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37th International Florida Artificial Intelligence Research Society Conference, FLAIRS 2024

作者： Khalghollah, Mahmood Shakeri, Esmaeil Zare, Azam Far, Behrouz H. Sanati-Nezhad, Amir Department of Electrical and Software Engineering Schulich School of Engineering University of Calgary Canada Department of Mechanical and Manufacturing Engineering Schulich School of Engineering University of Calgary Canada Department of Biomedical Engineering Schulich School of Engineering University of Calgary Canada

This paper explores the potential of Lab on a Chip (LOC) technologies in transforming diagnostic, biotechnology, and chemical/mechanical analysis fields. The proposed solution integrates advanced image processing into an automated tool, providing a robust and efficient method for precise data extraction from microfluidic chip images. In this study, we identify the fluid path in each frame, thereby improving the platform for tracking valuable fluid parameters over time, such as the viscosity of biofluids. Different patterns of LOC were developed then captured and related masks were established to create the 150 images dataset. Using the DeepLabv3+ deep learning model on the dataset, this study achieves remarkable validation accuracy of 98.95% and a low loss value of 0.012 for chip analysis path segmentation. The successful integration of DeepLabv3+ and meticulous preprocessing enhances understanding of fluid behavior within microfluidic chips, paving the way for advancements in chip design, diagnostics, and fluid feature-based analyses. Copyright © 2024 by the authors.

关键词： Microfluidic chips

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Disposable Planar Microwave Sensor for Real-time Monitoring of Lubricant Depletion on Lubricant-infused Coated Medical Implants

Disposable Planar Microwave Sensor for Real-time Monitoring ...

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2023 IEEE/MTT-S International Microwave Symposium, IMS 2023

作者： Yazdanicherati, Amirhossein Roberts, Erin L. Badv, Maryam Abbasi, Zahra University of Calgary Schulich School of Engineering Department of Electrical and Software Engineering Canada University of Calgary Schulich School of Engineering Department of Biomedical Engineering Canada Libin Cardiovascular Institute Canada

ISBN: (纸本)9798350347647

This paper proposes a passive disposable planar microwave resonator sensor for real-time monitoring of lubricant depletion on lubricant-infused surfaces. These surface coatings offer a state-of-the-art solution to minimize the complications associated with medical implants caused by non-specific adhesion of blood components and bacteria. The stability of the lubricant layer determines the function of the lubricant-infused coating. It is an essential factor that needs to be considered when applying these coatings on medical implants. The proposed passive split-ring resonator (SRR)-based sensor introduces the real-time monitoring of the thickness and evaporation rate of the lubricant layer. The performance and sensitivity of the sensor have been verified in simulation and measurement. The design is capable of monitoring lubricant presence in porous and no-porous surfaces. Additionally, using this SRR-based sensor, the drastic depletion zones on the surface can be detected. © 2023 IEEE.

关键词： Adhesion

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Investigating Association and Causal Relationships between Physiological Signals and Affective State

Investigating Association and Causal Relationships between P...

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2023 International Conference on Information and Digital Technologies, IDT 2023

作者： Jafari, Behnaz Lai, Kenneth Yanushkevich, Svetlana Schulich School of Engineering University of Calgary Biometric Technologies Laboratory Dept. of Biomedical Engineering Canada Schulich School of Engineering Cummings School of Medicine University of Calgary Biometric Technologies Laboratory Canada Biometric Technologies Laboratory Schulich School of Engineering University of Calgary Dept. of Software and Electrical Engineering Canada

ISBN: (纸本)9798350305869

This paper offers two approaches to detecting the association and causal relationships between multi-modal physiological signals and the human subjects' affective state. In particular, we focus on the emotional state called here 'stress'. The dataset used in this study is the WESAD which contains time series recorded using wearable devices. The first approach we studied is variance-covariance networks using a multivariate auto-regressive model. The second approach investigated causal relationships using the Granger causality test. The study concluded that respiratory, electrocardiogram, and accelerometer signals, measured using wearable sensors, have the strongest correlation with the state of emotional stress. In contrast, electrodermal activity, temperature and electromyogram signals show small or no correlation with such a state. The Granger causal test confirmed a strong causal relationship between the stress state and respiratory, electrocardiogram, and accelerometer. © 2023 IEEE.

