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Correction to: ArborTracking: a tree topology track pattern recognition algorithm

Radiation Detection technology and Methods 2020年第4期4卷 513-513页

作者： Zhao, Mingrui Ruan, Manqi Hu, Shouyang Zhou, Jing Yan, Yuliang Chen, Lei Liu, Wendi Li, Peiyu Jia, Shihai Zhang, Yunyu Li, Xiaomei Science and Technology on Nuclear Data Laboratory China Institute of Atomic Energy Beijing China Institute of High Energy Physics Chinese Academy of Sciences Beijing China

In the original publication the copyright text below the “Introduction” section is incorrectly published.

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Comprehensive Theoretical Quantification of Secondary Electron Emission from Silicon

SSRN

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SSRN 2023年

作者： Khan, Muhammad Saadat Shakoor Mao, Shifeng Zou, Yanbo Lu, Dabao Da, Bo Li, Yonggang Ding, Zejun Department of Physics University of Science and Technology of China Anhui Hefei230026 China Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of China Anhui Hefei230026 China Department of Nuclear Science and Engineering University of Science and Technology of China Anhui Hefei230026 China School of Physics and Electronic Engineering Xinjiang Normal University Xinjiang Urumchi830054 China Microscope Science and Technology Limited Anhui Hefei230093 China Research and Services Division of Materials Data and Integrated System National Institute for Materials Science 1-1 Namiki Ibaraki Tsukuba305-0044 Japan Research Center for Advanced Measurement and Characterization National Institute for Materials Science 1-2-1 Sengen Ibaraki Tsukuba305-0047 Japan Key Laboratory of Materials Physics Insititute of Solid State Physics Chinese Academy of Sciences Anhui Hefei230031 China

Though intensive experimental studies have been carried out on electron emission properties in past decades, the reliable data from accurate experimental measurements for clean and smooth surfaces are still quite limited. In this work, we have performed a comprehensive Monte Carlo simulation of electron emission yields, the secondary electron yield (SEY,δ), backscattered electron coefficient (BSC,η) and total electron yield (TEY,σ=δ+η), from silicon and the uncertainty quantification of the theoretical calculation results for the first time. The considered uncertainty factors in the physical modelling include work function data, optical energy loss function data, dielectric function models for electron inelastic scattering and the scattering potentials for electron elastic scattering. The calculation results show that δ is significantly influenced by the work function while the dielectric function model has a slight effect. Elastic scattering potential and energy loss function affects both δ and η. Our simulatedσ η data agree with most of the experimental measurements while the simulated mean σ data are well below most of the experimental data. The experimental σ data measured by Goto lie within the uncertainty range of our simulation results. This work has provided sufficient ground for the necessity of building a theoretical database of electron emission yield. © 2023, The Authors. All rights reserved.

关键词： Silicon

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γ-ray strength function for thallium isotopes relevant to the Pb205−Tl205 chronometry

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Physical Review C 2019年第2期99卷 024609-024609页

作者： H. Utsunomiya T. Renstrøm G. M. Tveten S. Goriely T. Ari-izumi D. Filipescu J. Kaur Y.-W. Lui W. Luo S. Miyamoto A. C. Larsen S. Hilaire S. Péru A. J. Koning Konan University Department of Physics 8-9-1 Okamoto Higashinada Japan Department of Physics University of Oslo N-0316 Oslo Norway Institut d'Astronomie et d'Astrophysique Université Libre de Bruxelles Campus de la Plaine CP-226 1050 Brussels Belgium National Institute for Physics and Nuclear Engineering Horia Hulubei (IFIN-HH) 30 Reactorului 077125 Bucharest-Magurele Romania Extreme Light Infrastructure Nuclear Physics “Horia Hulubei” National Institute for Physics and Nuclear Engineering (IFIN-HH) 30 Reactorului 077125 Bucharest-Magurele Romania Cyclotron Institute Texas A&M University College Station Texas 77843 USA School of Nuclear Science and Technology University of South China Hengyang 421001 China Laboratory of Advanced Science and Technology for Industry University of Hyogo 3-1-2 Kouto Kamigori Ako-gun Hyogo 678-1205 Japan CEA DAM DIF F-91297 Arpajon France Nuclear Data Section International Atomic Energy Agency A-1400 Vienna Austria

