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3D bioprinting of a dermal scaffold for full-thickness skin tissue regeneration

Bio-Design and Manufacturing 2025年第1期8卷 68-84,I0039-I0041页

作者： Lu Han Zixian Liu Meng Li Zhizhong Shen Jianming Wang Shengbo Sang Shanxi Key Laboratory of Micro Nano Sensors&Artificial Intelligence Perception College of Electronic Information and Optical EngineeringTaiyuan University of TechnologyTaiyuan 030024China Key Laboratory of Advanced Transducers and Intelligent Control System of the Ministry of Education Taiyuan University of TechnologyTaiyuan 030024China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030024China Shanxi Research Institute of 6D Artificial Intelligence Biomedical Science Taiyuan 030031China General Hospital of TISCO Taiyuan 030809China

Dermal substitutes have provided a template for the regeneration and reconstruction of the ***,the healed skin tissue often exhibits abnormal morphology and functionality,including scarring and *** this study,a composite bioink composed of methacrylated gelatin(GelMA)and chitosan oligosaccharide(COS)was proposed for printing a dermal scaffold using digital light processing(DLP)*** GelMA/COS bioink exhibited suitable porosity,swelling,degradation rate,and mechanical *** inclusion of COS demonstrated antibacterial effects against both Gram positive and Gram-negative bacteria,while simultaneously fostering the proliferation of human dermal fibroblasts(HDFs).Additionally,the application of COS could effectively reduce the expression levels of fibrosis-related genes,such as collagen I,collagen III,and fibronectin *** three-dimensionally printed cell-laden dermal scaffold exhibited excellent shape fidelity and high cellular viability,facilitating the extension of HDFs along the scaffold and the simultaneous secretion of extracellular matrix ***,the HDF-laden dermal scaffold transplanted into full-thickness skin defect sites in nude mice was shown to accelerate wound closure,reduce inflammation,and improve wound ***,the DLP-printed dermal scaffold provides an appealing approach for effectively treating full-thickness skin defects in clinical settings.

关键词： 3D printing Dermal scaffold Photo-cross-linking Skin tissue regeneration

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Development of an Integrated CMUTs-Based Resonant Biosensor for Label-Free Detection of DNA with Improved Selectivity by Ethylene-Glycol Alkanethiols

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Engineering 2024年第10期41卷 231-241页

作者： Zhikang Li Yihe Zhao Gian Luca Barbruni Jie Li Zixuan Li Jiawei Yuan Ping Yang Libo Zhao Zhuangde Jiang Sandro Carrara State Key Laboratory for Manufacturing Systems Engineering the International Joint Laboratory for Micro/Nano Manufacturing and Measurement TechnologiesXi’an Jiaotong UniversityXi’an 710049China Xi’an Jiaotong University(Yantai)Research Institute for Intelligent Sensing Technology and System Yantai 264003China School of Instrument Science and Technology Xi’an Jiaotong UniversityXi’an 710049China School of Mechanical Engineering Xi’an Jiaotong UniversityXi’an 710049China Shandong Laboratory of Yantai Advanced Materials and Green Manufacturing Yantai 265503China Bio/CMOS Interfaces Laboratory Institute of Electrical and MicroengineeringSchool of EngineeringÉcole Polytechnique Fédérale de LausanneNeuchâtel 2000Switzerland College of Mechanical and Electrical Engineering Shaanxi University of Science and TechnologyXi’an 710021China

