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A Coumarin-Thiazolidine Based Theranostic Fluorescent Probe with Divergent Fluorescence Responses for Cu（Ⅱ）,Hg（Ⅱ）,and Ag（Ⅰ） ions,and a Case Study of a Self-Threshold Fluorescent Probe

A Coumarin-Thiazolidine Based Theranostic Fluorescent Probe ...

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第十一届全国化学生物学学术会议

作者： Junwei Chen Na Wang Huan Xu Chao Song Yajun Zhang Feng Gao Kaiyan Lou Wei Wang State Key Laboratory of Bioengineering Reactor Shanghai Key Laboratory of New Drug Designand Shanghai Key Laboratory of Chemical BiologySchool of PharmacyEast China University of Science & Technology

Facile detection, differentiation, and detoxification of multiple heavy metal ions in a simple molecule design presents an ultimate challenge.[1] Here we reported a coumarin-thiazolidine based theranostic fluorescent probe 1（R=Et） with two latent metal ion binding sites and two distinctive hydrolysis sites which are promoted by metal-ion-complexation for achieving divergent fluorescence responses for the three heavy metal ions: an "on-off" response for Ag+, an "off-on" response for Hg2+, and a self-threshold ratiometric fluorescence response for Cu2+. The probe 1 also showed cell-protective effects comparable to D-penicillamine against Ag+, Cu2+, or Hg2+-induced cytotoxicity in MCF-7 cells.[2] By studying the fluorescence response and mechanism of the probe for Cu2+, we proposed a new concept of "self-threshold fluorescent probe" in fluorescent probe design. Such a probe gives cut-out fluorescence readout when the concentration of the analyte of interest above a certain threshold that is dependent on the probe’s concentration. The key to the self-threshold fluorescent probe design is the sequential binding of two different binding sites with differentiable fluorescence readout. Such a self-threshold fluorescent probe is particularly useful for determining whether concentration of the analyte of interest is over a certain limit or not. [2] Moreover, we also find that allosteric effect may also contribute to the sequential binding of the Cu2+ and the self-threshold fluorescence readout. [2]

关键词： fluorescent probe heavy metal ion detoxification threshold allosteric effect

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Gradient Elastic–Plastic Properties of Expanded Austenite Layer in 316L Stainless Steel

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Acta Metallurgica Sinica(English Letters) 2018年第8期31卷 831-841页

作者： Yong Jiang Yang Li Yun-Fei Jia Xian-Cheng Zhang Jian-Ming Gong School of Mechanical and Power Engineering Nanjing University of TechnologyNanjing 211816China Key Laboratory of Design and Manufacture of Extreme Pressure Equipment Nanjing 211816Jiangsu ProvinceChina Key Laboratory of Pressure System and Safety MOESchool of Mechanical and Power EngineeringEast China Universityof Science and TechnologyShanghai 200237China

The gradient mechanical properties, variation of stress with strain and surface cracking behavior of expanded austenite developed on 316L austenitic stainless steel were investigated by nanoindentation tests, X-ray residual stress analysis and scanning electron microscope observation in four-point bending tests. The results show that the plastic properties of the carburizing layer including true initial yield strengths and strain hardening exponents increase significantly from substrate to surface, while the true elastic modulus just improves slightly. Due to the onset of plastic flow, the residual stresses are almost equivalent to the true initial yield strengths from surface to the depth of ～10 lm. The results of four-point bending tests show that surface stress increases linearly with the increase in strain until the strain reaches～1.0%, after that the plastic yield happens. The expanded austenite surface layer is brittle, and the cracks will be created at the strain of ～1.4%.The cracking stress is about～2.4 GPa.

关键词： Low-temperature gaseous carburization Expanded austenite Nanoindentation Gradient elastic-plastic properties Four-point bending

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A comprehensive review on the need for integrated strategies and process modifications for per- and polyfluoroalkyl substances (PFAS) removal: Current insights and future prospects

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Case Studies in Chemical and Environmental Engineering 2024年 9卷

