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CHEMISTRY & BIOLOGY 2010年第4期17卷 311-312页

作者： McCarthy, Alice Main Text “In June 2003 the scientific and medical communities at MIT Harvard University and its affiliated hospitals and the Whitehead Institute banded together as collaborating partners to form the Eli and Edythe L. Broad Institute based in Cambridge MA. The Broad Institute established with initial funding from a $100 million philanthropic donation from the Los Angeles-based Broad family was primarily viewed as a marriage between the Whitehead Institute's Center for Genome Research (WICGR) and the Harvard Institute of Chemistry and Cell Biology (ICCB). Eli Broad founder and chairman of AIG SunAmerica Inc. explained “the purpose of the Broad Institute is to create a new type of research institute to build on the accomplishments of the human genome project and to move to clinical applications to both prevent and cure diseases.” Every Thursday morning we meet with perhaps 20 faculty members and 100 other researchers to discuss what we're all doing and should be doing next. -David Altschuler This paragraph was written five years ago when the Broad Institute was in its very earliest days as a life science research community (McCarthy 2005). Since that time “the Broad” as it's known has kept true to Eli Broad's vision having attracted a talented group of researchers faculty trainees and professional staff. This 1600 person research community known internally as “Broadies” includes faculty staff and students from throughout the MIT and Harvard biomedical research communities and beyond with collaborations spanning over a hundred private and public institutions in more than 40 countries worldwide. “What is special about the Broad is that we have people from Harvard MIT and the Harvard hospitals come together and work on problems of shared interest that could not be solved in their own individuals labs” explains David Altshuler M.D. Ph.D. Deputy Director and one of the Broad's six core faculty members. “These problems require expertise beyond any one principal investigator and in

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Domain Formation in the Plasma Membrane: Roles of Nonequilibrium Lipid Transport and Membrane Proteins

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Physical Review Letters 2008年第17期100卷 178102-178102页

作者： Jun Fan Maria Sammalkorpi Mikko Haataja Department of Mechanical and Aerospace Engineering Princeton Institute for the Science and Technology of Materials (PRISM) and Program in Applied and Computational Mathematics (PACM) Princeton University Princeton New Jersey 08544 USA

Compositional lipid domains (“lipid rafts”) in plasma membranes are believed to be important components of many cellular processes. The mechanisms by which cells regulate the sizes and lifetimes of these spatially extended domains are poorly understood at the moment. Here we show that the competition between phase separation in an immiscible lipid system and active cellular lipid transport processes naturally leads to the formation of such domains. Furthermore, we demonstrate that local interactions with immobile membrane proteins can spatially localize the rafts and lead to further clustering.

关键词： Lipids

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Implementing and Improving a method for non-invasive elicitation of probabilities for bayesian networks 07

Implementing and Improving a method for non-invasive elicita...

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International Conference on Computer Systems and Technologies and Workshop for PhD Students in Computing, CompSysTech '07

作者： De Jongh, Martinus Druzdzel, Marek Rothkrantz, Leon Faculty of Electrical Engineering Mathematics and Computer Science Man-Machine Interaction Group Delft University of Technology Delft Netherlands Decision Systems Laboratory School of Information Sciences and Intelligent Systems Program University of Pittsburgh Pittsburgh PA United States

ISBN: (纸本)9789549641509

Knowledge elicitation is difficult for expert systems that are based on probability theory. The elicitation of probabilities for a probabilistic model requires a lot of time and interaction between the knowledge engineer and the expert. Druzdzel and van der Gaag [5] have proposed a theoretical framework that would allow the use of multiple types of probabilistic information for elicitation of Bayesian networks. This framework has been used as a starting point for the implementation of a non-invasive elication method. © 2007 ACM.

关键词： Linear programming

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Work in Progress - Changes in Secondary School Teachers' Attitudes Following a Course in engineering Design

Work in Progress - Changes in Secondary School Teachers' Att...

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37th Annual Frontiers in Education Conference (FIE 2007), vol.4

作者： Linda L. Lindsley Veronica A. Burrows Science and Engineering if Materials Program Arizona State University Tempe USA Center for Research on Education in Science Mathematics Engineering and Technology and Department of Chemical Engineering Arizona State University Tempe USA

This paper discusses the changes in attitudes about engineering before and after an introductory course in engineering design offered to in-service secondary math and science teachers. The course is part of a series of courses offered through the NSF-sponsored MSP (Math and science Partnership): Project Pathways designed to help integrate mathematic and science and can be taken as partial fulfillment of a Master's degree in science/Math Education. An attitude survey based on the well-documented PFEAS (Pittsburgh Freshmen engineering Attitude Survey) was administered to the teachers taking the course. The survey was given at the beginning and end of the Fall 2006 semester. The greatest difference in the teachers' attitudes was in the area of engineering being perceived as an exact science. On a 5-point Likert scale, the teachers' mean responses to the group of questions regarding engineering being perceived as an exact science had a statistically significant mean difference of -.68, p<.01. The teachers showed significant differences on three other scales as well (engineering compatibility, confidence in basic engineering knowledge and skills, and overall computer skills). Additional open-ended questions showed a gain in the teachers' general knowledge about engineering as a profession and their ability to recognize students in their courses that might be successful as engineering students following their graduation from high school.

