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Hypoxia-triggered photothermal/drug combination therapy of tumors using a perylene diimide molecular capsule

science China Chemistry 2025年第3期68卷 1009-1017页

作者： Fei Yang Guo Wang Kecheng Huang Yanqing Xu Xiao Feng Weizhi Wang Wei Wei Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering Ministry of Industry and Information TechnologySchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 100081China Beijing Key Laboratory for Optical Materials and Photonic Devices Department of ChemistryCapital Normal UniversityBeijing 100048China

Hypoxia is a common characteristic of tumors and associated with poor outcome in most cancer types,thus hypoxia-triggered combined therapeutic systems with well-defined structure hold significant promise for achieving specific and effective tumor ***,a water-soluble perylene diimide(PDI)cyclophane“Gemini Box”(GBox-1^(4+))is demonstrated as both a hypoxia-responsive photothermal agent and a drug capsule for tumor-specific combination ***,owing to the covalent enclosure of PDI chromophore by double-sided molecular straps,GBox-1^(4+)can significantly stabilize labile PDI radical anions generated through bioreduction at the lesion site of hypoxic tumors,leading to high-efficiency near-infrared photothermal ablation of ***,GBox-1^(4+)can act as a molecular capsule to bind water-insoluble antitumor drugs camptothecin and hydroxycamptothecin in 1:1 host-guest stoichiometry with high affinities,greatly enhancing the water solubility of ***,such drug-loading cyclophane system as a hypoxia-activated photothermal/drug combined therapeutic platform exhibits more effective inhibition of tumor growth than the single treatment under identical *** study significantly extends the application range of host-guest cyclophane systems and opens a promising avenue to structurally uniform combined therapeutic agents against hypoxic tumors with improved specificity.

关键词： hypoxia-responsive photothermal agent cyclophanes host-guest system near-infrared combination therapy

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An optical carbon nanotube fibre probe for measurement of nano structures with large aspect ratio

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Nano Research 2025年第3期18卷 436-443页

作者： Weihao Tao Shuhao Zhao Hanjin Dong Ze Zhang Peirui Ji Shenghan Qin Wenbo Hu Jinlong Zhu Renjie Zhou Shuming Yang State Key Laboratory for Manufacturing Systems Engineering Xi’an Jiaotong UniversityXi’an 710049China State Key Laboratory of Intelligent Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan 430074China Department of Biomedical Engineering The Chinese University of Hong KongHong KongChina

With the development of imaging and measurement technologies,scanning near-field optical microscopy(SNOM)has achieved high signal-to-noise *** resolution of a fibre probe-based SNOM system is capable of reaching 10 ***,SNOM applications are presently constrained to the measurement of near-field optical information to relatively straightforward structures,including quantum dots,carbon nanotubes,graphene,and so *** geometry of conventional fibre probes,with tips at an angle of 30°-60°,presents a challenge for accurately imaging complex surface *** paper proposes a carbon nanotube composite fibre probe(CNT-FP)with a large aspect *** key point is that a carbon nanotube bundle is composited at the tip of conventional surface plasmon polaritons fibre probes(SPPs-FP),which are the fibre probes coated with gold film to excite the *** coupling,propagation,and focusing effects of SPPs on the carbon nanotube bundle are ***-FPs have been fabricated and applied to measure a grating with the depth of 400 nm and the width of 400 *** experimental results show that the measurement accuracy and imaging quality of CNT-FP are nearly one order of magnitude higher than that of conventional SPPs-FP,as evidenced by evaluation criteria such as line roughness and volatility ***,it achieves an optical resolution of 72.1 nm in the measurements of a nano structure with large aspect *** provides an effective solution of measuring structures with larger aspect ratios.

关键词： carbon nanotubes fibre optic probes surface plasmon polaritons nano-focusing large aspect ratio

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Alkaline leaching mechanism of MSWI bottom ash:the pivotal role of Si(Al)chemical bonding environments

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science China(Technological sciences) 2025年第2期68卷 73-85页

作者： Ningning SHAO Zekun JIAO Weipeng FENG Yu JIN Fanlong KONG Zhijun DONG Zuotai ZHANG Institute of Technology for Marine Civil Engineering Shenzhen Institute of Information Technology(SZIIT)Shenzhen 518172China School of Environmental Science and Engineering Key Laboratory of Municipal Solid Waste Recycling Technology and Management of Shenzhen CitySouthern University of Science and Technology(SUSTech)Shenzhen 518055China Guizhou NASH Ecological Technology Co. LTDGuiyang 550016China