作者： Sharma, Neha Kumar, Vinay Sugumar, Vimal Umesh, Mridul Sondhi, Sonica Chakraborty, Pritha Kaur, Komalpreet Thomas, Jithin Kamaraj, Chinnaperumal Maitra, Subhrangsu Sundar Department of Biochemistry Saveetha Medical College and Hospital Saveetha Institute of Medical and Technical Sciences (SIMATS) Thandalam Chennai 602105 India Bioconversion and Tissue Engineering (BITE) Laboratory Department of Community Medicine Saveetha Medical College and Hospital Saveetha Institute of Medical and Technical Sciences (SIMATS) Thandalam Chennai 602105 India Department of Life Sciences CHRIST (Deemed to Be University) Karnataka Bengaluru 560029 India Haryana State Pollution Control Board Haryana Panchkula India School of Allied Healthcare and Sciences Jain (Deemed to Be) University Whitefield Karnataka Bangalore 560066 India Punjab Agricultural University Institute of Agriculture Gurdaspur Punjab 143521 India Department of Biotechnology Mar Athanasius College Kerala India Interdisciplinary Institute of Indian System of Medicine (IIISM) SRM Institute of Science and Technology (SRMIST) Kattankulathur Tamilnadu Chennai 603203 India Metagenomics and Bioprocess Design Laboratory School of Biotechnology Jawaharlal Nehru University New Delhi India

Alarming concern over the persistence and toxicity of per- and polyfluoroalkyl substances (PFAS) in the environment has created an imperative need for designing and redesigning strategies for their detection and remediation. Conventional PFAS removal technologies that uses physical, chemical, or biological methods. Increase in the diversity and quantity of PFAS entering the environment has necessitated the need for developing more advanced and integrated strategies for their removal. Despite of the advances reported in this domain, there exist a huge research gap that need to be mentored to tackle the problems associated with mitigation of combined toxicity of wide variety of PFAS in the environment. The possibility of PFAS to combine with other emerging contaminants poses an additional threat to the existing treatment methods thereby stressing the need for a continuous monitoring and updating the treatment processes. This review work aims at understanding the structure, entry, and fate of different types of PFAS in to the environment. Further an in-depth discussion regarding the different levels of toxicity associated with PFAS is elaborated in the review. The process description of recent PFAS remediation techniques along with their significance, limitations and possibility of integration is discussed in detail. Further a detailed outlook on the advantages and limitations of PFAS removal methods and an insight into the recently developed PFAS removal methods is outlined in this review. © 2024 The Authors

关键词： PFAS degradation PFAS removal PFAS removal strategies PFAS toxicity PFAS transport

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Processing of a comprehensive windowed multipole library via vector fitting

Processing of a comprehensive windowed multipole library via...

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2018 International Conference on Physics of reactors: reactor Physics Paving the Way Towards More Efficient systems, PHYSOR 2018

作者： Liang, Jingang Peng, Xingjie Liu, Shichang Josey, Colin Forget, Benoit Smith, Kord Department of Nuclear Science and Engineering Massachusetts Institute of Technology CambridgeMA02139 United States Science and Technology on Reactor System Design Technology Laboratory Nuclear Power Institute of China ChengduSichuan610000 China Department of Engineering Physics Tsinghua University Beijing100084 China

ISBN: (纸本)9781713808510

The windowed multipole method is a promising technique to efficiently perform Doppler broadening of nuclear cross section data and has so far been based on the conversion of resolved resonance parameters to the pole representation. However, 40% of ENDF/B-VII. 1 nuclides cannot be directly converted in windowed multipole format because some nuclides are provided directly as point-wise data in the evaluation or the presence of non-smooth point-wise data that prevents the transformation. A new approach based on Vector Fitting technique was recently investigated to convert point-wise cross section data to poles and residues. This paper presents a generalized Vector Fitting algorithm which is able to generate optimized multipole parameters from ENDF point-wise data and applicable to a wide range of nuclides. Using this algorithm, a comprehensive windowed multipole library which contains all ENDF/B-VII.l nuclides was produced for the first time. Accuracy of the library was demonstrated by microscopic cross section comparisons at different temperatures, and calculation results of the BEAVRS benchmark were performed to demonstrate its applicability to realistic problems. © 2018 International Conference on Physics of reactors, PHYSOR 2018: reactor Physics Paving the Way Towards More Efficient systems. All rights reserved.