关键词： Attitudes engineering design K-12 education Teachers

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Work in progress - Instructor credibility: An analysis of engineering students’ reflective writing for evidence of attitude shifts

Work in progress - Instructor credibility: An analysis of en...

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Frontiers in Education (FIE) Conference

It is a common, puzzling, and often disheartening experience for teachers at all levels to realize that they may have little credibility in the eyes of their students, especially regarding the applicability of the lessons taught in the classroom to 'real world' situations. This paper analyzes the results of using a reflective writing/research paper in a freshman engineering design course to assist students in making real world connections to classroom topics. In addition to writing a standard research paper on topics related to engineering design, students were required to write a personal reflection on the assignment before and after its completion. Comparisons of these pre-assignment and post-assignment reflections show a substantial shift in the students' attitudes toward the credibility of their instructor and the choice of curriculum and topics for the course. The results also show that students spent time in metacognitive reflection on their own beliefs about the applicability of course work to the world of the working engineer. While not every student experienced these attitude shifts, review of these papers did show a substantial enough positive shift occurred through this writing process to promote further research in this area.

关键词： Writing Design engineering Reflection Process design engineering students Eyes Chemical engineering Electric breakdown Books Problem-solving

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Tfe Solberg Award

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Naval Engineers Journal 2009年第5期112卷

作者： Dr. Roy L. Streit Since 1992 Dr. Streit has focused a significant amount of his energy to assignment problems in acoustic warfare data fusion systems. This work led him to the formulation of the PDD Principle a broadly useful theoretical method that enables the derivation of new classes of discrete-continuous estimation algorithms for solving assignment problems without requiring enumeration and pruning. In recognition of his outstanding work in this area Dr. Streit received the NAVSEA Scientist of the Year Award for 1997. Dr. Streit has also been pursuing avenues for analyzing the loss in broadband detection performance of an acoustic array in the presence of interferences. Because examining all possible separations between the signal and many interferers is infeasible he has proposed a Poisson process model for the number and location (s) of the interferers. In this same time period Dr. Streit has also been investigating issues in environmental modeling and localization by proposing a novel integral method for solving the bearings-only target motion analysis problem which enables a natural heuristic for compensating for mismatch between the model predictions and the real world. Most recently Dr. Streit has proposed the Numerical ACoustic Hull ARray (NACHAR) Project as a revolutionary and ambitious approach to hull array design. Its premise is that optimizing the detection capability of large hull arrays requires the full integration of hull sensor array and beamformer design processes. Because NACHAR crosses an unusual number of technical disciplines it involves researchers from several departments. The diversity of Dr. Streif s technical background makes him uniquely suited to lead the project Dr. Streifs truly impressive scientific achievements are complemented by a noteworthy list of professional activities that accentuate his value to Division Newport and the Navy. He represents the United States in The Technical Cooperation Program Maritime Activities Panel 9 (Sonar Technology) and participates in the Division New

for his significant engineering research and development in sonar array research and acoustic transient signals as set forth in the following

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Revisiting the South Cañon Number 1 Coal Mine fire during a geologic excursion from Denver to Glenwood Springs, Colorado

GSA Field Guides

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GSA Field Guides 2007年 10卷 101-110页

作者： Stracher, Glenn B. Lindsley-Griffin, Nancy Griffin, John R. Renner, Steven Schroeder, Paul Viellenave, James H. Masalehdani, M. Naze-Nancy Kuenzer, Claudia Division of Science and Mathematics East Georgia College 131 College Circle Swainsboro GA 30401 United States Department of Geosciences University of Nebraska 214 Bessey Hall Lincoln NB 68588 United States Colorado Division of Minerals and Geology Inactive Mines Program 101 South 3rd Street Grand Junction CO 81501 United States Department of Geology University of Georgia 210 Field Street Athens GA 30602 United States Pinyon Environmental Engineering Resources Inc. 9600 West Jewell Avenue Lakewood CO 80232 United States Centre National de la Recherche Scientifique 8110 Processus et Bilans des Domaines Sédimentaires Université de Lille 1 59655 Villeneuve d'Ascq France Institute of Photogrammetry and Remote Sensing Vienna University of Technology Gusshausstrasse 27-29 A-1040 Wien Austria

