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A biomimetic micropillar wound dressing with flavone and polyphenol control release in vitro and in vivo

Journal of the Taiwan Institute of Chemical Engineers 2024年 160卷

作者： Cheng, Tien-Hsin Lin, Ruei-Hong Cheng, Yu-Shen Shih, Pin-Keng Show, Pau Loke Chen, Hsiao-Yi Nakmee, Pattarawadee Sumthong Chang, Jui-Jen Huang, Dong-Ming Wang, Hui-Min David Department of Chemical and Materials Engineering National Yunlin University of Science and Technology Yunlin Taiwan Graduate Institute of Biomedical Engineering National Chung Hsing University Xingda Rd. South Dist. Taichung402 China Department of Neurological Institute Taichung Veterans General Hospital Taichung China Doctoral Program in Tissue Engineering and Regenerative Medicine National Chung Hsing University Taichung China Department of Surgery China Medical University Hospital Taichung Taiwan School of Medicine China Medical University Taichung Taiwan Department of Chemical Engineering Khalifa University Abu Dhabi United Arab Emirates Faculty of Science at Sriracha Kasetsart University Sriracha Campus 199 Moo 6 Sukhumvit Rd. Chonburi Sriracha20230 Thailand Department of Medical Research China Medical University Hospital China Medical University Taichung China Institute of Biomedical Engineering and Nanomedicine National Health Research Institutes Miaoli County China Regenerative Medicine and Cell Therapy Research Center Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan Department of Medical Laboratory Science and Biotechnology China Medical University Taichung China

Background: Wound healing is a complex and dynamic process involving the replacement of devitalized and missing cellular structures and tissue layers. Methods: This study involved developing a drug-loaded biomimetic micropillar wound dressing based upon inspiration from witnessing the adhesive ability in a gecko's footpad. The conformal adhesion was set up by applying a soft elastomer thin film on the developed wound dressing surfaces. The results showed that the developed surfaces prepared based on polydimethylsiloxane (PDMS) had low surface free energy, high chemical stability, and good plasticity. Astaxanthin (AST) and curcumin were applied as the patch's bioactive compounds to help accelerate the wound healing process. Results: The results showed that the developed surfaces prepared based on polydimethylsiloxane (PDMS) had low surface free energy, high chemical stability, and good plasticity. Astaxanthin (AST) and curcumin were applied as the patch's bioactive compounds to help accelerate the wound healing process. The results indicate that the developed biomimetic micropillar patches could release the loaded drugs and significantly increase cell viability and collagen content to 20 % ∼ 25 % in vitro and in vivo. Conclusion: In summation, the primary purpose of this study has been to design a novel encapsulated carrier (micropillar patch) for use in adjustable drug release, while combining with the biomimetic microstructure to reach wound healing through percutaneous absorption. © 2024 Taiwan Institute of Chemical Engineers

关键词： Chemical stability

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Comparison of endoscopic third ventriculostomy versus cerebrospinal fluid shunt procedures for the treatment of pediatric hydrocephalus in Taiwan

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Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 2024年第9期40卷 2883-2891页

作者： Shu-Mei Chen Li-Ying Chen Jiann-Her Lin Nicole Salazar Tu-Hsueh Yeh Wei-Lun Lo Tai-Ngar Lui Yi-Chen Hsieh Li-Nien Chien Department of Neurosurgery Taipei Medical University Hospital Taipei Medical University Taipei Taiwan. Department of Surgery School of Medicine Taipei Medical University Taipei Taiwan. Health Data Analytics and Statistics Center Office of Data Science Taipei Medical University Taipei Taiwan. Julius L. Chambers Biomedical/Biotechnology Institute and Department of Biological & Biomedical Sciences North Carolina Central University Durham NC USA. Department of Neurology Taipei Medical University Hospital Taipei Taipei Medical University Taipei Taiwan. Department of Neurology School of Medicine College of Medicine Taipei Medical University Taipei Taiwan. Department of Neurosurgery Shuang Ho Hospital Taipei Medical University Taipei Taiwan. The PhD Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University 250 Wu-Hsing Street Taipei Taiwan. ychsieh@tmu.edu.tw. Institute of Health and Welfare Policy College of Medicine National Yang Ming Chiao Tung University No.155 Sec. 2 Linong St. Beitou District Taipei Taiwan. linien.chien@nycu.edu.tw. Graduate Institute of Data Science College of Management Taipei Medical University Taipei Taiwan. linien.chien@nycu.edu.tw.

