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26th International Conference on Miniaturized systems for Chemistry and Life sciences, MicroTAS 2022

作者： Dey, Koyel Goudar, Venkanagouda S. Tseng, Fan-Gang Santra, Tuhin Subhra Engineering and System Science National Tsing Hua University Hsinchu Taiwan Department of Engineering Design Indian Institute of Technology Madras India

ISBN: (纸本)9781733419048

During growth, tumor spheroids develop gradients of glucose. In this work, we unveiled real time glucose gradient in tumor spheroid using Confocal Raman Spectroscopy. For sensor preparation, 50 nm silver nanoparticle is conjugated with Raman based dye, mercapto-phenylboronic acid(MPBA). The sensor approach a detection limit of 1 mM and dynamic range from 1-100 mM of glucose. MPBA -glucose bonding being reversible, helps for continuous measurement inside 3D microenvironment. Sensors are mixed with co-cultured cells(colon cancer and fibroblast) and seeded in 3D culture chip for spheroid formation. Raman measurement showed an increased glucose concentration from center to surface of spheroid. © 2022 MicroTAS 2022 - 26th International Conference on Miniaturized systems for Chemistry and Life sciences. All rights reserved.

关键词： Glucose

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Deep Learning Based Fault Diagnosis for Chemical Process with Statistical Feature Fusion

Deep Learning Based Fault Diagnosis for Chemical Process wit...

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Chinese Control Conference (CCC)

作者： Lei Zhang Hao Xia Bao Cha School of Control Science and Control Engineering Dalian University of Technology Dalian P. R. China Science and Technology on Reactor System Design Technology Laboratory Nuclear Power Institute of China Chengdu P. R. China

The existing fault diagnosis methods based on deep neural networks mostly rely on process data for fault classification and diagnosis, which makes it difficult to distinguish minor faults with similar data features. Therefore, this paper proposes a deep learning-based fault diagnosis model that combines statistical indicators and neural networks. By analyzing and calculating the relevant information entropy to screen the statistical signal features of time domain and frequency domain, we can extract more hidden information from the raw data, and use the convolutional autoencoder to compress the statistical indicators for feature extraction, and use CNN network to extract features from raw data. Finally, the two sets of features are fused and input into the LSTM network to obtain temporal information for fault diagnosis. Tests conducted on the Tennessee Eastman (TE) process show that the proposed model outperforms typical classifiers and improves the diagnostic accuracy of minor faults.

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Multiscale mechanics of noncovalent interface in graphene oxide layered nanocomposites

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Theoretical & Applied Mechanics Letters 2022年第1期12卷 3-9页

作者： ZeZhou He YinBo Zhu HengAn Wu CAS Key Laboratory of Mechanical Behavior and Design of Materials Department of Modern MechanicsCAS Center for Excellence in Complex System MechanicsUniversity of Science and Technology of ChinaHefei 230027China

Noncovalent interfaces play a vital role in inelastic deformation and toughening mechanisms in layered nanocomposites due to their dynamical recoverability. When interfacial engineering is applied to design layered nanocomposites, shear-lag analysis is usually implemented to evaluate the capability of interfacial loading transfer. Here, we introduce a multiscale shear-lag model that correlates macroscale mechanical properties with the molecular mechanisms to quantify the effects of interfacial configuration in graphene oxide(GO) layered nanocomposites. By investigating the mechanical responses of commensurate and incommensurate interfaces, we identify that the commensurate interface exhibits a pronounced size effect due to the nucleation and propagation of interfacial defects, whereas the incommensurate interface displays uniform deformation. Our predictions are further validated through large-scale molecular dynamics simulations for GO layered nanocomposites. This work demonstrates how size effects and interfacial configurations can be exploited to fabricate layered nanocomposites with superior mechanical properties despite relying on weak noncovalent interfaces.