Municipal solid waste incineration bottom ash(MSWIBA)is a complex assemblage of aluminosilicate materials encompassing diverse solid ***,its complexity poses great challenges to their resource *** the sake of the alkali activation use of MSWIBA,this work focused on the characterizations and alkaline leaching experiments of various classified MSWIBA after *** the different categories of MSWIBA,waste glass(BA-G)and other unidentified slags(BA-O)were identified as potential precursors for alkali activation *** alkaline leaching experiments proved that alkaline concentration,reaction temperature,reaction time,and raw material classification influenced the leaching process and *** these,the Si/Al chemical bonding environments from the material type played a pivotal *** the materials had Q_(n)(n>2)as the primary bonding structure,steric hindrance by the chain frameworks affected the alkali dissolution process,resulting in gradual disintegration from the outer layers *** the materials dominated by Q1 frameworks,OH-could penetrate the frameworks,leading to their rapid depolymerization and outward ***,the Si/Al bonding environment played a crucial role in alkaline dissolution,providing theoretical guidance for classifying the alkali-activation utilization of MSWIBA and other aluminosilicate solid wastes.

关键词： municipal solid waste incineration bottom ash classification alkaline leaching chemical bonding environments mechanism

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Enhanced dynamics of Al^(3+)/H^(+) ions in aqueous aluminum ion batteries:Construction of metastable structures in vanadium pentoxide upon oxygen vacancies

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Journal of Energy Chemistry 2025年第2期101卷 562-569,I0011页

作者： Zhibao Wang Hanqing Gu Tianci Wu Wenming Zhang Zhanyu Li Hebei Key Laboratory of Optic-Electronic Information and Materials National&Local Joint Engineering Laboratory of New Energy Photoelectric DevicesCollege of Physics Science and TechnologyHebei UniversityBaoding 071002HebeiChina

In recent years,aqueous aluminum ion batteries have been widely studied owing to their abundant energy storage and high theo retical *** in-depth study of vanadium oxide materials is necessary to address the precipitation of insoluble products covered cathode surface and the slow reaction ***,a method using a simple one-step hydrothermal preparation and oxalic acid to regulate oxygen vacancies has been reported.A high starting capacity(400 mAh g^(-1))can be achieved by Ov-V2O5,and it is capable of undergoing 200 cycles at 0.4 A g^(-1),with a termination discharge capacity of103 mAh g^(-1).Mechanism analysis demonstrated that metastable structures(AlxV2O5and HxV2O5)were constructed through the insertion of Al^(3+)/H^(+)during discharging,which existed in the lattice intercalation with *** incorporation of oxygen vacancies lowers the reaction energy barrier while improving the ion transport *** addition,the metastable structure allows the electrostatic interaction between Al3+and the main backbone to establish protection and optimize the transport *** parallel,this work exploits ex-situ characterization and DFT to obtain a profound insight into the instrumental effect of oxygen vacancies in the construction of metastable structures during in-situ electrochemical activation,with a view to better understanding the mechanism of the synergistic participation of Al3+and H+in the *** work not only reports a method for cathode materials to modulate oxygen vacancies,but also lays the foundation for a deeper understanding of the metastable structure of vanadium oxides.

关键词： Vanadium pentoxide Oxygen vacancies Electrochemical activation Metastable structure

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Enhancing H^(+)intercalation kinetics and stability in Cu^(2+)pre-intercalatedδ-MnO_(2)for aqueous aluminum batteries

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Journal of Energy Chemistry 2025年第3期102卷 126-133页

作者： Hanqing Gu Mingjun Chen Zhibao Wang Wenming Zhang Zhanyu Li Hebei Key Laboratory of Optic-Electronic Information and Materials National&Local Joint Engineering Laboratory of New Energy Photoelectric DevicesCollege of Physics Science and TechnologyHebei UniversityBaoding 071002HebeiChina

Aqueous aluminum ion batteries(AAIBs)have garnered extensive attention due to their environmental friendliness,high theoretical capacity,and low ***,the sluggish reaction kinetics and severe structural collapse of the cathode material,especially manganese oxide,during the cycling process have hindered its further ***,Cu^(2+)pre-interca la ted layeredδ-MnO_(2)was synthesized via a hydrothermal *** pre-intercalated Cu^(2+)ions not only improve the conductivity of MnO_(2)cathode but also stabilize the structure to enhance stability.X-ray absorption fine structure(XAFS)combined with density functional theory(DFT)calculations confirm the formation of the covalent bond between Cu and O,increasing the electronegativity of O atoms and enhancing the H^(+)adsorption ***,ex-situ measurements not only elucidate the Al^(3+)/H^(+)co-insertion energy storage mechanism but also demonstrate the high reversibility of the Cu-MnO_(2)cathode during *** work provides a promising modification approach for the application of manganese oxides in AAIBs.