The origin of the subsurface fire burning since 1910 in the South Cañon Number 1 Coal Mine west of Glenwood Springs, Colorado, is unknown. Surface manifestations of the fire include gas vents (some encrusted with minerals), burnt vegetation, subsidence features, ash, sulfur, and red-oxidized shale. The minerals tschermigite, mascagnite, and gypsum formed in association with coal-fire gas exhaled from a gas vent on the western slope of South Canyon. Tschermigite and gypsum are reaction products of the gas with feldspar grains in the Williams Fork Formation. Gas collected from a vent and from soil above a burn zone in former underground workings on the eastern slope of South Canyon was found to contain numerous hydrocarbons, including n-alkanes, iso-alkanes, cyclo-alkanes, alkyl aromatics, alkenes, ketones, ethers, and a number of other volatile organic compounds, as well as sulfur compounds. Drill casings currently present in voids in the D coal seam on the western slope trail are useful for collecting gas samples, monitoring the temperature of subsurface burning, and measuring the concentration of gases, such as carbon monoxide and carbon dioxide, in the field. The likely success of conventional fire-containment methodologies in South Canyon is questionable, although additional studies includingdrilling data may eventually suggest a useful control procedure. The 2002 "Coal Seam Fire" that burned over 12,000 acres and destroyed numerous buildings in and around Glenwood Springs exemplifies the potential danger an underground coal fire poses for igniting a surface fire. Coal-fire gas and the solid by-products of combustion contribute to the destruction of floral and faunal habitats and may be responsible for a variety of human diseases;hence, the study of coal gas and its by-products may prove useful in understanding environmental pollution created by coal-mine fires. © 2007 The Geological Society of America. All rights reserved.

关键词： Coal mines

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Delay performance under the joint scheduling over Gilbert-Elliot channel

Delay performance under the joint scheduling over Gilbert-El...

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2006 Wireless Telecommunications Symposium, WTS

作者： Ishizaki, Fumio Hwang, Gang Uk Department of Mathematics Telecommunication Mathematics Research Center Korea University Division of Applied Mathematics and Telecommunication Engineering Program Korea Advanced Institute of Science and Technology

ISBN: (纸本)1424400465

In this paper, we consider a joint scheduling algorithm which is a combination of Knopp and Humblet (KH) scheduling, which fully exploits multiuser diversity, and round-robin (RR) scheduling, which does not use multiuser diversity at all. By assuming that the wireless channel process for each user is described by Gilbert-Elliot channel model, we develop a formula to estimate the tail distribution of packet delay for an arbitrary user under the joint scheduling. Numerical results exhibit that under the joint scheduling, the ratio of the number of slots assigned for the RR scheduling to that for the KH scheduling dominates the delay performance. © 2006 IEEE.

关键词： Scheduling

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Instantaneous radar polarimetry with multiple dually-polarized antennas

Instantaneous radar polarimetry with multiple dually-polariz...

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40th Asilomar Conference on Signals, Systems, and Computers, ACSSC '06

作者： Calderbank, A.R. Howard, S.D. Moran, W. Pezeshki, A. Zoltowski, M. Program in Applied and Computational Mathematics Princeton University Princeton NJ United States Defence Science and Technology Organization Edinburgh Australia Electrical Engineering and Computer Science University of Melbourne Melbourne Australia Electrical and Computer Engineering Purdue University West Lafayette IN United States

ISBN: (纸本)1424407850

Fully Polarimetric radar systems are capable of simultaneously transmitting and receiving in two orthogonal polarizations. Instantaneous radar polarimetry exploits both polarization modes of a dually-polarized radar transmitter and receiver on a pulse by pulse basis, and can improve the radar detection performance and suppress range sidelobes. In this paper, we extend the use of instantaneous radar polarimetry for radar systems with multiple dually-polarized transmit and receive antennas. Alamouti signal processing is used to coordinate transmission of Golay pairs of phase codes waveforms across polarizations and multiple antennas. The integration of multi-antenna signal processing with instantaneous radar polarimetry can further improve the detection performance, at a computational cost comparable to single channel matched filtering.

关键词： Polarimeters

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Delay Performance under the Joint Scheduling over Gilbert-Elliot Channel

Delay Performance under the Joint Scheduling over Gilbert-El...

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Wireless Telecommunications Symposium, WTS

作者： Fumio Ishizaki Gang Uk Hwang Department of Mathematics and Telecommunication Mathematics Korea University South Korea Division of Applied Mathematics and Telecommunication Engineering Program Korea Advanced Institute of Science and Technology

In this paper, we consider a joint scheduling algorithm which is a combination of Knopp and Humblet (KH) scheduling, which fully exploits multiuser diversity, and round-robin (RR) scheduling, which does not use multiuser diversity at all. By assuming that the wireless channel process for each user is described by Gilbert-Elliot channel model, we develop a formula to estimate the tail distribution of packet delay for an arbitrary user under the joint scheduling. Numerical results exhibit that under the joint scheduling; the ratio of the number of slots assigned for the RR scheduling to that for the KH scheduling dominates the delay performance

关键词： Delay estimation Scheduling algorithm Probability distribution Wireless networks Telecommunication traffic mathematics Fading Throughput Predictive models Performance analysis

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