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IEEE Conference on Wireless Communications and Networking

作者： Xiao Tong Ang Li Fan Liu Lei Lei School of Information and Communications Engineering Xi'an Jiaotong University Xi'an China The National Mobile Communications Research Laboratory Southeast University Nanjing China School of System Design and Intelligent Manufacturing Southern University of Science and Technology Shenzhen China

ISBN: (数字)9798350303582

ISBN: (纸本)9798350303599

This paper addresses the design of the receive combining matrix in a multiuser multiple-input multiple-output (MU-MIMO) downlink system, where the base station (BS) employs symbol-level precoding (SLP) to transmit multiple data streams to multiple users with multiple antennas. Unlike in the single-antenna user scenario, the design of the receive combining matrix becomes crucial in this context. To overcome the challenge of the receive combining matrix's dependency on the transmit signals, we propose a practical scheme utilizing the interference rejection combiner (IRC) for signal decoding. However, directly applying the IRC receiver to the considered MU-MIMO system presents challenges due to the rank-one transmit precoding matrix. To address this issue, we propose a new regularized IRC (RIRC) receiver. The problem is tackled by using the alternating optimization (AO) method, enabling the derivation of an optimal solution structure for the transmit precoding matrix. Numerical results demonstrate the substantial performance gain of the practical SLP scheme with the RIRC receiver over conventional Block Diagonalization (BD) based approach.

关键词： Precoding Receivers Interference Performance gain Downlink Decoding Iterative methods

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Uncertainty quantification research of reactor system under seismic load 27

Uncertainty quantification research of reactor system under ...

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27th International Conference on Nuclear Engineering: Nuclear Power Saves the World!, ICONE 2019

作者： Huang, Qian Xiong, Furui Bai, Xiaoming Yu, Xiaofei Zheng, Liangang Lu, Xifeng Song, Haiyang Science and Technology on Reactor System Design Technology Laboratory Chengdu Sichuan China

ISBN: (纸本)9784888983051

In the dynamic analysis of reactor system, the key mechanical input parameters are uncertain due to the design change, manufacturing, installation and calculation deviation, which affects the dynamic response, load distribution and final mechanical evaluation results. In order to quantify the influence of the uncertainty on seismic responses and load distribution, the uncertainty quantification of key structural input parameters of reactor system under seismic load is studied. Firstly, according to the fundamental characters of key input parameters (contact stiffness and gap among various assemblies), maximum entropy principle is adopted to construct the probability density function(PDF). Then, Markov Chain Monte Carlo technique is applied to sample according to the PDF, and the input and output data pool is constructed via finite element transient computations. According to the results, probabilistic distributions of dynamic responses caused by uncertainty from inputs parameters are evaluated and the reliability of nominal model is investigated. The studies show that the probabilistic distribution of reactor system dynamic response differs greatly with different output mechanical parameters, degrees of freedom and frequency bands. The uncertainty quantification method and process for reactor system are proposed in this paper. This method can be extended to other equipments easily. Therefore, it is an effective tools for the reliability of dynamic response. Copyright © 2018-2019 by JSME

关键词： Markov processes

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Development of self-healing coating on fuel cladding for water-cooling nuclear reactors 14

Development of self-healing coating on fuel cladding for wat...

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14th International Nuclear Fuel Cycle Conference, GLOBAL 2019 and Light Water reactor Fuel Performance Conference, TOP FUEL 2019

作者： Duan, Z.G. Xin, G.S. Zhou, Y. Li, Y.M. Abe, H. Yang, H.L. Kano, S. McGrady, J. Science and Technology on Reactor System Design Technology Laboratory Nuclear Power Institute of China Chengdu610041 China Nuclear Professional School School of Engineering University of Tokyo Tokai Ibaraki319-1188 Japan

A novel scheme for a bilayer coating with self-healing ability is proposed in this study. The candidate materials for the coatings and the potential self-healing reaction are assessed in high-temperature aqueous environments and high-temperature air. The pure Cr2O3 layer and the composite of Cr2O3 and MoO3 are the candidate materials for the outer layer and inner layer, respectively, due to their compatibility under normal condition. Fe2O3-MoO3 reactions exhibit a potential ability to heal the cracks because of a high reaction rate under normal condition. Copyright © GLOBAL 2019 - International Nuclear Fuel Cycle Conference and TOP FUEL 2019 - Light Water reactor Fuel Performance *** rights reserved.

关键词： Light water reactors

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Position-and-Force-Sensorless Control Considering Equivalent Mass Matrix and Cross-Coupling Factors

Position-and-Force-Sensorless Control Considering Equivalent...

