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Beyond biochemical patterning: How mechanical bistability governs robust organoid morphogenesis

Mechanobiology in Medicine 2025年第2期3卷

作者： Qigan Gao Yuehua Yang Haoxiang Yang Hongyuan Jiang CAS Key Laboratory of Mechanical Behavior and Design of Materials CAS Center for Excellence in Complex System Mechanics Department of Modern Mechanics University of Science and Technology of China Hefei Anhui 230026 China

Understanding the regulatory mechanisms of intestinal organoid morphogenesis remains a fundamental challenge in organoid biology. Emerging evidence highlights mechanical bistability as a critical regulator, mediated by dynamic lumen-actomyosin feedback. The recently developed 3D vertex model demonstrates that crypt curvature modulates actomyosin localization via mechanosensitive pathways, creating two stable morphological states—bulged or budded—depending on mechanical history. This model advances beyond static vertex models by incorporating epithelial thickness variations and lumen pressure effects, explaining previously unresolved phenomena like irreversible crypt budding and snap-through transitions. The findings establish a new framework for understanding mechanical decision-making in epithelial tissues, with implications for organoid engineering and developmental biology.

关键词： Mechanical bistability Intestinal organoids Vertex model Morphogenesis Epithelial mechanics

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Design of optimal trajectory transition controller for thrust-vectored V/STOL aircraft

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science China(Information sciences) 2021年第3期64卷 235-237页

作者： Zhiqiang CHENG Jihong ZHU Xiaming YUAN Xiangyang WANG Department of Computer Science and Technology Tsinghua University Key Laboratory of Complex Ship System Simulation

Dear editor,In recent years, vertical and/or short take-off and landing(V/STOL) aircraft have attracted much attention because they combine the efficiency of fixed-wing vehicles with the flexibility of traditional ver... 详细信息

关键词： backward propagation V/STOL transition control thrust-vector optimal trajectory

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A maneuvering penetration strategy via integrated flight/propulsion guidance and control method for air-breathing hypersonic vehicle

A maneuvering penetration strategy via integrated flight/pro...

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2018 IEEE CSAA Guidance, Navigation and Control Conference, CGNCC 2018

作者： Xue, Kong Guodong, Ning Ming, Yang Songyan, Wang Harbin Institute of Technology Control and Simulation Center and Science and Technology Complex System Control and Intelligent Agent Cooperation Laboratory China Beijing Electro-Mechanical Institute China Harbin Institute of Technology Control and Simulation Center China

ISBN: (纸本)9781538611715

Given a maneuvering control strategy for air-breathing hypersonic vehicle, which adopt the compound integrated flight/propulsion guidance and control method, further excavation the capability of scramjet to run stable and low fuel consumption, on this basis, implement accelerate snake maneuver, improve the survival probability of weapons, guarantee the practical application ability of the project. Take one certain type of air-breathing hypersonic vehicle as an example, on the basis of an accurate simulation model, several groups of simulation analysis are carried out, the simulation results show that the method is effective and reliable. © 2018 IEEE.

关键词： Hypersonic vehicles

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Intelligent optimization methods of phase-modulation waveform

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Journal of systems Engineering and Electronics 2022年第4期33卷 916-923页

作者： SUN Jianwei WANG Chao SHI Qingzhan REN Wenbo YAO Zekun YUAN Naichang College of Electronic Science and Technology National University of Defense TechnologyChangsha 410073China State Key Laboratory of Complex Electromagnetic Environment Effects on Electronics and Information System National University of Defense TechnologyChangsha 410073China

With the continuous improvement of radar intelligence, it is difficult for traditional countermeasures to achieve ideal results. In order to deal with complex, changeable, and unknown threat signals in the complex electromagnetic environment, a waveform intelligent optimization model based on intelligent optimization algorithm is proposed. By virtue of the universality and fast running speed of the intelligent optimization algorithm, the model can optimize the parameters used to synthesize the countermeasure waveform according to different external signals, so as to improve the countermeasure *** algorithm(GA) and particle swarm optimization(PSO)are used to simulate the intelligent optimization of interruptedsampling and phase-modulation repeater waveform. The experimental results under different radar signal conditions show that the scheme is feasible. The performance comparison between the algorithms and some problems in the experimental results also provide a certain reference for the follow-up work.

