检索结果-内蒙古大学图书馆

Automated Chemical Solid-Phase Synthesis of Glycans

Chinese Journal of Chemistry 2022年第14期40卷 1714-1728页

作者： Xiaona Li You Yang Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism Shanghai Key Laboratory of New Drug DesignEngineering Research Center of Pharmaceutical Process ChemistryMinistry of EducationSchool of PharmacyEast China University of Science and Technology130 Meilong RoadShanghai 200237China

Automated chemical solid-phase synthesis is an automation platform for rapid and reliable synthesis of *** the seminal work of Automated Glycan Assembly(AGA)disclosed by Seeberger in 2001,AGA has evolved from a proof-of-concept to a robust and reliable technology for streamlined production of various types of *** more than 20 years of unceasing efforts,the major breakthroughs in AGA including linkers,approved building blocks,and synthesizers have been acquired,and numerous influential achievements have been made in complex glycan *** addition,the HPLC-assisted automated synthesis emerges as a promising automation platform to access *** this review,we highlight the key advances in the field of automated chemical solid-phase synthesis,especially in *** synthesis of representative glycans based on AGA is also described.

关键词： Carbohydrates Oligosaccharides Glycosylation Solid-phase synthesis Automated glycan assembly

来源：评论

学校读者我要写书评

暂无评论

Research on Optimization of Momentum Source Model to Supercritical Carbon Dioxide Flow in Wire Wrapped Rods Bundle

SSRN

引用

SSRN 2023年

作者： Liu, Sichao Liu, Yu Yang, Xiaolei Li, Xiaochang Tian, Ruifeng College of Nuclear Science and Technology Harbin Engineering University Harbin150001 China Science and Technology on Reactor System Design Technology Laboratory Nuclear Power Institute of China Chengdu601213 China College of Aerospace and Civil Engineering Harbin Engineering University Harbin150001 China

Wrapped wire is widely used in new reactor core design. Simulation with traditional body fitted grid needs a large number of grids, which requires more computing resources. By optimizing the basic mathematical model of momentum source method, simulation of wire wrapped rod bundle with arbitrary wire shape can be carried out. By simulating the experimental data of 3 wire wrapped rod bundle, the model adaptability of momentum source method and mesh sensitivity analysis are carried out. Then optimized momentum source method and original momentum source method are compared based on simulation of supercritical carbon dioxide flow and heat transfer in wire wrapped rod bundle with different wire shapes. Through comparison with body fitted grid, the improvement of accuracy of optimized momentum source model can be proved. In conclusion, optimized momentum source method can greatly save the computational resources and calculated results is more accurate than original momentum source method. © 2023, The Authors. All rights reserved.

关键词： Wire

来源：评论

学校读者我要写书评

暂无评论

design, synthesis, molecular modeling, and biological evaluation of acrylamide derivatives as potent inhibitors of human dihydroorotate dehydrogenase for the treatment of rheumatoid arthritis

引用

Acta Pharmaceutica Sinica B 2021年第3期11卷 795-809页

作者： Fanxun Zeng Shiliang Li Guantian Yang Yating Luo Tiantian Qi Yingfan Liang Tingyuan Yang Letian Zhang Rui Wang Lili Zhu Honglin Li Xiaoyong Xu Shanghai Key Laboratory of Chemical Biology School of PharmacyEast China University of Science&TechnologyShanghai 200237China Shanghai Key Laboratory of New Drug Design State Key Laboratory of Bioreactor EngineeringSchool of PharmacyEast China University of Science&TechnologyShanghai 200237China

Human dihydroorotate dehydrogenase(DHODH) is a viable target for the development of therapeutics to treat cancer and immunological diseases, such as rheumatoid arthritis(RA), psoriasis and multiple sclerosis(MS). Herein, a series of acrylamide-based novel DHODH inhibitors as potential RA treatment agents were designed and synthesized. 2-Acrylamidobenzoic acid analog 11 was identified as the lead compound for structureeactivity relationship(SAR) studies. The replacement of the phenyl group with naphthyl moieties improved inhibitory activity significantly to double-digit nanomolar *** structure optimization revealed that an acrylamide with small hydrophobic groups(Me, Cl or Br)at the 2-position was preferred. Moreover, adding a fluoro atom at the 5-position of the benzoic acid enhanced the potency. The optimization efforts led to potent compounds 42 and 53-55 with IC50 values of 41, 44, 32, and 42 nmol/L, respectively. The most potent compound 54 also displayed favorable pharmacokinetic(PK) profiles and encouraging in vivo anti-arthritic effects in a dose-dependent manner.

