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Enhanced subacute ischemic stroke treatment via multistage drug delivery system design for combination therapy

science China Chemistry 2025年

作者： Xihan Xu Juan-Juan Li Jiamin Li Hui-Yan Zhang Yilin Qi Bing-Sen Shi Tianqi Li Shan-Shan Su Weitao Zhao Chang Chen Zhongying Gong Huiyu Liu Ke-Rang Wang Dong-Sheng Guo Xue Xue State Key Laboratory of Medicinal Chemical Biology College of Pharmacy Nankai University College of Chemistry State Key Laboratory of Elemento-Organic Chemistry Key Laboratory of Functional Polymer Materials (Ministry of Education) Frontiers Science Center for New Organic Matter Collaborative Innovation Center of Chemical Science and EngineeringNankai University College of Chemistry and Materials Science State Key Laboratory of New Pharmaceutical Preparations and Excipients Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education) Key Laboratory of Chemical Biology of Hebei Province Hebei Research Center of the Basic Discipline of Synthetic Chemistry Hebei University Department of Neurology Tianjin First Central Hospital School of Medicine Nankai University Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic-Inorganic Composites Beijing Laboratory of Biomedical Materials Bionanomaterials & Translational Engineering Laboratory Beijing Key Laboratory of BioprocessBeijing University of Chemical Technology

The management of acute ischemic stroke remains challenging due to its abrupt onset and the narrow treatment window,resulting in high rates of disability and *** therapy for neuroprotection and neurorepair strategies provided new hopes for subacute stroke *** we designed a multistage nanodelivery system that matches the unique microenvironment of the subacute phase of stroke,which utilizes calixarene as a building block to effectively load the neuroprotective drug *** calixarene is designed with glycosidic linkages targeting the glucose transporter 1 (GLUT1)on the blood-brain barrier (BBB) and azo bonds that are responsive to hypoxic ***,the decomposed calixarene molecules themselves possess intrinsic bio-activation to modulate inflammatory responses,achieving a multistage therapeutic approach that transitions from targeting to release and finally to *** approach combines anti-inflammation and neuroprotection,providing a multi-level treatment *** system was validated in a rat model of permanent middle cerebral artery occlusion (pMCAO),demonstrating that intravenous administration of the nanodelivery system repairs brain damage and improves motor function 24 h post-pMCAO *** work offers a precise and integrative strategy for stroke patients missing the acute therapy window to improve functional recovery and enhance the effect of comprehensive treatment.

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Broadened and enhanced blue emission of interstitial Eu2+ in α-cristobalite via Al3+ codoping for high color rendering white LEDs

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Ceramics International 2025年

作者： Xia, Zhiwei Wang, Yuhan Yang, Rujun Xu, Mengdi Lin, Cunjian Li, Zhongyuan Lv, Ying Chi, Xiaopeng You, Shihai Research Institute of Frontier Science Southwest Jiaotong University Chengdu610031 China Zijin School of Geology and Mining Fuzhou University Fuzhou350108 China Nanchang Key Laboratory of Photoelectric Conversion and Energy Storage Materials College of Science Nanchang Institute of Technology Nanchang330099 China College of Materials Xiamen University Xiamen361005 China Key Laboratory of Functional Molecular Solids Ministry of Education Anhui Normal University Wuhu241000 China of Advanced Science and Technology Japan Advanced Institute of Science and Technology Nomi923-1292 Japan

The interstitial site engineering that purposely creates interstitial luminescent centers in suitable hosts has become an intriguing strategy in designing novel inorganic phosphors. However, effectively tuning the photoluminescence of interstitial activators remains tough challenging at this stage. Here, we demonstrate the effective modulation of interstitial luminescence in inorganic phosphor. In detail, the blue emission band (λem = 446 nm) of interstitial Eu2+ doped α-cristobalite (SiO2:Eu2+) is largely enhanced and broadened via a partial, aliovalent substitution of Si4+ by Al3+. After introducing Al3+ ions into SiO2 lattice, the full width at half maximum of the blue emission band increase from 59 to 76 nm with a triple growth in quantum efficiency (10.82% → 35.56%). Moreover, the thermal stability improves significantly with a high emission retention of 60% at 325 °C (SiO2:0.06Al3+,0.005Eu2+), far higher than that of the parent SiO2:0.005Eu2+ (30%). Encapsulating blue-emitting SiO2:Al3+,Eu2+ along with two commercial green and red phosphors on an ultraviolet LED chip (λem = 375 nm), a white LED device with high color rendering index (Ra > 90) was successful fabricated, showing the great potential of this phosphor for achieving high-quality white LED lighting. This study not only provides a promising bule emitter but also sheds light on modulating interstitial luminescence properties in inorganic phosphors. © 2025 Elsevier Ltd and Techna Group S.r.l.

