检索结果-内蒙古大学图书馆

arXiv 2017年

作者： Ajello, M. Atwood, W.B. Baldini, L. Ballet, J. Barbiellini, G. Bastieri, D. Bellazzini, R. Bissaldi, E. Blandford, R.D. Bloom, E.D. Bonino, R. Bregeon, J. Britto, R.J. Bruel, P. Buehler, R. Buson, S. Cameron, R.A. Caputo, R. Caragiulo, M. Caraveo, P.A. Cavazzuti, E. Cecchi, C. Charles, E. Chekhtman, A. Cheung, C.C. Chiaro, G. Ciprini, S. Cohen, J.M. Costantin, D. Costanza, F. Cuoco, A. Cutini, S. D’Ammando, F. de Palma, F. Desiante, R. Digel, S.W. Di Lalla, N. Di Mauro, M. Di Venere, L. Domínguez, A. Drell, P.S. Dumora, D. Favuzzi, C. Fegan, S.J. Ferrara, E.C. Fortin, P. Franckowiak, A. Fukazawa, Y. Funk, S. Fusco, P. Gargano, F. Gasparrini, D. Giglietto, N. Giommi, P. Giordano, F. Giroletti, M. Glanzman, T. Green, D. Grenier, I.A. Grondin, M.-H. Grove, J.E. Guillemot, L. Guiriec, S. Harding, A.K. Hays, E. Hewitt, J.W. Horan, D. Jóhannesson, G. Kensei, S. Kuss, M. la Mura, G. Larsson, S. Latronico, L. Lemoine-Goumard, M. Li, J. Longo, F. Loparco, F. Lott, B. Lubrano, P. Magill, J.D. Maldera, S. Manfreda, A. Mazziotta, M.N. McEnery, J.E. Meyer, M. Michelson, P.F. Mirabal, N. Mitthumsiri, W. Mizuno, T. Moiseev, A.A. Monzani, M.E. Morselli, A. Moskalenko, I.V. Negro, M. Nuss, E. Ohsugi, T. Omodei, N. Orienti, M. Orlando, E. Palatiello, M. Paliya, V.S. Paneque, D. Perkins, J.S. Persic, M. Pesce-Rollins, M. Piron, F. Porter, T.A. Principe, G. Rainò, S. Rando, R. Razzano, M. Razzaque, S. Reimer, A. Reimer, O. Reposeur, T. Saz Parkinson, P.M. Sgrò, C. Simone, D. Siskind, E.J. Spada, F. Spandre, G. Spinelli, P. Stawarz, L. Suson, D.J. Takahashi, M. Tak, D. Thayer, J.G. Thayer, J.B. Thompson, D.J. Torres, D.F. Torresi, E. Troja, E. Vianello, G. Wood, K. Wood, M. Department of Physics and Astronomy Clemson University Kinard Lab of Physics ClemsonSC29634-0978 United States Santa Cruz Institute for Particle Physics Department of Physics Department of Astronomy and Astrophysics University of California at Santa Cruz Santa CruzCA95064 United States Università di Pisa Istituto Nazionale di Fisica Nucleare Sezione di Pisa PisaI-56127 Italy Laboratoire AIM CEA-IRFU CNRS Université Paris Diderot Service d’Astrophysique CEA Saclay Gif sur YvetteF-91191 France Istituto Nazionale di Fisica Nucleare Sezione di Trieste TriesteI-34127 Italy Dipartimento di Fisica Università di Trieste TriesteI-34127 Italy Istituto Nazionale di Fisica Nucleare Sezione di Padova PadovaI-35131 Italy Dipartimento di Fisica e Astronomia "G. Galilei" Università di Padova PadovaI-35131 Italy Istituto Nazionale di Fisica Nucleare Sezione di Pisa PisaI-56127 Italy Dipartimento di Fisica "M. Merlin" dell’Università e del Politecnico di Bari BariI-70126 Italy Istituto Nazionale di Fisica Nucleare Sezione di Bari BariI-70126 Italy W. W. Hansen Experimental Physics Laboratory Kavli Institute for Particle Astrophysics and Cosmology Department of Physics SLAC National Accelerator Laboratory Stanford University StanfordCA94305 United States Istituto Nazionale di Fisica Nucleare Sezione di Torino TorinoI-10125 Italy Dipartimento di Fisica Università degli Studi di Torino TorinoI-10125 Italy Laboratoire Univers et Particules de Montpellier Université Montpellier CNRS/IN2P3 MontpellierF-34095 France Department of Physics University of the Free State P.O. Box 339 Bloemfontein9300 South Africa Laboratoire Leprince-Ringuet École polytechnique CNRS/IN2P3 PalaiseauF-91128 France Deutsches Elektronen Synchrotron DESY ZeuthenD-15738 Germany NASA Goddard Space Flight Center GreenbeltMD20771 United States NASA Postdoctoral Program Fellow United States NASA Goddard Space Flight Center GreenbeltMD20771 United States INAF-Istituto di As

We present a catalog of sources detected above 10 GeV by the Fermi Large Area Telescope (LAT) in the first 7 years of data using the Pass 8 event-level analysis. This is the Third Catalog of Hard Fermi-LAT Sources (3FHL), containing 1556 objects characterized in the 10 GeV–2 TeV energy range. The sensitivity and angular resolution are improved by factors of 3 and 2 relative to the previous LAT catalog at the same energies (1FHL). The vast majority of detected sources (79%) are associated with extragalactic counterparts at other wavelengths, including 16 sources located at very high redshift (z > 2). Eight percent of the sources have Galactic counterparts and 13% are unassociated (or associated with a source of unknown nature). The high-latitude sky and the Galactic plane are observed with a flux sensitivity of 4.4 to 9.5 ×10−11 ph cm−2 s−1, respectively (this is approximately 0.5 % and 1 % of the Crab Nebula flux above 10 GeV). The catalog includes 214 new γ-ray sources. The substantial increase in the number of photons (more than 4 times relative to 1FHL and 10 times to 2FHL) also allows us to measure significant spectral curvature for 32 sources and find flux variability for 163 of them. Furthermore, we estimate that for the same flux limit of 10−12 erg cm−2 s−1, the energy range above 10 GeV has twice as many sources as above 50 GeV, highlighting the importance, for future Cherenkov telescopes, of lowering the energy threshold as much as possible. Copyright © 2017, The Authors. All rights reserved.