关键词： DHODH De novo pyrimidine biosynthesis DHODH inhibitors Acrylamide derivatives Rheumatoid arthritis

来源：评论

学校读者我要写书评

暂无评论

Static Yield Stress of Cement-based Grouting Material under Different Rheological Modes

引用

Journal of Wuhan University of technology(Materials science) 2022年第5期37卷 948-952页

作者： NAN Xueli CHEN Hao LI Rongyang JI Jianrui WANG Yi TANG Weibin School of Material Science and Engineering Lanzhou University of TechnologyLanzhou730050China State Key Laboratory of Advanced Processing and Recycling of Non-ferrous Metals Lanzhou University of TechnologyLanzhou730050China Gansu Province Transportat Planning Survey and Design Institute Co.LtdLanzhou730000China

To quantitatively estimate the workability of cement-based grouting material,from the perspective of rheology,the result of the static yield stress evaluated using the rate-controlled and stress-controlled modes,respectively,was compared using the Rheowin ***,the correlation of workability and solid concentration of slurry with static yield stress was *** show that the static yield stress of cement-based grouting slurry relates to the established slurry structure,and is the shear stress corresponding to the transformation of elastics to plastics;In rate-controlled mode,the static yield stress of the slurry is related to the shear *** higher the shear rate,the greater the yield stress of the *** the stress-controlled mode,the result is more accurate and suitable for testing static yield stress under different water-cement *** the water-cement ratio has a good correspondence with the static yield stress and the static yield stress has a good correspondence with the slump flow of the slurry,the static yield stress is the minimum stress to be overcome when the slurry begins to flow and it reflects the yield behavior and structural stability of the cement.

关键词： shear mode stress-controlled mode static yield stress solid concentration

来源：评论

学校读者我要写书评

暂无评论

An Adaptive Deep Learning Method Integrating Transfer Learning and Concept Drift Detection for Wind Power Forecasting 43

An Adaptive Deep Learning Method Integrating Transfer Learni...

引用

43rd Chinese Control Conference, CCC 2024

作者： Wang, Jingdi Cao, Yundong Jin, Huaikang Fan, Shouyuan Wang, Bin Jin, Huaiping Kunming University of Science and Technology Faculty of Information Engineering and Automation Kunming650500 China Kunming University of Science and Technology Yunnan Key Laboratory of Artificial Intelligence Kunming650500 China Huaneng Renewables Co. Ltd. Yunnan Branch Kunming650000 China Yunnan Electric Power Design Institute Kunming650051 China Energy Engineering Group China

ISBN: (纸本)9789887581581

With the continuous advancement of new energy technologies, wind power is becoming an increasingly crucial source of clean energy. Due to the stochastic and fluctuating nature of wind power data, there is a significant challenge known as concept drift, where the data distribution changes over time. This poses a substantial obstacle to accurate prediction, leading to performance degradation of predictors. To address this issue, an adaptive deep-learning wind power prediction method combining transfer learning and concept drift detection is proposed. This method incorporates the concept of online transfer learning, transferring offline-trained model parameters to adapt quickly to new data distributions during the online phase. Simultaneously, a combination of an online moving window and Kullback-Leibler (KL) divergence is employed to capture and analyze changes in the online predictor's output layer network parameters. This facilitates a more precise detection of concept drift in wind power prediction, determining whether model updates are necessary. By dynamically updating model parameters and effectively handling concept drift, the approach can maintain high accuracy and stability in wind power prediction. The effectiveness and superiority of the proposed method are validated through the analysis of real-world wind power field data. © 2024 Technical Committee on Control Theory, Chinese Association of Automation.

关键词： Wind forecasting

来源：评论

学校读者我要写书评

暂无评论

A human-sensitive frequency band vibration isolator for heavy-duty truck seats

引用

Applied Mathematics and Mechanics(English Edition) 2024年第10期45卷 1733-1748页

作者： Qingqing LIU Shenlong WANG Ge YAN Hu DING Haihua WANG Qiang SHI Xiaohong DING Huijie YU School of Mechanical Engineering University of Shanghai for Science and TechnologyShanghai 200093China State Key Laboratory of Mechanical System and Vibration School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai Frontier Science Center of MechnoinformaticsShanghai Institute of Applied Mathematics and MechanicsSchool of Mechanics and Engineering ScienceShanghai UniversityShanghai 200072China State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body College of Mechanical and Vehicle EngineeringHunan UniversityChangsha 410082China Yanfeng Adient Seating Co. Ltd.Shanghai 201315China College of Mechanical and Electrical Engineering Jiaxing Nanhu UniversityJiaxing 314001Zhejiang ProvinceChina

