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Optical Imaging of Epigenetic Modifications in Cancer:A Systematic Review

Phenomics 2022年第2期2卷 88-101页

作者： Yang Du Pei Zhang Wei Liu Jie Tian CAS Key Laboratory of Molecular Imaging Beijing Key Laboratory of Molecular Imagingthe State Key Laboratory of Management and Control for Complex SystemsInstitute of AutomationChinese Academy of SciencesBeijing 100190China The University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Supportive Care Center and Day Oncology UnitPeking University Cancer Hospital and InstituteBeijing 100142China Beijing Advanced Innovation Center for Big Data-Based Precision Medicine School of MedicineBeihang UniversityBeijing 100191China School of Life Science and Technology Xidian UniversityXi’an 710071ShaanxiChina

Increasing evidence has demonstrated that abnormal epigenetic modifications are strongly related to cancer ***,sensitive and specific detection of epigenetic modifications could markedly improve biological investigations and cancer precision medicine.A rapid development of molecular imaging approaches for the diagnosis and prognosis of cancer has been observed during the past few *** biomarkers unique to epigenetic modifications and targeted imaging probes have been characterized and used to discriminate cancer from healthy tissues,as well as evaluate therapeutic *** this study,we summarize the latest studies associated with optical molecular imaging of epigenetic modification targets,such as those involving DNA methylation,histone modification,noncoding RNA regulation,and chromosome remodeling,and further review their clinical application on cancer diagnosis and ***,we further propose the future direc-tions for precision imaging of epigenetic modification in *** by promising clinical and preclinical studies associated with optical molecular imaging technology and epigenetic drugs,the central role of epigenetics in cancer should be increasingly recognized and accepted.

关键词： Epigenetic modification Optical imaging Cancer Imaging probe

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Automated Assembly by Two-Fingered Microhand for Fabrication of Soft Magnetic Microrobots

Automated Assembly by Two-Fingered Microhand for Fabrication...

引用

IEEE International Conference on Robotics and Automation (ICRA)

作者： Yue Zhao Xiaoming Liu Ruixi Wang Dan Liu Masaru Kojima Qiang Huang Tatsuo Arai Key Laboratory of Biomimetic Robots and Systems Ministry of Education State Key Laboratory of Intelligent Control and Decision of Complex System Beijing Advanced Innovation Center for Intelligent Robots and Systems Beijing China School of Mechatronical Engineering Beijing Institute of Technology Beijing China Department of Intelligent Manufacturing Shenzhen International Graduate School Tsinghua University Shenzhen China Department of Materials Engineering Science Osaka University Osaka Japan Center for Neuroscience and Biomedical Engineering The University of Electro-Communications Tokyo Japan

ISBN: (数字)9798350384574

ISBN: (纸本)9798350384581

Micro-assembly is an emerging method to fabricate microrobots with multiple modules or particles. However, there is always a lack of a flexible and efficient method to freely create the desired magnetic soft microrobots. In this paper, an automated assembly system based on a two-fingered microhand is presented for fabricating magnetic soft microrobots. Our proposed system can automatically pick and place components to assemble microrobots with a two-fingered micromanipulator, and orient these components through an external magnetic field. The automated assembly has the advantages of high accuracy, high speed, and high success rate. It can endow magnetic microrobots with flexible material selection, arbitrary geometry design, and programable magnetization profile. We can make full use of this system to fabricate multiple magnetic soft microrobots. The experiment results demonstrate that this system can efficiently fabricate microrobots with excellent mechanical properties, which have application potential in robotics, biomedical engineering, and environmental governance.

关键词： Three-dimensional displays Shape Micromanipulators Magnetization Manuals Three-dimensional printing Soft magnetic materials

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Study of a droplet breakup process in decaying homogeneous isotropic turbulence based on the phase-field DUGKS approach

arXiv

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arXiv 2022年

作者： Lai, Jun Chen, Tao Zhang, Shengqi Xiao, Zuoli Chen, Shiyi Wang, Lian-Ping State Key Laboratory for Turbulence and Complex Systems College of engineering Peking University Beijing100871 China Guangdong Provincial Key Laboratory of Turbulence Research and Applications Center for Complex Flows and Soft Matter Research Department of Mechanics and Aerospace Engineering Southern University of Science and Technology Shenzhen518055 China Guangdong-Hong Kong-Macao Joint Laboratory for Data-Driven Fluid Mechanics and Engineering Applications Southern University of Science and Technology Shenzhen518055 China