关键词： Wearable sensors

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Influence of Biomimetic Apatite Coating on the Biobehavior of TiO_(2)Scaffolds

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Journal of Bionic engineering 2024年第4期21卷 1975-1986页

作者： Shima Mahtabian Seyed Mehdi Mirhadi Nahid Hassanzadeh Nemati Melika Sharifi Fariborz Tavangarian Department of Biomedical Engineering University of DelawareNewarkDE19716USA Department of Ceramic Engineering Islamic Azad University(Shahreza Branch)ShahrezaIsfahan86145-311Iran Department of Biomedical Engineering Islamic Azad University(Science and Research Branch)TehranIran Mechanical Engineering Program School of ScienceEngineering and TechnologyPennsylvania State UniversityHarrisburgMiddletownPA17057USA Department of Materials Science&Engineering Islamic Azad University(Najaf Abad Branch)Najaf AbadIsfahan***Iran Biomedical Engineering Department Pennsylvania State UniversityState CollegeUniversity ParkPennsylvania16802USA

Immersion of scaffolds in Simulated Body Fluid(10SBF)is a standardized method for evaluating their bioactivity,simulating in vivo conditions where apatite deposits can be formed on the surface of scaffold,facilitating bone integration and ensuring their suitability for bone implant purposes,ultimately contributing to long-term implant *** effect of apatite deposition on bioactivity and cell behavior of TiO_(2)scaffolds was *** were soaked in 10SBF for different durations to form HAP layer on their *** results proved the development of a hydroxyapatite film resembling the mineral composition of bone Extracellular Matrix(ECM)on the TiO_(2)*** XRD test findings showed the presence of hydroxyapatite layer similar to bone at the depth of 10 nm.A decrease in the specific surface area(18.913 m^(2)g^(−1)),the total pore volume(0.045172 cm^(3)g^(−1)(at p/p0=0.990)),and the mean pore diameter(9.5537 nm),were observed by BET analysis which confirmed the formation of the apatite *** was found that titania scaffolds with HAP coating promoted human osteosarcoma bone cell(MG63)cell attachment and *** seems that immersing the scaffolds in 10SBF to form HAP coating before utilizing them for bone tissue engineering applications might be a good strategy to promote bioactivity,cell attachment,and implant fixation.

关键词： Titania Hierarchical meso/macro porous 10SBF Biomimetic apatite Coating

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Role of pericytes in regulating penile angiogenesis and nerve regeneration

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Asian Journal of Andrology 2025年第1期27卷 13-19页

作者： Guo Nan Yin Ji-Kan Ryu National Research Center for Sexual Medicine and Department of Urology Inha University School of MedicineIncheon 22332Korea Program in Biomedical Scienceand Engineering Inha UniversityIncheon 22212Korea

Pericytes are multifunctional mural cells that surround the abluminal wall of endothelial cells and are associated with vascular development,vascular permeability,and ***,pericytes demonstrate stem cell-like properties and contribute to neuroinflammatory *** have been extensively studied in the central nervous ***,specific mechanisms underlying its involvement in various physiological and pathological conditions,especially in erectile dysfunction(ED),remain poorly *** in in vitro and in vitro techniques,such as single-cell RNA sequencing,are expanding our understanding of *** studies have shown that pericyte dysfunction is considered an important factor in the pathogenesis of vascular and neurological ***,this study aims to analyze the specific role of pericytes in ED,focusing on diabetic and neurogenic *** article provides a comprehensive review of research findings on PubMed from 2000 to 2023,concerning pericyte dysfunction in the process of ED,offering valuable insights,and suggesting directions for further research.

关键词： angiogenesis blood-brain barrier erectile dysfunction nerve regeneration pericyte stem cell

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Comparative study of different controllers in an autonomous vehicle system

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Materials Today: Proceedings 2023年 80卷 2390-2393页

作者： Balaji, T.S. Srinivasan, S. Research Scholar Department of Electronics and Communication Engineering Saveetha School of Engineering SIMATS Tamil Nadu Chennai India Professor and Program Director Department of Biomedical Engineering Saveetha School of Engineering SIMATS Tamil Nadu Chennai India

In recent days the entire world moving towards autonomous driving vehicle. For the last decades, the world started more research on Autonomous or Auto-pilot vehicle. It faces lot of challenges to design such a system. In recent, Google and tesla designs an autonomous vehicle in the name of waymo. The main aim of this research work is to provide healthy transportation with high safety and security. This waymo vehicle is now under testing with conditional and unconditional environment. In this paper it is focused on a controller part to take care of the vehicle in critical and non-critical environmental situation. In this perception, this research gives the overview of the various controllers with its merits and demerits. The controller is to imitate like a human driver. Normally the human eye focus on mobile and immobile objects, road sign, pedestrian etc., the controller need to focus the road condition, optimal steering control with less tracking error and cruise control. © 2021

关键词： Autonomous vehicles

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Detection of safety wearable's of the industry workers using deep neural network

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Materials Today: Proceedings 2023年 80卷 3064-3068页

Accidents can occur in work place or in place where people are gathering. Many such accidents are preventable. These types of accidents may occur due to carelessness or improper safety wears. These disasters could clearly be maintained a strategic distance from, or its viable force could be decreased with appropriate well-being wear. The fundamental target of this undertaking is to build up a fair-minded computerized framework that checks and investigates the well-being wear of representatives before allowing them to the work region or shop-floor. Along these lines, this framework will mean to forestall mishaps because of inappropriate security wear and the information gathered is utilized for further investigation. Consequently, this system will expect to thwart disasters on account of less than ideal security wear and the data accumulated is used for further investigation. These incidents could clearly be stayed away from, or its viable force could be decreased with appropriate well-being wear. © 2021

关键词： Accident prevention

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A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

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Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon C.Daeschler Katelyn J.W.So Konstantin Feinberg Marina Manoraj Jenny Cheung Jennifer Zhang Kaveh Mirmoeini JPaul Santerre Tessa Gordon Gregory HBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

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Evaluation of Segmentation Quality in Magnetic Resonance Images Using Singular Value Decomposition: A Feasibility Study 21

Evaluation of Segmentation Quality in Magnetic Resonance Ima...

