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Multifunctional stimuli responsive polymer-gated iron and gold-embedded silica nano golf balls:Nanoshuttles for targeted on-demand theranostics

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Bone Research 2017年第4期5卷 343-356页

作者： Liping Wang Grace Jang Deependra Kumar Ban Vrinda Sant Jay Seth Sami Kazmi Nirav Patel Qingqing Yang Joon Lee Woraphong Janetanakit Shanshan Wang Brian P Head Gennadi Glinsky Ratneshwar Lai School of Biomedical Engineering Shanghai Jiaotong UniverityShanghaiChina Department of Mechanical and Aerospace Engineering La JollaCAUSA Materials Science and Engineering Program La JollaCAUSA Department of Nanoengineering La JollaCAUSA Department of Chemical Engineering University of California San DiegoLa JollaCAUSA Departrnenf of Bioengineering La JollaCAUSA Department of Anesthesiology La JollaCAUSA Veterans Affairs San Diego Healthcare System San DiegoCAUSA Institute of Engineering in Medicine La JollaCAUSA

Multi-functional nanoshuttles for remotely targeted and on-demand delivery of therapeutic molecules and imaging to defined tissues and organs hold great potentials in personalized medicine, including precise early diagnosis, efficient prevention and therapy without toxicity. Yet, in spite of 25 years of research, there are still no such shuttles available. To this end, we have designed magnetic and gold nanoparticles （NP）-embedded silica nanoshuttles （MGNSs） with nanopores on their surface. Fluorescently labeled Doxombicin （DOX）, a cancer drug, was loaded in the MGNSs as a payload. DOX loaded MGNSs were encapsulated in heat and pH sensitive polymer P（NIPAM-co- MAA） to enable controlled release of the payload. Magnetically-guided transport of MGNSs was examined in：（a） a glass capillary tube to simulate their delivery via blood vessels; and （b） porous hydrogels to simulate their transport in composite human tissues, including bone, cartilage, tendon, muscles and blood-brain barrier {BBB）. The viscoelastic properties of hydrogels were examined by atomic force microscopy （AFM）. Cellular uptake of DOX- loaded MGNSs and the subsequent pH and temperature-mediated release were demonstrated in differentiated human neurons derived from induced pluripotent stem cells （iPSCs） as well as epithelial HeLa cells. The presence of embedded iron and gold NPs in silica shells and polymer-coating are supported by SEM and TEM. Fluorescence spectroscopy and microscopy documented DOX loading in the MGNSs. Time-dependent transport of MGNSs guided by an external magnetic field was observed in both glass capillary tubes and in the porous hydrogel. AFM results affirmed that the stiffness of the hydrogels model the rigidity range from soft tissues to bone. pH and temperature-dependent drug release analysis showed stimuli responsive and gradual drug release. Cells＇ viability MTT assays showed that MGNSs are non-toxic. The cell death from on-demand DOX release was observed in both neurons and ep

关键词： Multifunctional stimuli responsive polymer-gated iron

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Myocardial Cell Signaling During the Transition to Heart Failure

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Comprehensive Physiology 2019年第1期9卷 75-125页