The breakup of a spherical droplet in a decaying homogeneous isotropic turbulence is studied by solving the Cahn-Hilliard-Navier-Stokes equations, using the discrete unified gas kinetic scheme combined with the free-energy-based phase-field model. We focus on the combined effects of turbulence and surface tension on the breakup process by assuming that the two fluid phases have the same density and same viscosity. The key physical parameters of the system include the volume fraction ( = 6.54%), the initial Weber number (We = 21.7), and the initial Taylor microscale Reynolds number (Reλ = 58). Due to the turbulence decay, the Weber number decreases monotonically in time to a value of less than 0.01, providing a great opportunity to study the competing effects of turbulent kinetic energy and interfacial free energy on the dynamics of the two-phase system. Three distinct stages of droplet evolution are identified, namely, the deformation stage when the initially spherical droplet evolves into an irregular geometric shape with complex structures, the breakup stage when many daughter droplets are formed, and the restoration stage when the droplets relax towards spherical shape. These three stages are analyzed systematically from several perspectives: (1) a geometric perspective concerning the maximum equivalent diameter, the total number of droplets, total interface area, and probability distribution of droplet diameters, (2) a dynamic perspective concerning the evolution of local velocity and vorticity at the fluid-fluid interface, (3) a global perspective concerning the evolution of average kinetic energy / dissipation rate and their Fourier spectra, (4) spherical harmonics based energetics concerning simultaneous transfer of kinetic energy across different length scales and different radii relative to initial droplet center, and (5) the time evolution of global kinetic energy and free energy of the system. It is found that the ending time of the breakup stage can be e

关键词： Turbulence

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Comparison of gene clustering criteria reveals intrinsic uncertainty in pangenome analyses

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Genome Biology 2023年第1期24卷 1-27页

作者： Manzano-Morales, Saioa Liu, Yang González-Bodí, Sara Huerta-Cepas, Jaime Iranzo, Jaime Centro de Biotecnología y Genómica de Plantas Universidad Politécnica de Madrid (UPM) - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA-CSIC) Madrid Spain Barcelona Supercomputing Centre (BSC-CNS) - Institute for Research in Biomedicine (IRB Barcelona) The Barcelona Institute of Science and Technology Barcelona Spain Guangdong Province Key Laboratory of Microbial Signals and Disease Control Integrative Microbiology Research Centre South China Agricultural University Guangzhou China Institute for Biocomputation and Physics of Complex Systems (BIFI) University of Zaragoza Zaragoza Spain

Background: A key step for comparative genomics is to group open reading frames into functionally and evolutionarily meaningful gene clusters. Gene clustering is complicated by intraspecific duplications and horizontal gene transfers that are frequent in prokaryotes. In consequence, gene clustering methods must deal with a trade-off between identifying vertically transmitted representatives of multicopy gene families, which are recognizable by synteny conservation, and retrieving complete sets of species-level orthologs. We studied the implications of adopting homology, orthology, or synteny conservation as formal criteria for gene clustering by performing comparative analyses of 125 prokaryotic pangenomes. Results: Clustering criteria affect pangenome functional characterization, core genome inference, and reconstruction of ancestral gene content to different extents. Species-wise estimates of pangenome and core genome sizes change by the same factor when using different clustering criteria, allowing robust cross-species comparisons regardless of the clustering criterion. However, cross-species comparisons of genome plasticity and functional profiles are substantially affected by inconsistencies among clustering criteria. Such inconsistencies are driven not only by mobile genetic elements, but also by genes involved in defense, secondary metabolism, and other accessory functions. In some pangenome features, the variability attributed to methodological inconsistencies can even exceed the effect sizes of ecological and phylogenetic variables. Conclusions: Choosing an appropriate criterion for gene clustering is critical to conduct unbiased pangenome analyses. We provide practical guidelines to choose the right method depending on the research goals and the quality of genome assemblies, and a benchmarking dataset to assess the robustness and reproducibility of future comparative studies. © 2023, The Author(s).

关键词： Accessory genome Comparative genomics Core gene Genome plasticity Homology MAG Orthology Pangenome

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Existence of solutions to a conformally invariant integral equation involving Poisson-type kernels

arXiv

引用

arXiv 2023年

作者： Du, Xusheng Jin, Tianling Yang, Hui School of Mathematical Sciences Laboratory of Mathematics and Complex Systems MOE Beijing Normal University Beijing100875 China Department of Mathematics The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong School of Mathematical Sciences Shanghai Jiao Tong University Shanghai200240 China

In this paper, we study existence of solutions to a conformally invariant integral equation involving Poisson-type kernels. Such integral equation has a stronger non-local feature and is not the dual of any PDE. We obtain the existence of solutions in the antipodal symmetry *** Codes 45G05, 35B33 Copyright © 2023, The Authors. All rights reserved.