PURPOSE:Pediatric hydrocephalus is the most common cause of surgically treatable neurological disease in children. Controversies exist whether endoscopic third ventriculostomy (ETV) or cerebrospinal fluid (CSF) shunt placement is the most appropriate treatment for pediatric hydrocephalus. This study aimed to compare the risk of re-operation and death between the two procedures. METHODS:We performed a retrospective population-based cohort study and included patients younger than 20-years-old who underwent CSF shunt or ETV for hydrocephalus from the Taiwan National Health Insurance Research Database. RESULTS:A total of 3,555 pediatric patients from 2004 to 2017 were selected, including 2,340 (65.8%) patients that received CSF shunt placement and 1215 (34.2%) patients that underwent ETV. The incidence of all-cause death was 3.31 per 100 person-year for CSF shunt group and 2.52 per 100 person-year for ETV group, with an adjusted hazard ratio (HR) of 0.79 (95% confidence interval [CI] = 0.66-0.94, p = 0.009). The cumulative incidence competing risk for reoperation was 31.2% for the CSF shunt group and 26.4% for the ETV group, with an adjusted subdistribution HR of 0.82 (95% CI = 0.70-0.96, p = 0.015). Subgroup analysis showed that ETV was beneficial for hydrocephalus coexisting with brain or spinal tumor, central nervous system infection, and intracranial hemorrhage. CONCLUSION:Our data indicates ETV is a better operative procedure for pediatric hydrocephalus when advanced surgical techniques and instruments are available.

关键词： Cerebrospinal shunt Pediatric hydrocephalus Reoperation Third ventriculostomy

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Hexaazatriphenylene-Based Two-Dimensional Conductive Covalent Organic Framework with Anisotropic Charge Transfer

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Angewandte Chemie 2023年第42期135卷

作者： Seong-Wook Kim Hyeonjung Jung Dr. Mahmut Sait Okyay Dr. Hyuk-Jun Noh Sein Chung Young Hyun Kim Jong-Pil Jeon Prof. Dr. Bryan M. Wong Prof. Dr. Kilwon Cho Dr. Jeong-Min Seo Prof. Dr. Jung-Woo Yoo Prof. Dr. Jong-Beom Baek Department of Energy and Chemical Engineering/ Center for Dimension-Controllable Organic Frameworks Ulsan National Institute of Science and Technology (UNIST) Ulsan 44919 Republic of Korea These authors contributed equally to this work School of Materials Science and Engineering Ulsan National Institute of Science and Technology (UNIST) Ulsan 44919 Republic of Korea Materials Science & Engineering Program Department of Chemistry and Department of Physics & Astronomy University of California-Riverside Riverside CA 92521 USA Department of Chemistry Dartmouth College Hanover NH 03755 USA Department of Chemical Engineering Pohang University of Science and Technology Pohang 37673 Republic of Korea School of Materials Science and Engineering/ Graduate School of Semiconductor Materials and Devices Ulsan National Institute of Science and Technology (UNIST) Ulsan 44919 Republic of Korea

The development of covalent organic frameworks (COFs) with efficient charge transport is of immense interest for applications in optoelectronic devices. To enhance COF charge transport properties, electroactive building blocks and dopants can be used to induce extended conduction channels. However, understanding their intricate interplay remains challenging. We designed and synthesized a tailor-made COF structure with electroactive hexaazatriphenylene (HAT) core units and planar dioxin (D) linkages, denoted as HD-COF. With the support of theoretical calculations, we found that the HAT units in the HD-COF induce strong, eclipsed π–π stacking. The unique stacking of HAT units and the weak in-plane conjugation of dioxin linkages leads to efficient anisotropic charge transport. We fabricated HD-COF films to minimize the grain boundary effect of bulk COFs, which resulted in enhanced conductivity. As a result, the HD-COF films showed an electrical conductivity as high as 1.25 S cm −1 after doping with tris(4-bromophenyl)ammoniumyl hexachloroantimonate.