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Annual Conference of Industrial Electronics Society

作者： Keita Shimamoto Toshiyuki Murakami Tsukuba Research Laboratory YASKAWA Electric Corporation Ibaraki Japan Graduate School of Science and Technology Keio University Yokohama Japan Department of System Design Engineering Keio University Yokohama Japan

This paper presents a hybrid position/force control with equivalent mass matrices for position-and-force-sensorless manipulators and the evaluation of the control system. Position and force estimation methods in the controller are cascaded to estimate the position and force according to the respective characteristics of the electrical and mechanical systems. The proposed controller is designed to reduce vibration of the force control axes' motion from the cross-coupling factors of the dq-axis inductance, which cause position estimation error, and the cross-coupling effects among control axes from equivalent mass matrices, which expresses the relationship between the workspace force and acceleration. The position estimation based on the voltage equation, including the cross-coupling factors, derives compensation terms of the estimation error. The cross-coupling effects between position and force control axes in the equivalent mass matrices are designed to suppress the undesired force response vibrations. The experimental results show that the proposed system kept contact with an object during the rubbing motion by a 4-degree-of-freedom manipulator without position and force sensors. The utilized equivalent mass matrix reduced the force vibration caused by the vibration of the position estimation.

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Natural product 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose is a reversible inhibitor of glyceraldehyde 3-phosphate dehydrogenase

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中国药理学报（英文版） 2022年第2期43卷 470-482页

作者： Wen Li Li-ping Liao Ning Song Yan-jun Liu Yi-luan Ding Yuan-yuan Zhang Xiao-ru Zhou Zhong-ya Sun Sen-hao Xiao Hong-bo Wang Jing Lu Nai-xia Zhang Hua-liang Jiang Kai-xian Chen Chuan-peng Liu Jie Zheng Ke-hao Zhao Cheng Luo School of Pharmacy Key Laboratory of Molecular Pharmacology and Drug Evaluation(Yantai University)Ministry of EducationCollaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of ShandongYantai UniversityYantai 264005China Drug Discovery and Design Center the Center for Chemical BiologyState Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China University of Chinese Academy of Sciences Beijing 100049China Center of Immunological Diseases Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Drug Discovery and Design Center the Center for Chemical BiologyState Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Department of Gastroenterology Xinhua HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 201210China Department of Analytical Chemistry Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Drug Discovery and Design Center the Center for Chemical BiologyState Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Drug Discovery and Design Center the Center for Chemical BiologyState Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China School of Life Science and Technology Shanghai Tech UniversityShanghai 201210China Drug Discovery and Design Center the Center for Chemical BiologyState Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Life Science and Technology Harbin Institute of TechnologyHarbin 200092China Drug Discovery and Design Center the Center for Chemical BiologyState Key Laboratory of Drug ResearchSha

Aerobic glycolysis,also known as the Warburg effect,is a hallmark of cancer cell glucose metabolism and plays a crucial role in the activation of various types of immune *** 3-phosphate dehydrogenase(GAPDH)catalyzes the conversion of D-glyceraldehyde 3-phosphate to D-glycerate 1,3-bisphosphate in the 6th critical step in *** exerts metabolic flux control during aerobic glycolysis and therefore is an attractive therapeutic target for cancer and autoimmune ***,GAPDH inhibitors were reported to function through common suicide inactivation by covalent binding to the cysteine catalytic residue of ***,by developing a high-throughput enzymatic screening assay,we discovered that the natural product 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose(PGG)is an inhibitor of GAPDH with Ki=0.5 μ*** blocks GAPDH activity by a reversible and NAD+and Pi competitive mechanism,suggesting that it represents a novel class of GAPDH ***-depth hydrogen deuterium exchange mass spectrometry(HDX-MS)analysis revealed that PGG binds to a region that disrupts NAD+and inorganic phosphate binding,resulting in a distal conformational change at the GAPDH tetramer *** addition,structural modeling analysis indicated that PGG probably reversibly binds to the center pocket of ***,PGG inhibits LPS-stimulated macrophage activation by specific downregulation of GAPDH-dependent glucose consumption and lactate *** summary,PGG represents a novel class of GAPDH inhibitors that probably reversibly binds to the center pocket of *** study sheds new light on factors for designing a more potent and specific inhibitor of GAPDH for future therapeutic applications.

