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arXiv 2024年

作者： Makarov, Sergey S. Grigoryev, Sergey A. Zhakhovsky, Vasily V. Chuprov, Petr Pikuz, Tatiana A. Inogamov, Nail A. Khokhlov, Victor V. Petrov, Yuri V. Perov, Eugene Shepelev, Vadim Shobu, Takehisa Tominaga, Aki Rapp, Ludovic Rode, Andrei V. Juodkazis, Saulius Makita, Mikako Nakatsutsumi, Motoaki Preston, Thomas R. Appel, Karen Konopkova, Zuzana Cerantola, Valerio Brambrink, Erik Schwinkendorf, Jan-Patrick Mohacsi, István Vozda, Vojtech Hajkova, Vera Burian, Tomas Chalupsky, Jaromir Juha, Libor Ozaki, Norimasa Kodama, Ryosuke Zastrau, Ulf Pikuz, Sergey A. Joint Institute for High Temperatures Russian Academy of Sciences 13/2 Izhorskaya st. Moscow125412 Russia Institute for Computer Aided Design Russian Academy of Sciences Moscow123056 Russia Institute for Open and Transdisciplinary Research Initiatives Osaka University Suita Osaka565-0871 Japan Landau Institute for Theoretical Physics Russian Academy of Sciences 1-A Akademika Semenova av. Chernogolovka Region Moscow142432 Russia The facility is Material Science Research Center Japan Atomic Energy Agency Sayo Hyogo 679-5148 Japan Laser Physics Centre Department of Quantum Science and Technology Research School of Physics Australian National University CanberraACT2600 Australia School of Science Swinburne University of Technology HawthornVIC3122 Australia School of Materials and Chemical Technology Tokyo Institute of Technology Tokyo152-8550 Japan European XFEL Holzkoppel 4 Hamburg22869 Germany Università degli Studi di Milano Bicocca Piazza della Scienza 4 Milano20126 Italy Department of Radiation and Chemical Physics Institute of Physics Czech Academy of Sciences Na Slovance 1999/2 Prague 8182 00 Czech Republic Graduate School of Engineering Osaka University Suita Osaka565-0871 Japan Institute of Laser Engineering Osaka University Suita Osaka565-0871 Japan HB11 Energy Holdings FreshwaterNSW2095 Australia

Sub-picosecond optical laser processing of metals is actively utilized for modification of a heated surface layer. But for deeper modification of different materials a laser in the hard x-ray range is required. Here, we demonstrate that a single 9-keV x-ray pulse from a free-electron laser can form a µm-diameter cylindrical cavity with length of ~1 mm in LiF surrounded by shock-transformed material. The plasma-generated shock wave with TPa-level pressure results in damage, melting and polymorphic transformations of any material, including transparent and non-transparent to conventional optical lasers. Moreover, cylindrical shocks can be utilized to obtain a considerable amount of exotic high-pressure polymorphs. Pressure wave propagation in LiF, radial material flow, formation of cracks and voids are analyzed via continuum and atomistic simulations revealing a sequence of processes leading to the final structure with the long cavity. Similar results can be produced with semiconductors and ceramics, which opens a new pathway for development of laser material processing with hard x-ray pulses. Copyright © 2024, The Authors. All rights reserved.

关键词： Laser materials processing

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Design, synthesis, and biological evaluation of indolin-2-one derivatives as novel cyclin-dependent protein kinase 8 (CDK8) inhibitors

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Biomedicine and Pharmacotherapy 2023年 159卷 114258-114258页

作者： Hsu, Jui-Yi Hsu, Kai-Cheng Sun, Ching Chou, Ching-Hsuan Lin, Tony Eight Sung, Tzu-Ying Tseng, Hui-Ju Yen, Shih-Chung Yang, Chia-Ron Huang, Wei-Jan Ph.D. Program for Cancer Molecular Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University and Academia Sinica Taipei Taiwan Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei Taiwan Ph.D. Program for Cancer Molecular Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei Taiwan Ph.D. Program in Drug Discovery and Development Industry College of Pharmacy Taipei Medical University Taipei Taiwan TMU Research Center for Drug Discovery Taipei Medical University Taipei Taiwan TMU Research Center of Cancer Translational Medicine Taipei Medical University Taipei Taiwan Cancer Center Wan Fang Hospital Taipei Medical University Taipei Taiwan School of Pharmacy College of Medicine National Taiwan University Taipei Taiwan Biomedical Translation Research Center Academia Sinica Taipei Taiwan Department of Pharmacology and Pharmaceutical Sciences School of Pharmacy University of Southern California Los Angeles CA United States Warshel Institute for Computational Biology The Chinese University of Hong Kong (Shenzhen) Guangdong Shenzhen China School of Pharmacy Taipei Medical University Taipei Taiwan