Gravimetric resonant-inspired biosensors have attracted increasing attention in industrial and point-ofcare applications,enabling label-free detection of biomarkers such as DNA and *** micromachined ultrasonic transducers(CMUTs)are promising tools for developing miniaturized highperformance biosensing complementary metal–oxide–silicon(CMOS)***,their operability is limited by inefficient functionalization,aggregation,crosstalk in the buffer,and the requirement for an external high-voltage(HV)power *** this study,we aimed to propose a CMUTs-based resonant biosensor integrated with a CMOS front–end interface coupled with ethylene–glycol alkanethiols to detect single-stranded DNA oligonucleotides with large *** topography of the functionalized surface was characterized by energy-dispersive X-ray *** selectivity for onchip hybridization was demonstrated by comparing complementary and non-complementary singlestranded DNA oligonucleotides using fluorescence imaging *** sensor array was further characterized using a five-element lumped equivalent *** 4 mm^(2) application-specific integrated circuit chip was designed and developed through 0.18 lm HV bipolar-CMOS-double diffused metal–oxide–silicon(DMOS)technology(BCD)to generate on-chip 20 V HV boosting and to track feedback frequency under a standard 1.8 V supply,with a total power consumption of 3.8 mW in a continuous *** measured results indicated a detection sensitivity of 7.943×10^(-3) lmol·L^(-1)·Hz^(-1) over a concentration range of 1 to 100 lmol·L^(-1).In conclusion,the label-free biosensing of DNA under dry conditions was successfully demonstrated using a microfabricated CMUT array with a 2 MHz frequency on CMOS electronics with an internal HV ***,ethylene–glycol alkanethiols successfully deposited self-assembled monolayers on aluminum electrodes,which has never been attempted thus far on CMUTs,to enhance the sel

关键词： Capacitive micromachined ultrasonic transducers(CMUTs) DNA detection Self-assembled monolayer(SAM) Ethylene-glycol alkanethiols Application-specific integrated circuit(ASIC)

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Mobile Internet-oriented Data Preprocessing for Static Routes in Scenic Spots 7

Mobile Internet-oriented Data Preprocessing for Static Route...

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7th International Conference on Computer and Communications, ICCC 2021

作者： Zhang, Jinghe Hong, Miao Zhang, Xingfa Lu, Binghe Fang, Weidong Beihang University BUAA EMC Technology Institute Beijing100083 China Beihang Beidou Application Research Institute of Jinhua Jinhua321037 China Hangzhou LineZone Data Science and Technology Co.Ltds Hangzhou310051 China Science and Technology On Micro-system Laboratory Shanghai Institute of Micro-system and Information Technology Chinese Academy of Sciences Shanghai200051 China

ISBN: (纸本)9781665409506

To improve the tourist experience of tourists, we propose a data preprocessing method for the static route of the scenic spot. Specifically, the basic value of each scenic spot in the scenic spot is set, the basic data that affects the value of each scenic spot is determined, and the basic data obtained is combined Data, determine the weight that affects the value of each scenic spot;enter the value corresponding to each scenic spot, and get the default value of each scenic spot according to the weight corresponding to each scenic spot. By introducing the concept of the weight of external factors that affect the value of the scenic spot in the process of determining the value of the scenic spot, the actual value of each scenic spot under the influence of external factors can be obtained, so as to pave the way for the subsequent tourist route planning and improve the tour. The effective use of routes and tour time will ultimately improve the experience of tourists visiting scenic spots. © 2021 IEEE.

关键词： Internet of things

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arXiv

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arXiv 2023年

作者： Wang, Xiaonan Yang, Jinfeng Ying, Penghua Fan, Zheyong Zhang, Jin Sun, Huarui School of Science Harbin Institute of Technology Shenzhen518055 China College of Physical Science and Technology Bohai University Jinzhou121013 China Ministry of Industry and Information Technology Key Laboratory of Micro-Nano Optoelectronic Information System Harbin Institute of Technology Shenzhen518055 China