关键词： glyceraldehyde 3-phosphate dehydrogenase 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose hydrogen deuterium exchange mass spectrometry reversible inhibitor glycolysis

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被动标量湍流的约束亚格子模型

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Acta Mechanica Sinica 2023年第4期39卷 184-194页

作者：黄鹏陈宽宇彭怀午 Hsu-Chew Lee 史一蓬肖左利陈十一万敏平 Guangdong Provincial Key Laboratory of Turbulence Research and Applications Department of Mechanics and Aerospace EngineeringSouthern University of Science and TechnologyShenzhen518055China Guangdong-Hong Kong-Macao Joint Laboratory for Data-Driven Fluid Mechanics and Engineering Applications Southern University of Science and TechnologyShenzhen518055China State Key Laboratory for Turbulence and Complex System College of EngineeringPeking UniversityBeijing100871China Northwest Survey and Design Research Institute Xi’an710065China Eastern Institute for Advanced Study Ningbo315200China

本文采用约束大涡模拟(C-LES)模型来模拟湍流中的被动标量.通过施加一个基于被动标量大涡模拟(LES)中标量方差通量标度不变量的物理约束来计算动态混合非线性模型(MNLM)的系数.将约束亚格子(SGS)模型与不同的SGS模型在不可压各向同性湍... 详细信息

本文采用约束大涡模拟(C-LES)模型来模拟湍流中的被动标量.通过施加一个基于被动标量大涡模拟(LES)中标量方差通量标度不变量的物理约束来计算动态混合非线性模型(MNLM)的系数.将约束亚格子(SGS)模型与不同的SGS模型在不可压各向同性湍流被动标量中进行比较.此外,C-LES模型减少了SGS标量方差通量在惯性-对流尺度以及较大的黏性-扩散尺度上的变化.先验测试表明,C-LES模型在预测SGS标量通量的方向和大小方面表现最好.此外,C-LES模型减少了SGS标量方差通量在惯性-对流范围内以及粘性-扩散范围内大尺度的变化.在后验测试中,与传统的动态Smagorinsky(DSM)和MNLM模型相比,C-LES模型在预测标量谱和内部间歇性的演变中表现明显更好.这些结果表明,在SGS模型中施加物理约束是在被动标量湍流大涡模拟中的一种有前途的方法.

关键词： SGS模型亚格子模型 LES模型各向同性湍流物理约束扩散范围非线性模型动态混合

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The stress indices study for the pipe with trunnion welding attachment 27

The stress indices study for the pipe with trunnion welding ...

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27th International Conference on Nuclear Engineering: Nuclear Power Saves the World!, ICONE 2019

作者： Lu, Xifeng Bai, Xiaoming Zheng, Liangang Zhang, Rui Yuan, Feng Yuan, Yanli Huang, Qian Science and Technology on Reactor System Design Technology Laboratory Chengdu Sichuan China

ISBN: (纸本)9784888983051

In the nuclear power plant, the trunnion welding attachment is widely used to connect the pipe and support. According to ASME Code Cases the stress caused by the welded attachment is considered as the additional stress of the pipe. However, the calculation of the additional stress is very complex and time-consuming. A method based on the concept of stress indices is proposed in present work. To investigate the influence of size and constraint and the stress indices, the finite element analysis for pipe with different sizes trunnion welding attachment under different constraint forms are done. The stress indices are calculated for each case, respectively. Furthermore, the fitted expressions for stress indices are proposed for general case. To verify this method, an analysis according to ASME Code Case for piping with trunnion is done. The comparison of the result between present method and the ASME Code Case method show slight different. Therefore, the stress indices method for the stress analysis of pipe with trunnion welding attachment can be an alternative method for ASME Code Cases. The advantage of present method in that it simplified the analysis process by introduces the stress indices. This method is effective and practical during the design and analysis of piping system in the nuclear power plant. Copyright © 2019 by JSME

关键词： Welding

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Experimental and Numerical Investigation Integrated with Machine Learning (Ml) for the Prediction Strategy of Dp590/Cfrp Composite Laminates

SSRN

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SSRN 2024年

作者： Hu, Haichao Wei, Qiang Wang, Tianao Ma, Quanjin Jin, Peng Pan, Shupeng Li, Fengqi Wang, Shuxin Yang, Yuxuan Yan, Li School of Materials Science and Engineering Hebei University of Technology Tianjin300401 China School of Mechanical and Engineering Tianjin Sino-German University of Applied Sciences Tianjin300350 China Tianjin Sino-Spanish Machining Tool Vocational Training Center Tianjin Sino-German University of Applied Sciences Tianjin300350 China School of System Design and Intelligent Manufacturing Southern University of Science and Technology Shenzhen518055 China Tianjin University of Science and Technology China