关键词： Gamma rays

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GAMMA-RAY BLAZARS WITHIN THE FIRST 2 BILLION YEARS

arXiv

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arXiv 2017年

作者： Ackermann, M. Ajello, M. Baldini, L. Ballet, J. Barbiellini, G. Bastieri, D. Becerra Gonzalez, J. Bellazzini, R. Bissaldi, E. Blandford, R.D. Bloom, E.D. Bonino, R. Bottacini, E. Bregeon, J. Bruel, P. Buehler, R. Buson, S. Cameron, R.A. Caragiulo, M. Caraveo, P.A. Cavazzuti, E. Cecchi, C. Cheung, C.C. Chiang, J. Chiaro, G. Ciprini, S. Conrad, J. Costantin, D. Costanza, F. Cutini, S. D’Ammando, F. Palma, F.D.E. Desiante, R. Digel, S.W. Lalla, N.D.I. Mauro, M.D.I. Venere, L.D.I. Domínguez, A. Drell, P.S. Favuzzi, C. Fegan, S.J. Ferrara, E.C. Finke, J. Focke, W.B. Fukazawa, Y. Funk, S. Fusco, P. Gargano, F. Gasparrini, D. Giglietto, N. Giordano, F. Giroletti, M. Green, D. Grenier, I.A. Guillemot, L. Guiriec, S. Hartmann, D.H. Hays, E. Horan, D. Jogler, T. Jóhannesson, G. Johnson, A.S. Kuss, M. Mura, G.L.A. Larsson, S. Latronico, L. Li, J. Longo, F. Loparco, F. Lovellette, M.N. Lubrano, P. Magill, J.D. Maldera, S. Manfreda, A. Marcotulli, L. Mazziotta, M.N. Michelson, P.F. Mirabal, N. Mitthumsiri, W. Mizuno, T. Monzani, M.E. Morselli, A. Moskalenko, I.V. Negro, M. Nuss, E. Ohsugi, T. Ojha, R. Omodei, N. Orienti, M. Orlando, E. Ormes, J.F. Paliya, V.S. Paneque, D. Perkins, J.S. Persic, M. Pesce-Rollins, M. Piron, F. Porter, T.A. Principe, G. Rainò, S. Rando, R. Rani, B. Razzano, M. Razzaque, S. Reimer, A. Torres, D.F. Torresi, E. Tosti, G. Troja, E. Vianello, G. Wood, K.S. Reimer, O. Romani, R.W. Sgrò, C. Simone, D. Siskind, E.J. Spada, F. Spandre, G. Spinelli, P. Stalin, C.S. Stawarz, L. Suson, D.J. Takahashi, M. Tanaka, K. Thayer, J.B. Thompson, D.J. Deutsches Elektronen Synchrotron DESY ZeuthenD-15738 Germany Department of Physics and Astronomy Clemson University Kinard Lab of Physics ClemsonSC29634-0978 United States Università di Pisa Istituto Nazionale di Fisica Nucleare Sezione di Pisa PisaI-56127 Italy Laboratoire AIM CEA-IRFU CNRS Université Paris Diderot Service d’Astrophysique CEA Saclay Gif sur YvetteF-91191 France Istituto Nazionale di Fisica Nucleare Sezione di Trieste TriesteI-34127 Italy Dipartimento di Fisica Università di Trieste TriesteI-34127 Italy Istituto Nazionale di Fisica Nucleare Sezione di Padova PadovaI-35131 Italy Dipartimento di Fisica e Astronomia "G. Galilei" Università di Padova PadovaI-35131 Italy NASA Goddard Space Flight Center GreenbeltMD20771 United States Department of Physics Department of Astronomy University of Maryland College ParkMD20742 United States Istituto Nazionale di Fisica Nucleare Sezione di Pisa PisaI-56127 Italy Istituto Nazionale di Fisica Nucleare Sezione di Bari BariI-70126 Italy W. W. Hansen Experimental Physics Laboratory Kavli Institute for Particle Astrophysics and Cosmology Department of Physics SLAC National Accelerator Laboratory Stanford University StanfordCA94305 United States Istituto Nazionale di Fisica Nucleare Sezione di Torino TorinoI-10125 Italy Dipartimento di Fisica Università degli Studi di Torino TorinoI-10125 Italy Laboratoire Univers et Particules de Montpellier Université Montpellier CNRS/IN2P3 MontpellierF-34095 France Laboratoire Leprince-Ringuet École polytechnique CNRS/IN2P3 PalaiseauF-91128 France NASA Postdoctoral Program Fellow United States Dipartimento di Fisica "M. Merlin" dell’Università e del Politecnico di Bari BariI-70126 Italy INAF-Istituto di Astrofisica Spaziale e Fisica Cosmica Milano via E. Bassini 15 MilanoI-20133 Italy Science Data Center RomaI-00133 Italy Istituto Nazionale di Fisica Nucleare Sezione di Perugia PerugiaI-06123 Italy Dipartimento di Fisica Università

