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Synthetic gene circuits moving into the clinic

Quantitative Biology 2021年第1期9卷 100-103页

作者： Shuguang Peng Huiya Huang Ping Wei Zhen Xie MOE Key Laboratory of Bioinformatics and Bioinformatics Division Center for Synthetic and System BiologyDepartment of AutomationBeijing National Research Center for Information Science and TechnologyTsinghua UniversityBeijing 100084China Beijing Syngentech Co. LtdZhongguancun Life Science ParkChangping DistrictBeijing 102206China Center for Gene Circuit and Cell Design Shenzhen Institute of Synthetic BiologyShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055ChinaCenter for Quantitative BiologyAcademy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100871China

On November 28th 2020,SyngenTech,a China-based biotechnology company,announced that the company’s leading oncolytic virotherapeutic product,SynOVl.l,was approved for clinical trial by the *** and Drug *** synthetic bacterial or cell therapy[1,2],this is the first introduction of a viral therapy engineered using synthetic gene circuits into the *** with the clinical development of variable living therapeutics,we anticipate that synthetic gene circuits will receive increasing attention as a revolutionary technology to improve disease-treatment efficacy.

关键词： clinic clinical Together

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Finite Element Analysis of Series Elastic Actuator for Exoskeleton Robot Joint 17

Finite Element Analysis of Series Elastic Actuator for Exosk...

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17th IEEE International Conference on Mechatronics and Automation, ICMA 2020

作者： Xi, Pengyu Ge, Weimin Zhang, Sen Zhang, Zhili Zielinska, Teresa Tianjin University of Technology Tianjin Key Laboratory for Advanced Mechatronic System Design and Intelligent Control School of Mechanical Engineering Tianjin300384 China Tianjin Sino-German University of Applied Science Intelligent Manufacturing College Tianjin300384 China Institute of Aeronautics and Applied Mechanics Warsaw University of Technology Warsaw00665 Poland

ISBN: (纸本)9781728164151

The finite element simulation for the joints of an exoskeleton robot is conducted in this paper. Using software OpenSim to simulate the normal walking gait of the human body, the motion angle and moment of the human hip, knee and ankle joints are obtained. Using the obtained data as the input parameters in the finite element simulation of the simulation software Ls-dyna, the strain diagrams and contact force curves of the circular roller and cam disk were obtained. In this study, three commonly used materials are selected: alloy steel, ductile iron and hard aluminum alloy. Finally, the effects of different materials on the key components of the series elastic actuator are studied. © 2020 IEEE.

关键词： Finite element method

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Analysis on Stability of Three-loop Autopilot with An Acceleration Feedback Augmentation Loop

Analysis on Stability of Three-loop Autopilot with An Accele...

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第40届中国控制会议

作者： Hui Wang Tao Li Daoguang Tang Junfang Fan Yifang Yuan Luyao Zang Wugang Wang Chunyan Xiao School of Aerospace Engineering Beijing Institute of Technology Beijing Key Laboratory of UAV Autonomous Control Beijing Institute of Technology School of Electrical and Control Engineering North University of China Beijing Key Laboratory of High-Dynamic Navigation Technology Beijing Information Science and Technology University China PLA 63961 Unit Beijing System Design Institute of Electro-Mechanic Engineering Northwest Industries Group CO. Ltd.

In order to construct a stable augmentation loop, a novel three-loop autopilot structure with an acceleration feedback is proposed. Based on LQR and analytical methods, the design process of the controller parameters is deduced. For a static unstable missile, the control characteristics of a three-loop autopilot with acceleration feedback are compared with classical three-loop and pseudo-angle-of-attack feedback three-loop autopilots. It is pointed out that the closed-loop gain of the three-loop autopilot with acceleration signal feedback is 1, which is not affected by the control parameters. The autopilot can control the static unstable missile, and the acceleration signal is easier to obtain than the pseudo-angle-of-attack.

关键词： Acceleration feedback Stable augmentation loop Autopilot Static unstable missile

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Accelerated performance degradation test and analysis of high-temperature strain gauges

Accelerated performance degradation test and analysis of hig...