作者： Matthew R. Zeglinski Adel Rezaei Moghadam Sudharsana R. Ande Kimia Sheikholeslami Pooneh Mokarram Zahra Sepehri Haleh Rokni Nima Khadem Mohtaram Mansour Poorebrahim Anahita Masoom Mehnosh Toback Niketa Sareen Sekaran Saravanan Davinder S. Jassal Mohammad Hashemi Hassan Marzban Dedmer Schaafsma Pawan Singal Jeffrey T. Wigle Michael P. Czubryt Mohsen Akbari Ian M.C. Dixon Saeid Ghavami Joseph W. Gordon Sanjiv Dhingra St. Boniface Hospital Research Centre Department of Physiology and Pathophysiology University of Manitoba Winnipeg Canada Department of Human Anatomy & Cell Science Max Rady College of Medicine Rady Faculty of Health Sciences University of Manitoba Winnipeg Canada Department of Internal Medicine University of Manitoba Winnipeg Canada Faculty of Medicine University of Toronto Toronto Ontario Canada Colorectal Research Center and Department of Biochemistry School of Medicine Shiraz University of Medical Sciences Shiraz Iran Department of Internal Medicine Zabol University of Medical Sciences Zabol Iran Laboratory for Innovation in Microengineering (LiME) Department of Mechanical Engineering University of Victoria Victoria British Columbia Canada Department of System Design Engineering Program of Biomedical Engineering University of Waterloo Department of Medical Biotechnology School of Advanced Technologies in Medicine Tehran University of Medical Sciences Tehran Iran Faculty of Medicine Mashhad Islamic Azad University Mashhad Iran Foothills Hospital Libin Cardiovascular Institute of Alberta Calgary Alberta Canada CeNTAB Department of Bioengineering SCBT SASTRA University Thanjavur India Department of Clinical Biochemistry School of Medicine Zahedan University of Medical Sciences Zahedan Iran Biology of Breathing Theme Children's Hospital Research Institute of Manitoba University of Manitoba Winnipeg Canada Health Policy Research Center Institute of Health Shiraz University of Medical Sciences Shiraz Iran College of Nursing and Children's Hospital Research Institute of Manitoba Rady Faculty of Health Sciences University of Manitoba Winnipeg Canada

Cardiovascular disease leading to heart failure (HF) remains a leading cause of morbidity and mortality worldwide. Improved pharmacological and interventional coronary procedures have led to improved outcomes following acute myocardial infarction. This success has translated into an unforeseen increased incidence in HF. This review summarizes the signaling pathways implicated in the transition to HF following cardiac injury. In addition, we provide an update on cell death signaling and discuss recent advances in cardiac fibrosis as an independent event leading to HF. Finally, we discuss cell-based therapies and their possible use to avert the deteriorating nature of HF. © 2019 American Physiological Society. Compr Physiol 9:75-125, 2019.

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Author Correction: Stretchable, dynamic covalent polymers for soft, long-lived bioresorbable electronic stimulators designed to facilitate neuromuscular regeneration

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Nature communications 2021年第1期12卷 415页

作者： Yeon Sik Choi Yuan-Yu Hsueh Jahyun Koo Quansan Yang Raudel Avila Buwei Hu Zhaoqian Xie Geumbee Lee Zheng Ning Claire Liu Yameng Xu Young Joong Lee Weikang Zhao Jun Fang Yujun Deng Seung Min Lee Abraham Vázquez-Guardado Iwona Stepien Ying Yan Joseph W Song Chad Haney Yong Suk Oh Wentai Liu Hong-Joon Yoon Anthony Banks Matthew R MacEwan Guillermo A Ameer Wilson Z Ray Yonggang Huang Tao Xie Colin K Franz Song Li John A Rogers Center for Bio-Integrated Electronics Northwestern University Evanston IL 60208 USA. Querrey Simpson Institute for Biotechnology Northwestern University Evanston IL 60208 USA. Department of Materials Science and Engineering Northwestern University Evanston IL 60208 USA. Department of Bioengineering University of California Los Angeles Los Angeles CA 90095 USA. Division of Plastic and Reconstructive Surgery Department of Surgery National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan 70456 Taiwan. International Research Center for Wound Repair and Regeneration National Cheng Kung University Tainan 70456 Taiwan. School of Biomedical Engineering Korea University Seoul 02841 Republic of Korea. Interdisciplinary Program in Precision Public Health Korea University Seoul 02841 Republic of Korea. Department of Mechanical Engineering Northwestern University Evanston IL 60208 USA. Department of Medicine University of California Los Angeles Los Angeles CA 90095 USA. State Key Laboratory of Structural Analysis for Industrial Equipment Dalian University of Technology 116024 Dalian China. Department of Engineering Mechanics Dalian University of Technology 116024 Dalian China. International Research Center for Computational Mechanics Dalian University of Technology 116024 Dalian China. State Key Laboratory of Chemical Engineering College of Chemical and Biological Engineering Zhejiang University 310027 Hangzhou China. Department of Biomedical Engineering Northwestern University Evanston IL 60208 USA. State Key Laboratory of Mechanical System and Vibration Shanghai Jiao Tong University 200240 Shanghai China. Center for Developmental Therapeutics Chemistry Life Processes Institute Northwestern University Evanston IL 60208 USA. Department of Neurological Surgery Washington University School of Medicine St. Louis MO 63110 USA. Center for Advanced Molecular Imaging Northwestern University Evanston IL

