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Graded porous scaffold mediates internal fluidic environment for 3D in vitro mechanobiology

Computers in Biology and Medicine 2025年 186卷 109674-109674页

作者： De Rosa, Chiara Angela Wright, Christopher J. Xiong, Yi Del Giudice, Francesco Zhao, Feihu Department of Biomedical Engineering Faculty of Science and Engineering Swansea University Swansea United Kingdom Zienkiewicz Institute for Modelling Data and AI Swansea University Swansea United Kingdom School of System Design and Intelligent Manufacturing Southern University of Science and Technology Guangdong Province Shenzhen China Complex Fluid Research Group Department of Chemical Engineering Faculty of Science and Engineering Swansea University Swansea United Kingdom

Most cell types are mechanosensitive, their activities such as differentiation, proliferation and apoptosis, can be influenced by the mechanical environment through mechanical stimulation. In three dimensional (3D) mechanobiological in vitro studies, the porous structure of scaffold controls the local mechanical environment that applied to cells. Many previous studies have focused on the topological design of homogeneous scaffold struts. However, the impact of scaffold inhomogeneity on the mechanical environment, which is essential in mechanobiological application (e.g. for multi-cells co-culture), remains elusive. In this study, we use a computational fluid dynamics (CFD) approach together with data analysis to study the influence of a porosity gradient (10 %–30 % porosity difference) on the local and global mechanical environment (wall shear stress - WSS) within the commonly used structures of triple periodic minimal surfaces (TPMS). In addition, the anisotropy of internal WSS and scaffold permeability caused by the porosity gradient is investigated. It is found that the influence of anisotropy on the average WSS and permeability is up to 11 % and 31 %, respectively. These results, as theoretical references will be useful to tissue engineers and mechanobiologists for scaffold design and in vitro experiment planning such as integrated use of graded scaffold and bioreactors for specific cell types. © 2025 The Authors

关键词： Shear stress

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RKSeg+: make full use of Runge–Kutta methods in medical image segmentation

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Multimedia systems 2024年第2期30卷 65-65页

作者： Zhu, Mai Fu, Chong Wang, Xingwei School of Computer Science and Engineering Northeastern University Shenyang110819 China Engineering Research Center of Security Technology of Complex Network System Ministry of Education Shenyang110819 China Key Laboratory of Intelligent Computing in Medical Image Ministry of Education Northeastern University Shenyang110819 China

The dynamical system perspective has been used to build efficient image classification networks and semantic segmentation networks. Furthermore, the Runge–Kutta (RK) methods are powerful tools for building networks from the dynamical systems perspective. Hence, the Runge–Kutta segmentation network (RKSeg) for medical image segmentation was born. Skip connections and multiple scaling are often used in common models but lack mathematical explanations. RKSeg interprets and uses skip connections based on the RK methods. Therefore, RKSeg greatly improves segmentation efficiency. However, it does not explain and use multiple scales from a dynamical system perspective but only inherits the multi-scale scheme of existing models. We compensate for this shortcoming by interpreting and using multiple scales based on the RK methods. In addition, the network structure also limits the excellent image classification networks as the backbones of RKSegs. Therefore, we modify the network structure to support more image classification networks as backbones. As a result, we propose a novel network structure RKSeg+. Our proposed RKSeg+ achieves better segmentation results with fewer parameters than RKSeg. Furthermore, RKSeg+, well configured with few parameters, outperforms state-of-the-art models on six of the ten organ datasets in the Medical Segmentation Decathlon. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.