Cyclin-dependent protein kinase 8 (CDK8) plays important roles in regulating fibrotic growth factors and inflammatory signaling pathways. Long-term chronic inflammation of the lungs can lead to idiopathic pulmonary fibrosis (IPF). Abnormal alveolar epithelial regeneration leads to the release of various fibrotic growth factors and the activation of inflammatory cells. CDK8 regulates profibrotic cytokines broadly implicated in the pathogenesis of fibrosis. Therefore, inhibition of CDK8 is considered a promising strategy for treating IPF. Here, CDK8 inhibitors were designed and optimized using a fragment-based drug design strategy. Testing results revealed that 71% of the synthesized compounds inhibited CDK8 activity better than the original compound E966–0530. Of these compounds, compound 4k exhibited the strongest CDK8 enzyme-inhibiting activity (IC₅₀ =129 nM). Notably, it displayed a 13-fold increase in potency when compared to E966–0530. Experiments on toxicity and inhibition of epithelial-mesenchymal transition (EMT) protein expressions showed that compound 4k can inhibit EMT protein expressions, but with no significant cytotoxicity for alveolar epithelial cells. Compound 4k showed a potent inhibitory effect in cell migration assays. Furthermore, compound 4k significantly inhibited the phosphorylation of p-Smad3 and RNA Pol II, which are critical mediators in the fibrotic response signaling pathway. Compound 4k remarkably reduced TGF-β1-induced oxidative stress. The above results reveal optimized CDK8 inhibitors with potential use for IPF therapeutic treatment. © 2023 The Authors

关键词： Cyclin-dependent protein kinase 8 (CDK8) Idiopathic pulmonary fibrosis (IPF) Indolin-2-one Kinase inhibitor Lead optimization

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Evaluation of pedaling skill based on muscle synergy in lower extremities during pedaling exercise

IEEJ Transactions on Electronics, Information and Systems

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IEEJ Transactions on Electronics, Information and Systems 2019年第7期139卷 774-779页

作者： Sato, Takuhiro Kurematsu, Riki Tokuyasu, Tatsushi Graduate School Fukuoka Institute of Technology 3-30-1 Wajiro-higashi Higashi-ku Fukuoka811-0295 Japan Computer Science and Engineering Fukuoka Institute of Technology 3-30-1 Wajiro-higashi Higashi-ku Fukuoka811-0295 Japan

The central nervous system does not control multiple muscles independently, whereas it manipulates a musculoskeletal system with redundant degrees of freedom. In specific, muscle synergy that represents muscle coordination realizes an advanced motion control of human body. In the pedaling exercise, the coordinated muscle activity between lower extremities is key for high-efficient exercise when cyclists use binding pedals which fixes both pedals and shoes via cleats. Under the present circumstances, few reports focused on the muscle coordination of both legs. Thus, the relationship between the coordination of both legs and the mechanism of pedaling has not yet been clarified. In this study, we investigated the muscle synergy hidden in lower extremities by measuring surface electromyography and crank rotation angle during pedaling exercise under different mechanical constraints. In the results, this study confirmed the muscle cooperativeness formed by both the left and right leg during pedaling. Besides, the muscle cooperativeness had different roles on both legs because this coordination was asymmetrical regardless of the changes in cadence and workload. The muscle coordination formed by both legs was considered to be an evaluation index that could explain how the left and right leg were coordinated for effective pedaling with binding pedals. © 2019 The Institute of Electrical Engineers of Japan.