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Loading Dependent Electrical Properties of Hybrid Perovskite Composite Media

Loading Dependent Electrical Properties of Hybrid Perovskite...

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MRS Advances

作者： Murphy, John P. Andriolo, Jessica M. Sutton, Nathan J. Wyss, Gary Skinner, Jack L. Montana Tech Nanotechology Laboratory 1300 W. Park Street ButteMT59701 United States Materials Science PhD Program Montana State University System United States Individual Interdisiplinary PhD Program University of Montana 32 Campus Drive MissoulaMT59812 United States Mechanical Engineering Department Montana Tech 1300 W. Park Street ButteMT59701 United States Center for Advanced Mineral and Metallurgical Processing Montana Tech ButteMT59701 United States

Hybrid organic-inorganic perovskites (HOIPs) have been previously compounded with hydrophobic polymers in order to improve the resilience of HOIPs in humid environments. In this study HOIP particles were synthesized and dispersed into a polymer solution. The weight loading of the HOIP phase in the composite was increased until an abrupt change in the electrical conduction was observed indicating a percolation threshold was approached. Additionally, the CH3NH3PbI3/ polystyrene composite media was characterized to assess morphology and the effect it has on the observed electrical properties. Copyright © Materials Research Society 2017.

关键词： Perovskite

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Comparison of load calculation between IEC and GL offshore wind turbine design guideline using NREL 5 MW reference wind turbine 25

Comparison of load calculation between IEC and GL offshore w...

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25th International Ocean and Polar engineering Conference, ISOPE 2015

作者： Su, Wei-Nian Huang, Chin-Cheng Lin, Huei-Jeng Mechanical and System Engineering Program Institute of Nuclear Energy Research Taoyuan City Taiwan Department of Engineering Science and Ocean Engineering National Taiwan University Taipei City Taiwan

ISBN: (纸本)9781880653890

IEC 61400-3 (2009) and GL Offshore guideline (2012) are two commonly adopted guidelines for certification of offshore wind turbines worldwide. Comparison of load calculation during normal and idling situations between these two guidelines is performed in this paper. The NREL 5 MW wind turbine with monopile support structure is selected as the reference wind turbine system. Study of the impact on the loading conditions is conducted in this paper. Design load case (DLC) 1, 6, and 7 are considered in this work and the focus is on the Class I system with different turbulence characteristics (category A, B, and C). Both of extreme and fatigue loads are derived at critical components such as blade, shaft, tower, and foundation. The major impact is investigated and identified in this paper. Copyright © 2015 by the International Society of Offshore and Polar Engineers (ISOPE).

关键词： Offshore wind turbines

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Rotor load analysis method for twin Screw compressors with considering gaseous pressure and working temperature 14

Rotor load analysis method for twin Screw compressors with c...

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14th International Federation for the Promotion of Mechanism and Machine science World Congress, IFToMM 2015

作者： Hsu, Ruei-Hung Wu, Yu-Ren Wu, Wei-Te Tran, Van-The Bachelor's Program in Precision System Design Feng Chia University Taichung Taiwan Department of Mechanical Engineering National Central University Taoyuan Taiwan Department of Biomechatronics Engineering National Pingtung University of Science and Technology Pingtung Taiwan

ISBN: (纸本)9789860460988

Screw rotors of a twin screw compressor often deform and interfere due to the cyclic gas pressure and working temperature, which lead to noise, vibration and abrasion of the screw rotors. Therefore, this paper proposed a simplified CAE (Computer Aided engineering) method instead of the past massive and complex CFD (Computational Fluid Dynamics) method to simulate and estimate reasonably the screw rotor load and deformation with considering the gas pressure and working temperature applied on its operating process. The analysis results could provide the possible maximum rotor deformation and cyclic load acting on the rotors for design consideration.