关键词： Phosphors

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Secrets of high thermal emission of transition metal disilicides TMSi_(2)(TM=Ta,Mo)

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Journal of Materials science & technology 2021年第30期89卷 114-121页

作者： Huimin Xiang Fuzhi Dai Yanchun Zhou Science and Technology on Advanced Functional Composite Laboratory Aerospace Research Institute of Materials and Processing TechnologyBeijing 100076China

TMSi_(2)(TM=Ta,Mo)are extensively used as thermal emissivity agents in high emission coatings due to their well-known"high"emissivity in infrared ***,there is a paucity of the high temperature(HT)emissivity property of these two ***,room temperature(RT)spectrometer measurements have demonstrated that the emittance in infrared range of two silicides was considerably ***,providing critical HT data and satisfactory elucidation on the emission incompatibility of TMSi_(2)is eagerly *** this contribution,combining first principles calculations and Drude model,the reflectance spectra of TMSi_(2)were predicted at both RT and *** with spectrometer measurements,the intrinsic emittance of silicides was relatively low in the entire investigated *** explain the incompatible emission behavior,two simplified models including the majority of high emissivity coating,SiO_(2),were ***,with SiO_(2)considered in simulations,no matter covered on the surface or blended in the composites,the emittance of the TMSi_(2)enhanced *** theoretical results demonstrate the non-negligible significance of oxides on the high temperature performance of silicides and provide the guidelines for improving the emission performance of silicides and searching for potential high emissivity agents.

关键词： Disilicide Optical properties Thermal emission First-principles calculations Drude model

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Gate-tuned antiferromagnetic MnBi4Te7: A candidate for high-temperature high-Chern-number insulator at zero magnetic field

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Physical Review B 2025年第11期111卷 115420-115420页

作者： Hengning Wang Ding Li Yan Feng Tao Qin Yingze Jia Hongwei Zhang Chuandi Pan Yan Wang Wei Ning Anhui Key Laboratory of Low-Energy Quantum Materials and Devices High Magnetic Field Laboratory HFIPS Chinese Academy of Sciences Hefei Anhui 230031 China University of Science and Technology of China Hefei 230026 China Department of Materials Science & Engineering Hefei National Research Center for Physical Sciences at the Microscale CAS Key Lab of Materials for Energy Conversion Anhui Laboratory of Advanced Photon Science and Technology University of Science and Technology of China Hefei China School of Physics and Optoelectronics Engineering Anhui University Hefei Anhui Province 230601 People's Republic of China Information Materials and Intelligent Sensing Laboratory of Anhui Province Anhui Key Laboratory of Magnetic Functional Materials and Devices Institutes of Physical Science and Information Technology Anhui University Hefei 230601 China Department of Physics Shaanxi University of Science and Technology Xi'an 710021 China

The quantum anomalous Hall insulator is characterized by a quantized Hall resistance plateau of h/(Ce2) with C being the Chern number. Previously, high-Chern-number insulators with C≥2 that intrinsically suppress the energy dissipation in quantized electrical transport have been realized in few-layer MnBi2Te4 nanoflakes under moderate magnetic fields or in Cr-doped topological insulators at extremely low temperatures. It has nevertheless proven elusive to achieve a high-temperature high-Chern-number insulator at zero magnetic field. Here, we demonstrate that the magnetic state in MnBi4Te7 nanoflakes can be consecutively tuned from an antiferromagnetic (AFM) state to an AFM-ferromagnetic (FM) coexistence state, and finally to a robust ferromagnetic (FM) state with large coercivities at temperatures up to 3 K via a protonic gate. This AFM-FM phase transition is well captured by density functional theory simulations that the FM state develops in MnBi4Te7 under hole doping. Notably, we find that the Chern number of FM MnBi4Te7 can be largely tuned not merely by the Zeeman field but also by the sample thickness. Our work demonstrates that gate-tuned MnBi4Te7 nanoflakes hold high potentials for realizing a high-temperature high-Chern-number insulator at zero magnetic field and promising applications in the field of low-energy electronics.