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13th International Conference on Quality, Reliability, Risk, Maintenance, and Safety Engineering (QR2MSE 2023)

作者： L. Li Z. Wang N. Yang Q. Wu H. Wang Z. Mao K. Ren Q. Wang Y. Wang National Key Laboratory of Strength and Structural Integrity School of Aeronautic Science and Engineering Beihang University Beijing People's Republic of China Shenyang Aircraft Design and Research Institute Shenyang People's Republic of China Institute of Spacecraft System Engineering China Academy of Space Technology Beijing People's Republic of China Navigation Instrument Research Institute Tianjin People's Republic of China Beijing Institute of Control Engineering Beijing People's Republic of China

ISBN: (数字)9781839539275

With the extension of the service time of the structure and the worse service temperature conditions, the drift problem of hightemperature strain gauges gradually becomes prominent. This research aims to address the issue of the drift of measurement results because of the performance degradation of high-temperature strain gauges, and investigate the drift law under different temperatures considering complex service environments. In this paper, a combination of experimental research and theoretical analysis is utilized to design and conduct the accelerated performance degradation test on high-temperature strain gauges. Based on the result of the test, an accelerated performance degradation model is developed using the Wiener process and Arrhenius model. Finally, estimation curves for the average value and percentile value of the performance parameters of the hightemperature strain gauges are obtained, which demonstrates that the established accelerated performance degradation model can reasonably describe the degradation law. Additionally, the established accelerated performance degradation model enables effective analysis and compensation of gauge drift at any temperature.

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Tension Characteristics Analysis of Scraper Chain of Heavy-Duty Scraper Conveyor with Time-Varying Loads

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Shock and Vibration 2024年第1期2024卷

作者： Shuai Li Zhencai Zhu Hao Lu Yujun Xue School of Mechatronics Engineering Henan University of Science and Technology Luoyang 471003 China *** Henan Key Laboratory for Machinery Design and Transmission System Luoyang 471003 China Collaborative Innovation Center of Henan Province for High-End Bearing Henan University of Science and Technology Luoyang 471000 China *** Longmen Laboratory Luoyang 471000 China School of Mechatronics Engineering Jiangsu Key Laboratory of Mine Mechanical and Electrical Equipment China University of Mining and Technology Xuzhou 221116 Jiangsu China ***

With the intensification and large scale of coal mining, scraper conveyors are developing towards high power, large volume, long haul distance, and high reliability. It is more and more important to obtain the dynamic tension of the scraper chain with time-varying loads. The purpose of this paper is to obtain the dynamic tension of scraper chains of the scraper conveyor with time-varying loads. First, according to the structural characteristics and working environment of the scraper conveyor and the polygon effect of the sprocket, the scraper conveyor dynamic model under the action of the time-varying loads is established by the finite unit method. Second, the load variation rule of the bearing section is explored when the scraper conveyor and shearer work together. Furthermore, the element resistance of each discrete element, the stiffness coefficient of the scraper chain, and the influence of polygonal effect of sprocket wheel are analyzed. And then, the dynamic tension of the scraper chain is obtained by the Hilber–Hughes–Taylor (HHT) method. Finally, the validity of the scraper conveyor dynamic model is verified by the example analysis and field measurement experiment. Due to the influence of heavy starting, the maximum tension of the scraper chain during the starting process is 751.6 kN, which is 12.25% higher than the tension with smooth running (669.6 kN). During the startup stage, significant impacts occur on both motors and scraper chains which may lead to damage. To protect these components effectively, control strategies such as “soft start” or no-load start hold crucial engineering significance in achieving reliable operation of the scraper conveyor. The obtained results can provide a theoretical basis for the reliability evaluation and parameter optimization of the scraper conveyor.

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Study on surface pore characteristic and hydrophilicity of carbon materials in HTGR 27

Study on surface pore characteristic and hydrophilicity of c...