关键词： Semantic Segmentation

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Muscle-Synergy-Based Planning and Neural-Adaptive Control for a Prosthetic Arm

IEEE Transactions on Artificial Intelligence

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IEEE Transactions on Artificial Intelligence 2021年第5期2卷 424-436页

作者： Li, Guoxin Li, Zhijun Li, Junjun Liu, Yueyue Qiao, Hong The Department of Automation University of Science and Technology of China Hefei230026 China The Institute of Artificial Intelligence Hefei Comprehensive National Science Center Hefei230026 China The School of Automation Science and Engineering South China University of Technology Guangzhou511442 China The State Key Laboratory of Management and Control for Complex System Institute of Automation Chinese Academy of Science Beijing100190 China The School of Artificial Intelligence University of Chinese Academy of Sciences Beijing100049 China The Center for Excellence in Brain Science and Intelligence Technology Institute of Neuroscience Chinese Academy of Science Shanghai200031 China

Upper limb loss has significant effects on the individual's quality of life. Artificial prosthetic limbs as an alternative to the lost limb are designed to allow amputees to regain motor function. Motion classification via extracted surface electromyogram (sEMG) signals is widely utilized to realize a friendly human-robot interface in the control of the prosthesis. However, limited classification of discrete motion patterns from sEMG prevents intuitive motor control. Thus, instead of using discrete patterns, decoding the human intention continuously from sEMG would significantly benefit the prosthesis control. In this article, we propose a muscle-synergy-based intention decoding and motion planning that can model a broad set of complex upper limb movements as a combination of motor primitives. A novel muscle activation-to-force mapping model is developed to detect muscular effort of the healthy side to drive the affected side. A neural-network-approximation-based controller is developed for the bionic neuroprosthetic arm to execute the movement. Operational experiments with prosthetic movement control were performed on four healthy participants and an upper limb amputee participant. Results of controlling prosthetic arm (0.94 ± 0.02 of R2 in the horizontal reaching tasks and 0.95 ± 0.01 in the vertical reaching tasks for the healthy subjects, 0.95 and 0.97 for the amputee) demonstrate that our control method could successfully capture human movement intention and effectively control the movement of prosthesis. Impact Statement-Powered robotic prostheses have enabled individuals with limb amputations to regain motor function via motion intention decoding from extracting surface electromyogram signals. Most research works have provided human-robot interaction through motion classification obtained from pattern recognition using surface electromyogram signals and simple movement control. However, decoding the human intent continuously from surface electromyogram is con

关键词： Matrix algebra

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Prediction of exosomal piRNAs based on deep learning for sequence embedding with attention mechanism

Prediction of exosomal piRNAs based on deep learning for seq...

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2022 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2022

作者： Liu, Yajun Ding, Yulian Li, Aimin Fei, Rong Guo, Xie Wu, Fangxiang Xi'an University of Technology Shaanxi Key Laboratory for Network Computing and Security Technology Xi'an China University of Saskatchewan Division of Biomedical Engineering Saskatoon Canada Xi'an University of Technology Shaanxi Key Laboratory of Complex System Control and Intelligent Information Processing Xi'an China University of Saskatchewan Division of Biomedical Engineering Department of Computer Science Department of Mechanical Engineering Saskatoon Canada

ISBN: (纸本)9781665468190

PIWI-interacting RNAs (piRNAs) are a type of small non-coding RNAs which bind with the PIWI proteins to exert biological effects in various regulatory mechanisms. A growing amount of evidence reveals that exosomal piRNAs are potential biomarkers for diagnosis and treatment of complex diseases. Effective methods for the prediction of exosomal piRNAs are the foundation of piRNA functional research. In this study, we propose an end-to-end deep network for identifying exosomal piRNAs based on features learned from natural language processing (NLP) models for sequence embedding with attention mechanism. First, a benchmark dataset is constructed by processing piRNA subcellular localization annotated data and sequence data. Moreover, bagging positive unlabeled learning is applied to get the reliable negative set. Finally, we treat a piRNA sequence as a sentence and its k-mer subsequence as a token. Sequence embedding models with self-attention mechanism is designed to extract features from exosome piRNA sequences, which are used for the prediction task. Compared with three competing methods, our model achieves the best performance and reveals the key factors of exosomal piRNA sequences by the attention mechanism. Our model characterizes exosomal piRNAs and could be beneficial for researchers to investigate exosomal piRNAs' functions. © 2022 IEEE.

关键词： Embeddings

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Research on Test Data Expansion Method Based on UAV Typical Index Evaluation

Research on Test Data Expansion Method Based on UAV Typical ...