关键词： Ferromagnetism

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Significant photothermoelectric effect of topological semimetals at infrared bands

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Physical Review Applied 2025年第3期23卷 034077-034077页

作者： Cheng-Hao Yin Hong-Tao Jiang Yang-Yang Lv Shu-Hua Yao Jian Zhou Y. B. Chen Yan-Feng Chen National Laboratory of Solid State Microstructures Nanjing University Nanjing 210093 China Department of Physics Nanjing University Nanjing 210093 China Jiangsu Key Laboratory of Artificial Functional Materials & Department of Materials Science and Engineering Nanjing University Nanjing 210093 China Hubei Key Laboratory of Plasma Chemistry and Advanced Materials Wuhan Institute of Technology Wuhan 430205 China Collaborative Innovation Center of Advanced Microstructures Nanjing University Nanjing 210093 China

We theoretically explore the photothermoelectric effect (PTE) of topological semimetals using the static two-temperature model. The interaction between the Dirac or Weyl fermions and electromagnetic waves is described by the dielectric constant in the model Hamilton of topological semimetals. Numerical calculations predict a significant PTE in the conventional plasmon mode with infrared bands of both the Dirac and Weyl semimetals. In addition to the PTE with a plasmon mode, the Weyl semimetals exhibit an enormous PTE at the frequencies of the two unconventional modes (helicon waves) in the infrared region. The helicon-wave modes originate from the resonant coupling between left- and right-circularly polarized electromagnetic waves and the helical motion of Weyl electron under an effective magnetic field induced by the Berry curvature. The frequencies of the helicon-wave modes depend on the carrier concentration, the Fermi velocity, and the distance between the positive and negative Weyl points in the Weyl semimetals, as well as the transport lifetime of the Weyl fermion. Using real parameters for the topological semimetals, we propose ideal materials for detecting the specific infrared bands of electromagnetic waves. This work strongly suggests that topological semimetals are promising for detecting electromagnetic waves in the infrared region, taking advantage of their significant PTE.

关键词： Helicons

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Room-temperature field-tunable radiofrequency rectification in epitaxial SrIrO3 films

arXiv

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arXiv 2025年

作者： Zhou, Liang Du, Zongzheng Wang, Jinhua H. Chen, Pingbo Ye, Bicong Feng, Tao Yang, Jiahao Xiao, Zehao H. Yang, Meng Li, Junxue X. Zhang, Wenqing Lu, Hai-Zhou He, Hongtao Department of Physics Southern University of Science and Technology Shenzhen518055 China Shenzhen Institute for Quantum Science and Engineering Southern University of Science and Technology Shenzhen518055 China Shenzhen Key Laboratory of Quantum Science and Engineering Shenzhen518055 China International Quantum Academy Shenzhen518048 China Department of Materials Science and Engineering Southern University of Science and Technology Shenzhen518055 China Shenzhen Key Laboratory for Advanced Quantum Functional Materials and Devices Southern University of Science and Technology Shenzhen518055 China Guangdong Provincial Key Laboratory of Advanced Thermoelectric Materials and Device Physics Southern University of Science and Technology Shenzhen518055 China

Although significant advancements have been made in wireless technologies and portable devices, it remains a challenge for high-frequency and nanowatt-level radiofrequency rectification. In this work, we report a pronounced radiofrequency rectification up to 37 GHz in nominally centrosymmetric SrIrO3 epitaxial films, with the minimum detectable power as low as ~300 nanowatts. Strikingly, the SrIrO3 rectifier is highly field-tunable and exhibits a strong in-plane field anisotropy, thus showing a unique advantage in broad-band radiofrequency rectification. The rectification effect can persist up to at least 360 K and shows a sensitive temperature dependence including a sign inversion. By a systematic study of the nonlinear transport properties of SrIrO3, it’s further revealed that the radiofrequency rectification originates from the nonlinear Hall effect with the dominant contribution from field-induced Berry curvature dipole. Our work demonstrates the superior performance of the field-tunable SrIrO3 rectifiers, unleashing the great application potential of centrosymmetric materials in harvesting and detecting ambient electromagnetic energy. © 2025, CC BY.