关键词： Anisotropic Charge Transfer Conductivity Covalent Organic Frameworks Doping

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Authors’ Response to Peer Reviews of “The Role of Animal-Assisted Therapy in Enhancing Patients’ Well-Being: Systematic Study of the Qualitative and Quantitative Evidence”

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JMIRx Med 2024年 5卷

作者： Ramendra Pati Pandey Himanshu Gunjan Riya Mukherjee Chung-Ming Chang School of Health Sciences & Technology University of Petroleum and Energy Studies Dehradun Uttarakhand India Graduate Institute of Biomedical Sciences Chang Gung University Taoyuan Taiwan Master & PhD Program in Biotechnology Industry Chang Gung University Taoyuan Taiwan Department of Medical Biotechnology and Laboratory Science Chang Gung University Taoyuan Taiwan

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Collecting the public perception of AI and robot rights

arXiv

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arXiv 2020年

作者： Lima, Gabriel Kim, Changyeon Ryu, Seungho Jeon, Chihyung Cha, Meeyoung School of Computing KAIST Daejeon Korea Republic of Dept. of Computer Science Dept. of Mathematics HKUST Hong Kong Hong Kong Graduate School of Science and Technology Policy KAIST Daejeon Korea Republic of IBS & School of Computing KAIST Daejeon Korea Republic of

Whether to give rights to artificial intelligence (AI) and robots has been a sensitive topic since the European Parliament proposed advanced robots could be granted "electronic personalities." Numerous scholars who favor or disfavor its feasibility have participated in the debate. This paper presents an experiment (N=1270) that 1) collects online users’ first impressions of 11 possible rights that could be granted to autonomous electronic agents of the future and 2) examines whether debunking common misconceptions on the proposal modifies one’s stance toward the issue. The results indicate that even though online users mainly disfavor AI and robot rights, they are supportive of protecting electronic agents from cruelty (i.e., favor the right against cruel treatment). Furthermore, people’s perceptions became more positive when given information about rights-bearing non-human entities or myth-refuting statements. The style used to introduce AI and robot rights significantly affected how the participants perceived the proposal, similar to the way metaphors function in creating laws. For robustness, we repeated the experiment over a more representative sample of U.S. residents (N=164) and found that perceptions gathered from online users and those by the general population are similar. Copyright © 2020, The Authors. All rights reserved.

关键词： Autonomous agents

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A polarization-insensitive fishnet/spacer/mirror plasmonic absorber for hot electron photodetection application

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Chinese Optics Letters 2020年第5期18卷 63-67页

作者： Zhiqiang Yang Kang Du Wending Zhang Soojin Chua Ting Mei Key Laboratory of Space Applied Physics and Chemistry Ministry of Educationand Shaanxi Key Labora tory of Optical Information TechnologySchool of ScienceNorth Western Polytechnical UniversityXi'an 710072China Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore LEES Program Singapore-MIT Alliance for Research&Technology(SMART)Singapore 138602Singapore

A polarization-insensitive plasmonic absorber is designed consisting of Au fishnet structures on a TiO2 spacer/Ag mirror. The fishnet structures excite localized surface plasmon and generate hot electrons from the absorbed photons, while the TiO2 layer induces Fabry–Perot resonance, and the Ag mirror acts as a back *** optimizing the TiO2 layer thickness, numerical simulation shows that 97% of the incident light is absorbed in the Au layer. The maximum responsivity and external quantum efficiency of the device can approach 5 mA/W and ~1%, respectively, at the wavelength of 700 nm.

关键词： plasmonic absorber Fabry–Perot resonance internal photoemission surface plasmon

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Joint Observation of the Galactic Center with MAGIC and CTA-LST-1 38

Joint Observation of the Galactic Center with MAGIC and CTA-...