关键词： Muscle

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Information system model for maize research to anticipate the impact of climate change on Indonesian food security

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AIP Conference Proceedings 2023年第1期2594卷

作者： A. S. Perbangsa F. A. Munawwar M. B. Pabendon B. Pardamean Information Systems Department School of Information Systems Bina Nusantara University Jakarta 11480 Indonesia Bioinformatics and Data Science Research Center Bina Nusantara University Jakarta 11480 Indonesia Indonesia Cereals Research Institute Maros South Sulawesi 90514 Indonesia Computer Science Department BINUS Graduate Program Master of Computer Science Bina Nusantara University Jakarta 11480 Indonesia

As a rich country in genetic resources, Indonesia has the potential for strengthening food security. Maize is one of the commodities that greatly affect food security in Indonesia. Maize is also widely used as animal feed. The high demand for maize requires efforts to increase the productivity of sustainable cultivation. Various research efforts that have been carried out require the support of a comprehensive information system. This study aimed to build a research model for maize genetic resource information systems that can help search for superior varieties. The data collection method used was collecting genotype, phenotype, climate data and interviewing the maize breeders or researchers. As for the design of the model, this study used the Object-Oriented Analysis & Design (OOAD) method with notation from Unified Modelling Language (UML). The result of this research was a web-based model of information systems for maize research.

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Modeling and Analysis of Energy/Exergy for Absorber Pipes of Linear Parabolic Concentrating Systems

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International Journal of Photoenergy 2021年第1期2021卷

作者： Alayi, Reza Mohkam, Mahdi Monfared, Hossein Issakhov, Alibek Khalilpoor, Nima Department of Mechanics Germi Branch Islamic Azad University Germi Iran Department of Renewable Energy and Energy Conversion Institute of Science and High Technology and Environmental Sciences Graduate University of Advanced Technology Kerman Iran Department of Mathematics Germi Branch Islamic Azad University Germi Iran Faculty of Mechanics and Mathematics Department of Mathematical and Computer Modelling Al-Farabi Kazakh National University Almaty Kazakhstan Department of Energy Engineering Graduate School of the Environment and Energy Science and Research Branch Islamic Azad University Tehran Iran

In this paper, the physical parameters of the absorber pipe of a linear parabolic collector have been investigated. The types of solar collectors, specifically the linear parabolic collector, have been comprehensively studied. Then, the mathematical model of heat transfer in the absorber pipe of the collector has been presented based on valid references. Numerical solutions of the equations related to the absorber pipe were performed by MATLAB software, and the effects of the physical parameters of the absorber pipe on its efficiency were investigated. The results show that increasing the length of the absorber pipe causes a nonlinear decrease in the efficiency of the absorber pipe. One of the important results is the increase in fluid temperature due to the increase in the diameter of the adsorbent tube, which increases the diameter of the fluid temperature by 60 K, in which the parameter increases the efficiency by 0.38%. © 2021 Reza Alayi et al.

关键词： MATLAB

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An efficient multi-objective evolutionary approach for solving the operation of multi-reservoir system scheduling in hydro-power plants

arXiv

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arXiv 2021年

作者： Marcelino, Carolina Gil Leite, G.M.C. Delgado, C.A.D.M. De Oliveira, L.B. Wanner, E.F. Jiménez-Fernández, S. Salcedo-Sanz, S. Department of Signal Processing and Communications Universidad de Alcalá Spain Institute of Computing Federal University of Rio de Janeiro Brazil Post-Graduate Program in Systems Engineering and Computer Science Federal University of Rio de Janeiro Brazil Computing Department Federal Center of Technology Education of Minas Gerais Brazil

This paper tackles the short-term hydro-power unit commitment problem in a multi-reservoir system - a cascade-based operation scenario. For this, we propose a new mathematical modelling in which the goal is to maximize the total energy production of the hydro-power plant in a sub-daily operation, and, simultaneously, to maximize the total water content (volume) of reservoirs. For solving the problem, we discuss the Multi-objective Evolutionary Swarm Hybridization (MESH) algorithm, a recently proposed multiobjective swarm intelligence-based optimization method which has obtained very competitive results when compared to existing evolutionary algorithms in specific applications. The MESH approach has been applied to find the optimal water discharge and the power produced at the maximum reservoir volume for all possible combinations of turbines in a hydro-power plant. The performance of MESH has been compared with that of well-known evolutionary approaches such as NSGA-II, NSGA-III, SPEA2, and MOEA/D in a realistic problem considering data from a hydro-power energy system with two cascaded hydro-power plants in Brazil. Results indicate that MESH showed a superior performance than alternative multi-objective approaches in terms of efficiency and accuracy, providing a profit of $412,500 per month in a projection analysis carried out. © 2021, CC BY-NC-ND.

