All rights reserved.

关键词： Mobile edge computing

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Data-driven soft constrained model predictive control for sludge bulking in wastewater treatment process

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Journal of Process Control 2025年 151卷

作者： Han, Hong-Gui Wang, Yan Sun, Hao-Yuan Liu, Zheng Qiao, Jun-Fei School of Information Science and Technology Beijing University of Technology Beijing100124 China Beijing Key Laboratory of Computational Intelligence and Intelligent System Beijing100124 China Engineering Research Center of Digital Community Ministry of Education Beijing100124 China Beijing Laboratory of Smart Environmental Protection Beijing100124 China

The complex causes of sludge bulking, strict system constraints, and dynamic operating conditions increase the challenges of controlling wastewater treatment process. To address this issue, a data-driven soft constrained model predictive control (DD-SCMPC) strategy is proposed, which can adaptively adjust the control law in response to the identified fault cause. First, an intelligent diagnosis algorithm is utilized to identify the key cause variable according to the relative reconstruction contribution of process variables. Consequently, the priority control order of the controlled variables can be determined based on the correlation between the cause variable and output variables. Second, a soft constrained MPC strategy is designed to regulate the concentrations of dissolved oxygen and nitrate nitrogen in accordance with the predetermined control order, thereby avoid sludge bulking caused by abnormal process variables. The incorporation of soft constraints alleviates the strict constraints on system outputs, enhancing the adaptability of the controller. Third, a predictive control barrier function is designed to obtain an enlarged attractive domain, ensuring the stability of the system under soft constraints. Then, the feasibility and stability analysis provide theoretical support for the application of DD-SCMPC. Finally, the effectiveness of the proposed DD-SCMPC strategy is verified on the benchmark simulation model 1. © 2025 Elsevier Ltd

关键词： Predictive control systems

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Dual Encoders for Diffusion-based Image Inpainting

Dual Encoders for Diffusion-based Image Inpainting

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International Conference on Acoustics, Speech, and Signal Processing (ICASSP)

作者： Dezhi Zheng Kaijun Deng Jinbao Wang Linlin Shen Computer Vision Institute School of Computer Science and Software Engineering Shenzhen University Shenzhen China National Engineering Laboratory for Big Data System Computing Technology Shenzhen University Shenzhen China Guangdong Provincial Key Laboratory of Intelligent Information Processing Shenzhen China

ISBN: (数字)9798350368741

ISBN: (纸本)9798350368758

Current diffusion-based inpainting models struggle to preserve unmasked regions or generate highly coherent content. Additionally, it is hard for them to generate meaningful content for 3D inpainting. To tackle these challenges, we design a plug-and-play branch that runs through the entire generation process to enhance existing models. Specifically, we utilize dual encoders - a Convolutional Neural Network (CNN) encoder and the pre-trained Variational AutoEncoder (VAE) encoder, to encode masked images. The latent code and the feature map from the dual encoders are fed to diffusion models simultaneously. In addition, we apply Zero-padded initialization to solve the problem of mode collapse caused by this branch. Experiments on BrushBench and EditBench demonstrate that models with our plug-and-play branch can improve the coherence of inpainting, and our model achieves new state-of-the-art results.

关键词： Visualization Three-dimensional displays Codes Autoencoders Coherence Signal processing Diffusion models Decoding Convolutional neural networks Speech processing

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Unsupervised Multivariate Time Series Anomaly Detection by Feature Decoupling in Federated Learning Scenarios

IEEE Transactions on Artificial Intelligence

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IEEE Transactions on Artificial Intelligence 2025年

作者： He, Yifan Ding, Xi Tang, Yateng Guan, Jihong Zhou, Shuigeng Fudan University School of Computer Science Shanghai200433 China Shanghai Key Laboratory of Intelligent Information Processing Shanghai200433 China Tencent Weixin Group Guangzhou510308 China Tongji University Department of Computer Science and Technology Shanghai201804 China Ministry of Education Key Laboratory of Embedded System and Service Computing Tongji University Shanghai200092 China

