Cooperation of CPU and hardware accelerator on SoC FPGA to accomplish computational intensive tasks, provides significant advantages in performance and energy efficiency. However, current operating systems provide lit...
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The key escrow problem and high computational cost are the two major problems that hinder the wider adoption of hierarchical identity-based signature (HIBS) scheme. HIBS schemes with either escrow-free (EF) or online/...
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As the application scenarios of convolutional neural network (CNN) become more and more complex, the general CNN accelerator based on matrix multiplication has become a new research focus. The existing mapping methods...
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Document-level event extraction task has achieved significant progress based on template generation methods. However, there is no reasonable regulation and restriction in the existing template-based generation methods...
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We here devise a new method for detecting and assessing RNA secondary structure by using multiple sequence alignment. The central idea of the method is to first detect conserved stems in the alignment using a special ...
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ISBN:
(纸本)1595934804;9781595934802
We here devise a new method for detecting and assessing RNA secondary structure by using multiple sequence alignment. The central idea of the method is to first detect conserved stems in the alignment using a special matrix and then assess them by evaluating the ratio of the signal to the noise. We tested the method on data sets composed of pairwise and three-way alignments of known ncRNAs. For the pairwise tests, our method has sensitivity 61.42% and specificity 97.05% for structural alignments, and sensitivity 42.05% and specificity 98.15% for BLAST alignments. For the three-way tests, our method has sensitivity 65.17% and specificity 97.96% for structural alignments, and sensitivity 40.70% and specificity 97.87% for CLUSTALW alignments. Our method can detect conserved secondary structures in gapped or ungapped RNA alignments. Copyright 2007 ACM.
MapReduce is commonly used as a parallel massive data processing model. When deploying it as a service over the open systems, the computational integrity of the participants is becoming an important issue due to the u...
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High-dimensional data arising from diverse scientific research fields and industrial development have led to increased interest in sparse learning due to model parsimony and computational advantage. With the assumptio...
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High-dimensional data arising from diverse scientific research fields and industrial development have led to increased interest in sparse learning due to model parsimony and computational advantage. With the assumption of sparsity, many computational problems can be handled efficiently in practice. Structured sparse learning encodes the structural information of the variables and has been quite successful in numerous research fields. With various types of structures discovered, sorts of structured regularizations have been proposed. These regularizations have greatly improved the efficacy of sparse learning algorithms through the use of specific structural information. In this article, we present a systematic review of structured sparse learning including ideas, formulations, algorithms, and applications. We present these algorithms in the unified framework of minimizing the sum of loss and penalty functions, summarize publicly accessible software implementations, and compare the computational complexity of typical optimization methods to solve structured sparse learning problems. In experiments, we present applications in unsupervised learning, for structured signal recovery and hierarchical image reconstruction, and in supervised learning in the context of a novel graph-guided logistic regression.
Extracting fault features with the error logs of fault injection tests has been widely studied in the area of large scale distributed systems for decades. However, the process of extracting features is severely affect...
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Spin-transfer torque random access memory (STT-RAM) is one of the most promising substitutes for universal main memory and cache due to its excellent scalability, high density and low leakage power. Nevertheless, the ...
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Accurate prediction of gene regulation rules is important for understanding complex life processes. Existing computational algorithms designed for bulk transcriptome datasets typically require a large number of time p...
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ISBN:
(纸本)9781450396868
Accurate prediction of gene regulation rules is important for understanding complex life processes. Existing computational algorithms designed for bulk transcriptome datasets typically require a large number of time points to infer gene regulatory networks (GRNs), are suitable for a small number of genes, and cannot efficiently detect potential regulatory relationships. We propose an approach based on a deep learning framework to reconstruct GRNs from bulk transcriptome datasets, assuming that the expression levels of transcription factors involved in gene regulation are strong predictors of the expression of their target genes. The algorithm uses multilayer perceptrons to infer the regulatory relationship between multiple transcription factors and a gene, and uses genetic algorithms to search for the best regulatory gene combination. The results show that our approach is more accurate than other methods for reconstructing gene regulatory networks on real-world and simulated bulk transcriptome gene expression datasets.
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