The detection of high-redshift (z >3) blazars enables the study of the evolution of the most luminous relativistic jets over cosmic time. More importantly, high-redshift blazars tend to host massive black holes and can be used to constrain the space density of heavy black holes in the early Universe. Here, we report the first detection with the Fermi-Large Area Telescope of five γ-ray emitting blazars beyond z = 3.1, more distant than any blazars previously detected in γ-rays. Among these five objects, NVSS J151002+570243 is now the most distant known γ-ray emitting blazar at z = 4.31. These objects have steeply falling γ-ray spectral energy distributions (SEDs) and, those that have been observed in X-rays, a very hard X-ray spectrum, both typical of powerful blazars. Their Compton dominance (ratio of the inverse Compton to synchrotron peak luminosities) is also very large (> 20). All of these properties place these objects among the most extreme members of the blazar population. Their optical spectra and the modeling of their optical-UV SEDs confirm that these objects harbor massive black holes (MBH ∼ 108−10M.). We find that, at z ≈ 4, the space density of > 109M. black holes hosted in radio-loud and radio-quiet active galactic nuclei are similar, implying that radio-loudness may play a key role in rapid black hole growth in the early Universe. Copyright © 2017, The Authors. All rights reserved.

关键词： Cosmology

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Characterizing the population of pulsars in the inner galaxy with the fermi large area telescope

arXiv

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arXiv 2017年

作者： Ajello, M. Baldini, L. Ballet, J. Barbiellini, G. Bastieri, D. Bellazzini, R. Bissaldi, E. Blandford, R.D. Bloom, E.D. Bottacini, E. Bregeon, J. Bruel, P. Buehler, R. Cameron, R.A. Caputo, R. Caragiulo, M. Caraveo, P.A. Cavazzuti, E. Cecchi, C. Charles, E. Chekhtman, A. Chiaro, G. Ciprini, S. Costantin, D. Costanza, F. D’Ammando, F. Palma, F.D.E. Desiante, R. Digel, S.W. Lalla, N.D.I. Mauro, M.D.I. Venere, L.D.I. Favuzzi, C. Ferrara, E.C. Franckowiak, A. Fukazawa, Y. Funk, S. Fusco, P. Gargano, F. Gasparrini, D. Giglietto, N. Giordano, F. Giroletti, M. Green, D. Guillemot, L. Guiriec, S. Harding, A.K. Horan, D. Jóhannesson, G. Kuss, M. Mura, G.L.A. Larsson, S. Latronico, L. Li, J. Longo, F. Loparco, F. Lovellette, M.N. Lubrano, P. Maldera, S. Malyshev, D. Marcotulli, L. Martin, P. Mazziotta, M.N. Meyer, M. Michelson, P.F. Mirabal, N. Mizuno, T. Monzani, M.E. Morselli, A. Moskalenko, I.V. Nuss, E. Omodei, N. Orienti, M. Orlando, E. Palatiello, M. Paliya, V.S. Paneque, D. Perkins, J.S. Persic, M. Pesce-Rollins, M. Piron, F. Principe, G. Rainò, S. Rando, R. Razzano, M. Reimer, A. Reimer, O. Parkinson, P.M. Saz Sgrò, C. Siskind, E.J. Smith, D.A. Spada, F. Spandre, G. Spinelli, P. Tajima, H. Thayer, J.B. Thompson, D.J. Tibaldo, L. Torres, D.F. Troja, E. Vianello, G. Wood, K. Wood, M. Zaharijas, G. Department of Physics and Astronomy Clemson University Kinard Lab of Physics ClemsonSC29634-0978 United States Università di Pisa Istituto Nazionale di Fisica Nucleare Sezione di Pisa PisaI-56127 Italy Laboratoire AIM CEA-IRFU CNRS Université Paris Diderot Service d’Astrophysique CEA Saclay Gif sur YvetteF-91191 France Istituto Nazionale di Fisica Nucleare Sezione di Trieste TriesteI-34127 Italy Dipartimento di Fisica Università di Trieste TriesteI-34127 Italy Istituto Nazionale di Fisica Nucleare Sezione di Padova PadovaI-35131 Italy Dipartimento di Fisica e Astronomia "G. Galilei" Università di Padova PadovaI-35131 Italy Istituto Nazionale di Fisica Nucleare Sezione di Pisa PisaI-56127 Italy Dipartimento di Fisica "M. Merlin" dell’Università e del Politecnico di Bari BariI-70126 Italy Istituto Nazionale di Fisica Nucleare Sezione di Bari BariI-70126 Italy W. W. Hansen Experimental Physics Laboratory Kavli Institute for Particle Astrophysics and Cosmology Department of Physics SLAC National Accelerator Laboratory Stanford University StanfordCA94305 United States Laboratoire Univers et Particules de Montpellier Université Montpellier CNRS/IN2P3 MontpellierF-34095 France Laboratoire Leprince-Ringuet École polytechnique CNRS/IN2P3 PalaiseauF-91128 France Deutsches Elektronen Synchrotron DESY ZeuthenD-15738 Germany NASA Goddard Space Flight Center GreenbeltMD20771 United States INAF-Istituto di Astrofisica Spaziale e Fisica Cosmica Milano via E. Bassini 15 MilanoI-20133 Italy Italian Space Agency Via del Politecnico snc Roma00133 Italy Istituto Nazionale di Fisica Nucleare Sezione di Perugia PerugiaI-06123 Italy Dipartimento di Fisica Università degli Studi di Perugia PerugiaI-06123 Italy College of Science George Mason University Fairfax Naval Research DC20375 United States ASI Space Science Data Center Via del Politecnico snc Roma00133 Italy INAF Istituto di Radioastronomia BolognaI-40129 Italy Dipartimento di Ast

An excess of γ-ray emission from the Galactic Center (GC) region with respect to predictions based on a variety of interstellar emission models and γ-ray source catalogs has been found by many groups using data from the Fermi Large Area Telescope (LAT). Several interpretations of this excess have been invoked. In this paper we search for members of an unresolved population of γ-ray pulsars located in the inner Galaxy that are predicted by the interpretation of the GC excess as being due to a population of such sources. We use cataloged LAT sources to derive criteria that efficiently select pulsars with very small contamination from blazars. We search for point sources in the inner 40◦ × 40◦ region of the Galaxy, derive a list of approximately 400 sources, and apply pulsar selection criteria to extract pulsar candidates among our source list. We performed the entire data analysis chain with two different interstellar emission models (IEMs), and found a total of 135 pulsar candidates, of which 66 were selected with both IEMs. Copyright © 2017, The Authors. All rights reserved.