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High Performance and Smart Computing (HPSC), IEEE International Conference on

作者： Huapin Geng Hongtao Ma Jiahui Tong Ning Wang Science and Technology on Complex System Control and Intelligent Agent Cooperation Laboratory Beijing Electro-mechanical Engineering Institute Beijing China Beijing Xinghang Electro-mechanical Equipment Beijing China Beijing Electro-mechanical Engineering Institute Beijing China

ISBN: (数字)9798350389463

ISBN: (纸本)9798350389470

In order to scientifically and effectively evaluate the performance indexes of aircraft, the common Bayes multi-source data fusion method can comprehensively utilize a variety of information types under the condition that the decision risk is as small as possible, but there are risks such as insufficient data utilization and small sample data being “submerged” by large sample data in the fusion. This paper proposes a test data expansion method based on the combination of probability features and BP neural network model, and is verified by typical application to ensure that the sample size of multi-source data is comparable. Supplementary data not only retains the probability features of the original data, but also the sample generation has physical connotation.

关键词： Atmospheric modeling Computational modeling Neural networks Data integration Data models Performance analysis Bayes methods

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Prediction of Hybrid Asynchronous Frequency Hopping Pattern based on Deep Learning in Wideband Spectrum

Prediction of Hybrid Asynchronous Frequency Hopping Pattern ...

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Chinese Automation Congress (CAC)

作者： Ya Wang Jiaqi Wang Shuai Yuan Naijin Liu Yuanming Lu Qian Xuesen Laboratory of Space Technology China Academy of Space Technology Beijing China Science and Technology on Complex System Control and Intelligent Agent Cooperation Laboratory Beijing Electro-Mechanical Engineering Institute Beijing China Unit 63893 of PLA Luoyang China

In non-cooperative scenarios, wideband frequency hopping (FH) communication reconnaissance including FH signal detection, parameter estimation, and network sorting under single-channel reception is challenging. The FH pattern contains the most information about FH signals. So it is the core of FH parameter estimation. Based on the task analysis, this paper proposes a blind prediction framework combining deep learning (DL) and clustering methods to improve the accuracy and efficiency of FH pattern estimation for mixed signals in the wideband spectrum. The unique advantage of this framework is that it requires no prior signal information and anchors but exploits the inherent time-frequency (TF) properties of asynchronous FH signals. It has a strong generalization ability and can adapt to signals of any shape. Moreover, a new comprehensive evaluation metric, normalized root mean square error including missed detection (NRMSE-MD), suitable for sequence data prediction is proposed to evaluate the level of missed detection and false detection in signal monitoring. Experimental results demonstrate the superiority of the proposed framework and the effectiveness of the proposed evaluation metric.

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An SIE Formulation With Loop Analysis for Large-Scale Arbitrarily Shaped Interconnects

An SIE Formulation With Loop Analysis for Large-Scale Arbitr...

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Antennas and Propagation Society International Symposium

作者： Zekun Zhu Ningbo Gong Guijie Diao Shunchuan Yang School of Electronic and Information Engineering Beihang University Beijing China Beijing Electro-mechanical Engineering Institute Beijing China Science and Technology on Complex System Control and Intelligent Agent Cooperation Laboratory China

A magneto-quasi-static (MQS) surface integral equation (SIE) formulation with loop analysis is proposed to extract the impedance of interconnects in packages. The loop analysis is developed with an independent and complete set of unknowns according to the graph theory, which can significantly reduce the dimension of the final matrix. With the pre-corrected fast Fourier Transform (pFFT), large-scale interconnects can be efficiently modelled. A practical example in packages is carried out to validate the effectiveness and scalability of the proposed formulation. Results show that the proposed formulation is accurate and flexible to model complex interconnects in packages compared with the industrial solver.

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Flight Parameter Prediction and Fault Propagation based on Machine Learning and Symbolic Directed Graph

Flight Parameter Prediction and Fault Propagation based on M...