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38th International Cosmic Ray Conference, ICRC 2023

作者： Abe, Shotaro Berti, Alessio Di Pierro, Federico López-Coto, Rubén Moralejo, Abelardo Ohtani, Yoshiki Sitarek, Julian Strzys, Marcel Suda, Yusuke Vovk, Ievgen Abe, H. Abe, K. Abe, S. Abhir, J. Acciari, V.A. Aguasca-Cabot, A. Agudo, I. Alvarez Crespo, N. Aniello, T. Ansoldi, S. Antonelli, L.A. Aramo, C. Arbet-Engels, A. Cornelia, A. Artero, M. Asano, K. Aubert, P. Baack, D. Babić, A. Baktash, A. Bamba, A. Baquero Larriva, A. Baroncelli, L. Barres de Almeida, U. Barrio, J.A. Batkovic, I. Baxter, J. Becerra González, J. Bednarek, W. Bernardini, E. Bernardos, M.I. Bernete Medrano, J. Berti, A. Besenrieder, J. Bhattacharjee, P. Biederbeck, N. Bigongiari, C. Biland, A. Bissaldi, E. Blanch, O. Bonnoli, G. Bordas, P. Bošnjak, Ž. Bulgarelli, A. Burelli, I. Burmistrov, L. Buscemi, M. Busetto, G. Campoy-Ordaz, A. Cardillo, M. Caroff, S. Carosi, A. Carosi, R. Carrasco, M.S. Carretero-Castrillo, M. Cassol, F. Castro-Tirado, A.J. Cauz, D. Cerasole, D. Ceribella, G. Chai, Y. Cheng, K. Chiavassa, A. Chikawa, M. Chilingarian, A. Chytka, L. Cifuentes, A. Cikota, S. Colombo, E. Contreras, J.L. Cortina, J. Costantini, H. Covino, S. D’Amico, G. Dalchenko, M. D’Elia, V. Da Vela, P. Dazzi, F. De Angelis, A. de Bony de Lavergne, M. De Lotto, B. De Lucia, M. de Menezes, R. Del Peral, L. Deleglise, G. Delfino, M. Delgado, C. Delgado Mengual, J. della Volpe, D. Dellaiera, M. Del Popolo, A. Depaoli, D. Di Piano, A. Di Pierro, F. Di Pilato, A. Di Tria, R. Di Venere, L. Díaz, C. Dominik, R.M. Dominis Prester, D. Donini, A. Dorner, D. Doro, M. Eisenberger, L. Elsässer, D. Emery, G. Escudero, J. Fallah Ramazani, V. Fariña, L. Fattorini, A. Ferrara, G. Ferrarotto, F. Fiasson, A. Foffano, L. Font, L. Freixas Coromina, L. Fröse, S. Fukami, S. Fukazawa, Y. Garcia, E. Garcia López, R. Garczarczyk, M. Gasbarra, C. Gasparrini, D. Gasparyan, S. Gaug, M. Geyer, D. Giesbrecht Paiva, J. Giglietto, N. Giordano, F. Gliwny, P. Godinovic, N. Grau, R. Green, J. Green, D. Gunji, S. Günther, P. Hackfeld, J. Hadasch, D. Hahn, A. Institute for Cosmic Ray Research Kashiwa-no-ha 5-1-5 Kashiwa-shi Chiba Japan Max-Planck-Institut für Physik Föhringer Ring 6 München80805 Germany INFN Sezione di Torino Via P. Giuria 1 Torino10125 Italy Instituto de Astrofísica de Andalucía-CSIC Glorieta de la Astronomía s/n Granada18008 Spain The Barcelona Institute of Science and Technology Campus UAB Bellaterra Barcelona08193 Spain Faculty of Physics and Applied Informatics University of Lodz ul. Pomorska 149-153 Lodz90-236 Poland Physics Program Graduate School of Advanced Science and Engineering Hiroshima University Hiroshima739-8526 Japan Institute for Cosmic Ray Research University of Tokyo Japan Department of Physics Tokai University Japan ETH Zürich Switzerland Instituto de Astrofísica de Canarias Departamento de Astrofísica Universidad de La Laguna Spain Departament de Física Quàntica i Astrofísica Institut de Ciències del Cosmos Universitat de Barcelona IEEC-UB Spain EMFTEL department IPARCOS Universidad Complutense de Madrid Spain Italy INFN Sezione di Trieste Università degli Studi di Udine Italy Italy INAF Osservatorio Astronomico di Roma Italy INFN Sezione di Napoli Italy INFN Sezione di Padova Università degli Studi di Padova Italy LAPP Univ. Grenoble Alpes Univ. Savoie Mont Blanc CNRS-IN2P3 Annecy France Department of Physics TU Dortmund University Germany Croatia Universität Hamburg Institut für Experimentalphysik Germany Graduate School of Science University of Tokyo Japan Universidad del Azuay Ecuador INAF Osservatorio di Astrofisica e Scienza dello spazio di Bologna Italy Centro Brasileiro de Pesquisas Físicas Brazil CIEMAT Spain INFN Sezione di Bari Politecnico di Bari Italy INAF Osservatorio Astronomico di Brera Italy University of Geneva Département de physique nucléaire et corpusculaire Switzerland INFN Sezione di Catania Italy Departament de Física CERES-IEEC Universitat Autónoma de Barcelona Spain Italy Università di Pisa INFN Pisa Italy Aix Mars