关键词： Aqueous aluminum-ion batteries Energy storage mechanism MnO_(2)cathodes Cu^(2+)pre-intercalated

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Innovative Approaches to Task Scheduling in Cloud Computing Environments Using an Advanced Willow Catkin Optimization Algorithm

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Computers, Materials & Continua 2025年第2期82卷 2495-2520页

作者： Jeng-Shyang Pan Na Yu Shu-Chuan Chu An-Ning Zhang Bin Yan Junzo Watada College of Computer Science and Engineering Shandong University of Science and TechnologyQingdao266590China Department of Information Management Chaoyang University of TechnologyTaichung41349Taiwan College of Electronics Communication and PhysicsShandong University of Science and TechnologyQingdao266590China Graduate School of Information Production and SystemsWaseda UniversityKitakyushu808-0135Japan

The widespread adoption of cloud computing has underscored the critical importance of efficient resource allocation and management, particularly in task scheduling, which involves assigning tasks to computing resources for optimized resource utilization. Several meta-heuristic algorithms have shown effectiveness in task scheduling, among which the relatively recent Willow Catkin Optimization (WCO) algorithm has demonstrated potential, albeit with apparent needs for enhanced global search capability and convergence speed. To address these limitations of WCO in cloud computing task scheduling, this paper introduces an improved version termed the Advanced Willow Catkin Optimization (AWCO) algorithm. AWCO enhances the algorithm’s performance by augmenting its global search capability through a quasi-opposition-based learning strategy and accelerating its convergence speed via sinusoidal mapping. A comprehensive evaluation utilizing the CEC2014 benchmark suite, comprising 30 test functions, demonstrates that AWCO achieves superior optimization outcomes, surpassing conventional WCO and a range of established meta-heuristics. The proposed algorithm also considers trade-offs among the cost, makespan, and load balancing objectives. Experimental results of AWCO are compared with those obtained using the other meta-heuristics, illustrating that the proposed algorithm provides superior performance in task scheduling. The method offers a robust foundation for enhancing the utilization of cloud computing resources in the domain of task scheduling within a cloud computing environment.

关键词： Willow catkin optimization algorithm cloud computing task scheduling opposition-based learning strategy

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A DECOUPLED,LINEARLY IMPLICIT AND UNCONDITIONALLY ENERGY STABLE SCHEME FOR THE COUPLED CAHN-HILLIARD systems

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Journal of Computational Mathematics 2025年第3期43卷 708-730页

作者： Dan Zhao Dongfang Li Yanbin Tang Jinming Wen School of Mathematics and Statistics Huazhong University of Science and TechnologyWuhan 430074China Hubei Key Laboratory of Engineering Modeling and Scientific Computing Huazhong University of Science and TechnologyWuhan 430074China College of Information Science and Technology Jinan UniversityGuangzhou 510632China

We present a decoupled,linearly implicit numerical scheme with energy stability and mass conservation for solving the coupled Cahn-Hilliard *** time-discretization is done by leap-frog method with the scalar auxiliary variable(SAV)*** only needs to solve three linear equations at each time step,where each unknown variable can be solved *** is shown that the semi-discrete scheme has second-order accuracy in the temporal *** convergence results are proved by a rigorous analysis of the boundedness of the numerical solution and the error estimates at different *** examples are presented to further confirm the validity of the methods.

关键词： Coupled Cahn-Hilliard system Leap-frog method Scalar auxiliary variable Error estimate

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Micromachined High Gain Diagonal Horn Array Antenna With Suppressed Grating Lobes for 190 GHz-250 GHz

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IEEE Transactions on Terahertz science and technology 2025年第3期15卷 464-472页

作者： Zhao, Yun Zhang, Shao-Min Ye, Fan Li, Sheng Yang, Shi-Cheng Wang, Cai-Xia Ding, Jiang-Qiao Nanjing University of Information Science and Technology School of Electronic and Information Engineering Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment Technology Nanjing210044 China China Academy of Space Technology National Key Laboratory of Science and Technology on Space Microwave Xi'an710100 China