关键词： Integral equations

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Phase composition, microstructure, and properties of Al 4 O 4 C–(Al 2 OC) 1- x (AlN) x –Zr 2 Al 3 C 4 –Al 2 O 3 refractories prepared at high temperatures in nitrogen

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Ceramics International 2021年第21期47卷 30298-30309页

作者： Mingwei Yan Jiayu Zhang Guangchao Sun Kaiqi Liu Yong Li State Key Laboratory of Multiphase Complex Systems Institute of Process Engineering Chinese Academy of Sciences Beijing 100190 China School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China

The novel Al 4 O 4 C–(Al 2 OC) 1- x (AlN) x –Zr 2 Al 3 C 4 –Al 2 O 3 refractories with ultra-low carbon content have been successfully prepared by constructing the core-shell structure of aluminum at 1300–1700°C in nitrogen. The phase composition, microstructure, and properties of the novel refractories are deeply investigated. The cracking temperature on the core-shell structure of aluminum is further explored and the reaction mechanism of Zr 2 Al 3 C 4 has also added explanation. The results show that the novel refractories have excellent physical properties and cannot be corroded by molten iron. There exist two different Al 2 OC solid solutions in the novel refractories, Al 2 OC-rich (Al 2 OC) 1- x (AlN) x and AlN-rich (Al 2 OC) 1- x (AlN) x . The temperatures affect their relative content. When temperatures are less than 1600°C, the relative content of Al 2 OC-rich (Al 2 OC) 1- x (AlN) x is more than that of AlN-rich (Al 2 OC) 1- x (AlN) x . When temperatures are above 1700°C, the relative content of AlN-rich (Al 2 OC) 1- x (AlN) x is more than that of Al 2 OC-rich (Al 2 OC) 1- x (AlN) x . The core-shell structure of aluminum fully ruptures at about 1200°C. Zr 2 Al 3 C 4 begins to form at about 1000°C and generates in large at 1200°C.

关键词： Ultra-low carbon content (Al 2 OC) 1- x (AlN) x Zr 2 Al 3 C 4 Properties

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Ferroelectrets:Heterogenous polymer electrets with high piezoelectric sensitivity for transducers

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Journal of Advanced Dielectrics 2023年第4期13卷 3-26页

作者： Xunlin Qiu Peng Fang Axel Mellinger Ruy Alberto Pisani Altafim Werner Wirges Gunnar Gidion Dmitry Rychkov Shanghai Key Laboratory of Intelligent Sensing and Detection Technology School of Mechanical and Power Engineering East China University of Science and Technology Shanghai 200237P.R.China CAS Key Laboratory of Human-Machine Intelligence-Synergy Systems Shenzhen Institutes of Advanced Technology Shenzhen 518055P.R.China Department of Physics Central Michigan University 223 Dow Science ComplexMount PleasantMI 48859USA Computer Systems Department Informatics Center Federal University of ParáıbaJoão Pessoa-PBBrazil Department of Physics and Astronomy University of Potsdam PotsdamBrandenburgGermany Laboratory for Electrical Instrumentation Department of Microsystems Engineering-IMTEK University of FreiburgGeorges-Köhler-Allee 106Freiburg 79110Germany Technology and Study Center Weissenburg Deggendorf Institute of Technology WeissenburgBavariaGermany

Nowadays,the demand for advanced functional materials in transducer technology is growing *** materials transform mechanical variables(displacement or force)into electrical signals(charge or voltage)and vice *** are interesting from both fundamental and application points of ***(also called piezoelectrets)are a relatively young group of piezo-,pyro-and ferroelectric *** exhibit ferroic behavior phenomenologically undistinguishable from that of traditional ferroelectrics,although the materials per se are essentially non-polar space-charge electrets with artificial macroscopic dipoles(i.e.,internally charged cavities).A lot of work has been done on ferroelectrets and their applications up to *** this paper,we review and discuss mostly the work done at University of Potsdam on the research and development of *** will,however,also mention important results from other teams,and prospect the challenges and future progress trend of the field of ferroelectret research.

关键词： Ferroelectret piezoelectret space-charge electret transducer advanced functional materials

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Numerical Study of Percolation and Seepage Behaviors in Ion-Adsorption-Type Rare Earth Ore Leaching Process

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Mathematical Problems in Engineering 2023年第1期2023卷

作者： Dianyu, E. Su, Zhongfang Zeng, Jia Yang, Liuyimei Li, Jing Xu, Qiang Wang, Lin Cui, Jiaxin Jiangxi Provincial Key Laboratory for Simulation and Modelling of Particulate Systems Jiangxi University of Science and Technology Nanchang330013 China International Institute for Innovation Jiangxi University of Science and Technology Nanchang330013 China Ganjiang Innovation Academy Chinese Academy of Sciences Ganzhou341000 China ARC Research Hub for Computational Particle Technology Department of Chemical and Biological Engineering Monash University ClaytonVIC3800 Australia State Key Laboratory of Multiphase Flow in Power Engineering Xi'An Jiaotong University Xi'an710049 China Delft University of Technology Delft Netherlands