Photoneutron cross sections were measured for Tl203 and Tl205 at energies between the one- and two-neutron thresholds using quasimonochromatic γ-ray beams produced in laser Compton scattering at the NewSUBARU synchrotron radiation facility. Our measurement results in cross sections significantly different from the previously reported bremsstrahlung experiment, leading to rather different giant dipole resonance (GDR) parameters, in particular to lower GDR peak energies and higher peak cross sections. The photoneutron data are used to constrain the γ-ray strength function on the basis of the Hartree-Fock-Bogolyubov plus quasiparticle random-phase approximation using the Gogny D1M interaction. Supplementing the experimentally constrained γ-ray strength function with the zero-limit E1 and M1 contributions for the de-excitation mode, we estimate the Maxwellian-averaged cross section for the s-process branching-point nucleus Tl204 in the context of the Pb205−Tl205 chronometry.

关键词： Hydrostatic stellar nucleosynthesis Lifetimes & widths nuclear astrophysics nuclear reactions Photonuclear reactions Thermal & statistical models 190 ≤ A ≤ 219

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Protocol for Brain Magnetic Resonance Imaging and Extraction of Imaging‑Derived Phenotypes from the China Phenobank Project

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Phenomics 2023年第6期3卷 642-656页

作者： Chengyan Wang Zhang Shi Yan Li Xueqin Xia Xutong Kuang Shufang Qian Le Xue Lizhen Lan Yudan Wu Na Zhang Ji Tao Xumei Hu Wenzhao Cao Naying He Yike Guo Weibo Chen Jun Zhang Jingchun Luo He Wang Mei Tian Human Phenome Institute Fudan University825 Zhangheng RoadPudong New DistrictShanghai 201203China Department of Radiology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Radiology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Nuclear Medicine and Medical PET Center The Second Afliated Hospital of Zhejiang University School of MedicineHangzhou 310003China Department of Computer Science Hong Kong Baptist UniversityHong Kong Special Administrative Region 999077China Data Science Institute Imperial College LondonLondon SW72AZUK Philips Healthcare Co.Shanghai 200070China Department of Radiology Huashan HospitalNational Center for Neurological DisordersFudan UniversityShanghai 200040China Institute of Science and Technology for Brain-Inspired Intelligence Fudan UniversityShanghai 200433China Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence Ministry of EducationFudan UniversityShanghai 200433China

Imaging-derived phenotypes(IDPs)have been increasingly used in population-based cohort studies in recent *** widely reported,magnetic resonance imaging(MRI)is an important imaging modality for assessing the anatomical structure and function of the brain with high resolution and excellent soft-tissue *** purpose of this article was to describe the imaging protocol of the brain MRI in the China Phenobank Project(CHPP).Each participant underwent a 30-min brain MRI scan as part of a 2-h whole-body imaging protocol in *** brain imaging sequences included T1-magnetization that prepared rapid gradient echo,T2 fuid-attenuated inversion-recovery,magnetic resonance angiography,difusion MRI,and resting-state functional *** detailed descriptions of image acquisition,interpretation,and post-processing were provided in this *** measured IDPs included volumes of brain subregions,cerebral vessel geometrical parameters,microstructural tracts,and function connectivity metrics.

关键词： Human phenome project Phenobank Brain magnetic resonance imaging Imaging derived phenotypes Standard protocol

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GSMorph: Gradient Surgery for cine-MRI Cardiac Deformable Registration

arXiv

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arXiv 2023年

作者： Dou, Haoran Bi, Ning Han, Luyi Huang, Yuhao Mann, Ritse Yang, Xin Ni, Dong Ravikumar, Nishant Frangi, Alejandro F. Huang, Yunzhi University of Leeds Leeds United Kingdom Department of Radiology and Nuclear Medicine Radboud University Medical Centre Nijmegen Netherlands Department of Radiology Netherlands Cancer Institute Amsterdam Netherlands National-Regional Key Technology Engineering Laboratory for Medical Ultrasound School of Biomedical Engineering Health Science Center Shenzhen University China Lab Shenzhen University China Marshall Laboratory of Biomedical Engineering Shenzhen University China Shenzhen RayShape Medical Technology Co. Ltd China Division of Informatics Imaging and Data Science Schools of Computer Science and Health Sciences University of Manchester Manchester United Kingdom Electrical Engineering and Cardiovascular Sciences Departments KU Leuven Leuven Belgium Alan Turing Institute London United Kingdom Institute for AI in Medicine School of Artificial Intelligence Nanjing University of Information Science and Technology Nanjing China