关键词： Pulsars

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MB-94 IMMUNOLOGIC PROFILE OF PATIENTS WITH NEWLY-DIAGNOSED MEDULLOBLASTOMA AT INITIAL DIAGNOSIS AND DURING STANDARD RADIATION AND CHEMOTHERAPY (PBTC-N11)

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Neuro-Oncology 2016年第SUPPL_3期18卷 iii118-iii118页

作者： Sridharan Gururangan Elizabeth Reap Renee Reynolds Gerald Grant Arzu Onar-Thomas Mehmet Kodak Patricia Baxter Ian Pollack Peter Phillips James Boyett Maryam Fouladi Duane Mitchell Preston A. Wells Center for Brain Tumor Therapy University of Florida Gainesville FL USA Immunotherapy Program Duke University Medical Center Durham NC USA Department of Neurosurgery State University of New York at Buffalo Buffalo NY USA Department of Neurosurgery Stanford University Palo Alto CA USA Operations Biostatistics and Data Management Center The Pediatric Brain Tumor Consortium Memphis TN USA University of Tennessee Health Science Center Memphis TN USA Texas Children's Cancer Center Houston TX USA Department of Neurosurgery Children's Hospital of Pittsburgh Pittsburgh PA USA Neuro-Oncology Program Children's Hospital of Philadelphia Philadelphia PA USA Cincinnati Children's Hospital Medical Center Cincinnati OH USA

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Personalized medicine and Hispanic health: improving health outcomes and reducing health disparities - a National Heart, Lung, and Blood Institute workshop report

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BMC proceedings 2017年第SUPPL 11期11卷 11页

作者： M Larissa Avilés-Santa John Heintzman Nangel M Lindberg Rafael Guerrero-Preston Kenneth Ramos Ana L Abraído-Lanza Jonca Bull Adolph Falcón Mary Ann McBurnie Ernest Moy George Papanicolaou Ileana L Piña Jennifer Popovic Shakira F Suglia Miguel A Vázquez Division of Cardiovascular Sciences National Heart Lung and Blood Institute 6701 Rockledge Drive Room 10188 Bethesda MD 20892-7936 USA. Department of Family Medicine Oregon Health and Science University 318 SW Sam Jackson Park Rd Portland OR 97239 USA. Kaiser Permanente Northwest Center for Health Research 3800 N. Interstate Ave Portland OR 97227 USA. Johns Hopkins University School of Medicine 1550 Orleans Street CRB2 Room 5M Baltimore MD 21231 USA. University of Arizona Health Sciences 1295 North Martin Avenue PO Box 210202 Tucson AZ 86721 USA. Columbia University Mailman School of Public Health 722 West 168th Street New York NY 10032 USA. Office of Minority Health U.S. Food and Drug Administration 10903 New Hampshire Avenue Silver Spring MD 20993 USA. National Alliance for Hispanic Health 1600 P St NW Washington DC 20009 USA. National Center for Health Statistics 3311 Toledo Road Hyattsville MD 20782 USA. Albert Einstein College of Medicine Montefiore Heart and Vascular Center 111 East 210th Street Bronx NY 10467-2401 USA. Program for Health Data and Standardized Methods Center for Health Data Analytics | eHealth Quality & Analytics Division RTI International | 307 Waverley Oaks Road Suite 101 Waltham MA 02452 USA. Rollins School of Public Health Emory University 1518 Clifton Rd Rm 4005 Atlanta GA 30322 USA. Department of Internal Medicine University of Texas Southwestern Medical Center 5323 Harry Hines Boulevard Dallas TX 75390-8856 USA.

Persons of Hispanic/Latino descent may represent different ancestries, ethnic and cultural groups and countries of birth. In the U.S., the Hispanic/Latino population is projected to constitute 29% of the population by 2060. A personalized approach focusing on individual variability in genetics, environment, lifestyle and socioeconomic determinants of health may advance the understanding of some of the major factors contributing to the health disparities experienced by Hispanics/Latinos and other groups in the U.S., thus leading to new strategies that improve health care outcomes. However, there are major gaps in our current knowledge about how personalized medicine can shape health outcomes among Hispanics/Latinos and address the potential factors that may explain the observed differences within this heterogeneous group, and between this group and other U.S. demographic groups. For that purpose, the National Heart, Lung, and Blood Institute (NHLBI), in collaboration with the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), and the Food and Drug Administration (FDA), held a workshop in which experts discussed (1) potential approaches to study medical treatments and health outcomes among Hispanics/Latinos and garner the necessary evidence to fill gaps of efficacy, effectiveness and safety of therapies for heart, lung, blood and sleep (HLBS) disorders and conditions--and their risk factors; (2) research opportunities related to personalized medicine to improve knowledge and develop effective interventions to reduce health disparities among Hispanics/Latinos in the U.S.; and (3) the incorporation of expanded sociocultural and socioeconomic data collection and genetic/genomic/epigenetic information of Hispanic/Latino patients into their clinical assessments, to account for individual variability in ancestry; physiology or disease risk; culture; environment; lifestyle; and socioeconomic determinants of health. The experts also provided recommendat

