This paper proposes the ungrounded force display using the grooved cam. Using the human illusion, the user can feel the force in the one direction when they use proposed device. It is mainly configured the cam and the...
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Quality of images used in a variety of systems contributes to the success of discovering beneficial details used in different fields of computing. The quality of the image plays a vital role in increasing the success ...
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IT Governance are one of the needs in managing Enterprise Level IT. This study shows part of the decision domain of IT Governance Help, which are IT Investment and Prioritization. The purpose of this study is to deter...
IT Governance are one of the needs in managing Enterprise Level IT. This study shows part of the decision domain of IT Governance Help, which are IT Investment and Prioritization. The purpose of this study is to determine feasibility of implementation open source ERP system Odoo project management module that replaces current system based on operational, economic, and technical aspects. The method used are Fit / Gap Analysis and Cost Benefit model using economic impact worksheet. The analysis is done by comparing the requirement with features owned by current system and Odoo ERP system. This research resulted that Odoo ERP System is feasible in the 3 aspects, the operational feasibility Odoo reaching 72% Fit, the economic feasibility with ROI of 84%, and technical feasibility indicating the technical requirement can be fulfilled by leasing AWS server. The conclusion is the open source ERP system Odoo project management module is feasible to be applied in terms of 3 aspects that have been studied, those are operational, economic, and technical.
Ferroptosis, a cell death process driven by cellular metabolism and iron-dependent lipid peroxidation, has been implicated in diseases such as ischaemic organ damage and cancer1,2. The enzyme glutathione peroxidase 4 ...
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Ferroptosis, a cell death process driven by cellular metabolism and iron-dependent lipid peroxidation, has been implicated in diseases such as ischaemic organ damage and cancer1,2. The enzyme glutathione peroxidase 4 (GPX4) is a central regulator of ferroptosis, and protects cells by neutralizing lipid peroxides, which are by-products of cellular metabolism. The direct inhibition of GPX4, or indirect inhibition by depletion of its substrate glutathione or the building blocks of glutathione (such as cysteine), can trigger ferroptosis3. Ferroptosis contributes to the antitumour function of several tumour suppressors such as p53, BAP1 and fumarase4,5,6,7. Counterintuitively, mesenchymal cancer cells—which are prone to metastasis, and often resistant to various treatments—are highly susceptible to ferroptosis8,9. Here we show that ferroptosis can be regulated non-cell-autonomously by cadherin-mediated intercellular interactions. In epithelial cells, such interactions mediated by E-cadherin suppress ferroptosis by activating the intracellular NF2 (also known as merlin) and Hippo signalling pathway. Antagonizing this signalling axis allows the proto-oncogenic transcriptional co-activator YAP to promote ferroptosis by upregulating several ferroptosis modulators, including ACSL4 and TFRC. This finding provides mechanistic insights into the observations that cancer cells with mesenchymal or metastatic property are highly sensitive to ferroptosis8. Notably, a similar mechanism also modulates ferroptosis in some non-epithelial cells. Finally, genetic inactivation of the tumour suppressor NF2, a frequent tumorigenic event in mesothelioma10,11, rendered cancer cells more sensitive to ferroptosis in an orthotopic mouse model of malignant mesothelioma. Our results demonstrate the role of intercellular interactions and intracellular NF2-YAP signalling in dictating ferroptotic death, and also suggest that malignant mu
The advancements of neural dialogue generation models show promising results on modeling short-text conversations. However, training such models usually needs a large-scale high-quality dialogue corpus, which is hard ...
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In this paper, we describe the GPU implementation of our City-LES code, which is developed at the Center for Computational sciences (CCS), University of Tsukuba for detailed large eddy simulations, including surface c...
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ISBN:
(数字)9781728189468
ISBN:
(纸本)9781728189475
In this paper, we describe the GPU implementation of our City-LES code, which is developed at the Center for Computational sciences (CCS), University of Tsukuba for detailed large eddy simulations, including surface conditions such as buildings, surface materials, and sunlight effect Wefocus on the 1) performance comparison between CUDA and OpenACC, and 2) how to reduce the data exchange between CPU and GPU memories. Using a number of GPU devices of NVIDIA Tesla V 100, we found that the current OpenACC compiler by PGI can achieve a comparable performance with CUDA in the main part of the LES calculation. We also apply OpenACC aggressively even for performances that are lower than that of a CPU to avoid data copying between the GPU and CPU, encapsulating all the data only on the GPU memory. In our optimized OpenACC (partially in CUDA) code, the results show that the performance of the full GPU version of code is doubled, and most of the GPU-CPU data copying is removed from the original GPU code. For the scaling performance test, a full GPU version achieves a 4. 7 x to 10x performance of the CPU version; this is done on a GPU cluster Cygnus at CCS, where each node is equipped with two Intel Xeon CPUs and four NVIDIA Tesla V100 GPUs, with strong scaling up to 32 nodes with 128 GPUs. For weak scaling, the full GPU version achieves a performance of more than 9x that of the CPU version for up to 32 nodes with 128 GPUs of parallel execution.
Petrópolis, located in the mountainous region of Rio de Janeiro, Brazil, is frequently impacted by severe landslides, exacerbated by intense rainfall, steep topography, and unregulated urban growth. This study em...
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Petrópolis, located in the mountainous region of Rio de Janeiro, Brazil, is frequently impacted by severe landslides, exacerbated by intense rainfall, steep topography, and unregulated urban growth. This study employs machine learning to assess and predict landslide susceptibility, integrating geological, hydrological, and anthropogenic factors. Five models—Random Forest, CatBoost, Support Vector Machine, Artificial Artificial Neural Network (ANN), and XGBoost—were evaluated, with CatBoost emerging as the optimal model (F1-score: 0.82; AUC-ROC: 0.88). Variable importance analysis revealed soil type and erodibility as critical soil parameters influencing susceptibility, alongside lithology, underscoring the significance of geological over purely topographic factors. These findings emphasize the utility of machine learning for landslide modeling, providing scalable methodologies applicable to similar geospatial risk assessments worldwide. Beyond local applications, this work offers actionable insights for urban planning and disaster risk management in mountainous urban regions.
The water management in various countries of the world provides a comprehensive understanding of the international movement on healthy watershed management. Watershed characteristics including River basin management i...
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In this paper, a highly reliable SRAM cell, namely SESRS cell, is proposed. Since the cell has a special feedback mechanism among its internal nodes and has more access transistors compared to a standard SRAM cell, th...
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ISBN:
(数字)9781728189444
ISBN:
(纸本)9781728189451
In this paper, a highly reliable SRAM cell, namely SESRS cell, is proposed. Since the cell has a special feedback mechanism among its internal nodes and has more access transistors compared to a standard SRAM cell, the SESRS cell provides the following advantages: (1) it can self-recover from single node upsets (SNUs) and double-node upsets (DNUs); (2) it can reduce power consumption by 49.78% and silicon area by 7.92%, compared with the only existing SRAM cell which can self-recover from all possible DNUs. Simulation results validate the robustness of the proposed SESRS cell. Moreover, compared with the state-of-the-art hardened SRAM cells, the proposed SESRS cell can reduce read access time by 61.93% on average.
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