The lattice thermal conductivity (LTC) of Ga2O3 is an important property due to the challenge in the thermal management of high-power devices. We develop machine-learned neuroevolution potentials for single-crystalline β-Ga2O3 and κ-Ga2O3, and apply them to perform homogeneous nonequilibrium molecular dynamics simulations to predict their LTCs. The LTC of β-Ga2O3 was determined to be 10.3 ± 0.2 W/(m K), 19.9 ±0.2 W/(m K), and 12.6 ±0.2 W/(m K) along [100], [010], and [001], respectively, aligning with previous experimental measurements. For the first time, we predict the LTC of κ-Ga2O3 along [100], [010], and [001] to be 4.5 W/(m K), 3.9 W/(m K), and 4.0 ± 0.1 W/(m K), respectively, showing a nearly isotropic thermal transport property. The reduced LTC of κ-Ga2O3 versus β-Ga2O3 stems from its restricted low-frequency phonons up to 5 THz. Furthermore, we find that the β phase exhibits a typical temperature dependence slightly stronger than ∼ T−1, whereas the κ phase shows a weaker temperature dependence, ranging from ∼ T−0.5 to ∼ T−0.7 Copyright © 2023, The Authors. All rights reserved.

关键词： Gallium compounds

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Magnetic Properties of NH4H2PO4 and KH2PO4: Emergence of Multiferroic Salts

arXiv

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arXiv 2024年

作者： Meng, Lei He, Chen Ji, Wei Yen, Fei State Key Laboratory on Tunable Laser Technology Ministry of Industry and Information Technology Key Laboratory of Micro-Nano Optoelectronic Information System The School of Science Harbin Institute of Technology Shenzhen University Town Guangdong Shenzhen518055 China Education Center of Experiments and Innovations Harbin Institute of Technology Shenzhen University Town Guangdong Shenzhen518055 China

We observe sharp step-down discontinuities in the magnetic susceptibility of NH4H2PO4 and NH4H2PO4-d60 (60% deuterated) along the a and c-axes occurring exactly at their antiferroelectric transition temperatures. For the case of KH2PO4, less pronounced discontinuities occur at the ferroelectric transition temperature. To explain this, we treat the acid protons as individual oscillators that generate current elements which translate to magnetic forces in near resonance with each other. With decreasing temperature, the resonant forces become more commensurate which amplifies a disproportionate drop off of two types of magnetic forces to eventually trigger the structural phase transitions. For the case of NH4H2PO4, the associated internal magnetic field appears to aid the NH4+ to order at higher temperature. At 49 K, a shoulder-like anomaly in both NH4H2PO4 and KH2PO4 is attributed to a possible onset of macroscopic quantum tunneling of protons. Our findings bring forth a new category of intrinsic multiferroic systems. © 2024, CC BY-NC-ND.

关键词： Temperature

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Exceptional point empowered near-field routing of hyperbolic polaritons

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science Bulletin 2024年第22期69卷 3491-3495页

作者： Zhiwei Guo Jiayue Jiang Yuqian Wang Jose Alvarez-Cuervo Aitana Tarazaga Martin-Luengo Shengyu Hu Jie Jiang Pablo Alonso Gonzalez Jiahua Duan Hong Chen MOE Key Laboratory of Advanced Micro-Structured Materials School of Physics Science and EngineeringTongji UniversityShanghai 200092China Department of Physics University of OviedoOviedo 33003Spain Center of Research on Nanomaterials and Nanotechnology CINN(CSIC-Universidad de Oviedo)El Entrego 33003Spain Center for Quantum Physics Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurement(MOE)School of PhysicsBeijing Institute of TechnologyBeijing 100081China Beijing Key Laboratory of Nanophotonics and Ultrafine Optoelectronic System Beijing Institute of TechnologyBeijing 100081China

Subwavelength-scale manipulation of electromagnetic waves forms the cornerstone of next-generation photonic devices and quantum information processing[1],where extensive efforts have focused on momentum-frequency dispersion through modification of the sizes,shape topology,and symmetry of the isofrequency contours(IFCs)[2,3].For instance,twisting of the multi-layers of stacked vdW materials results in a topological transition from open(hyperbolic-like)to closed(elliptical-like)IFCs(i.e.,control of the propagation wavefront).In contrast,the symmetry of IFCs,which is deeply rooted in the system symmetry,is more difficult to modulate[4].For example,hyperbolic polaritons exhibit four mirrorsymmetric beams in high-symmetry orthorhombic crystals,while asymmetric propagation of tilted hyperbolic shear polaritons only emerges in low-symmetry monoclinic crystals[3].