A machine learning (ML)-assisted composite design framework is established as a high-efficiency tool to obtain optimal layup stacking sequence and laminate orientation selections. This paper uses ML, numerical and experimental investigations to predict the mechanical properties of CFRP/metal composite laminates under quasi-static loading. An initial data set was established with the required experimental database and the finite element modelling. A suitable ML data set is established through the data enhancement process. Based on the augmented data set, nine ML models predict and evaluate the mechanical properties of CFRP/metal composite laminates. The comprehensive comparison of nine ML models to predict the tensile strength showed that XGBoost and gradient boosting models provided the best prediction results regarding low prediction error rate and high interpretability. To predict the bending strength, decision trees, K nearest neighbours, and random forest models were shown the accurate prediction data in terms of maximum error prediction. Moreover, XGBoost and decision trees models provided stable performance on multiple performance indicators, which were suitable and precise models. The tree-based models (such as decision tree, random forest, gradient boosting, and XGBoost) showed excellent overall performance, which was mainly attributed to the CFRP/DP590 composite laminates. In addition, this paper aims to discuss the effect of layup sequences on tensile and bending properties of CFRP/DP590 composite laminates based on ML, numerical and experimental methods. The ML-assisted model method provides deeper insights into the complex mechanisms behind material type, which provides an essential tool for designing and optimising fiber/metal composite laminates. © 2024, The Authors. All rights reserved.

关键词： Forecasting

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Enhanced optical imaging and fluorescent labeling for visualizing drug molecules within living organisms

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2428-2446页

作者： Ting Sun Huanxin Zhao Luyao Hu Xintian Shao Zhiyuan Lu Yuli Wang Peixue Ling Yubo Li Kewu Zeng Qixin Chen School of Pharmaceutical Sciences National Key Laboratory of Advanced Drug Delivery SystemMedical Science and Technology Innovation CenterShandong First Medical University&Shandong Academy of Medical SciencesJinan 250062China Departments of Diagnostic Radiology SurgeryChemical and Biomolecular Engineeringand Biomedical EngineeringYong Loo Lin School of Medicine and College of Design and EngineeringNational University of SingaporeSingapore 119074Singapore Institute of Biochemical and Biotechnological Drugs School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China Key Laboratory of Biopharmaceuticals Postdoctoral Scientific Research WorkstationShandong Academy of Pharmaceutical ScienceJinan 250098China State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China School of Life Sciences Science and Technology Innovation CenterShandong First Medical University&Shandong Academy of Medical SciencesJinan 250062China School of Chinese Materia Medica Tianjin University of Traditional Chinese MedicineTianjin 301617China Tianjin Pharmaceutical DA REN TANG Group Corporation Limited Traditional Chinese Pharmacy Research Institute Tianjin 300457China Key Laboratory of Systems Bioengineering(Ministry of Education) School of Chemistry Engineering and TechnologyTianjin UniversityTianjin 300072China

The visualization of drugs in living systems has become key techniques in modern *** advancements in optical imaging technologies and molecular design strategies have revolutionized drug *** the subcellular level,super-resolution microscopy has allowed exploration of the molecular landscape within individual cells and the cellular response to *** beyond subcellular imaging,researchers have integrated multiple modes,like optical near-infrared II imaging,to study the complex spatiotemporal interactions between drugs and their *** combining these visualization approaches,researchers gain supplementary information on physiological parameters,metabolic activity,and tissue composition,leading to a comprehensive understanding of drug *** review focuses on cutting-edge technologies in drug visualization,particularly fluorescence imaging,and the main types of fluorescent molecules ***,we discuss current challenges and prospects in targeted drug research,emphasizing the importance of multidisciplinary cooperation in advancing drug *** the integration of advanced imaging technology and molecular design,drug visualization has the potential to redefine our understanding of pharmacology,enabling the analysis of drug micro-dynamics in subcellular environments from new perspectives and deepening pharmacological research to the levels of the cell and organelles.

关键词： Optical imaging Drug visualization Fluorophore labeling Therapeutics

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Correction to:Study on the resource utilization of high fluorine-containing organic waste through fluidized incineration

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Waste Disposal and Sustainable Energy 2023年第2期5卷 245-245页

作者： Wenhan Li Zengyi Ma Jianhua Yan Qianming Huang Xingjian Wen Zian Zhai Bochen Huang Shuang Wang Yongqiang Chen Science and Technology on Reactor System Design Technology Laboratory Nuclear Power Institute of ChinaChengdu610213China State Key Laboratory of Clean Energy Utilization Institute for Thermal Power EngineeringZhejiang UniversityHangzhou310027China Zhejiang Xianchuang Energy&Technology Co.Ltd Jinhua321000China

Correction to:Waste Disposal&Sustainable Energy(2022)4:117-129 https://***/10.1007/s42768-022-00101-7 The section Confict of interest'has been amended:'Jian-hua Yan is the Editor in-Chief of Waste Disposal&Sustain-able Energy.'The revised'Confict of interest'is as follows:Jianhua Yan is the Editor-in-Chief of Waste Disposal&Sustainable *** behalf of all authors,the corresponding author states that there is no conflict of interest.

关键词： Sustainable fluorine behalf

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