关键词： Deformation

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Experimental study on spreading flame behavior over inclined electrical wire with AC electric fields 10

Experimental study on spreading flame behavior over inclined...

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10th Asia-Pacific Conference on Combustion, ASPACC 2015

作者： Lim, S.J. Kim, M.K. Park, J. Fujita, O. Chung, S.H. Interdisciplinary Program of Biomechanical Engineering Pukyong National University Busan Korea Republic of Environmental and Energy System Research Division Korea Institute of Machinery and Materials Daejeon Korea Republic of Department of Mechanical Engineering Pukyong National University Busan Korea Republic of Division of Mechanical and Science Hokkaido University Sapporo Japan Clean Combustion Research Center King Abdullah University of Science and Technology Thuwal Saudi Arabia

The effect of applied electric fields on the spreading flame over slanted Polyethylene (PE) insulated electrical wire was investigated experimentally by varying the AC frequency and voltage. The result showed that the spread rate of downwardly spreading flame decreased in increase of voltage and frequency, while that of upward flame spread rate exhibited complicated behavior with applied voltage and frequency. Downwardly spreading flame size became smaller in increase of applied voltage and frequency, while the flame leaned toward burnt side. When the flame spread upwardly, the flame size experienced large variation with applied voltage and frequency. Such flames leaned toward unburned side. Based on flame shape and the slanted direction of flame, the flame spread rate could be explained by thermal balance mechanism.

关键词： Electric fields

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WPA MKII: An innovative pump package for the international space station 66

WPA MKII: An innovative pump package for the international s...

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66th International Astronautical Congress 2015: Space - The Gateway for Mankind's Future, IAC 2015

作者： Di Francescantonio, N. Gargioli, E. Freddi, M. Falcetti, G. Pastor, S. Persson, J. Frerker, H. Szigetvari, Z. Schwientek, A. Thales Alenia Space Turin Italy European Space Agency Noordwijk Netherlands Airbus DS Bremen Germany DESI Engineering WPA Mk II System Engineering Manager Germany Head System Architectures and Verification DESI Engineering Germany Project Leader -Scientific equipment Germany Head of Science Unit France ISS Program and Exploration Department Head of ISS System Development Unit United States Mechanical Engineering Department Thermal Control Section United States IOT/COLUMBUS System Engineering and P/L integration United States TCS/ECLS Subsystem Manager France WPA Mk II Delivery Manager France

ISBN: (纸本)9781510818934

WPA Mk II Project started in 2011 in response to the ESA spare procurement philosophy for ISS life extension up to 2020 (and possibly beyond 2020). The project involves TASI as responsible for the design, development, manufacturing, integration and testing of this new water pump package for the ISS Columbus module. This pump package is responsible for the circulation of water inside Columbus pipelines to ensure proper thermal control not only for the Payloads (PL's), but also for the cabin where astronauts work and live, and consequently represents the core of the Thermal Control system in Columbus. WPA Mk II is characterized by several innovations in comparison with the current WPA Mk I installed in Columbus, like new functionalities (on board SW uploading capability), or new technologies (ultrasonic flow meter), up to a high level modular design (characterized by several ORUs, on Orbit Removable Units, conceived to optimize R&R operations and associated time and costs). A successful Critical Design Review has been achieved in July 2014, in Turin, with the support of the European Space Agency and Airbus. Now TASI is approaching MAIT phase: in the 2015 there will be the integration and testing of the various ORUs while the 2016 will be characterized by the integration and testing of the two pump packages WPA Mk II to demonstrate system compliance to the launchers and Columbus environmental and functional requirements. The present article provides an overview of the Project, the main features, the mission scenarios, and a general overview about the associated Qualification plan at Component, ORUs and Assy level. Copyright © 2015 by the American Institute Federation of Aeronautics and Astronautics. Inc. All rights reserved.