关键词： hyperbolic symmetry polar

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A comprehensive review of miniatured wind energy harvesters

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Nano Materials science 2021年第2期3卷 170-185页

作者： Quan Wen Xianming He Zhuang Lu Reinhard Streiter Thomas Otto Key Laboratory of Fundamental Science of Micro/Nano-Device and System Technology Chongqing UniversityChongqing400044People's Republic of China Microsystem Research Center Chongqing UniversityChongqing400044People's Republic of China Fraunhofer Institute for Electronic Nano Systems(ENAS) Chemnitz09131Germany

Following the current rapid development of the Internet of Things(IoT)and wireless condition monitoring systems,energy harvesters which use ambient energy have become a key part of achieving an energy-autonomous *** wind energy harvesters have attracted widespread attention because of their great potential of power density as well as the rich availability of wind energy in many possible areas of *** article provides readers with a glimpse into the state-of-the-art of miniature wind energy *** crucial factors for them to achieve high working efficiency under lower operational wind speed excitation are *** potential energy coupling mechanisms are discussed in *** approaches for broadening operational wind-speed-range given a variety of energy coupling mechanisms are also presented,as observed in the *** enhancement mechanisms including hydrodynamic configuration optimization,and non-linear vibration pick-up structure are *** are drawn and the outlook for each coupling mechanisms is presented.

关键词： Energy harvester Wind energy Miniature wind-induced vibration energy harvester Energy coupling mechanism Performance enhancement mechanisms

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Hypoxia endothelial cells-derived exosomes facilitate diabetic wound healing through improving endothelial cell function and promoting M2 macrophages polarization

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Bioactive Materials 2024年第3期33卷 157-173页

作者： Peng Cheng Xudong Xie Liangcong Hu Wu Zhou Bobin Mi Yuan Xiong Hang Xue Kunyu Zhang Yuxiao Zhang Yiqiang Hu Lang Chen Kangkang Zha Bin Lv Ze Lin Chuanlu Lin Guandong Dai Yixin Hu Tengbo Yu Hankun Hu Guohui Liu Yingze Zhang Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration Wuhan430022China School of Biomedical Sciences and Engineering South China University of TechnologyGuangzhou International CampusGuangzhou511442China Department of Orthopaedics Pingshan District People’s Hospital of ShenzhenPingshan General Hospital of Southern Medical UniversityShenzhenGuangdong518118China Hubei Micro-explore Innovative Pharmaceutical Research Co LtdWuhanHubei430071China Suzhou Organ-on-a-Chip System Science and Technology Co LtdSuzhouJiangsu215000China Department of Sports Medicine The Affiliated Hospital of Qingdao UniversityQingdaoChina Department of Pharmacy Zhongnan Hospital of Wuhan UniversitySchool of Pharmaceutical SciencesWuhan UniversityWuhan430071China Department of Orthopaedic Surgery The Third Hospital of Hebei Medical UniversityNO.139 Ziqiang RoadShijiazhuang050051China