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International Symposium on Autonomous systems (ISAS)

作者： Wenzhuo Li Kun Guo Yuehua Cheng Hengsong Hu Cheng Xu Ziquan Yu College of Automation Engineering Nanjing University of Aeronautics and Astronautics Nanjing China Science and Technology on Complex System Control and Intelligent Agent Cooperation Laboratory Beijing Institute of Mechanical and Electrical Engineering Beijing China

Fault influence and propagation analysis of flight vehicle systems is an important element of flight vehicle health management and also an important problem to be solved. A fault influence model based on data-driven is established, including a prediction model of flight parameters under fault, a dynamic influence path, and an influence degree model. Based on the historical experimental data, a long and short-term memory neural network (LSTM) model is proposed to predict the time-series data of each flight parameter of the flight vehicle under fault; based on the prediction results, a symbolic directed graph (SDG) is used to describe the fault of the flight vehicle system, and then introduce the concept of a compatible path with time-series characteristics to describe the dynamic propagation process of the fault. The case shows that the method proposed in this paper enables qualitative and quantitative analysis of the fault influence, and can reasonably describe the fault propagation path and influence characteristics.

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An Approach for Upper Limb Movement Intention Recognition Using EEG and sEMG Fusion based on the MCPSA-CIIM

An Approach for Upper Limb Movement Intention Recognition Us...

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WRC Symposium on Advanced Robotics and Automation (WRC SARA)

作者： Weiming Zhang Xiaodong Zhang Cheng Xu Guchuan Zhou Teng Zhang Yu Wang Shaanxi Key Laboratory of Intelligent Robot School of Mechanical Engineering Xi’an Jiaotong University Xi’an Shaanxi China Science and Technology on Complex System Control and Intelligent Agent Cooperative Laboratory Beijing China

The upper limb motion intention recognition method based on electroencephalography (EEG) and surface electromyography (sEMG) fusion has achieved significant results in fields such as prosthetic control. However, most existing fusion methods use manual means to select features, which cannot capture temporal and spatial features at different scales, and ignore the correlation features between the two types of signals. To address these issues, this article proposes a fusion recognition method for upper limb motion intention EEG and sEMG based on Multi-scale Convolution, Polarized Self-Attention, and Cross Intelligence Integration Module. This article extracts multidimensional temporal and spatial features of EEG and sEMG through multi-scale convolution, and introduce polarized self-attention mechanism to filter the extracted multi-scale features. Simultaneously using cross enhancement strategy to extract correlation features between EEG and sEMG. Finally, the features are input into the classification network for recognition. This method was validated on the Jeong database, and the results showed that compared with CNN-LSTM and EEGNet, the recognition accuracy of this method increased by 2.63% and 3.15%, respectively.

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Activation of Topological Defects Induces a Brittle-to-Ductile Transition in Epithelial Monolayers

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Physical Review Letters 2022年第1期128卷 018101-018101页

作者： Yixia Chen Qigan Gao Jingchen Li Fangtao Mao Ruowen Tang Hongyuan Jiang Hefei National Laboratory for Physical Science at the Microscale CAS Key Laboratory of Mechanical Behavior and Design of Materials CAS Center for Excellence in Complex System Mechanics Department of Modern Mechanics University of Science and Technology of China Hefei Anhui 230026 China

Epithelial monolayers are subjected to various mechanical forces, such as stretching, shearing, and compression. Thus, its mechanical response to external loadings is essential for its biological functions. However, the mechanism of the fracture failure of the epithelial monolayer remains poorly understood. Here, by introducing a new type of topological transition, i.e., detach transition or T4 transition, we develop a modified cellular vertex model to investigate the rupture of the cell monolayer. Interestingly, we find a brittle-to-ductile transition in epithelial monolayers, which is controlled by the mechanical properties of single cells and cell-cell contacts. We reveal that the external loadings can activate cell rearrangement in ductile cell monolayers. The plastic deformation results from the nucleation and propagation of “pentagon-heptagon defects” in analogy with the topological defects commonly seen in 2D materials. By using a simplified four-cell model, we further demonstrate that the brittle-to-ductile transition is induced by the competition between cell rearrangement and cell detachment. Our work provides a new theoretical framework to study the rupture of living tissues and may have important implications for many other biological processes, such as wound healing and tissue morphogenesis.

关键词： Cell aggregation Cell mechanics Epithelial cells Tissues

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