关键词： Electromagnetic waves

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Regulating the formation ability and mechanical properties of high-entropy transition metal carbides by carbon stoichiometry

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Journal of Materials science & technology 2022年第26期121卷 181-189页

作者： Juntao Song Guiqing Chen Huimin Xiang Fuzhi Dai Shun Dong Wenbo Han Xinghong Zhang Yanchun Zhou Science and Technology on Advanced Composite in Special Environments Laboratory Harbin Institute of TechnologyHarbin150080China Science and Technology on Advanced Functional Composite Laboratory Aerospace Research Institute of Materials&Processing TechnologyBeijing100076China

Tremendous efforts have been dedicated to promote the formation ability of high-entropy transition metal ***,the majority of methods for the synthesis of high-entropy transition metal carbides still face the challenges of high temperature,low efficiency,additional longtime post-treatment and uncontrollable *** cope with these challenges,high-entropy transition metal carbides with regulatable carbon stoichiometry(HE TMC)were designed and synthesized,achieving improved ability for single phase solid solutions formation,promoting of sintering and controllable mechanical *** typical composition series,i.e.,easily synthesized(ZrHfTaNb)C(ZHTNC)and difficultly synthesized(Zr_(0.25)Hf_(0.25)Ta_(0.25)Ti_(0.25))C(ZHTTC)are selected to demonstrate the promoting formation ability of single phase solid solutions from carbon stoichiometry *** phase high-entropy ZHTTC,which has been proven difficult in forming a single phase solid solution,can be prepared with the decrease of C/TM ratio under 2000℃;while the high-entropy ZHTNC,which has been proven easy in forming a single phase solid solution,can be synthesized at lower temperatures with the decrease of C/TM *** synergistic effect of entropy stabilization and reduced chemical bond strength gaining from carbon stoichiometry deviations is responsible for the formation of single phase solid solutions and the promoted sintering of HE *** example,the relative density of bulk(ZrHfTaNb)C(SPS-ZHTNC)increases from 90.98%to 94.25%with decreasing the C/TM atomic ratio from 0.9 to *** importantly,the room temperature flexural strength,fracture toughness and brittleness index of SPS-ZHTNCcan be tuned in the range of 384 MPa–419 MPa,4.41 MPam–4.73 MPamand 3.679μm–4.083μm,***,the HE TMCprepared by adjusting the ratio of carbon to refractory transition metal oxides have great potential for achieving low temperature synthesis,promoted sintering and tunable properties.

关键词： Carbon stoichiometry High-entropy ceramics Transition metal carbide Low temperature synthesis Tunable mechanical properties

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Correction to: Durable Fe3O4/PPy Particle Flow Spun Textile for Electromagnetic Interference Shielding and Joule Heating (advanced Fiber Materials, (2025), 7, 2, (513-527), 10.1007/s42765-024-00498-2)

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advanced Fiber Materials 2025年 1-1页

作者： Liu, Jiaxin Qi, Shuo Wang, Hongshan Fu, Chiyu Xu, Weilin Su, Bin Tang, Wenyang Xia, Zhigang State Key Laboratory of New Textile Materials and Advanced Processing Technologies School of Textile Science and Engineering Industry Research and Development Center of Functional Materials and Textile New Technology Textile Industry Key Laboratory of Yarn and Its Functionalization Wuhan Textile University Hubei Wuhan430200 China State Key Laboratory of Material Processing and Die and Mould Technology School of Materials Science and Engineering Huazhong University of Science and Technology Hubei Wuhan430074 China National Local Joint Engineering Laboratory of Resin-Based Structure and Functional Material Technology Hubei Xiaogan432100 China

In this article the first affiliation details for Jiaxin Liu were incorrectly given as 'State Key laboratory of New Textile Materials and advanced Processing Technologies, School of Textile science and Engineering, Wuhan Textile University, Wuhan, 430200, Hubei, People’s Republic of China' but should have been 'State Key laboratory of New Textile Materials and advanced Processing Technologies, School of Textile science and Engineering, Industry Research and Development Center of functional Materials and Textile New technology, Textile Industry Key laboratory of Yarn and Its functionalization, Wuhan Textile University, Wuhan, 430200, Hubei, People’s Republic of China'. The original article has been corrected. © Donghua University, Shanghai, China 2025.

