Animals in nature, such as geckos, inchworms, and felines can climb on various surfaces using different mechanisms and serve as references for the study of bio-inspired robots. This paper presents an inchworm-inspired...
Animals in nature, such as geckos, inchworms, and felines can climb on various surfaces using different mechanisms and serve as references for the study of bio-inspired robots. This paper presents an inchworm-inspired climbing robot that consists of soft body and feet. The soft robot is actuated by shape memory alloy wires and utilizes microspine arrays to attach its feet to rough or soft surfaces. A series of experiments to test the functionality of the feet and torso of the designed robot have verified the theoretical feasibility of the robot. Results have shown that the designed bio-inspired robot can climb on inclined or vertical curved surfaces and flat surfaces. The robot can also adapt to the underwater environment. Thus, this robot has great potential for various applications such as pipeline inspection.
A multi-objective optimization of non-uniform beams is presented for minimum radiated sound power and weight. The transfer matrix method is used to compute the structural and acoustic responses of a non-uniform beam a...
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In order to detect the healthy running state of wire rope efficiently and accurately in multi-point synchronous hoisting system, this paper proposed a method based on orthogonal image technology to detect the spatial ...
In order to detect the healthy running state of wire rope efficiently and accurately in multi-point synchronous hoisting system, this paper proposed a method based on orthogonal image technology to detect the spatial transverse vibration displacement of wire rope. Firstly, two sets of images were captured synchronously at the same frequency by two high-speed video cameras where set vertically each other. Secondly, binarization and calculation of actual vibration displacement of wire rope were carried out with LabVIEW, and recording the real-time vibration of wire rope. At last, empirical mode decomposition method was used to remove the periodic excitation caused by the displacement of rope-arranging. The spatial vibration shape of the wire rope and the vibration trajectory in the cross section of the wire rope were obtained by fitting these data on Matlab. The experimental results show that this method can accurately reflect the law of the spatial transverse vibration of wire rope. It can provide technical support for the study of the detection and evaluation of the safety parameters of the hoisting system.
作者：
Ling-Ling WuWeihua DiLitao ShaoJie ZhouYu-Yu QiuMengrui ZhangZhenye LiYanqun ZhangPengcheng LuanJifan LiGongchang YuGuiqian FangCaicai MengBin ShiXuemei ZhaoQixin ChenXintian ShaoSchool of Pharmaceutical Sciences
National Key Laboratory of Advanced Drug Delivery System Medical Science and Technology Innovation Center Shandong First Medical University & Shandong Academy of Medical Sciences Jinan Shandong 250062 PR China. Department of Traditional Chinese Medicine Orthopedics
Neck-Shoulder and Lumbocrural Pain Hospital of Shandong First Medical University Shandong First Medical University & Shandong Academy of Medical Sciences Jinan Shandong 250062 PR China. School of Life Sciences
Medical Science and Technology Innovation Center Shandong First Medical University & Shandong Academy of Medical Sciences Jinan Shandong 250117 PR China. Department of Traditional Chinese Medicine Orthopedics
Neck-Shoulder and Lumbocrural Pain Hospital of Shandong First Medical University Shandong First Medical University & Shandong Academy of Medical Sciences Jinan Shandong 250062 PR China. Electronic address: bshi@***. School of Pharmaceutical Sciences
National Key Laboratory of Advanced Drug Delivery System Medical Science and Technology Innovation Center Shandong First Medical University & Shandong Academy of Medical Sciences Jinan Shandong 250062 PR China. Electronic address: zhaoxm@***. School of Pharmaceutical Sciences
National Key Laboratory of Advanced Drug Delivery System Medical Science and Technology Innovation Center Shandong First Medical University & Shandong Academy of Medical Sciences Jinan Shandong 250062 PR China Departments of Diagnostic Radiology
Surgery Chemical and Biomolecular Engineering and Biomedical Engineering Yong Loo Lin School of Medicine and College of Design and Engineering National University of Singapore Singapore 119074 Singapore. School of Life Sciences
Medical Science and Technology Innovation Center Shandong First Medical University & Shandong Academy of Medical Sciences Jinan Shandong 250117 PR China Department of Traditional Chinese Medicine Orthopedics
Neck-Shoulder and Lumbocrural Pain Hospital of Shandong First Medical Univ
BACKGROUND:RECQL4 is a critical factor in DNA repair and serves as a significant biomarker for liver cancer. Inhibiting RECQL4 induces apoptosis in liver cancer cells. Given the role of mitochondria in regulating apop...
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BACKGROUND:RECQL4 is a critical factor in DNA repair and serves as a significant biomarker for liver cancer. Inhibiting RECQL4 induces apoptosis in liver cancer cells. Given the role of mitochondria in regulating apoptosis and the dual localization of RECQL4 in both the mitochondria and nucleus, targeting mitochondrial RECQL4 may induce mitochondrial dysfunction, thereby enhancing the therapeutic efficacy of liver cancer treatments.
PURPOSE:Unlike traditional drug structure optimization, which focuses solely on protein target interactions, our approach optimizes drug structure based on both organelle distribution and protein interactions.