关键词： Multiscale mechanics Noncovalent interface Commensurate and incommensurate Shear-lag model Layered nanocomposites

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THREE-DIMENSIONAL FRAME ANALYSIS OF Q-? RESONANCE OF CENTER-CORE BIAXIALLY SYMMETRICAL HIGH-RISE BUILDING UNDER LONG-PERIOD EARTHQUAKE MOTION 9

THREE-DIMENSIONAL FRAME ANALYSIS OF Q-? RESONANCE OF CENTER-...

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9th ECCOMAS Thematic Conference on Computational Methods in Structural Dynamics and Earthquake Engineering, COMPDYN 2023

作者： Kohiyama, Masayuki Maki, Shiori Department of System Design Engineering Faculty of Science and Technology Keio University 3-14-1 Hiyoshi Kohoku-ku Yokohama223-8522 Japan School of Science for Open and Environmental Systems Graduate School of Science and Technology Keio University 3-14-1 Hiyoshi Kohoku-ku Yokohama223-8522 Japan

When large displacements occur in buildings with different stiffnesses in the two horizontal directions, torsional moments are generated owing to geometric nonlinearities. Consequently, when the sum or difference of the translational mode natural frequencies in the two horizontal directions is close to the torsional mode natural frequency, the torsional mode is excited. This is known as Q-? resonance. Therefore, we created a three-dimensional frame model of a center-core high-rise building with a biaxially symmetrical plane that satisfied the Q-? resonance condition and examined whether the torsional response was excited by long-period design waves. A time-history response analysis was conducted assuming elastic response and considering geometric nonlinearities. It was confirmed that the torsional mode could be induced. © 2023 COMPDYN Proceedings. All rights reserved

关键词： Natural frequencies

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STUDY ON TENSILE PERFORMANCE OF COLUMN-TO-BEAM CONNECTION WITH SAO-SHACHI JOINT FOR TRADITIONAL WOODEN BUILDINGS

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AIJ Journal of technology and design 2023年第73期29卷 1268-1272页

作者： Urakubo, Mikiya Miyamoto, Mitsuhiro Utsunomiya, Naoki Nakao, Masato Ohashi, Yoshimitsu Graduate School of Science for Creative Emergence Kagawa Univ Japan Faculty of Engineering and Design Kagawa Univ. Japan Dept. of Architectural System Technology Kinki Polytechnic College Japan Dept. of Architecture and Building Science Yokohama National Univ. Japan Tokyo City Univ. Japan

Column-to-beam connections are important to evaluate the seismic performance of traditional wooden buildings accurately. However, there are many types of traditional joints. Some of them have not been studied for evaluating their seismic performance, such that almost no experimental data and no evaluation methods are available. This study aims to evaluate the tensile performance of column-to-beam connections with Sao-shachi joint based on the full-scale tests. It is shown that the evaluation formula for the column-to-beam connections with Yatoi-saoshachi joint in the past is applicable to evaluate the tensile performance of these connections. © 2023 Architectural Institute of Japan. All rights reserved.

关键词： Seismic waves

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Bioinspired polysaccharide-based nanocomposite membranes with robust wet mechanical properties for guided bone regeneration

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National science Review 2024年第3期11卷 215-226页

作者： Jian-Hong Xiao Zhen-Bang Zhang JiaHao Li Si-Ming Chen Huai-Ling Gao YinXiu Liao Lu Chen ZiShuo Wang YiFan Lu YuanZhen Hou HengAn Wu DuoHong Zou Shu-Hong Yu Department of Chemistry New Cornerstone Science Laboratory Institute of Biomimetic Materials&Chemistry Anhui Engineering Laboratory of Biomimetic MaterialsDivision of Nanomaterials&Chemistry Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of China Department of Dental Implant Center Stomatologic Hospital and College Key Laboratory of Oral Diseases Research of Anhui Province Anhui Medical University CAS Key Laboratory of Mechanical Behavior and Design of Materials Department of Modern Mechanics CAS Center for Excellence in Complex System Mechanics University of Science and Technology of China Department of Oral Surgery College of Stomatology National Clinical Research Center for Oral DiseasesShanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Institute of Innovative Materials(I2M) Department of Chemistry Department of Materials Science and Engineering Southern University of Science and Technology