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27th International Conference on Nuclear Engineering: Nuclear Power Saves the World!, ICONE 2019

作者： Ma, Sheng-Chao Shen, Kai-Yue Yin, Hua-Qiang He, Xue-Dong Li, Jun Meng, Ying-Chao Institute of Nuclear and New Energy Technology Collaborative Innovation Center of Advanced Nuclear Energy Technology Key Laboratory of Advanced Reactor Engineering and Safety of Ministry of Education Tsinghua University Beijing100084 China Nuclear Power Design and Research Sub-institute Science and Technology on Reactor System Design Technology Laboratory Nuclear Power Institute of China Chengdu610213 China Institute for Chemical and Bioengineering Department of Chemistry and Applied Biosciences Swiss Federal Institute of Technology Zurich Zurich8093 Switzerland

ISBN: (纸本)9784888983051

Lots of porous carbon materials, including boron-containing carbon (BC) and isostatic pressure graphite (IG-110), are used in high-temperature gas cooled reactor (HTGR). To prevent corrosion caused by carbon-water reaction at high temperature, water absorbed in the materials needs to be removed before the reactor operation. It has become the consensus of the researchers that the pore morphology of the material has an important influence on the physical adsorption and desorption process of the gas. Therefore, it is significant to explore the migration mechanism of moisture in carbon materials by studying the pore characteristics and hydrophilic properties of the material surface. Scanning electron microscopy (SEM) and contact angles tests were used to study the surface pore characteristic and hydrophilicity of BC and IG-110. The results of SEM scanning show that a large number of irregular micropores and cracks were found on the surface of BC, while the structure of IG-110 was more compact, and the size and number of pores were obviously smaller. 3 μL and 5 μL water drops were used to contact angle tests, it was found that the average contact angle of the BC surface with water droplets is 118.04°, which is greater than that of IG-110, measured as 112°. Finally, the water vapor absorption experiment of these two materials were carried out to verify that the pore structure and hydrophilicity have an effect on water absorption, and the pore structure has a more decisive effect on moisture absorption than the hydrophilicity. © 2019 American Society of Mechanical Engineers (ASME). All rights reserved.

关键词： Scanning electron microscopy

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Improvements of the CMFD acceleration capability of OpenMOC

Improvements of the CMFD acceleration capability of OpenMOC

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2019 International Conference on Mathematics and Computational Methods Applied to Nuclear science and Engineering, M and C 2019

作者： Wu, Wenbin Giudicelli, Guillaume Smith, Kord Forget, Benoit Yao, Dong Luo, Qi Department of Nuclear Science and Engineering Massachusetts Institute of Technology 77 Massachusetts Ave CambridgeMA02139 United States Science and Technology on Reactor System Design Technology Laboratory Nuclear Power Institute of China NO. 328 Section 1 Changshun Ave Shuangliu District Chengdu Sichuan Province610213 China

ISBN: (纸本)9780894487699

Due to its computational efficiency and geometrical flexibility, the Method of Characteristics (MOC) has been widely used for light water reactor lattice physics analysis. Usually acceleration methods are necessary for MOC to achieve acceptable convergence on practical reactor physics problems. Among them, Coarse Mesh Finite Difference (CMFD) is very popular and can drastically reduce the number of transport iterations. In OpenMOC, CMFD acceleration was implemented but had the limitation of supporting only a uniform CMFD mesh, which would often lead to splitting MOC source regions, thus creating an unnecessary increase in computation and memory use. In this study, CMFD acceleration with a nonuniform Cartesian mesh is implemented into OpenMOC. We also propose a quadratic fit based CMFD prolongation method in the axial direction to further improve the acceleration when multiple MOC source regions are contained in one CMFD coarse cell. Numerical results are presented to demonstrate the improvement of the CMFD acceleration capability in OpenMOC in terms of both efficiency and stability. © 2019 American Nuclear Society. All rights reserved.

关键词： Acceleration

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Recent development of chemically complex metallic glasses: from accelerated compositional design, additive manufacturing to novel applications

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Materials Futures 2022年第1期1卷 9-31页