关键词： Integration testing

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Integrating artificial neural networks and cluster analysis to assess energy efficiency of buildings

Integrating artificial neural networks and cluster analysis ...

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IIE Annual Conference and Expo 2014

作者： Aqlan, Faisal Ahmed, Abdulaziz Srihari, Krishnaswami Khasawneh, Mohammad T. Industrial and System Engineering Program Department of Mechanical Civil and Environmental Engineering University of New Haven West HavenCT06516 United States Department of Systems Science and Industrial Engineering State University of New York at Binghamton BinghamtonNY13902 United States

ISBN: (纸本)9780983762430

Energy consumption of buildings worldwide has steadily increased over the past couple of decades. Furthermore, energy performance of buildings is one of the factors that contribute to energy waste and its perennial adverse impact on the environment. This paper presents a data mining approach for assessing the heating and cooling requirements of residential buildings. The proposed approach combines Artificial Neural Networks (ANNs) and cluster analysis to assess and predict the heating and cooling energy efficiency of residential buildings. The ANN-based model uses eight input variables (i.e., relative compactness, surface area, wall area, roof area, overall height, orientation, glazing area, and glazing area distribution) to predict both the heating and cooling loads of residential buildings. Buildings are then clustered based on the output variables using the K-means clustering method. The proposed approach is used to assess and evaluate 768 diverse residential buildings based on simulated literature data. The research results showed that the proposed approach can effectively predict the heating and cooling requirements of residential buildings based on the input variables considered with a very high level of accuracy.

关键词： Energy efficiency

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Abstracts from Hydrocephalus 2016 Abstracts

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FLUIDS AND BARRIERS OF THE CNS 2017年第SUPPL 1期14卷 1-21页

作者： [Anonymous] Johns Hopkins University Baltimore MD USA. Department of Neurosurgery Johns Hopkins University Baltimore MD USA. Johns Hopkins Biostatistics Center Johns Hopkins Bloomberg School of Public Health Baltimore MD USA. Johns Hopkins Bloomberg School of Public Health Baltimore MD USA. Department of Neurosurgery Johns Hopkins University School of Medicine Baltimore MD USA. Johns Hopkins Aramco Healthcare Dhahran Saudi Arabia. Johns Hopkins Hopkins Aramco Healthcare Dhahran Saudi Arabia. Johns Hopkins Aramco Healthcare Ras Tanura Saudi Arabia. Primary Care Johns Hopkins Aramco Healthcare Ras Tanura Saudi Arabia. Bloomberg School of Public Health Johns Hopkins University Baltimore MD USA. Department of Neurosurgery Rhode Island Hospital Providence RI USA. Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore MD USA. The Interface Group Institute of PhysiologyUniversity of Zurich Zurich Switzerland. Institute of Physiology University of Zurich Zurich Switzerland. Neuroscience Center Zurich and the Zurich Center for Integrative Human Physiology University of Zurich Zurich Switzerland. BioFlowImage Laboratory University of Picardie Jules Verne Amiens France. Reims Mathematics Laboratory University of Reims Champagne-Ardenne Reims France. Image Processing Laboratory University Hospital of Amiens-Picardie Amiens France. BioFlowImage Laboratory Department of Medical Image Processing University Hospital of Picardie Jules Verne Amiens France. Department of Geriatric University Hospital of Toulouse Toulouse France. Departments of Geriatric University Hospital of Toulouse Toulouse France. Department of Geriatry University Hospital Toulouse Toulouse France. Neurosciences department University of Cambridge Cambridge UK. Brain Physics Lab Academic Neurosurgery University of Cambridge Cambridge UK. Department of Nuclear Medicine University Hospital of Toulouse Toulouse France. Department of Nuclear Medicine University Hospit

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