Polysaccharide-based membranes with excellent mechanical properties are highly desired. However, severe mechanical deterioration under wet conditions limits their biomedical applications. Here, inspired by the structural heterogeneity of strong yet hydrated biological materials, we propose a strategy based on heterogeneous crosslink-and-hydration（HCH） of a molecule/nano dual-scale network to fabricate polysaccharide-based nanocomposites with robust wet mechanical properties. The heterogeneity lies in that the crosslink-and-hydration occurs in the molecule-network while the stress-bearing nanofiber-network remains unaffected. As one demonstration, a membrane assembled by bacterial cellulose nanofiber-network and Ca2+-crosslinked and hydrated sodium alginate molecule-network is designed. Studies show that the crosslinked-and-hydrated molecule-network restricts water invasion and boosts stress transfer of the nanofiber-network by serving as interfibrous bridge. Overall, the molecule-network makes the membrane hydrated and flexible; the nanofiber-network as stress-bearing component provides strength and *** HCH dual-scale network featuring a cooperative effect stimulates the design of advanced biomaterials applied under wet conditions such as guided bone regeneration membranes.

关键词： bioinspiration heterogeneous crosslink-and-hydration dual-scale network nanocomposite membrane wet mechanical properties guided bone regeneration

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Verification of Anode Position and Generated Force Vector of EHD at Wire-cylinder Electrode 32

Verification of Anode Position and Generated Force Vector of...

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32nd IEEE International Symposium on Industrial Electronics, ISIE 2023

作者： Kitamura, Tomoya Katagiri, Hiroaki Yashita, Shigeki Saito, Yuki Asai, Hiroshi Ohnishi, Kouhei Nozaki, Takahiro Keio University Haptics Research Center Kawasaki Japan Keio University Graduate School of Integrated Design Engineering Yokohama Japan Kanagawa Institute of Industrial Science and Technology Kawasaki Japan Keio University Department of System Design Engineering Yokohama Japan

ISBN: (纸本)9798350399714

Electrohydrodynamics (EHD) is a thrust force produced when high voltage is applied to two electrodes, and actuators using EHD are expected to reduce equipment size and the effects of friction. However, the EHD effect of multiple anode electrodes has yet to be verified and should be considered when fabricating a multi-degree-of-freedom actuator using EHD. This paper examines the relationship between the applied voltage and the generated EHD to verify the effect of multiple anode electrodes on the EHD. Experiments were conducted using a device with two anode electrodes at right angles and another with two parallel electrodes. The results showed that the two anode electrodes placed at right angles interfered with each other, and the generated forces were not superposed. The direction of the generated force was approximately 45 deg. When the electrodes were placed horizontally, it was confirmed that the generated forces were superposed, indicating that the arrangement, not the number of anode electrodes, was the cause of the interference. © 2023 IEEE.

关键词： Actuators

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EXPERIMENT AND SIMULATION OF Q-? RESONANCE USING FOUR-LAYER BENDING-SHEAR TYPE SPECIMEN 9

EXPERIMENT AND SIMULATION OF Q-? RESONANCE USING FOUR-LAYER ...

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9th ECCOMAS Thematic Conference on Computational Methods in Structural Dynamics and Earthquake Engineering, COMPDYN 2023

作者： Kai, Ryohei Kohiyama, Masayuki School of Science for Open and Environmental Systems Graduate School of Science and Technology Keio University 3-14-1 Hiyoshi Kohoku-ku Yokohama223-8522 Japan Department of System Design Engineering Faculty of Science and Technology Keio University 3-14-1 Hiyoshi Kohoku-ku Yokohama223-8522 Japan