Deep learning-based deformable registration methods have been widely investigated in diverse medical applications. Learning-based deformable registration relies on weighted objective functions trading off registration accuracy and smoothness of the deformation field. Therefore, they inevitably require tuning the hyperparameter for optimal registration performance. Tuning the hyperparameters is highly computationally expensive and introduces undesired dependencies on domain knowledge. In this study, we construct a registration model based on the gradient surgery mechanism, named GSMorph, to achieve a hyperparameter-free balance on multiple losses. In GSMorph, we reformulate the optimization procedure by projecting the gradient of similarity loss orthogonally to the plane associated with the smoothness constraint, rather than additionally introducing a hyperparameter to balance these two competing terms. Furthermore, our method is model-agnostic and can be merged into any deep registration network without introducing extra parameters or slowing down inference. In this study, We compared our method with state-of-the-art (SOTA) deformable registration approaches over two publicly available cardiac MRI datasets. GSMorph proves superior to five SOTA learning-based registration models and two conventional registration techniques, SyN and Demons, on both registration accuracy and smoothness. © 2023, CC BY.

关键词： Medical applications

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Measurement of Neutron Total Cross Section of Ag and Sm at Pohang Neutron Facility

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Journal of nuclear science and technology 2004年 41卷 388-392页

作者： Kim, Guinyim Lee, Yoimgseok Rachid, Machrafi Ahmed, Hossain Son, Dongchul Skoy, Vadim Sik Kang, Heng Ko, In Soo Cho, Moo Hyun Namkung, Won Chang, Jong Hwa Yoo, Kun Joong Institute of High Energy Physics Kyungpook National University Taegu 702-701 1370 Sankyuck-dong Buk-gu South Korea Pohang Accelerator Laboratory Pohang University of Science and Technology Pohang 790-784 San 31 Hyoja-dong Nam-gu South Korea Nuclear Data Evaluation Laboratory Korea Atomic Energy Research Institute Dajeon 305-600 PO Box 105 Yusung South Korea

The neutron total cross section of natural Ag and Sm has been measured in the energy region from 0.1 eV to 100 eV by the neutron time-of-flight method at Pohang Neutron Facility, which consists of an electron linear accelerator, a water-cooled Ta target with a water moderator, and an 11 m long time-of-flight path. A ⁶Li-ZnS(Ag) scintillator with a diameter of 12.5 cm and a thickness of 1.6 cm has been used as a neutron detector and metallic plates of Ag and Sm samples have been used for the neutron transmission measurement. The background level has been deterrnined by using notch-filters of Co, In, and Cd sheets. In order to reduce the gamma rays from Bremsstrahlung and that from neutron capture, we have employed a neutron-gamma separation system based on their different pulse shapes. The present measurements are in general agreement with the previous ones and the evaluated data in ENDF/B-VI. The resonance parameters of Ag isotopes (¹⁰⁷Ag and ¹⁰⁹Ag) have been extracted from the transmission data by using the SAMMY code. © 2014 Atomic Energy Society of Japan.

关键词： Ag Electron linear accelerator Neutron time-of-flight OA eV to 100 eV energy range Pohang Neutron Facility Resonance parameter SAMMY fitting Sm Ta target Total cross section

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Strong decays of the Ξ(1620) as a ΛK¯ and ΣK¯ molecule

arXiv

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arXiv 2020年

作者： Huang, Yin Geng, Lisheng School of Physical Science and Technology Southwest Jiaotong University Chengdu610031 China School of Physics Beihang University Beijing102206 China Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang University Beijing102206 China School of Physics and Microelectronics Zhengzhou University ZhengzhouHenan450001 China Beijing Advanced Innovation Center for Big Data-based Precision Medicine Beihang University Beijing100191 China

In this work, we study the strong decays of the newly observed Ξ(1620)0 assuming that it is a meson-baryon molecular state of ΛK¯ and ΣK¯ . We consider four possible spin-parity assignments JP = 1/2± and 3/2± for the Ξ(1620)0, and evaluate its partial decay width into Ξπ via hadronic loops with the help of effective Lagrangians. In comparison with the Belle data, the calculated decay width favors the spin-party assignment 1/2− while the other spin-parity assignments do not yield a decay width consistent with data in the molecule picture. We find that about 52%-68% of the total width comes from the KΛ ¯ channel, while the rest is provided by the KΣ ¯ channel. As a result, both channels are important in explaining the strong decay of the Ξ(1620)0. This information is helpful to further understand the nature of the Ξ(1620)0. Copyright © 2020, The Authors. All rights reserved.