关键词： waveform optimization intelligent optimization phase-modulation genetic algorithm(GA) particle swarm optimization(PSO)

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Mitigation of cross-eye jamming using a dual-polarization array

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Journal of systems Engineering and Electronics 2018年第3期29卷 491-498页

作者： MA Jiazhi SHI Longfei XIAO Shunping WANG Xuesong State Key Laboratory of Complex Electromagnetic Environmental Effects on Electronics and Information System National University of Defense Technology Changsha 410073China School of Science National University of Defense TechnologyChangsha 410073China

This paper presents an approach for mitigating the cross-eye jamming using a dual-polarization array. By transmitting a sum beam and a difference beam in two orthogonal polarimetric channels, a synthesized transmitted beam with spatially varying polarization is produced, such that the polarization of the transmitted radar wave varies in azimuth or elevation. Thus, the phases of the signals received on the two antennas of a cross-eye jammer become unequal, and an additional phase difference is introduced to disrupt the 180？ phase shifting in the retrodirective loop of the jammer. By means of beam scanning in a small angular range,the optimal beam steering configuration can be found to maximize the phase error for the mitigation of cross-eye jamming. As a result, the jamming performance of the cross-eye jammer degrades largely. Theoretical analysis and simulation results indicate that the proposed method is valid and feasible.

关键词： cross-eye jamming monopulse radar spatially varying polarization insertion phase beam scanning

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Experimental Model Identification of Liquid-Circular Angular Accelerometer using Subspace Method 35

Experimental Model Identification of Liquid-Circular Angular...

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第35届中国控制会议

作者： WANG Meiling LI Xiang CHENG Siyuan FU Mengyin XIAO Meifeng Beijing Institute of Technology Key Laboratory of Complex System Intelligent Control and Decision Nanjing University of Science and Technology

ISBN: (纸本)9781509009107

In this paper, the model of a novel liquid-circular angular accelerometer is studied. Due to the absence of theoretical model of liquid-circular angular accelerometer, a subspace identification method(SIM) based on Akaike Information Criterion(AIC) is chosen for model identification of angular accelerometer. The proposed identification method is tested on a liquid-circular angular accelerometer prototype. The experimental results indicate that SIM could obtain a more accurate model than least square method, with a degree of fitting above 90%. In addition, SIM possesses good repeatability and stability. The experimental model identified by SIM in this paper can be applied in engineering practice.

关键词： system Identification Angular Accelerometer Subspace Method

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Method for constructing multi-dimensional feature map of malicious code 5

Method for constructing multi-dimensional feature map of mal...

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2020 5th International Seminar on Computer technology, Mechanical and Electrical Engineering, ISCME 2020

作者： Ma, Haocong Zhang, Ji Zhou, Junhua Zhai, Xiang Xue, Junjie Ji, Hang State Key Laboratory of Intelligent Manufacturing System Technology Beijing Institute of Electronic System Engineering Beijing100854 China School of Computer Science and Technology Beijing Institute of Technology Beijing100081 China Beijing Complex Product Advanced Manufacturing Engineering Research Center Beijing Simulation Center Beijing100854 China Science and Technology on Space System Simulation Laboratory Beijing Simulation Center Beijing100854 China

Malicious code is characterized by a large number of types, rapid increase in number, continuous update of transmission routes, and continuous enhancement of back analysis and back detection methods. Therefore, how to effectively detect and analyze malicious code has been a problem of great concern. This paper studies the features of binary file and disassembly file of malicious code, introduces the concept of information gain, and proposes a method to construct the multi-dimensional characteristic graph of malicious code. Finally, the convolutional neural network is used to classify the multi-dimensional feature graph of malicious code, which provides a new idea for the feature extraction of malicious code. © Published under licence by IOP Publishing Ltd.