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Publisher Correction: Shared heritability and functional enrichment across six solid cancers

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Nature communications 2019年第1期10卷 4386页

作者： Xia Jiang Hilary K Finucane Fredrick R Schumacher Stephanie L Schmit Jonathan P Tyrer Younghun Han Kyriaki Michailidou Corina Lesseur Karoline B Kuchenbaecker Joe Dennis David V Conti Graham Casey Mia M Gaudet Jeroen R Huyghe Demetrius Albanes Melinda C Aldrich Angeline S Andrew Irene L Andrulis Hoda Anton-Culver Antonis C Antoniou Natalia N Antonenkova Susanne M Arnold Kristan J Aronson Banu K Arun Elisa V Bandera Rosa B Barkardottir Daniel R Barnes Jyotsna Batra Matthias W Beckmann Javier Benitez Sara Benlloch Andrew Berchuck Sonja I Berndt Heike Bickeböller Stephanie A Bien Carl Blomqvist Stefania Boccia Natalia V Bogdanova Stig E Bojesen Manjeet K Bolla Hiltrud Brauch Hermann Brenner James D Brenton Mark N Brook Joan Brunet Hans Brunnström Daniel D Buchanan Barbara Burwinkel Ralf Butzow Gabriella Cadoni Trinidad Caldés Maria A Caligo Ian Campbell Peter T Campbell Géraldine Cancel-Tassin Lisa Cannon-Albright Daniele Campa Neil Caporaso André L Carvalho Andrew T Chan Jenny Chang-Claude Stephen J Chanock Chu Chen David C Christiani Kathleen B M Claes Frank Claessens Judith Clements J Margriet Collée Marcia Cruz Correa Fergus J Couch Angela Cox Julie M Cunningham Cezary Cybulski Kamila Czene Mary B Daly Anna deFazio Peter Devilee Orland Diez Manuela Gago-Dominguez Jenny L Donovan Thilo Dörk Eric J Duell Alison M Dunning Miriam Dwek Diana M Eccles Christopher K Edlund Digna R Velez Edwards Carolina Ellberg D Gareth Evans Peter A Fasching Robert L Ferris Triantafillos Liloglou Jane C Figueiredo Olivia Fletcher Renée T Fortner Florentia Fostira Silvia Franceschi Eitan Friedman Steven J Gallinger Patricia A Ganz Judy Garber José A García-Sáenz Simon A Gayther Graham G Giles Andrew K Godwin Mark S Goldberg David E Goldgar Ellen L Goode Marc T Goodman Gary Goodman Kjell Grankvist Mark H Greene Henrik Gronberg Jacek Gronwald Pascal Guénel Niclas Håkansson Per Hall Ute Hamann Freddie C Hamdy Robert J Hamilton Jochen Hampe Aage Haugen Florian Heitz Rolando Herrero Peter Hillemanns Michael Hoffmeister Estrid Høgdall Yun-Ch Program in Genetic Epidemiology and Statistical Genetics Harvard T.H. Chan School of Public Health 677 Huntington Ave Boston MA 02115 USA. xiajiang@hsph.harvard.edu. Unit of Cardiovascular Epidemiology Institute of Environmental Medicine Karolinska Institutet Nobels vagen 13 17177 Stockholm Sweden. xiajiang@hsph.harvard.edu. Department of Epidemiology Harvard T.H. Chan School of Public Health 677 Huntington Ave Boston MA 02115 USA. Program in Medical and Population Genetics Broad Institute of MIT and Harvard 75 Ames St Cambridge MA 02142 USA. Department of Population and Quantitative Health Sciences Case Western Reserve University 10900 Eucid Avenue Cleveland OH 44106 USA. Seidman Cancer Center University Hospitals Cleveland OH 44106 USA. Department of Cancer Epidemiology H. Lee Moffitt Cancer Center and Research Institute 12902 Magnolia Dr. MRC-CANCONT Tampa FL 33612 USA. Department of Gastrointestinal Oncology H. Lee Moffitt Cancer Center and Research Institute 12902 Magnolia Dr. MRC-CANCONT Tampa FL 33612 USA. Centre for Cancer Genetic Epidemiology Department of Oncology University of Cambridge 2 Worts' Causeway Cambridge CB1 8RN UK. Department of Biomedical Data Science The Geisel School of Medicine at Dartmouth 1 Medical Center Drive Lebanon NH 03756 USA. Centre for Cancer Genetic Epidemiology Department of Public Health and Primary Care University of Cambridge 2 Worts' Causeway Cambridge CB1 8RN UK. Department of Electron Microscopy/Molecular Pathology The Cyprus Institute of Neurology and Genetics 1683 Nicosia Cyprus. Genetic Epidemiology Group International Agency for Research on Cancer 150 Cours Albert Thomas 69008 Lyon France. Section of Genetics International Agency for Research on Cancer 150 cours Albert Thomas 69008 Lyon France. Division of Psychiatry University College London Maple House 149 Tottenham Court Road London W1T 7NF UK. UCL Genetics Institute University College London Gower Street London WC1E 6BT UK.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Resolving the Extragalactic γ-Ray Background above 50 GeV with the Fermi Large Area Telescope

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Physical Review Letters 2016年第15期116卷 151105-151105页