关键词： Hadrons

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FENDL: A library for fusion research and applications

arXiv

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arXiv 2023年

作者： Schnabel, G. Aldama, D.L. Bohm, T. Fischer, U. Kunieda, S. Trkov, A. Konno, C. Capote, R. Koning, A.J. Breidokaite, S. Eade, T. Fabbri, M. Flammini, D. Isolan, L. Kodeli, I. Kosál, M. Kwon, S. Laghi, D. Leichtle, D. Nakayama, S. Ohta, M. Packer, L.W. Qiu, Y. Sato, S. Sawan, M. Schulc, M. Stankunas, G. Sumini, M. Valentine, A. Villari, R. Žohar, A. NAPC–Nuclear Data Section International Atomic Energy Agency Vienna Austria Centro de Aplicaciones Tecnológicas y Desarrollo Nuclear Havana Cuba University of Wisconsin-Madison MadisonWI United States Hermann-von-Helmholtz-Platz 1 Eggenstein-Leopoldshafen76344 Germany Nuclear Science and Engineering Center Japan Atomic Energy Agency Ibaraki Tokai Japan Josef Stefan Institute Ljubljana Slovenia Lithuanian Energy Institute Laboratory of Nuclear Installation Safety Kaunas Lithuania United Kingdom Atomic Energy Authority Culham Science Centre Abingdon OxonOX14 3DB United Kingdom Fusion for Energy Barcelona Spain ENEA Fusion and Technology for Nuclear Safety and Security Department C.R. Frascati Italy Industrial Engineering Department University of Bologna Bologna Italy Research Center Rez Ltd Husinec Rez25068 130 Czech Republic Rokkasho Fusion Institute National Institutes for Quantum Science and Technology Aomori Rokkasho Japan NIER Engineering Castel Maggiore Italy

The Fusion Evaluated nuclear data Library (FENDL) is a comprehensive and validated collection of nuclear cross section data coordinated by the International Atomic Energy Agency (IAEA) nuclear data Section (NDS). FENDL assembles the best nuclear data for fusion applications selected from available nuclear data libraries and has been under development for decades. FENDL contains sublibraries for incident neutron, proton, and deuteron cross sections including general purpose and activation files used for particle transport and nuclide inventory calculations. In this work, we describe the history, selection of evaluations for the various sub-libraries (neutron, proton, deuteron) with the focus on transport and reactor dosimetry applications, the processing of the nuclear data for application codes (e.g. MCNP), and the development of the TENDL-2017 library which is the currently recommended activation library for FENDL. We briefly describe the IAEA IRDFF library as the recommended library for dosimetry fusion applications. We also present work on validation of the neutron sub-library using a variety of fusion relevant computational and experimental benchmarks using the MCNP transport code and ACE-formatted cross section libraries. A variety of cross section libraries are used for the validation work including FENDL-2.1, FENDL-3.1d, FENDL-3.2, ENDF/B-VIII.0, and JEFF-3.2 with the emphasis on the FENDL libraries. The results of the validation using computational benchmarks showed generally good agreement among the tested neutron cross section libraries for neutron flux, nuclear heating, and primary displacement damage (dpa). Gas production (H/He) in structural materials showed substantial differences to the reference FENDL-2.1 library. The results of the experimental validation showed that the performance of FENDL-3.2b is at least as good and in most cases better than FENDL-2.1. Future work will consider improved evaluations developed by the International nuclear data Eva

关键词： Libraries

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Search for the rare decay B^(0)→J/ψФ

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Chinese Physics C 2021年第4期45卷 47-60页