Anomalies are usually regarded as data errors or novel patterns previously unseen, which are quite different from most observed data. Accurate detection of anomalies is crucial in various application scenarios. This paper focuses on unsupervised anomaly detection from Multivariate Time Series (MTS), as real-world data collected from sources such as wearable devices, medical equipment and industrial machines typically manifest as MTS and are often unlabeled. Anomaly detection in MTS represents a data-driven challenge that traditionally requires substantial centralized data for training models. However, in practice, data are frequently distributed among multiple institutions, with privacy concerns restricting unrestricted access. To address these issues, we introduce Feature Decoupling Federated Learning (FDFL), an approach designed to collaboratively train a representation learning network over multiple clients for unsupervised anomaly detection in MTS. Unlike previous methods that simply integrate MTS anomaly detection algorithms with federated learning strategies, FDFL specifically addresses heterogeneity among clients by decoupling the representation network into shared and private branches through a contrastive learning mechanism. This method aggregates shared parameters during each federated round while maintaining client-specific private parameters locally. Additionally, we develop a self-attention block that integrates the representations derived from both shared and private parameters to reconstruct MTS and identify anomalies based on reconstruction errors. Extensive experiments conducted on three publicly available datasets demonstrate that FDFL outperforms existing algorithms in most cases, highlighting the effectiveness and superiority of our proposed method in MTS anomaly detection. © 2020 IEEE.

关键词： Federated learning

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Secure-by-Construction Synthesis for Control systems

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IEEE Transactions on Automatic Control 2025年第6期70卷 4170-4177页

作者： Zhong, Bingzhuo Liu, Siyuan Caccamo, Marco Zamani, Majid Thrust of Artificial Intelligence Information Hub The Thrust of Intelligent Transportation System Hub China KTH Royal Institute of Technology Division of Decision and Control Systems Stockholm Sweden Technical University of Munich TUM School of Engineering and Design Germany University of Colorado Boulder Department of Computer Science United States Ludwig Maximilian University Department of Computer Science Munich Germany

In this note, we present the synthesis of secure-by-construction controllers that address safety and security properties simultaneously in cyber-physical systems. Our focus is on studying a specific security property called opacity, which characterizes the system's ability to maintain plausible deniability of its secret behavior in the presence of an intruder. These controllers are synthesized based on a concept of so-called (augmented) control barrier functions. We propose conditions that facilitate the construction of the desired (augmented) control barrier functions and their corresponding secure-by-construction controllers. To compute these functions, we propose an iterative scheme that leverages iterative sum-of-square programming techniques. This approach enables efficient computation of these functions, particularly for polynomial systems. Finally, we validate the effectiveness of our results through a case study of a vehicle. © 1963-2012 IEEE.

关键词： Iterative methods

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Effectiveness Evaluation for Clinical Depression Detection Using Deep Learning Based Synthetic House-Tree-Person Test

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IEEE Journal of Biomedical and Health Informatics 2025年 PP卷 PP页

作者： Chen, Zhuolong Yin, Xiaoqing Yang, Fan Li, Xiaofan Zhao, Zixuan Li, Xueying Liu, Jianghu Zhao, Yubin Xu, Cheng-Zhong Zheng, Fangfang Lin, Yong Sun Yat-Sen University School of Microelectronics Science and Technology 0000 China The Fifth Affiliated Hospital of Sun Yat-Sen University Department of Psychiatry 0000 China The Fifth Affiliated Hospital of Sun Yat-Sen University Pediatrics Department 0000 China Jinan University School of Intelligent System Science and Engineering 0000 China University of Macau State Key Laboratory of IoTSC Department of Computer and Information Science Macau0000 China

Depression is one of the most common mood disorders and the number of patients increases significantly in recent years. Due to the lack of biomarkers, conversation between patients and psychiatrists is still the main clinical diagnostic method which is easily influenced by subjectivity of both patients and psychiatrists. Synthetic House-tree-person test (S-HTP), a convenient and efficient mental assessment tool, minimizes subjective influences from patients, while its effectiveness is limited by the professional ability of analyst. Here we introduce a deep learning model DeHTP, a flexible and convenient depression detection method based on S-HTP without interaction between people. Experimental results demonstrate that DeHTP achieves 0.963 AUC and 0.9 accuracy, and outperforms the conventional manual analysis of S-HTP, which is conducted on the guideline of 50 conclusions from previous study related to depression. In addition, it reveals 22 depression-correlated drawing features aligned with conclusions above from the perspective of our proposed model. Leveraging the advantages of deep learning and S-HTP, this approach has the potential for widespread promotion and adoption as the available tool for daily self-mental monitoring, as well as the promising auxiliary diagnostic method in clinical. © 2013 IEEE.