In this study,a human-sensitive frequency band vibration isolator(HFBVI)with quasi-zero stiffness(QZS)characteristics for heavy-duty truck seats is designed to improve the comfort of heavy-duty truck drivers on uneven ***,the analytical expressions for the force and displacement of the HFBVI are derived with the Lagrange equation and d'Alembert's principle,and are validated through the prototype restoring force ***,the harmonic balance method(HBM)is used to obtain the dynamic responses under harmonic excitation,and further the influence of pre-stretching on the dynamic characteristics and transmissibility is ***,the experimental prototype of the HFBVI is fabricated,and vibration experiments are conducted under harmonic excitation to verify the vibration isolation performance(VIP)of the proposed vibration *** experimental results indicate that the HFBVI can effectively suppress the frequency band(4-8 Hz)to which the human body is sensitive to vertical *** addition,under real random road spectrum excitation,the HFBVI can achieve low-frequency vibration isolation close to 2 Hz,providing new prospects for ensuring the health of heavy-duty truck drivers.

关键词： human-sensitive frequency band quasi-zero stiffness(QZS) heavy-duty truck seat real random road spectrum low-frequency vibration isolation

来源：评论

学校读者我要写书评

暂无评论

Improving Generalization of Deep Neural Networks by Optimum Shifting

arXiv

引用

arXiv 2024年

作者： Zhou, Yuyan Li, Ye Feng, Lei Huang, Sheng-Jun MIIT Key Laboratory of Pattern Analysis and Machine Intelligence College of Computer Science and Technology Nanjing University of Aeronautics and Astronautics Nanjing211106 China Information Systems Technology and Design Pillar Singapore University of Technology and Design Singapore

Recent studies showed that the generalization of neural networks is correlated with the sharpness of the loss landscape, and flat minima suggests a better generalization ability than sharp minima. In this paper, we propose a novel method called optimum shifting, which changes the parameters of a neural network from a sharp minimum to a flatter one while maintaining the same training loss value. Our method is based on the observation that when the input and output of a neural network are fixed, the matrix multiplications within the network can be treated as systems of under-determined linear equations, enabling adjustment of parameters in the solution space, which can be simply accomplished by solving a constrained optimization problem. Furthermore, we introduce a practical stochastic optimum shifting technique utilizing the Neural Collapse theory to reduce computational costs and provide more degrees of freedom for optimum shifting. Extensive experiments (including classification and detection) with various deep neural network architectures on benchmark datasets demonstrate the effectiveness of our method. Copyright © 2024, The Authors. All rights reserved.

关键词： Deep neural networks

来源：评论

学校读者我要写书评

暂无评论

Acoustic Comfort and Sound Preference in the Nursing Home for Blind Older Adults 24

Acoustic Comfort and Sound Preference in the Nursing Home fo...

引用

24th International Congress on Acoustics, ICA 2022

作者： Huo, Sijia Wu, Yue Kang, Jian Meng, Qi Liu, Fangfang Yang, Da Key Laboratory of Cold Region Urban and Rural Human Settlement Environment Science and Technology Ministry of Industry and Information Technology School of Architecture Harbin Institute of Technology China UCL Institute for Environmental Design and Engineering United Kingdom

There have been many studies exploring the perception of the acoustic environment in older adults, but do blind older adults make a difference? This study conducted a subjective evaluation of the acoustic environment in an all-blind nursing home in China, investigating acoustic comfort and sound preference for different types of sound sources. The study found that 36.7% of the blind older adults were highly satisfied with the acoustic environment in nursing homes;blind older adults preferred natural sound and informational sounds and were more receptive and dependent on artificial sounds than others;the results indicated that blind older adults with light perception were more sensitive to sound and preferred an audible environment than blind older adults with no light perception, and they needed the feeling of having someone around them. This study may help nursing homes to provide environmental support for blind older adults. © ICA *** rights reserved

关键词： Acoustic comfort Blind older adults Sound preference

来源：评论

学校读者我要写书评

暂无评论

A novel approach of jet polishing for interior surface of small-grooved components using three developed setups

引用

极端制造(英文) 2024年第2期6卷 426-446页

作者： Qinming Gu Zhenyu Zhang Hongxiu Zhou Jiaxin Yu Dong Wang Junyuan Feng Chunjing Shi Jianjun Yang Junfeng Qi State Key Laboratory of High-performance Precision Manufacturing Dalian University of TechnologyDalian 116024People's Republic of China School of Energy and Power Engineering Dalian University of TechnologyDalian 116024People's Republic of China Key Laboratory of Testing Technology for Manufacturing Process Ministry of EducationSouthwest University of Science and TechnologyMianyang 621010People's Republic of China State Key Laboratory of High-performance Precision Manufacturing Dalian University of TechnologyDalian 116024People's Republic of China Beijing Spacecraft Manufacturing Co. LtdChina Academy of Space TechnologyBeijing 100094People's Republic of China School of Mechanical Engineering Hangzhou Dianzi UniversityHangzhouZhejiangPeople's Republic of China Facility Design and Instrumentation Institute China Aerodynamics Research and Development Center(CARDC)Mianyang 621000People's Republic of China Beijing Spacecraft Manufacturing Co. LtdChina Academy of Space TechnologyBeijing 100094People's Republic of China