作者： R.Aaij C.Abellin Beteta T.Ackernley B.Adeva M.Adinolfi H.Afsharnial C.A.Aidala S.Aiola Z.Ajaltouni S.Akar J.Albrecht F.Alessio M.Alexander A.Alfonso Albero Z.Aliouche G.Alkhazov P.Alvarez Cartelle S.Amato Y.Amhis L.An L.Anderlini A.Andreianov M.Andreotti F.Archilli A.Artamonov M.Artuso K.Arzymatov E.Aslanides M.Atzeni B.Audurier S.Bachmann M.Bachmaver J.J.Back S.Baker P.Baladron Rodriguez V.Balagura W.Baldinit J.Baptista Leite R.J.Barlow S.Barsuk W.Barter M.Bartolini F.Baryshnikov J.M.Basels G.Bassi B.Batsukh A.Battig A.Bay M.Becker F.Bedeschis I.Bediaga A.Beiter V.Belavin S.Belin V.Bellee K.Belous I.Belov I.Belyaev G.Bencivenni E.Ben-Haim A.Berezhnoy *** D.Berninghoff H.C.Bernstein C.Bertella E.Bertholet A.Bertolin C.Betancourt F.Betti M.O.Bettler Ia.Bezshyiko S.Bhasin J.Bhom L.Bian M.S.Bieker S.Bifani P.Billoir M.Birch F.C.R.Bishop A.Bizzeti M.Biorn M.P.Blago T.Blake F.Blanc S.Blusk D.Bobulska J.A.Boelhauve O.Boente Garcia T.Boettcher A.Boldyrev A.Bondar N.Bondar S.Borghi M.Borisyak M.Borsato J.T.Borsuk S.A.Bouchiba T.J.V.Bowcock A.Boyer C.Bozzi M.J.Bradley S.Braun A.Brea Rodriguezs M.Brodski J.Brodzicka A.Brossa Gonzalo D.Brundu A.Buonaura C.Burr A.Burschee A.Butkevich J.S.Butter J.Buytaert W.Byczynski S.Cadeddu H.Cai R.Calabrese L.Calefice L.Calero Diaz S.Cali R.Calladine M.Calvi M.Calvo Gomez P.Camargo Magalhaes A.Camboni P.Campana D.H.Campora Perez A.F.Campoverde Quezada S.Capelli L.Capriotti A.Carbonel G.Carboni R.Cardinale A.Cardini I.Carli P.Carniti L.Carus K.Carvalho Akiba A.Casais Vidal G.Casse M.Cattaneo G.Cavallero S.Celani J.Cerasoli A.J.Chadwick M.G.Chapman M.Charles Ph.Charpentier G.Chatzikonstantinidis C.A.Chavez Barajas M.Chefdeville C.Chen S.Chen A.Chernov S.-G.Chitic V.Chobanova S.Cholak M.Chrzaszcz A.Chubykin V.Chulikov P.Ciambrone M.F.Cicala X.Cid Vidal G.Ciezarek P.E.L.Clarke M.Clemencic H.V.Cliff J.Closier J.L.Cobbledick V.Coco J.A.B.Coelho J.Cogan E.Cogneras L.Cojocariu P.Collins T.Colombo L.Congedo A.Contu N.Cooke G.Coombs G.Corti C.M.Costa Sobral B.Couturier D.C.Craik J.Crkovska M.Cruz Centro Brasileiro de Pesquisas Fisicas(CBPF) Riode JaneiroBrazil Universidade Federal do Riode Janeiro(UFRJ) Riode JaneiroBrazil Center for High Energy Physics Tsinghua UniversityBeijingChina School of Physics State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijingChina University of Chinese Academy of Sciences BeijingChina Institute Of High Energy Physics(IHEP) BejingChina Institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Univ.Grenoble Alpes Univ.Savoie Mont BlancCNRSIN2P3-LAPPAnnecyFrance Universite Clermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance Universitq Paris-Saclay CNRS/IN2P3IJCLabOrsayFrance LPNHE Sorbonne UniversiteParis Diderot Sorbonne Paris CiteCNRS/IN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultat Physik Technische Universitat DortmundDortmundGermany Max-Planck-Institut fir Kernphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universitat HeidelbergHeidelbergGermany School of Physics University College DublinDublinIreland INFN Sezione di Bari BariItaly INFN Sezione di Bologna BolognaItaly INFN Sezione di Ferrara FerraraItaly INFN Sezione di Firenze FirenzeItaly INFN Laboratori Nazionali di Frascati Frascatiltaly INFN Sezione di Genova GenovaItaly INFN Sezione di Milano Bicocca Milanolaly INFN Sezione di Milano MilanoItaly INFN Sezione di Cagliari Monserratoltaly Universita degli Studi di Padova Universita e INFNPadovaPadovaItaly INFN Sezione di Pisa PisaItaly INFN Sezione di Roma Tor Vergata RomaItaly INFN Sezione di Roma La Sapienza RomaItaly Nikhef National Institute for Subatomic Physics AmsterdamNetherlands Nikhef National Institute for Subatomic Physics and VU University Amsterdam AmsterdamNetherlands Henryk Niewodniczanski Institute of Nuclear Physics Polish Academy of Sciences KrakowPoland AGH-University of Science and Technology Faculty of Physics and Applied Computer Science