Ionic rare earth ore is a type of featured rare earth ore in China. Its mining process suffers from a long leaching cycle and considerable consumption of leaching agents. Improving mining efficiency requires a sound physical understanding of the leaching process. In this study, the CFD-based numerical model is used to analyze the physical process of leaching through porous media formed by particles. The simulation results indicate that a lower packing porosity and smaller particles packed granular porous medium result in much larger energy dissipation during seepage, and the energy dissipation increases with seepage velocity. It is found that when the seepage velocity increases to a certain high value, the energy dissipation exceeds the value predicted by Darcy's law, which is mainly caused by liquid turbulence. Additionally, the effect of particle shape is examined. The results show that the granular medium composed of prolate particles causes larger energy dissipation than oblate particles, and spherical particles play the least role. This phenomenon may result from the particle shape affecting the area of the frontal contact surface between particles and liquid. The results provide new insights into the fundamental understanding of percolation and seepage behaviors in the ion-adsorption-type rare earth ore leaching process. © 2023 E. Dianyu et al.

关键词： Energy dissipation

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Deciphering interventional dynamical causality from non-intervention systems

arXiv

引用

arXiv 2024年

作者： Shi, Jifan Li, Yang Zhao, Juan Leng, Siyang Aihara, Kazuyuki Chen, Luonan Lin, Wei Research Institute of Intelligent Complex Systems Fudan University Shanghai200433 China Shanghai Artificial Intelligence Laboratory Shanghai200232 China State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan University Shanghai200032 China International Research Center for Neurointelligence The University of Tokyo Institutes for Advanced Study The University of Tokyo Tokyo113-0033 Japan School of Pharmacy Shanghai University of Traditional Chinese Medicine Shanghai201203 China Academy for Engineering and Technology Fudan University Shanghai200433 China Key Laboratory of Systems Biology Shanghai Institute of Biochemistry and Cell Biology Center for Excellence in Molecular Cell Science Chinese Academy of Sciences Shanghai200031 China Key Laboratory of Systems Health Science of Zhejiang Province School of Life Science Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences Chinese Academy of Sciences Hangzhou310024 China

Detecting and quantifying causality is a focal topic in the fields of science, engineering, and interdisciplinary studies. However, causal studies on nonintervention systems attract much attention but remain extremely challenging. To address this challenge, we propose a framework named Interventional Dynamical Causality (IntDC) for such non-intervention systems, along with its computational criterion, Interventional Embedding Entropy (IEE), to quantify causality. The IEE criterion theoretically and numerically enables the deciphering of IntDC solely from observational (non-interventional) time-series data, without requiring any knowledge of dynamical models or real interventions in the considered system. Demonstrations of performance showed the accuracy and robustness of IEE on benchmark simulated systems as well as real-world systems, including the neural connectomes of C. elegans, COVID-19 transmission networks in Japan, and regulatory networks surrounding key circadian genes. © 2024, CC BY-NC-ND.

关键词： Benchmarking

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A New Total Variation Denoising Algorithm for Piecewise Constant Signals Based on Non-convex Penalty 1

引用

2nd International Conference on Neural Computing for Advanced Applications, NCAA 2021

作者： Lv, Donghao Cao, Weihua Hu, Wenkai Wu, Min School of Automation China University of Geosciences Wuhan430074 China School of Information Engineering Inner Mongolia University of Science and Technology Baotou014010 China Hubei Key Laboratory of Advanced Control and Intelligent Automation for Complex Systems Wuhan China Engineering Research Center of Intelligent Technology for Geo-Exploration Ministry of Education Wuhan China

ISBN: (数字)9789811651885

ISBN: (纸本)9789811651878

Total variation signal denoising is an effective nonlinear filtering method, which is suitable for the restoration of piecewise constant signals disturbed by white Gaussian noises. Towards efficient denoising of piecewise constant signals, a new total variation denoising algorithm based on an improved non-convex penalty function is proposed in this paper. While ensuring the objective function is convex, a new non-convex penalty is designed. The denoising efficiency is improved by updating the dynamic total variational adjustment in the penalty function to the static adjustment. Experimental results demonstrated that the proposed denoising algorithm improved the denoising efficiency without affecting the denoising effect. The overall performance was shown better than the current excellent denoising algorithm. © 2021, Springer Nature Singapore Pte Ltd.

关键词： Efficiency

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