作者： M. Ackermann M. Ajello A. Albert W. B. Atwood L. Baldini J. Ballet G. Barbiellini D. Bastieri K. Bechtol R. Bellazzini E. Bissaldi R. D. Blandford E. D. Bloom R. Bonino J. Bregeon R. J. Britto P. Bruel R. Buehler G. A. Caliandro R. A. Cameron M. Caragiulo P. A. Caraveo E. Cavazzuti C. Cecchi E. Charles A. Chekhtman J. Chiang G. Chiaro S. Ciprini J. Cohen-Tanugi L. R. Cominsky F. Costanza S. Cutini F. D’Ammando A. de Angelis F. de Palma R. Desiante S. W. Digel M. Di Mauro L. Di Venere A. Domínguez P. S. Drell C. Favuzzi S. J. Fegan E. C. Ferrara A. Franckowiak Y. Fukazawa S. Funk P. Fusco F. Gargano D. Gasparrini N. Giglietto P. Giommi F. Giordano M. Giroletti G. Godfrey D. Green I. A. Grenier S. Guiriec E. Hays D. Horan G. Iafrate T. Jogler G. Jóhannesson M. Kuss G. La Mura S. Larsson L. Latronico J. Li L. Li F. Longo F. Loparco B. Lott M. N. Lovellette P. Lubrano G. M. Madejski J. Magill S. Maldera A. Manfreda M. Mayer M. N. Mazziotta P. F. Michelson W. Mitthumsiri T. Mizuno A. A. Moiseev M. E. Monzani A. Morselli I. V. Moskalenko S. Murgia M. Negro E. Nuss T. Ohsugi C. Okada N. Omodei E. Orlando J. F. Ormes D. Paneque J. S. Perkins M. Pesce-Rollins V. Petrosian F. Piron G. Pivato T. A. Porter S. Rainò R. Rando M. Razzano S. Razzaque A. Reimer O. Reimer T. Reposeur R. W. Romani M. Sánchez-Conde J. Schmid A. Schulz C. Sgrò D. Simone E. J. Siskind F. Spada G. Spandre P. Spinelli D. J. Suson H. Takahashi J. B. Thayer L. Tibaldo D. F. Torres E. Troja G. Vianello M. Yassine S. Zimmer Deutsches Elektronen Synchrotron DESY D-15738 Zeuthen Germany Department of Physics and Astronomy Clemson University Kinard Lab of Physics Clemson SC 29634-0978 USA W. W. Hansen Experimental Physics Laboratory Kavli Institute for Particle Astrophysics and Cosmology Department of Physics and SLAC National Accelerator Laboratory Stanford University Stanford CA 94305 USA Santa Cruz Institute for Particle Physics Department of Physics and Department of Astronomy and Astrophysics University of California at Santa Cruz Santa Cruz CA 95064 USA Università di Pisa and Istituto Nazionale di Fisica Nucleare Sezione di Pisa I-56127 Pisa Italy Laboratoire AIM CEA-IRFU/CNRS/Université Paris Diderot Service d’Astrophysique CEA Saclay F-91191 Gif sur Yvette France Istituto Nazionale di Fisica Nucleare Sezione di Trieste I-34127 Trieste Italy Dipartimento di Fisica Università di Trieste I-34127 Trieste Italy Istituto Nazionale di Fisica Nucleare Sezione di Padova I-35131 Padova Italy Dipartimento di Fisica e Astronomia “G. Galilei” Università di Padova I-35131 Padova Italy Dept. of Physics and Wisconsin IceCube Particle Astrophysics Center University of Wisconsin Madison WI 53706 USA Istituto Nazionale di Fisica Nucleare Sezione di Pisa I-56127 Pisa Italy Istituto Nazionale di Fisica Nucleare Sezione di Bari I-70126 Bari Italy Istituto Nazionale di Fisica Nucleare Sezione di Torino I-10125 Torino Italy Dipartimento di Fisica Generale “Amadeo Avogadro” Università degli Studi di Torino I-10125 Torino Italy Laboratoire Univers et Particules de Montpellier Université Montpellier CNRS/IN2P3 Montpellier France Department of Physics University of Johannesburg PO Box 524 Auckland Park 2006 South Africa Laboratoire Leprince-Ringuet École polytechnique CNRS/IN2P3 Palaiseau France Consorzio Interuniversitario per la Fisica Spaziale (CIFS) I-10133 Torino Italy Dipartimento di Fisica “M. Merlin” dell’Università e del Politecnico di Bari I-70126 Bari Italy INAF-Istituto di As

The Fermi Large Area Telescope (LAT) Collaboration has recently released a catalog of 360 sources detected above 50 GeV (2FHL). This catalog was obtained using 80 months of data re-processed with Pass 8, the newest event-level analysis, which significantly improves the acceptance and angular resolution of the instrument. Most of the 2FHL sources at high Galactic latitude are blazars. Using detailed Monte Carlo simulations, we measure, for the first time, the source count distribution, dN/dS, of extragalactic γ-ray sources at E>50 GeV and find that it is compatible with a Euclidean distribution down to the lowest measured source flux in the 2FHL (∼8×10−12 ph cm−2 s−1). We employ a one-point photon fluctuation analysis to constrain the behavior of dN/dS below the source detection threshold. Overall, the source count distribution is constrained over three decades in flux and found compatible with a broken power law with a break flux, Sb, in the range [8×10−12,1.5×10−11] ph cm−2 s−1 and power-law indices below and above the break of α2∈[1.60,1.75] and α1=2.49±0.12, respectively. Integration of dN/dS shows that point sources account for at least 86−14+16% of the total extragalactic γ-ray background. The simple form of the derived source count distribution is consistent with a single population (i.e., blazars) dominating the source counts to the minimum flux explored by this analysis. We estimate the density of sources detectable in blind surveys that will be performed in the coming years by the Cherenkov Telescope Array.