This article presents a high gain, broadband silicon micromachined diagonal horn array antenna for the 190 to 250 GHz frequency band. The antenna array is configured to be built from 34 silicon layers. The upper 25 layers of silicon wafers create an 8 × 8 diagonal horn array antenna and the lower 9 layers form the feed network. The diagonal horn is selected as a radiation element for its 45° polarization direction, which suppresses side and grating lobes in the E-plane and H-plane after array formation. Polarization converters are innovatively employed in the feed network to resolve the issue of opposite polarization from waveguide T-junctions. In order to meet the silicon micromachining criteria, all diagonal horns and the feed network are step-profiled designed based on silicon wafer thickness. The 34 silicon layers are aligned and fixed by computer numerical control-milling metal tooling. Monte Carlo analysis is utilized to quantify the interlayer offset errors introduced during the assembly of the wafers. The measurement results are within the error allowance. The antenna achieves a peak gain of 30.9 dBi and a working frequency bandwidth of 27%. Characterized by highly directive radiation patterns with low side lobe levels in the E-plane and H-plane, the antenna is well-suited for next-generation THz point-to-point communication systems. © 2011-2012 IEEE.

关键词： Silicon wafers

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Thermo-Hydraulic Performances of Microchannel Heat Sinks with Different Types of Perforated Rectangular Blocks

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Fluid Dynamics & Materials Processing 2025年第1期21卷 87-105页

作者： Heng Zhao Honghua Ma Hui Liu Xiang Yan Huaqing Yu Yongjun Xiao Xiao Xiao School of Physics and Electronic Information Engineering Hubei Engineering UniversityXiaogan432000China Wuhan National Laboratory for Optoelectronics(WNLO) Huazhong University of Science and TechnologyWuhan430074China Institute of Engineering and Technology Hubei University of Science and TechnologyXianning437100China

The behavior of single-phase flow and conjugate heat transfer in micro-channel heat sinks(MCHS)subjected to auniform heat flux is investigated by means of numerical *** geometrical configurations areexamined,particularly,the combinations of rectangular solid and perforated blocks,used to create a disturbancein the *** analysis focuses on several key aspects and related metrics,including the temperature distribution,the mean Fanning friction factor,the pressure drop,the Nusselt number,and the overall heat transfer coefficientacross a range of Reynolds numbers(80–870).It is shown that the introduction of such blocks significantlyenhances the heat transfer performances of the MCHS compared to the straight-through flow ***,a case is found where the Nusselt number increases by 2.3 times relative to the reference *** integrationof perforated blocks facilitates the generation of vorticity within the channel,promoting the mixing of coldand hot ***,MCHS incorporating perforated rectangular blocks exhibit more pronounced heat transferbenefits at Reynolds numbers smaller than 400.

关键词： Micro-channel heat sink(MCHS) perforated rectangular blocks thermal performance convection heat transfer

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A Novel Consensus Mechanism Based on Dynamic Sharding 20th

A Novel Consensus Mechanism Based on Dynamic Sharding

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20th IFIP WG 10.3 International Conference on Network and Parallel Computing, NPC 2024

作者： Zhang, Jingyu Teng, Yilong Sun, Yongtao Zhu, Shi Yang, Fangliao Luo, Lailong School of Computer and Communication Engineering Changsha University of Science and Technology Changsha China Science and Technology on Information Systems Engineering Laboratory School of Systems Engineering National University of Defense Technology Changsha China Data Operations Center State Grid Hunan Electric Power Information and Communication Corporation Hunan Changsha China

ISBN: (纸本)9789819628292

Blockchain, as an emerging technology, has been widely studied by the researchers from academia and industry. Alliance chain, as an important form of blockchain, is often applied to smart grids, smart city and the Internet of Things to ensure the authenticity and reliability of data. Practical Byzantine Fault Tolerance (PBFT) algorithm is a key technology to ensure data consistency in the alliance chains, and it plays a critical role in improving system performance, security and scalability. However, with the increase of the number of nodes and transactions, the ability of PBFT to process transactions is challenged. In particular, PBFT’s linear transaction processing also limits its ability to process transactions in parallel. In view of the problems existing in PBFT, this paper studies the consensus mechanism optimization, and puts forward a consensus mechanism with better performance. In this paper, in order to solve the problem of weak parallel transaction processing capability of PBFT, we propose a novel Consensus Mechanism based on Dynamic Sharding (CMDS). CMDS firstly constructs a dynamic fragmentation model based on consistent hash algorithm to segment nodes, and then constructs a voting consensus mechanism based on reputation weight to achieve global state consistency. The experimental results show that CMDS can significantly improve the ability of parallel transaction processing and the performance of blockchain system. © IFIP International Federation for information Processing 2025.

关键词： Blockchain

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