It is imperative to develop and implement newer,more effective strategies to address refractory diabetic *** of now,there is currently no optimal solution for these *** human umbilical vein endothelial cells(HUVECs)-derived exosomes have been postulated to promote diabetic wound healing,however,its effect and molecular mechanism need further *** this study,we aimed to investigate whether hypoxic exosomes enhance wound healing in *** on our high-throughput sequencing,differentially expressed lncRNAs(including 64 upregulated lncRNAs and 94 downregulated lncRNAs)were found in hypoxic exosomes compared to normoxic ***,lncHAR1B was one of the prominently upregulated lncRNAs in hypoxic exosomes,showing a notable correlation with diabetic wound *** specifically,hypoxic exosomes were transmitted to surrounding cells,which resulted in a significant increase in lncHAR1B level,thereby relieving the dysfunction of endothelial cells and promoting the switch from M1 to M2 macrophages under high glucose ***,lncHAR1B directly interacted with the transcription factor basic helix-loop-helix family member e23(BHLHE23),which subsequently led to its binding to the KLF transcription factor 4(KLF4)and promoted KLF4 *** our in vivo experiments,the use of hypoxic exosomes-loaded HGM-QCS hydrogels(Gel-H-Exos)resulted in rapid wound healing compared to that of normoxic exosomes-loaded HGM-QCS hydrogels(Gel-N-Exos)and diabetic ***,our study provides potentially novel therapeutic approaches aimed at accelerating wound healing and developing a practical exosomes delivery platform.

关键词： Diabetic wound Hypoxic exosomes lncHAR1B KLF4 Macrophage polarization

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Giant Tunneling Magnetoresistance Based on Spin-Valley-Mismatched Ferromagnetic Metals

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Physical Review Letters 2025年第3期134卷 036302-036302页

作者： Kun Yan Li Cheng Yizhi Hu Junjie Gao Xiaolong Zou Xiaobin Chen School of Science State Key Laboratory on Tunable Laser Technology and Ministry of Industry and Information Technology Key Lab of Micro-Nano Optoelectronic Information System Harbin Institute of Technology Shenzhen Shenzhen 518055 China Shenzhen Geim Graphene Center and Shenzhen Key Laboratory of Advanced Layered Materials for Value-added Applications Institute of Materials Research Tsinghua Shenzhen International Graduate School Tsinghua University Shenzhen 518055 China Collaborative Innovation Center of Extreme Optics Shanxi University Taiyuan 030006 China

Half metals, which are amenable to perfect spin filtering, can be utilized for high-magnetoresistive devices. However, available half metals are very limited. Here, we demonstrate that materials with intrinsic spin-valley-mismatched (SVM) states can be used to block charge transport, resembling half metals and leading to giant tunneling magnetoresistance. As an example, by using first-principles transport calculations, we show that ferromagnetic 1T−VSe2, 1T−VS2, and 2H−VS2 are such spin-valley-mismatched metals, and giant magnetoresistance of more than 99% can be realized in spin-valve van der Waals (vdW) junctions using these metals as electrodes. Owing to the intrinsic mismatch of spin states, the central-layer materials for the vdW junctions can be arbitrary nonmagnetic materials, in principle. Our research provides clear physical insights into the mechanism for high magnetoresistance and opens new avenues for the search and design of high-magnetoresistance devices.

关键词： Van der Waals forces

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Effect of Mo doping on phase change performance of Sb_(2)Te_(3)

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Chinese Physics B 2021年第8期30卷 440-443页

作者： Wan-Liang Liu Ying Chen Tao Li Zhi-Tang Song Liang-Cai Wu State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Micro-system and Information TechnologyChinese Academy of SciencesShanghai 200050China University of Chinese Academy of Sciences Beijing 100049China College of Science Donghua UniversityShanghai 201620China Member of Magnetic Confinement Fusion Research Center Ministry of EducationChina

Mo,as a dopant,is doped into SbTe to improve its thermal *** is shown in this paper that the Mo-doped Sb_(2)Te_(3)(Mo_(0.26)Sb_(2)Te_(3),MST)material possesses phase change memory(PCM)*** has better thermal stability than Sb_(2)Te_(3)(ST)and will crystallize only when the annealing temperature is higher than 250℃.With the good thermal stability,MST-based PCM cells have a fast crystallization time of 6 ***,endurance up to 4×10^(5) cycles with a resistance ratio of more than one order of magnitude makes MST a promising candidate for PCM applications.

关键词： phase-change memory Sb_(2)Te_(3) thin films nanocomposites

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