MAGIC is a system of two Imaging Atmospheric Cherenkov Telescopes (IACTs), designed to detect very-high-energy gamma rays, and is operating in stereoscopic mode since 2009 at the Observatorio del Roque de Los Muchachos in La Palma, Spain. In 2018, the prototype IACT of the Large-Sized Telescope (LST-1) for the Cherenkov Telescope Array, a next-generation ground-based gamma-ray observatory, was inaugurated at the same site, at a distance of approximately 100 meters from the MAGIC telescopes. Using joint observations between MAGIC and LST-1, we developed a dedicated analysis pipeline and established the threefold telescope system via software, achieving the highest sensitivity in the northern hemisphere. Based on this enhanced performance, MAGIC and LST-1 have been jointly and regularly observing the Galactic Center, a region of paramount importance and complexity for IACTs. In particular, the gamma-ray emission from the dynamical center of the Milky Way is under debate. Although previous measurements suggested that a supermassive black hole Sagittarius A* plays a primary role, its radiation mechanism remains unclear, mainly due to limited angular resolution and sensitivity. The enhanced sensitivity in our novel approach is thus expected to provide new insights into the question. We here present the current status of the data analysis for the Galactic Center joint MAGIC and LST-1 observations. © Copyright owned by the author(s) under the terms of the Creative Commons.

关键词： Cosmology

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Enhancement of Angry Birds Level Generation from Sketches Using Cycle-Consistent Adversarial Networks

Enhancement of Angry Birds Level Generation from Sketches Us...

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IEEE Global Conference on Consumer Electronics (GCCE)

作者： Mury F. Dewantoro Febri Abdullah Pujana Paliyawan Ruck Thawonmas Fitra A. Bachtiar Graduate School of Information Science and Engineering Ritsumeikan University Shiga Japan Research Organization of Science and Technology Ritsumeikan University Shiga Japan College of Information Science and Engineering Ritsumeikan University Shiga Japan Faculty of Computer Science Brawijaya University Malang Indonesia

ISBN: (数字)9781728198026

ISBN: (纸本)9781728198033

This paper presents our work to enhance a state-of-the-art level generator (Sketch-to-Level Generator) that generates levels for an Angry-Birds-like game from drawn sketches. To achieve this task, Cycle-Consistent Adversarial Networks (Cycle-GAN) are used. CycleGAN is trained using two datasets: sketch drawings and typical level-structures. The former are taken from Google's Quick, Draw! datasets, and the latter from the winning level generator at the 2017 and 2018 AIBIRDS level generation competitions. The output of the trained CycleGAN is used as the input of Sketch-to-Level Generator. Our results show that the proposed preprocessing technique using CycleGAN allows Sketch-to-Level Generator to more successfully generate levels from arbitrary sketch drawings.