METHODS:As a proof of concept, we selected Rhein (4,5-dihydroxyanthraquinone-2-carboxylic acid), an auto-fluorescent, lipophilic anthraquinone found in a variety of different medicinal herbs used in TCM that is known to bind to RECQL4, a protein that is distributed throughout the cytosol, mitochondria, and other subcellular locations, albeit unevenly. Rhein has the tendency to accumulate in different subcellular organelles, which reduces the overall efficacy of the drug. To overcome this limitation, we conjugated a triphenylphosphonium group Rhein to direct the drug to the mitochondria, resulting in Rh-Mito.
RESULTS:Our results demonstrated that this chemical modification retains the ability to intervene in the expression of RECQL4 protein while also improving the cellular uptake of Rh-Mito. Utilizing advanced imaging techniques, we show that Rh-Mito preferentially accumulated in the mitochondria, where it targeted RECQL4 to inhibit the repair of mtDNA, altered the morphology of mitochondrial cristae, and induced apoptosis. Notably, Rh-Mito displayed superior anti-tumor efficacy compared to unmodified Rhein.
CONCLUSION:Rh-Mito was designed to selectively target mitochondria, avoiding interactions with other organelles. This modification strengthens its binding to RECQL4, disrupts mitochondrial cristae, inhibits tumor cell migration
Effects of different age groups and different external loading distribution on lower extremity muscle activation during obstacle crossing tasks were tested in this study. Four young participants and five healthy senio...
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Effects of different age groups and different external loading distribution on lower extremity muscle activation during obstacle crossing tasks were tested in this study. Four young participants and five healthy senior participants performed different walking tasks at their own speed carrying multiple different weights while their lower extremity muscle activation patterns were recorded and compared. Older adults showed significantly increased muscle activation patterns in obstacle negotiation. Furthermore, participants showed altered lower extremity muscle activation patterns with different load distribution.
Combustion of Aluminum nanoparticles(AlNPs) has long been investigated experimentally because of its use in various energetic formulations for propellants and explosives. But the limited spatio-temporal resolution in ...
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Combustion of Aluminum nanoparticles(AlNPs) has long been investigated experimentally because of its use in various energetic formulations for propellants and explosives. But the limited spatio-temporal resolution in experiments in particular makes it challenging to explore the microstructural evolution of AlNPs oxidation and associated mechanisms. Here we perform large-scale reactive molecular dynamics simulations to study the structural evolution of AlNPs with 2-4 nm thick oxide shell in oxygen environment. We find the temporal hollowing processes of AlNPs for both symmetrical and asymmetrical oxidations, in which the morphological evolution can be understood by discrepant electric field and temperature distributions for different system. In the early time, core Aluminum atoms experience a fast reaction with oxide shell. Environmental oxygen does not react with AlNPs until the surface O/Al ratio decreases to ～1.2. Moreover, based on our simulation results, previous experimental data agree well with the proposed model, which can well describe the relationship between combustion efficiency and oxide shell thickness, reveling that oxide shell promotes other than hinders combustion of AlNPs. The molecular insights obtained here would be significant for understanding the underlying mechanism and further modelling of AlNPs combustion
Metallic glasses(MGs)or amorphous alloys are an important engineering material that has a history of research of about 80-90 *** different fast cooling methods were developed for multi-component MGs between 1960s and ...
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Metallic glasses(MGs)or amorphous alloys are an important engineering material that has a history of research of about 80-90 *** different fast cooling methods were developed for multi-component MGs between 1960s and 1980s,1990s witnessed a surge of research interest in the development of bulk metallic glasses(BGMs).Since then,one central theme of research in the metallic-glass community has been compositional design that aims to search for MGs with a better glass forming ability,a larger size and/or more interesting properties,which can hence meet the demands from more important *** this review article,we focus on the recent development of chemically complex MGs,such as high entropy MGs,with new tools that were not available or mature yet until recently,such as the state-of-the-art additive manufacturing technologies,high throughput materials design techniques and the methods for big data analyses(*** learning and artificial intelligence).We also discuss the recent use of MGs in a variety of novel and important applications,from personal healthcare,electric energy transfer to nuclear energy that plays a pivotal role in the battle against global warming.
Metal-organic frameworks (MOFs) have drawn growing attention as promising electrode candidates for rechargeable batteries. However, most studies focus on the direct use of MOF electrodes without any modification. Post...
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Metal-organic frameworks (MOFs) have drawn growing attention as promising electrode candidates for rechargeable batteries. However, most studies focus on the direct use of MOF electrodes without any modification. Post-synthetic modification, a judicious tool to modify targeted properties of MOFs, has been long-neglected in the field of batteries. Herein, crystal-facet engineering is proposed to design MOF-based electrodes with high capacity and fast electrochemical kinetics. We found that a thermally-modified strategy can regulate the dominant exposed facet of Ni-based MOF (PFC-8). With the optimally exposed facets, the battery exhibited admirable rate capability (139.4 mAh g −1 at 2.5 A g −1 and 110.0 mAh g −1 at 30 A g −1 ) and long-term stability. Furthermore, density functional theory calculations demonstrate that stronger OH − adsorption behaviors and optimized electronic structures induced by the regulated exposed facets boost the electrochemical performance.
Stress intensity factors for penetrate radial crack at center of keyway and at keyway corner under the plane stress, the plane strain and the three dimensional, based on weight function method, is determined by finite...
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