关键词： Gamma ray astronomy Galactic nuclei & quasars

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DDX5 and its associated lncRNA Rmrp modulate T_H17 cell effector functions

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Nature 2015年第7583期528卷 517-522页

作者： Huang, Wendy Thomas, Benjamin Flynn, Ryan A. Gavzy, Samuel J. Wu, Lin Kim, Sangwon V. Hall, Jason A. Miraldi, Emily R. Ng, Charles P. Rigo, Frank W. Meadows, Sarah Montoya, Nina R. Herrera, Natalia G. Domingos, Ana I. Rastinejad, Fraydoon Myers, Richard M. Fuller-Pace, Frances V. Bonneau, Richard Chang, Howard Y. Acuto, Oreste Littman, Dan R. Kimmel Center for Biology and Medicine Skirball Institute New York University School of Medicine New York 10016 NY United States Sir William Dunn School of Pathology University of Oxford Oxford OX1 3RE United Kingdom Center for Personal Dynamic Regulomes Stanford University Stanford 94305 CA United States Center for Genomics and Systems Biology Department of Biology New York University New York 10003 NY United States Courant Institute of Mathematical Sciences Computer Science Department New York University New York 10012 NY United States Simons Center for Data Analysis Simons Foundation New York 10010 NY United States Isis Pharmaceuticals Carlsbad 92010 CA United States HudsonAlpha Institute for Biotechnology Huntsville 35806 AL United States Instituto Gulbenkian de Ciencia Oeiras 2780-156 Portugal Integrative Metabolism Program Sanford Burnham Prebys Medical Discovery Institute Orlando 32827 FL United States Division of Cancer Research University of Dundee Dundee DD1 9SY United Kingdom Howard Hughes Medical Institute New York University School of Medicine New York 10016 NY United States

T helper 17 (TH17) lymphocytes protect mucosal barriers from infections, but also contribute to multiple chronic inflammatory diseases. Their differentiation is controlled by RORγt, a ligand-regulated nuclear recepto...

T helper 17 (T_H17) lymphocytes protect mucosal barriers from infections, but also contribute to multiple chronic inflammatory diseases. Their differentiation is controlled by RORγt, a ligand-regulated nuclear receptor. Here we identify the RNA helicase DEAD-box protein 5 (DDX5) as a RORγt partner that coordinates transcription of selective T_H17 genes, and is required for T_H17-mediated inflammatory pathologies. Surprisingly, the ability of DDX5 to interact with RORγt and coactivate its targets depends on intrinsic RNA helicase activity and binding of a conserved nuclear long noncoding RNA (lncRNA), Rmrp, which is mutated in patients with cartilage-hair hypoplasia. A targeted Rmrp gene mutation in mice, corresponding to a gene mutation in cartilage-hair hypoplasia patients, altered lncRNA chromatin occupancy, and reduced the DDX5-RORγt interaction and RORγt target gene transcription. Elucidation of the link between Rmrp and the DDX5-RORγt complex reveals a role for RNA helicases and lncRNAs in tissue-specific transcriptional regulation, and provides new opportunities for therapeutic intervention in T_H17-dependent diseases. © 2015 Macmillan Publishers Limited. All rights reserved.

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Measurement of the high-energy gamma-ray emission from the Moon with the Fermi Large Area Telescope

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Physical Review D 2016年第8期93卷 082001-082001页

作者： M. Ackermann M. Ajello A. Albert W. B. Atwood L. Baldini G. Barbiellini D. Bastieri R. Bellazzini E. Bissaldi R. D. Blandford R. Bonino E. Bottacini J. Bregeon P. Bruel R. Buehler G. A. Caliandro R. A. Cameron M. Caragiulo P. A. Caraveo E. Cavazzuti C. Cecchi A. Chekhtman J. Chiang G. Chiaro S. Ciprini R. Claus J. Cohen-Tanugi F. Costanza A. Cuoco S. Cutini F. D’Ammando A. de Angelis F. de Palma R. Desiante S. W. Digel L. Di Venere P. S. Drell C. Favuzzi S. J. Fegan W. B. Focke A. Franckowiak S. Funk P. Fusco F. Gargano D. Gasparrini N. Giglietto F. Giordano M. Giroletti T. Glanzman G. Godfrey I. A. Grenier J. E. Grove S. Guiriec A. K. Harding J. W. Hewitt D. Horan X. Hou G. Iafrate G. Jóhannesson T. Kamae M. Kuss S. Larsson L. Latronico J. Li L. Li F. Longo F. Loparco M. N. Lovellette P. Lubrano J. Magill S. Maldera A. Manfreda M. Mayer M. N. Mazziotta P. F. Michelson W. Mitthumsiri T. Mizuno M. E. Monzani A. Morselli S. Murgia E. Nuss N. Omodei E. Orlando J. F. Ormes D. Paneque J. S. Perkins M. Pesce-Rollins V. Petrosian F. Piron G. Pivato S. Rainò R. Rando M. Razzano A. Reimer O. Reimer T. Reposeur C. Sgrò E. J. Siskind F. Spada G. Spandre P. Spinelli H. Takahashi J. B. Thayer D. J. Thompson L. Tibaldo D. F. Torres G. Tosti E. Troja G. Vianello B. L. Winer K. S. Wood M. Yassine F. Cerutti A. Ferrari P. R. Sala Deutsches Elektronen Synchrotron DESY D-15738 Zeuthen Germany Department of Physics and Astronomy Clemson University Kinard Lab of Physics Clemson South Carolina 29634-0978 USA W. W. Hansen Experimental Physics Laboratory Kavli Institute for Particle Astrophysics and Cosmology Department of Physics and SLAC National Accelerator Laboratory Stanford University Stanford California 94305 USA Santa Cruz Institute for Particle Physics Department of Physics and Department of Astronomy and Astrophysics University of California at Santa Cruz Santa Cruz California 95064 USA Università di Pisa and Istituto Nazionale di Fisica Nucleare Sezione di Pisa I-56127 Pisa Italy Istituto Nazionale di Fisica Nucleare Sezione di Trieste I-34127 Trieste Italy Dipartimento di Fisica Università di Trieste I-34127 Trieste Italy Istituto Nazionale di Fisica Nucleare Sezione di Padova I-35131 Padova Italy Dipartimento di Fisica e Astronomia “G. Galilei” Università di Padova I-35131 Padova Italy Istituto Nazionale di Fisica Nucleare Sezione di Pisa I-56127 Pisa Italy Istituto Nazionale di Fisica Nucleare Sezione di Bari I-70126 Bari Italy Istituto Nazionale di Fisica Nucleare Sezione di Torino I-10125 Torino Italy Dipartimento di Fisica Generale “Amadeo Avogadro” Università degli Studi di Torino I-10125 Torino Italy Laboratoire Univers et Particules de Montpellier Université Montpellier CNRS/IN2P3 F-34095 Montpellier France Laboratoire Leprince-Ringuet École polytechnique CNRS/IN2P3 F-91128 Palaiseau Cedex France Consorzio Interuniversitario per la Fisica Spaziale (CIFS) I-10133 Torino Italy Dipartimento di Fisica “M. Merlin” dell’Università e del Politecnico di Bari I-70126 Bari Italy INAF-Istituto di Astrofisica Spaziale e Fisica Cosmica I-20133 Milano Italy Agenzia Spaziale Italiana (ASI) Science Data Center I-00133 Roma Italy Istituto Nazionale di Fisica Nucleare Sezione di Perugia I-06123 Perugia Italy Dipartimento di Fisica Università degli Studi di Perugia I-06123 Perugia