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21st International Conference on Electrical engineering, Computing Science and Automatic Control, CCE 2024

作者： Lagunas, Donaldo F. Vega Vargas-Olivares, Arturo Chong-Quero, J. Enrique Cervantes-Culebro, Hector Cruz-Villar, Carlos A. Curiel, Laura Pichardo, Samuel School of Engineering and Sciences Tecnologico de Monterrey State of Mexico Mexico CINVESTAV-IPN Electrical Engineering Department Mexico City Mexico Schulich School of Engineering University of Calgary Biomedical Engineering Calgary Canada Cumming School of Medicine University of Calgary Radiology and Clinical Neurosciences Calgary Canada

ISBN: (纸本)9798350377545

In the present research work, the use of Singular Value Decomposition is investigated as part of an evaluation metric for the segmentation quality of regions of interest in magnetic resonance imaging used in an experiment of High-Intensity Focused Ultrasound therapy. Accurate segmentation is essential for clinical and research applications in computer vision. However, current evaluation methods have limitations in sensitivity to the shape of segmented objects, highlighting the need for a quantitative shape-sensitive metric. SVD is a promising tool for assessing segmentation similarity to ground truths in therapy planning images through component comparison. The proposed SF metric shows strong positive correlations with Global Consistency Error scores across transverse and sagittal images. In the air region, correlations range from 0.66 (transverse) to 0.75 (sagittal), in the gel-pad from 0.72 to 0.91, in tissue from 0.87 to 0.91, in the transducer from 0.78 to 0.91, and in water from 0.93 to 0.94, indicating that SF can capture structural similarities and segmentation consistency as GCE evaluates alignment with the ground truth, focusing on boundary accuracy and region continuity. The findings suggest that this tool could enhance sensitivity to object shapes in medical image analysis, improving segmentation quality assessments, clinical diagnostics, and treatment planning. © 2024 IEEE.

关键词： Clinical research

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Synthesis of Methotrexate-Loaded Dumbbell-Shaped Titanium Dioxide/Gold Nanorods Coated with Mesoporous Silica and Decorated with Upconversion Nanoparticles for Near-Infrared-Driven Trimodal Cancer Treatment

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ACS Applied Materials and Interfaces 2023年第28期15卷 33335-33347页

作者： Dash, Pranjyan Thirumurugan, Senthilkumar Tseng, Ching-Li Lin, Yu-Chien Chen, Sung-Lung Dhawan, Udesh Chung, Ren-Jei Taipei10608 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei110 Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei110 Taiwan Research Center of Biomedical Device College of Biomedical Engineering Taipei Medical University Taipei110 Taiwan International Ph.D. Program in Cell Therapy and Regenerative Medicine College of Medicine Taipei Medical University Taipei110 Taiwan Centre for the Cellular Microenvironment Division of Biomedical Engineering James Watt School of Engineering Mazumdar-Shaw Advanced Research Centre University of Glasgow GlasgowG116EW United Kingdom Taipei10608 Taiwan

This study prepared dumbbell-shaped titanium dioxide (TiO2)/gold nanorods (AuNRs) coated with mesoporous silica shells (mS) (AuNRs-TiO2@mS). Methotrexate (MTX) was further loaded into the AuNRs-TiO2@mS, and then upconversion nanoparticles (UCNPs) were decorated to form AuNRs-TiO2@mS-MTX: UCNP nanocomposites. TiO2 is used as an intense photosensitizer (PS) to produce cytotoxic reactive oxygen species (ROS), leading to photodynamic therapy (PDT). Concurrently, AuNRs exhibited intense photothermal therapy (PTT) effects and photothermal conversion efficiency. In vitro results suggested that these nanocomposites can kill oral cancer cells (HSC-3) without toxicity through irradiation of NIR laser, owing to the synergistic effect. The in vivo studies indicated that these nanocomposites exhibited excellent antitumor effects through synergistic PDT/PTT/chemotherapy under a near-infrared (NIR) 808 nm laser irradiation. Thus, these AuNRs-TiO2@mS: UCNP nanocomposites have great potential to undergo deep tissue penetration with enhanced synergistic effects through NIR-triggered light for cancer treatment. © 2023 American Chemical Society

关键词： Titanium dioxide

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