A search for the rare decay B^(0)→J/ψФis performed using Pp collision data collected with the LHCb dete-ctor at centre-of-mass energies of 7,8 and 13 TeV,corresponding to an integrated luminosity of9 *** significant signal of the decay is observed and an upper limitof 1.1x 10^(-7)at 90%confidence level is set on the branching fraction.

关键词： B physics flavour physics rare decay ω-Фmixing branching fraction

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ERCC6L2 promotes DNA orientation-specific recombination in mammalian cells

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细胞研究（英文版） 2020年第9期30卷 732-744页

作者： Xiaojing Liu Tingting Liu Yafang Shang Pengfei Dai Wubing Zhang Brian J.Lee Min Huang Dingpeng Yang Qiu Wu Liu Daisy Liu Xiaoqi Zheng Bo O.Zhou Junchao Dong Leng-Siew Yeap Jiazhi Hu Tengfei Xiao Shan Zha Rafael Casellas X.Shirley Liu Fei-Long Meng State Key Laboratory of Molecular Biology Shanghai Institute of Biochemistry and Cell Biology Center for Excellence in Molecular Cell Science Chinese Academy of Sciences Shanghai 200031 China University of Chinese Academy of Sciences Beijing 100049 China Clinical Translational Research Center Shanghai Pulmonary Hospital School of Life Sciences and Technology Tongji University Shanghai 200092 China Institute for Cancer Genetics Vagelos College of Physicians and Surgeons Columbia University New YorkNY 10032 USA Department of Mathematics Shanghai Normal University Shanghai 200234 China Department of Immunology Zhongshan School of Medicine Sun Yat-sen University Guangzhou 510080 China Shanghai Institute of Immunology Department of Immunology and Microbiology Shanghai Jiao Tong University School of MedicineShanghai 200025 China The MOE Key Laboratory of Cell Proliferation and Differentiation Genome Editing Research Center School of Life Sciences Peking-Tsinghua Center for Life Sciences Peking University 100871 Beijing China Department of Medical Oncology Dana-Farber Cancer Institute Boston MA 02115 USA Lymphocyte Nuclear Biology NIAMS Center of Cancer Research NCI NIH Bethesda MD 20892 USA Department of Data Sciences Dana-Farber Cancer Institute and Harvard T.H.Chan School of Public Health Boston MA 02215 USA

Programmed DNA recombination in mammalian cells occurs predominantly in a directional *** random DNA breaks are typically repaired both by deletion and by inversion at approximately equal proportions,V(D)J and class switch recombination (CSR) of immunoglobulin heavy chain gene overwhelmingly delete intervening sequences to yield productive *** factors channel chromatin breaks to deletional CSR in lymphocytes is *** CRISPR knockout and chemical perturbation screening we here identify the Snf2-family helicase-like ERCC6L2 as one such *** show that ERCC6L2 promotes double-strand break end-joining and facilitates optimal CSR in *** the cellular levels,ERCC6L2 rapidly engages in DNA repair through its C-terminal ***,ERCC6L2 interacts with other end-joining factors and plays a functionally redundant role with the XLF end-joining factor in V(D)J ***,ERCC6L2 controls orientation-specific joining of broken ends during CSR,which relies on its helicase ***,ERCC6L2 facilitates programmed recombination through directional repair of distant breaks.

关键词： Double-strand DNA breaks Immunology

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