作者： J Y Zhang Z Q Zhou Z B Zhang M H Park Q Yu Z Li J Ma A D Wang H G Huang M Song B S Guo Q Wang Y Yang Department of Mechanical Engineering College of EngineeringCity University of Hong KongKowloon TongKowloonHong KongPeople’s Republic of China Shenzhen Key Laboratory of High Performance Nontraditional Manufacturing College of Mechatronics and Control EngineeringShenzhen UniversityShenzhenGuangdong 518060People’s Republic of China School of Materials Science and Engineering Dongguan University of TechnologyDongguanGuangdong 523808People’s Republic of China Institute of Materials China Academy of Engineering PhysicsJiangyouSichuan 621907People’s Republic of China State Key Laboratory of Powder Metallurgy Central South UniversityChangshaHunan 410083People’s Republic of China Institute of Advanced Wear&Corrosion Resistant and Functional Materials Jinan UniversityGuangzhouGuangdong 510632People’s Republic of China Institute of Materials Laboratory for MicrostructuresShanghai UniversityShanghai 200444People’s Republic of China Department of Materials Science and Engineering College of EngineeringCity University of Hong KongKowloon TongKowloonHong KongPeople’s Republic of China Department of Advanced Design and System Engineering College of EngineeringCity University of Hong KongKowloon TongKowloonHong KongPeople’s Republic of China

Metallic glasses(MGs)or amorphous alloys are an important engineering material that has a history of research of about 80–90 *** different fast cooling methods were developed for multi-component MGs between 1960s and 1980s,1990s witnessed a surge of research interest in the development of bulk metallic glasses(BGMs).Since then,one central theme of research in the metallic-glass community has been compositional design that aims to search for MGs with a better glass forming ability,a larger size and/or more interesting properties,which can hence meet the demands from more important *** this review article,we focus on the recent development of chemically complex MGs,such as high entropy MGs,with new tools that were not available or mature yet until recently,such as the state-of-the-art additive manufacturing technologies,high throughput materials design techniques and the methods for big data analyses(*** learning and artificial intelligence).We also discuss the recent use of MGs in a variety of novel and important applications,from personal healthcare,electric energy transfer to nuclear energy that plays a pivotal role in the battle against global warming.

关键词： metallic glasses amorphous alloys alloy design additive manufacturing machine learning high throughput materials design

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Reform and Practice in Experimental Teaching from the View of "Emerging Engineering": Case Study on the Field of Energy and Power Engineering

Reform and Practice in Experimental Teaching from the View o...

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Information Communication Technologies Conference (ICTC)

作者： He Tian Lijian Liu Miao Tian Shimin Zhou Tianjin Key Laboratory for Advanced Mechatronic System Design and Intelligent Control National Demonstration Center for Experimental Mechanical and Electrical Engineering Education (Tianjin University of Technology) School of Mechanical Engineering Tianjin University of Technology Tianjin China Tianjin Academy of Educational Science Tianjin China Tianjin Newborn New Energy Technology Co. Ltd Tianjin China

According to the idea of "Emerging Engineering Education" talent training model of Ministry of Education, students should be trained to have "metaphysical" concept, connection, imagination, macro thinking. Project-driven experiment teaching focuses on a project, and the goal is the completion of the project; the student is the center of teaching activities, which is supported by the inquiry process. This study analyzes the significance of the project-driven method in experimental teaching. This paper describes the implementation process of experimental teaching in the field of energy and power engineering in terms of project design, teaching system construction and so on under the project-driven method. By analyzing the results of a questionnaire survey distributed to students of energy and power in the College of Mechanical Engineering at the Tianjin University of technology, it is found that the students are satisfied with the effects of project-driven experimental teaching, and the use of experimental teaching has greatly aroused the students' enthusiasm for learning. The ability of the students to engage in autonomous learning, engineering practice and innovation has been greatly improved, and a good teaching effect has been achieved.

关键词： Training Power engineering Technological innovation Education Solids Communications technology Mechanical engineering

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The application of Deep Reinforcement Learning in Coordinated Control of Nuclear reactors

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Journal of Physics: Conference Series 2021年第1期2113卷

作者： Jing Li Yanyang Liu Xianguo Qing Kai Xiao Ying Zhang Pengcheng Yang Yue (Marco) Yang Science and Technology on Reactor System Design Technology Laboratory Nuclear Power Institute of China Chengdu 610213 China Department of Engineering The University of Sydney Sydney 2006 Australia

The nuclear reactor control system plays a crucial role in the operation of nuclear power plants. The coordinated control of power control and steam generator level control has become one of the most important control problems in these systems. In this paper, we propose a mathematical model of the coordinated control system, and then transform it into a reinforcement learning model and develop a deep reinforcement learning control algorithm so-called DDPG algorithm to solve the problem. Through simulation experiments, our proposed algorithm has shown an extremely remarkable control performance.

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