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Medium and high-entropy transition mental disilicides with improved infrared emissivity for thermal protection applications

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Journal of Materials science & technology 2023年第5期136卷 149-158页

作者： Juntao Song Yuan Cheng Huimin Xiang Fu-Zhi Dai Shun Dong Guiqing Chen Ping Hu Xinghong Zhang Wenbo Han Yanchun Zhou Science and Technology on Advanced Composite in Special Environments Laboratory Harbin Institute of TechnologyHarbin 150080China Science and Technology on Advanced Functional Composite Laboratory Aerospace Research Institute of Materials&Processing TechnologyBeijing 100076China

Transition metal disilicides are widely used as heating elements and infrared emission ***,the limited intrinsic infrared emissivity and high thermal conductivity are the main limitations to their applications as infrared emission coatings in the thermal protection *** cope with these prob-lems,four medium and high-entropy transition metal disilicides,i.e.,(V_(0.25)Ta_(0.25)Mo_(0.25)W_(0.25))Si_(2)(ME-1),(Nb_(0.25)Ta_(0.25)Mo_(0.25)W_(0.25))Si_(2)(ME-2),(V_(0.2)Nb_(0.2)Ta_(0.2)Mo_(0.2)W_(0.2))Si_(2)(HE-1),and(Cr_(0.2)Nb_(0.2)Ta_(0.2)Mo_(0.2)W_(0.2))Si_(2)(HE-2),were designed and synthesized by spark plasma sintering method using transition metal binary disilicides as *** introduction of multi-elements into transition metal disilicides not only im-proved the infrared emissivity but also reduced the electrical and thermal *** them,(Cr_(0.2)Nb_(0.2)Ta_(0.2)Mo_(0.2)W_(0.2))Si_(2)(HE-2)had the lowest electrical conductivity of 3789 S cm-1,which is over one order of magnitude lower than that of MoSi_(2)(50000 S cm^(-1)),and total infrared emissivity of 0.42 at room temperature,which is nearly double of that of TaSi_(2).Benefiting from low electrical conductivity and phonon scattering due to lattice distortion,the medium and high-entropy transition metal disilicides also demonstrated a significant decline in thermal conductivity compared to their binary *** all samples,HE-2 exhibited the lowest thermal conductivity of 6.4 W m^(−1)K^(−1).The high-entropy tran-sition metal disilicides also present excellent oxidation resistance at high *** improved infrared emissivity,reduced thermal conductivity,excellent oxidation resistance,and lower densities of these medium and high-entropy transition metal disilicides portend that they are promising as infrared emission coating materials for applications in thermal protection systems.

关键词： High-entropy ceramics Transition metal disilicides Electrical conductivity Infrared emissivity Thermal conductivity

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Integrated Design of Polysulfide Shuttling and Lithium Dendrite Suppressing Framework: In2o3-In2s3 Embedded Carbon Cloth for Lithium-Sulfur Full Batteries

SSRN

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SSRN 2025年

作者： Li, Junting Li, Wenjiang Tian, Yuan Wang, Cheng Institute for New Energy Materials and Low-Carbon Technologies Tianjin Key Laboratory of Advanced Functional Porous Materials School of Materials Science and Engineering Tianjin University of Technology Tianjin300384 China School of Materials Science and Engineering Tianjin University of Technology Tianjin300384 China

The formidable polysulfide shuttling in conjunction with sluggish sulfur redox kinetics on the sulfur cathode and unlimited lithium dendrite growth on the anode severely impede their popularization of lithium-sulfur (Li-S) batteries. Here, the In2O3-In2S3 heterogeneous nanosheets in-situ grown on carbon cloth (In2O3-In2S3@CC) is synthesized by a simple hydrothermal method, which is simultaneously served as an efficient sulfphilic and lithiophilic host to enable stable cycling and boost high-performance Li-S full batteries. Concretely, one side of loading sulfur with In2O3-In2S3@CC acts as S/In2O3-In2S3@CC cathode to strengthen chemical anchoring and propel redox reaction kinetics, while the other side via electrochemical deposition of lithium uses as In2O3-In2S3@CC/Li anode to induce uniform Li deposition. Moreover, the three-dimensional carbon network framework is endowed with long-range effective electron/ion channels, sufficient storage space for sulfur physically confining and homogeneous Li distribution, as well as alleviating the volume change of electrode. As a result, the flexible self-standing dual-functional In2O3-In2S3@CC host significantly suppresses polysulfide shuttling and mitigates lithium dendrite growth, as revealed by theoretical simulations. The assembled Li-S full battery (S/In2O3-In2S3@CC||In2O3-In2S3@CC/Li) exhibits a high discharge capacity of 832.6 mAh g-1 at 1 C with a minimum capacity fading rate of 0.065% per cycle and superb rate capability up to 5 C under sulfur loading of 3 mg cm-2. This work offers insight into the practical application for modified carbon cloth towards advanced energy storage and conversion fields. © 2025, The Authors. All rights reserved.

关键词： Redox reactions

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