关键词： Doppler effect

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A novel method to increase energy density of permanent magnet machine based on multi-physical field analysis

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UPB Scientific Bulletin, Series D: Mechanical Engineering 2020年第4期82卷 79-92页

作者： Zheng, Qingchun Zhao, Yangyang Zhu, Peihao Wang, Sen Liu, Jingna Ma, Wenpeng Li, Xiang Xiao, Yinhong Wang, Naixin Tianjin Key Laboratory for Advanced Mechatronic System Design and Intelligent Control School of Mechanical Engineering Tianjin University of Technology Tianjin300384 China School of Computer Science Tianjin University of Technology Tianjin300384 China School of Automation Shenyang Institute of Engineering Shenyang110136 China Baoding Power Supply Company Hebei Electric Power Company State Grid Corporation of China Baoding071000 China

As an important component of all-electric aircraft, the main propulsion machine is developing towards high energy density, high efficiency and high fault tolerance. In order to improve the energy density of main propulsion machine for all-electric aircraft, a novel approach, which can be used for excellent performance improvement of electric machine of all-electric aircraft, is reported in this paper. The analytical formula of energy density is put forward and the design method of high energy density permanent magnet machine is presented. A high energy density machine with rated power of 30kW is designed, and the electromagnetic field simulation analysis, strength and stress structure verification, temperature field simulation analysis and multi-physical field coupling analysis are obtained. A prototype is developed, the experiment platform is established, and experiments are performed. The energy density of main propulsion machine designed is up to 21kW·N·m/kg2, and the index is increased by 3.2 times. The optimal method based on the multi-physical field analysis can be also applied to other high energy density machines. © 2020, Politechnica University of Bucharest. All rights reserved.

关键词： Electromagnetic fields

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Flexible data handling in the flight control decision software for space science satellites 15th

Flexible data handling in the flight control decision softwa...

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15th International Conference on Space Operations, SpaceOps 2018

作者： Zhang, Y.Z. Peng, X.D. Gao, C. Laboratory of System Simulation and Concurrent Design Technology National Space Science Center Chinese Academy of Sciences Beijing100190 China Laboratory of System Simulation and Concurrent Design Technology University of Chinese Academy of Sciences Beijing100049 China

ISBN: (纸本)9781624105623

In order to support the in-orbit operation of the satellites in the Strategic Priority Program on Space science, the Flight Control Decision Support Software (FCDSS) is developed. It belongs to the mission operation subsystem of the ground support system of the Strategic Priority Program on Space science. The FCDSS is responsible for the comprehensive analysis of the operating status of the onboard equipment, the use of the satellite resources, the scientific detection results, and full life cycle visualization of the scientific mission in real time and afterwards, and mission situation analysis. The software contains two parts--"Flight Control Decision Analysis and Comprehensive Situation Visualization Unit" and "Full-lifecycle Data Processing Unit". The latter is the main focus in this paper. It is responsible for acquiring required data (such as telemetry data) from the database and do calculations for coverage analysis, observation plan analysis and etc. Due to the various types and massive amount of data need to be processed, it posed high requirements to data processing. In brief, in this paper, we will first describe the software architecture in detail. Then, give detailed information on the design and implementation of the data processing layer. At last, mission applications of the software will be shown with conclusions on the performance and lessons we have learned as the four mission carries on. © 2018, American Institute of Aeronautics and Astronautics Inc, AIAA. All rights reserved.

关键词： Visualization

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All-Electric Aircraft Nose Wheel Steering system with Two Worm Gears

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Transactions of Nanjing University of Aeronautics and Astronautics 2018年第1期35卷 170-180页

作者： Zhang Ming Li Chuang Wu Xin Zhu Yin Key Laboratory of Fundamental Science for National Defense-Advanced Design Technology of Flight Vehicle Nanjing University of Aeronautics&AstronauticsNanjing 210016P.R.China Shanghai Aircraft Design and Research Institute Shanghai 201210P.R.China Aviation Key Laboratory of Science and Technology on Aero Electromechanical System Integration Nanjing 211106P.R.China

As all-electric aircraft has many advantages,an aircraft nose wheel steering system would be developed to the all-electric *** the control demand of the nose wheel steering system,based on the basic principles of nose wheel steering system and the design technique of mechanotronics,an all-electric aircraft nose wheel steering system,composed of a nose wheel steering mechanism of two worm gear and a control servo system of fly-by-wire with both steering and anti-shimmy functions is designed to meet the demand for operation control in the nose wheel steering ***,based on the LMS-AMESim software,the simulation model of the system is established to simulate the dynamics for the verification of its steering *** simulation results indicate that the nose wheel steering system is reasonable,and can meet the requirements of the general ***,the prototypes of the steering mechanism and control system are studied to validate the design,and the steering test bench is prepared to test the designed *** test results,such as steer angle,rotate speed of motor are analyzed in details and compared with the theoretical *** analysis and comparison results show that the design is reasonable and the property of the prototype can achieve the design objectives.