关键词： Multiobjective optimization

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Enhancing wound healing and adhesion through dopamine-assisted gelatin-silica hybrid dressings

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International Journal of Biological Macromolecules 2024年第PT 2期258卷 128845页

作者： Lin, Yu-Chien Wang, Huey-Yuan Tang, Yao-Chun Lin, Wan-Rong Tseng, Ching-Li Hu, Chih-Chien Chung, Ren-Jei Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei10608 Taiwan School of Materials Science and Engineering Nanyang Technological University 50 Nanyang Avenue Singapore639798 Singapore Department of Stomatology MacKay Memorial Hospital Taipei104217 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan International Ph. D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Research Center of Biomedical Device College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan International Ph. D. Program in Cell Therapy and Regenerative Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Bone and Joint Research Center Chang Gung Memorial Hospital Linkou33305 Taiwan Taipei10608 Taiwan

Gelatin, widely employed in hydrogel dressings, faces limitations when used in high fluid environments, hindering effective material adhesion to wound sites and subsequently reducing treatment efficacy. The rapid degradation of conventional hydrogels often results in breakdown before complete wound healing. Thus, there is a pressing need for the development of durable adhesive wound dressings. In this study, 3-glycidoxypropyltrimethoxysilane (GPTMS) was utilized as a coupling agent to create gelatin-silica hybrid (G-H) dressings through the sol-gel method. The coupling reaction established covalent bonds between gelatin and silica networks, enhancing structural stability. Dopamine (DP) was introduced to this hybrid (G-H-D) dressing to further boost adhesiveness. The efficacy of the dressings for wound management was assessed through in-vitro and in-vivo tests, along with ex-vivo bioadhesion testing on pig skin. Tensile bioadhesion tests demonstrated that the G-H-D material exhibited approximately 2.5 times greater adhesion to soft tissue in wet conditions compared to pure gelatin. Moreover, in-vitro and in-vivo wound healing experiments revealed a significant increase in wound healing rates. Consequently, this material shows promise as a viable option for use as a moist wound dressing. © 2023

关键词： Adhesion

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40.1-GHz sub-freezing 850-nm VCSEL: microwave extraction of cavity lifetimes and small-signal equivalent circuit modeling

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Optics express 2023年第7期31卷 11408-11422页

作者： Hao-Tien Cheng Cheng-Han Wu Milton Feng Chao-Hsin Wu Graduate Institute of Electronics Engineering National Taiwan Universityhttps://***/05bqach95 No. 1 Sec. 4 Roosevelt Rd. Taipei 106319 Taiwan Center for Quantum Science and Engineering National Taiwan Universityhttps://***/05bqach95 No. 1 Sec. 4 Roosevelt Rd. Taipei 106319 Taiwan Nick Holonyak Jr. Micro and Nanotechnology Laboratory Department of Electrical and Computer Engineering the University of Illinois at Urbana-Champaign 208 N. Wright St. Urbana IL 61801 USA Graduate School of Advanced Technology National Taiwan Universityhttps://***/05bqach95 No. 1 Sec. 4 Roosevelt Rd. Taipei 106319 Taiwan Graduate Institute of Photonics and Optoelectronics National Taiwan Universityhttps://***/05bqach95 No. 1 Sec. 4 Roosevelt Rd. Taipei 106319 Taiwan

We present an 850-nm vertical-cavity surface-emitting laser (VCSEL) constructed for a wide operating temperature range from 25°C to -50°C sub-freezing temperature, demonstrating 40.1-GHz at -50°C. The optical spectra, junction temperature, and microwave equivalent circuit modeling of a sub-freezing 850-nm VCSEL between -50°C and 25°C are also discussed. Reduced optical losses, higher efficiencies, and shorter cavity lifetimes at sub-freezing temperatures are the leading causes of the improved laser output powers and bandwidths. The e-h recombination lifetime and the cavity photon lifetime are shortened to 113 and 4.1 ps, respectively. Could potentially supercharge VCSEL-based sub-freezing optical links for applications in frigid weather, quantum computing, sensing, aerospace, etc.