关键词： Contrastive Learning

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Multi-sensor Deep Clustering Networks with Joint Learning Strategy for Fault Diagnosis Considering Consensus-specific Constraint

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IEEE Sensors Journal 2025年第11期25卷 19921-19936页

作者： Xu, Yihao Lu, Mingfeng Wang, Gang Fang, Fang University of Science and Technology of China School of Management Hefei230026 China Hefei University of Technology School of Management Hefei230009 China Hefei University of Technology School of Management Key Laboratory of Process Optimization and Intelligent Decision-Making of the Ministry of Education Ministry of Education Engineering Research Center for Intelligent Decision-Making and Information System Technologies Hefei230009 China

The deep clustering method has been successfully employed for fault diagnosis due to its remarkable ability to extract deep representation features, particularly in scenarios where labeled data is unavailable. However, the separate learning strategy utilized in deep clustering-based fault diagnosis methods leads to sub-optimal fault diagnosis results, and the consensus representation feature present in multi-sensor industrial data is not fully explored to improve the effectiveness of fault diagnosis. To address the above problems, a novel deep clustering method named Multi-sensor Deep Clustering Networks with joint learning strategy (MsDCN) is proposed for fault diagnosis, which can comprehensively utilize the industrial multi-sensor data and enable joint optimization. First, the Commonality-net uses a sensor-aware attentive encoder (SaAE) to integrate multi-sensor industrial data and extract the consensus representation feature. Second, the Individuality-net is established to extract the specific representation features of multi-sensor industrial data. Finally, a joint multisensor deep clustering learning strategy including consensus-specific constraints is designed to optimize the networks jointly and learn the consensus representation feature with consistent and complementary information. Extensive experiments on the gearbox and bearing datasets validate the proposed MsDCN. The results indicate that the proposed MsDCN can generate a reliable consensus representation feature to achieve better fault diagnosis performance than other benchmark methods. Moreover, its capability to enhance multi-sensor fault diagnosis with unlabeled data highlights its potential for real-world applications. © 2001-2012 IEEE.

关键词： Labeled data

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A Novel Scheme for Data Security in UAV Communication Networks for Preventing Data Breach

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IEEE Transactions on Consumer Electronics 2025年

作者： Zhang, Gaoyuan Si, Ruisong Ma, Congfang Ji, Baofeng Wang, Weiguang Mu, Yu Li, Yiwei Mumtaz, Shahid the School of Information Engineering Henan University of Science and Technology Luoyang471023 China the Science and Technology Innovation Center of Intelligent system Longmen Laboratory Luoyang471000 China the Institute of Physics Henan Academy of Sciences Zhengzhou451451 China the School of mechanical and electrical engineering Guangdong University of Science and Technology Dongguan523083 China the Department of Applied Informatics Silesian University of Technology Akademicka 16 Gliwice44-100 Poland the Department of Engineering Nottingham Trent University United Kingdom

The data security is crucial for unmanned aerial vehicles (UAVs) to ensure the integrity of data, prevent fraud, and authentication process. In order to achieve unconditional security for data in UAVs communication networks, this research study proposes a simple feedback method for wiretap channel-I (WTC-I) to establish a communication with the receiving link. The threshold effect (decides the error correction capability of the system) in the proposed research uses soft-decision decoding for low-density parity-check (LDPC) codes for secured communication channels over additive white Gaussian noise (BI-AWGN) channel as well as Binary Symmetric Channel (BSC). There is no channel state information (CSI) required for the legitimate receiver to build the WTC-I which eventually minimizes the implementation complexity. The empirical results and theory analysis indicate that the suggested approach is robust and has the characteristics of simple implementation with low energy consumption. The results also show minimal loss of safe capacity, which is crucial for secured transmissions in battery-operated UAV communication networks. The proposed study helps to achieve secured transmission of data without affecting the performance of the system with optimal consumption of power and lower maintenance complexity. © 2025 IEEE. All rights reserved,

关键词： Gaussian noise (electronic)

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