Torsional vibration of buildings subjected to earthquake motion has been studied for many years, but the torsional vibration of high-rise buildings has not yet been clarified. Many previous studies have focused on eccentricity, the mismatch between the center of gravity and the rigid center, as the cause of torsional vibration. However, in buildings with no eccentricity, torsional vibrations could be observed. The authors' research group focused on the "Q-? effect," a phenomenon in which torsional torque is generated due to geometric nonlinearity and "Q-? resonance," a phenomenon in which resonance occurs when the period of torsional torque generation coincides with the natural period of the torsional mode. In order to analyze the characteristics of Q-? resonance, a small-scale specimen was designed and fabricated from an 81-story high-rise building with biaxially symmetrical plans, which was reduced to four stories. As a result, the torsional response of the experimental and simulation results generally agreed, confirming that the torsional response increases when the Q-? resonance condition is satisfied. In addition, a comparison of the torsional response with a specimen with a smaller tower ratio and less bending deformation was conducted, and it was confirmed that the peak of the torsional response was steeper in the present study case. © 2023 COMPDYN Proceedings. All rights reserved

关键词： Finite element method

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Direct Numerical Simulation of Turbulent Flow and Heat Transfer in a Rectangular Duct with High Aspect Ratio

SSRN

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SSRN 2023年

作者： Sun, Yumeng Li, Jie Wei, Zonglan Ai, Zhelun Miao, Heng Deng, Jian Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen University Guangdong Zhuhai519082 China Science and Technology on Reactor System Design Technology Laboratory Nuclear Power Institute of China Sichuan Chengdu610213 China

Plate-type fuel is widely used due to its strong heat transfer capability, and its narrow rectangular geometry has different effects on flow heat transfer than traditional rectangular channels. Therefore, in this work, In this work, Direct Numerical Simulation(DNS) of a narrow rectangular duct was performed with the aim of analyzing flow and heat transfer phenomena and constructing a database of turbulent flow. The open-source program Nek5000 based on the spectral element method is used, the geometry is 0.57×0.00367×0.05 m with a high Aspect Ratio(AR) of 13.6, and the bulk Reynolds number is 24000 with a heat flux of 560 kW/m2. Common turbulence statistics like the time mean field, reynolds stress, turbulent heat flux distribution profile, and turbulent kinetic energy budget are obtained. The distribution of Reynolds stress and turbulent kinetic energy budget was analyzed, and the impact of high aspect ratio and material properties on flow and heat transfer was investigated. Additionally, the effects of single-sided and double-sided heating were studied. The turbulent flow database obtained from this study will be utilized for the later evaluation of turbulence models. © 2023, The Authors. All rights reserved.

关键词： Direct numerical simulation

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Performance Enhancement of Piezoresistive Tactile Sensor Based on Mechanical Metamaterial with Negative Poisson's Ratio

Performance Enhancement of Piezoresistive Tactile Sensor Bas...

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IEEE SENSORS

作者： Mingyu Kang Honggap Choi Keun Park Soonjae Pyo Deparment of Mechanical Design and Robot Engineering Seoul National University of Science and Technology Seoul Republic of Korea Department of Mechanical System Design Engineering Seoul National University of Science and Technology Seoul Republic of Korea

ISBN: (数字)9798350363517

ISBN: (纸本)9798350363524

This work proposes a piezoresistive tactile sensor based on a metamaterial with a negative Poisson's ratio, utilizing a more cost-effective and straightforward method compared to previous processes for fabricating microstructures. To demonstrate the impact of negative Poisson's ratio on piezoresistive sensor performance, comparison structures with a positive Poisson's ratio are designed, manufactured, and tested. The metamaterial-based sensor exhibits a high sensitivity at low pressures, which is 2.8 times higher than that of a body-centered cubic structure and 10 times higher than a simple cubic structure. Additionally, the fabricated sensor demonstrates excellent flexibility and minimal physical interference due to the integration of flexible electrodes and substrates. The sensor shows potential for various applications, including wearable devices, which have recently gained significant attention.

关键词： Performance evaluation Electrodes Sensitivity Tactile sensors Interference Metamaterials Microstructure Wearable devices Piezoresistance Substrates

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