关键词： Astronomical telescopes Optical interconnects Quantum computing Quantum efficiency Semiconductor lasers Vertical cavity surface emitting lasers

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Efficient spin-orbit torque driven magnetization switching of GdFe using phosphorus-implanted platinum layers

arXiv

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arXiv 2025年

作者： Shintaku, Kazuki Mathew, Arun Jacob Iwamoto, Akihisa Mohammadi, Mojtaba Awano, Hiroyuki Asada, Hironori Fukuma, Yasuhiro Department of Physics and Information Technology Faculty of Computer Science and Systems Engineering Kyushu Institute of Technology Iizuka820-8502 Japan Memory Engineering Laboratory Toyota Technological Institute Nagoya468-8511 Japan Graduate School of Sciences and Technology for Innovation Yamaguchi University Ube755-8611 Japan Research Center for Neuromorphic AI hardware Kyushu Institute of Technology Kitakyushu808-0196 Japan

The capability of the spin-orbit torque (SOT) generated via phenomena such as the spin Hall effect in heavy metals, in switching the magnetization of an adjacent magnetic material, has been studied extensively over the last decade. The efficiency of SOT generation is commonly quantified in terms of the spin Hall angle θSH. In this work, we demonstrate experimentally that implanting platinum (Pt) with phosphorus (P), resulting in Pt (P) d, where d denotes the implantation dose, increases θSH by a factor of 7, from 0.06 (d = 0) to 0.43 (d = 10 × 1016 ions/cm2). The enhanced θSH along with factors such as perpendicular magnetic anisotropy and resistivity, lead to reduction of the critical current density for switching the perpendicular magnetization of ferrimagnetic rare earth-transition metal alloy Gd26Fe74, by a factor of nearly 27, from 4.0 × 1011 A/m2 (d = 0) to 1.5 × 1010 A/m2 (d = 10 × 1016 ions/cm2). Further, the switching current density at zero thermal fluctuations and thermal stability factor were evaluated and found to be 2.0 × 1010 A/m2 and 61.4 (d = 10 × 1016 ions/cm2), with the latter being sufficiently above the required threshold for commercial memory applications. Our results suggest that Pt (P) could be a strong candidate in realizing efficient SOT driven magnetization switching leading to the development of improved memory and logic devices in the future. Copyright © 2025, The Authors. All rights reserved.

关键词： Iron alloys

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Chern-Protected Flatband Edge State in Metaphotonics

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Physical Review Letters 2025年第22期134卷 223806-223806页

作者： Jianfeng Chen Yidong Zheng Shuihua Yang Andrea Alù Zhi-Yuan Li Cheng-Wei Qiu Department of Electrical and Computer Engineering National University of Singapore Singapore Singapore School of Physics and Optoelectronics South China University of Technology Guangzhou 510640 China Physics Program Graduate Center City University of New York New York New York 10016 USA Photonics Initiative Advanced Science Research Center City University of New York New York New York 10031 USA

Two-dimensional Dirac semimetals feature flatband edge states but a zero Chern number, while Chern insulators support one-way edge states associated with a nonzero Chern number. Here, we demonstrate a two-dimensional photonic crystal combining the response of a semimetal and of a Chern insulator, termed a Chern semimetal. This photonic semimetal is characterized by a nonzero Chern number, simultaneously hosting both a flatband edge state and a one-way edge state. We experimentally realize such a photonic Chern semimetal using a gyromagnetic photonic crystal with programmable magnetic bias, tailoring its second-neighbor coupling within each sublattice. We also verify the ability to control over the light speed while preserving topological protection. Our findings open new avenues toward exploring topological phases and their applications across fermionic and bosonic systems, providing an exciting platform for nanophotonic applications and a playground for topological physics discoveries.

关键词： Nanophotonics

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