关键词： Conferences Games Birds Generators Task analysis Consumer electronics

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Super-Resolution Coherent Diffractive Imaging via Titled-Incidence Multi-Rotation-Angle Fusion Ptychography

arXiv

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arXiv 2025年

作者： Zhou, Youyang Shi, Weiren Xie, Yun Zhao, Bianli Luo, Xinyu Yao, Mingjie Zhang, Rui Tan, Xin Li, Kui Yang, Hao Liu, Qi Nan, Yinggang Bao, Jie Zhang, Yuping Shu, Feng Li, Shaopan Zhang, Xiaoshi School of Physics and Astronomy Yunnan University Yunnan Kunming650500 China School of Automation Engineering University of Electronic Science and Technology of China Chengdu611731 China Academy for Engineering and Technology Fudan University Shanghai200433 China School of Materials and Energy Yunnan University Yunnan Kunming650500 China South west United Graduate school Yunnan Kunming650092 China School of Instrumentation and Optoelectronic Engineering Beihang University Beijing100191 China School of Engineering Yunnan University Yunnan Kunming650500 China School of Chemical Science and Engineering Yunnan University Yunnan Kunming650500 China School of Electrical and Computer Engineering The University of Sydney CamperdownNSW2006 Australia Aerospace Information Research Institute Chinese Academy of Sciences Beijing100094 China

Coherent diffractive imaging (CDI) enables lensless imaging with experimental simplicity and a flexible field of view, yet its resolution is fundamentally constrained by the Abbe diffraction limit. To overcome this limitation, we introduce a novel Tilted-Incidence Multi-Rotation-Angle Fusion Ptychography technique. This approach leverages a tilted-incidence geometry to extend the collection angle beyond the Abbe limit, achieving up to a √2-fold resolution enhancement. By acquiring diffraction patterns at multiple sample rotation angles, we capture complementary spatial frequency information. A tilted-incidence multirotation-angle fusion ptychographic iterative engine (tmf-PIE) algorithm is then employed to integrate these datasets, enabling super-resolution image reconstruction. Additionally, this method mitigates the anisotropic resolution artifacts inherent to tilted CDI geometries. Our technique represents a novel advancement in super-resolution imaging, providing a novel alternative alongside established methods such as STED, SIM, and SMLM. © 2025, CC BY.

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Angle control of antagonistic pneumatic driven and inflatable arm joint 17

Angle control of antagonistic pneumatic driven and inflatabl...

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17th IEEE International Conference on Industrial Informatics, INDIN 2019

作者： Ogasawara, Hirofusa Yokota, Sho Matsumoto, Akihiro Chugo, Daisuke Hashimoto, Hiroshi Toyo University Graduate School of Science and Eng. Kawagoe Japan Toyo University Dept. of Mechanical Engineering Kawagoe Japan Kwansei Gakuin University School of Science and Technology Hyogo Japan Advanced Institute of Industrial Technology Master Program of Innovation for Design and Eng. Tokyo Japan

ISBN: (纸本)9781728129273

The conventional robot arms applied in various fields are demanded to have high force output, high accuracy, high efficiency. But they are seldom applied in human life, because of large weight, rigidity, hazards to people caused by collisions. Therefore the soft robotic arm that is stretchable, light weight, softness without possible of hazards, and high precision control is suitable to deploy in human life. Thus the purpose of this research is to develop the soft robotic arm by using antagonistic pneumatic driven system. In order to realize this concept, the joint activation mechanism is the key component. This study focuses on the angle control of the joint. In this paper, the robot arm made by polyethylene is proposed. Air bags made of polyethylene inside the joint achieve antagonistic driven states. Helical tube made of polyethylene is adhered joint outside for realizing rigidity. It is characterized that control rigidity is realized by controlling the pressure in the helical tube and joint angle is preciously controlled in two degree of freedom by controlling pressure in the air bags. Furthermore, the joint angle can be controlled by controlling the air pressures in the air bags using stretch sensor measuring joint angle. The experimental result confirmed that the driving concept of the joint was well functioned, and the joint angle control was realized by feedback control. © 2019 IEEE.

关键词： Robotic arms

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