关键词： mechanotronics design nose wheel steering system all-electric aircraft design landing gear

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Research on power characteristics matching of electric drive crawler bulldozer 3

Research on power characteristics matching of electric drive...

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3rd IEEE International Conference on Electronic Information technology and Computer Engineering, EITCE 2019

作者： Lun, Li Du, Bo-Feng Yang, Shao-Dong Li, Ji-Shun Henan University of Science and Technology Henan Key Laboratory for Machinery Design and Transmission System Luoyang471003 China Shenzhen Zhaowei Machinery and Electronics Co. Ltd. Shenzhen518105 China Mechanical and Electrical Equipment Engineering Co. Ltd Luoyang471003 China

ISBN: (数字)9781728135847

ISBN: (纸本)9781728135847

According to the composition of the electric drive system of the electric drive crawler bulldozer, the basic parameters of the main components in the electromechanical transmission system were calculated by using theoretical knowledge. The original and improved electric drive crawler bulldozer were simulated and compared respectively by using ADVISOR simulation software in order to verify the power performance of the improved electric drive crawler bulldozer. The studying result shows that the improved drive motor can meet the load characteristics of the crawler bulldozer under the bulldozing conditions through theoretical analysis and simulation research, and the improved electric drive system can meet the power characteristics of the D320E electric drive crawler bulldozer. © 2019 IEEE.

关键词： Computer software

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SI-YOLO: A Deep Learning Algorithm Suitable for Surgical Instrument Detection

SSRN

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SSRN 2022年

作者： Liu, Zhenzhong Zhou, Yifan Sun, Qiyuan Wang, Yan Polat, Kemal Nour, Majid Alenezi, Fayadh Alhudhaif, Adi Tianjin Key Laboratory for Advanced Mechatronic System Design and Intelligent Control School of Mechanical Engineering Tianjin University of Technology Tianjin300384 China Tianjin300384 China Department of Electrical and Electronics Engineering Bolu Abant Izzet Baysal University Bolu14280 Turkey Department of Electrical and Computer Engineering Faculty of Engineering King Abdulaziz University Jeddah21589 Saudi Arabia Department of Electrical Engineering College of Engineering Jouf University 72238 Saudi Arabia Department of Computer Science College of Computer Engineering and Sciences in Al-kharj Prince Sattam bin Abdulaziz University P.O. Box 151 Al-Kharj 11942 Saudi Arabia

Surgical instrument detection and tracking is one of the core technologies of surgical robots, which can assist clinicians in completing operations. However, existing methods need further improvement in terms of real-time performance and accuracy. We propose a deep learning algorithm, SI-YOLO, for detection of surgical instruments. SimAM attention mechanism is used to improve the feature extraction ability of YOLOv5. Replacing PANet with BiFPN in the neck network improves the feature fusion strategy. The α-IoU loss function is used to improve the regression accuracy of detection boxes. The mAP and FPS of the SI-YOLO reach 99.2% and 120 frames/sec, respectively. Aiming at the problem of ID transformation in the disappearance and occlusion of surgical instruments, the Inception-ResNet-v2 structure is added on the basis of the appearance feature extraction network Cosine of the DeepSort tracking algorithm. Combining SI-YOLO with the improved DeepSort implements the Tracking by Detection (TBD) algorithm. In the case of device disappearance or occlusion, the frequency of ID transitions is reduced by approximately 30%. Finally, we built a simulated surgery experimental platform, established our own data set, and realized the preliminary application of the proposed algorithm. © 2022, The Authors. All rights reserved.

关键词： Object detection

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Corrigendum to “A comprehensive multi-parameter optimization method of squeeze film damper-rotor system using hunter-prey optimization algorithm” [Tribol Int 194 (2024)109538]

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Tribology International 2024年 195卷

作者： Yufei Xu Hongrui Cao Jianghai Shi Shiyuan Pei Bo Zhang Kailang She School of Mechanical Engineering Xi’an Jiaotong University Xi’an 710049 PR China National and Local Joint Engineering Research Center of Equipment Operation Safety and Intelligent Monitoring Xi’an Jiaotong University Xi’an 710049 PR China Key Laboratory of Education Ministry for Modern Design and Rotor-Bearing System Xi’an Jiaotong University Xi’an 710049 PR China Department of Mechanics and Aerospace Engineering Southern University of Science and Technology Shenzhen 518055 PR China

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