关键词： Malware

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Towards optimized tensor code generation for deep learning on sunway many-core processor

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Frontiers of Computer science 2024年第2期18卷 1-15页

作者： Mingzhen LI Changxi LIU Jianjin LIAO Xuegui ZHENG Hailong YANG Rujun SUN Jun XU Lin GAN Guangwen YANG Zhongzhi LUAN Depei QIAN State Key Laboratory of Software Development Environment Beijing 100191China School of Computer Science and Engineering Beihang UniversityBeijing 100191China National University of Singapore Singapore 119077Singapore State Key Laboratory of Mathematical Engineering and Advanced Computing Wuxi 214000China Science and Technology on Special System Simulation Laboratory Beijing Simulation Center Beijing 100854China Department of Computer Science and Technology Tsinghua UniversityBeijing 100084China

The flourish of deep learning frameworks and hardware platforms has been demanding an efficient compiler that can shield the diversity in both software and hardware in order to provide application *** the existing deep learning compilers,TVM is well known for its efficiency in code generation and optimization across diverse hardware *** the meanwhile,the Sunway many-core processor renders itself as a competitive candidate for its attractive computational power in both scientific computing and deep learning *** paper combines the trends in these two ***,we propose swTVM that extends the original TVM to support ahead-of-time compilation for architecture requiring cross-compilation such as *** addition,we leverage the architecture features during the compilation such as core group for massive parallelism,DMA for high bandwidth memory transfer and local device memory for data locality,in order to generate efficient codes for deep learning workloads on *** experiment results show that the codes generated by swTVM achieve 1.79x improvement of inference latency on average compared to the state-of-the-art deep learning framework on Sunway,across eight representative *** work is the first attempt from the compiler perspective to bridge the gap of deep learning and Sunway processor particularly with productivity and efficiency in *** believe this work will encourage more people to embrace the power of deep learning and Sunwaymany-coreprocessor.

关键词： sunway processor deep learning compiler code generation performance optimization

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Consensus disturbance rejection control of directed multi-agent networks with extended state observer

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Chinese Journal of Aeronautics 2020年第5期33卷 1486-1493页

作者： Shaopan GUO Zhongkui LI Yifeng NIU Lizhen WU State Key Laboratory for Turbulence Complex System Department of Mechanics and Aerospace EngineeringPeking UniversityBeijing 100871China College of Intelligence Science and Technology National University of Defense TechnologyChangsha 410073China

This paper investigates the consensus disturbance rejection problem among multiple high-order agents with directed *** on disturbance observers,distributed consensus disturbance rejection protocols are constructed in leaderless and leader-follower consensus *** from the previous related papers,the consensus protocols in this paper are developed in a fully distributed fashion,relying on only the state information of each agent and its *** conditions are provided to guarantee that the asymptotic stability of high-order multi-agent systems can be reached with matched disturbances.

关键词： Adaptive control Consensus control Distributed control Disturbance rejection Multi-agent systems

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Molecular transport under extreme confinement

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science China(Physics,Mechanics & Astronomy) 2022年第6期65卷 1-10页

作者： FengChao Wang JianHao Qian JingCun Fan JinChuan Li HengYu Xu HengAn Wu CAS Key Laboratory of Mechanical Behavior and Design of Materials Department of Modern MechanicsCAS Center for Excellence in Complex System MechanicsUniversity of Science and Technology of ChinaHefei 230027China

Mass transport through the nanoporous medium is ubiquitous in nature and *** the macroscale transport phenomena which have been well understood by the theory of continuum mechanics,the relevant physics and mechanics on the nanoscale transport still remain *** developments in fabrication of slit-like nanocapillaries with precise dimensions and atomically smooth surfaces have promoted the fundamental research on the molecular transport under extreme *** this review,we summarized the contemporary progress in the study of confined molecular transport of water,ions and gases,based on both experiments and molecular dynamics *** liquid exhibits a pronounced layered structure that extends over several intermolecular distances from the solid surface,which has a substantial influence on static properties and transport behaviors under *** studies have also shown that those molecular details could provide some new understanding on the century-old classical theory in this field.

关键词： confined mass transport nanocapillary solid-liquid interface confinement effect

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