It is a challenge to polish the interior surface of an additively manufactured component with complex structures and groove sizes less than 1 *** polishing methods are disabled to polish the component,meanwhile keeping the structure *** overcome this challenge,small-grooved components made of aluminum alloy with sizes less than 1 mm were fabricated by a custom-made printer.A novel approach to multi-phase jet(MPJ)polishing is proposed,utilizing a self-developed polisher that incorporates solid,liquid,and gas *** contrast,abrasive air jet(AAJ)polishing is recommended,employing a customized polisher that combines solid and gas *** jet polishing,surface roughness(Sa)on the interior surface of grooves decreases from pristine 8.596 μm to 0.701 μm and 0.336 μm via AAJ polishing and MPJ polishing,respectively,and Sa reduces 92％and 96％,***,a formula defining the relationship between linear energy density and unit defect volume has been *** optimized parameters in additive manufacturing are that linear energy density varies from 0.135 J mm-1 to 0.22 J *** unit area defect volume achieved via the optimized parameters decreases to 1/12 of that achieved via non-optimized *** fluid dynamics simulation results reveal that material is removed by shear stress,and the alumina abrasives experience multiple collisions with the defects on the heat pipe groove,resulting in uniform material *** is in good agreement with the experimental *** novel proposed setups,approach,and findings provide new insights into manufacturing complex-structured components,polishing the small-grooved structure,and keeping it unbroken.

关键词： abrasive air jet polishing aluminum alloy interior curved surface multi-phase jet polishing small-grooved component

来源：评论

学校读者我要写书评

暂无评论

Wastewater surveillance and an automated robot:effectively tracking SARS-CoV-2 transmission in the post-epidemic era

引用

National science Review 2023年第6期10卷 86-95页

作者： Guanyong Ou Yuxuan Tang Shiyu Niu Liwen Wu Shaxi Li Yang Yang Jun Wang Yun Peng Chuanfu Huang Wei Hu Qinghua Hu Yinghui Li Yang Ping Chao Lin Boping Yu Qi Han Yabin Hao Zhiguang Luo Wende Tian Han Zhang Yingxia Liu National Clinical Research Center for Infectious Disease State Key Discipline of Infectious Disease The Third People's Hospital of Shenzhen Second Hospital Affiliated to Southern University of Science and Technology School of Medicine Southern University of Science and Technology International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education Institute of Microscale Optoelectronics College of Physics and Optoelectronic Engineering Shenzhen University Shenzhen Longhua Drainage Co. Ltd. Shenzhen Center for Disease Control and Prevention Microbiology Laboratory Shenzhen Center for Disease Control and Prevention Power China Eco-Environmental Group Co. Ltd. Shenzhen Water Planning & Design Institute Co. Ltd. Shenzhen Academy of Environmental Sciences School of Civil and Environmental Engineering Harbin Institute of Technology (Shenzhen) 1Institute of Solid Wastes and Physical Environment Research Shenzhen Academy of Environmental Sciences Shenzhen Metasensing Technology Co. Ltd. Zhongmin (Shenzhen) intelligent ecology Co. Ltd. Research Centre for Eco-Environmental Sciences Chinese Academy of Sciences

Wastewater-based epidemiology(WBE) has exhibited great utility in the early and rapid identification of SARS-C ***,the efficacy of wastewater surveillance under China' s previous strict epidemic prevention policy remains to be *** collected the WBE data of wastewater treatment plants(WWTPs) in the Third People's Hospital of Shenzhen and several communities to determine the significant effectiveness of routine wastewater surveillance in monitoring the local spread of SARS-C oV-2under tight containment of the *** results of 1 month of continuous wastewater surveillance showed that positive signals for SARS-C oV-2 RNA were detected in the wastewater samples,and a significant positive correlation was observed between the virus concentration and the number of daily *** addition,the community' s domestic wastewater surveillance results were confirmed even 3 days before,or simultaneously with,the infected patient being confirmed as having the ***,an automated sewage virus detection robot,ShenNong No.l robot,was developed,showing a high degree of agreement with experimental data,offering the possibility of large-scale multi-point ***,our results illustrated the clear indicative role of wastewater surveillance in combating COVID-19 and provided a practical basis for rapidly expanding the feasibility and value of routine wastewater surveillance for future emerging infectious diseases.

关键词： SARS-CoV-2 wastewater surveillance wastewater-based epidemiology WWTP automated robot

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：