We have measured the gamma-ray emission spectrum of the Moon using the data collected by the Large Area Telescope onboard the Fermi satellite during its first seven years of operation, in the energy range from 30 MeV up to a few GeV. We have also studied the time evolution of the flux, finding a correlation with the solar activity. We have developed a full Monte Carlo simulation describing the interactions of cosmic rays with the lunar surface. The results of the present analysis can be explained in the framework of this model, where the production of gamma rays is due to the interactions of cosmic-ray proton and helium nuclei with the surface of the Moon. Finally, we have used our simulation to derive the cosmic-ray proton and helium spectra near Earth from the Moon gamma-ray data.

关键词： Cosmic ray sources Cosmic rays & astroparticles Gamma ray astronomy Solar cycles

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Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

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Nature communications 2019年第1期10卷 2068页

作者： Gail Davies Max Lam Sarah E Harris Joey W Trampush Michelle Luciano W David Hill Saskia P Hagenaars Stuart J Ritchie Riccardo E Marioni Chloe Fawns-Ritchie David C M Liewald Judith A Okely Ari V Ahola-Olli Catriona L K Barnes Lars Bertram Joshua C Bis Katherine E Burdick Andrea Christoforou Pamela DeRosse Srdjan Djurovic Thomas Espeseth Stella Giakoumaki Sudheer Giddaluru Daniel E Gustavson Caroline Hayward Edith Hofer M Arfan Ikram Robert Karlsson Emma Knowles Jari Lahti Markus Leber Shuo Li Karen A Mather Ingrid Melle Derek Morris Christopher Oldmeadow Teemu Palviainen Antony Payton Raha Pazoki Katja Petrovic Chandra A Reynolds Muralidharan Sargurupremraj Markus Scholz Jennifer A Smith Albert V Smith Natalie Terzikhan Anbupalam Thalamuthu Stella Trompet Sven J van der Lee Erin B Ware B Gwen Windham Margaret J Wright Jingyun Yang Jin Yu David Ames Najaf Amin Philippe Amouyel Ole A Andreassen Nicola J Armstrong Amelia A Assareh John R Attia Deborah Attix Dimitrios Avramopoulos David A Bennett Anne C Böhmer Patricia A Boyle Henry Brodaty Harry Campbell Tyrone D Cannon Elizabeth T Cirulli Eliza Congdon Emily Drabant Conley Janie Corley Simon R Cox Anders M Dale Abbas Dehghan Danielle Dick Dwight Dickinson Johan G Eriksson Evangelos Evangelou Jessica D Faul Ian Ford Nelson A Freimer He Gao Ina Giegling Nathan A Gillespie Scott D Gordon Rebecca F Gottesman Michael E Griswold Vilmundur Gudnason Tamara B Harris Annette M Hartmann Alex Hatzimanolis Gerardo Heiss Elizabeth G Holliday Peter K Joshi Mika Kähönen Sharon L R Kardia Ida Karlsson Luca Kleineidam David S Knopman Nicole A Kochan Bettina Konte John B Kwok Stephanie Le Hellard Teresa Lee Terho Lehtimäki Shu-Chen Li Christina M Lill Tian Liu Marisa Koini Edythe London Will T Longstreth Oscar L Lopez Anu Loukola Tobias Luck Astri J Lundervold Anders Lundquist Leo-Pekka Lyytikäinen Nicholas G Martin Grant W Montgomery Alison D Murray Anna C Need Raymond Noordam Lars Nyberg William Ollier Goran Papenberg Alison Pattie Ozren Polasek Russell A Poldrack Bruce M Psaty Sim Centre for Cognitive Ageing and Cognitive Epidemiology Department of Psychology School of Philosophy Psychology and Language Sciences The University of Edinburgh Edinburgh EH8 9JZ UK. Institute of Mental Health Singapore 539747 Singapore. Medical Genetics Section Centre for Genomic & Experimental Medicine MRC Institute of Genetics & Molecular Medicine University of Edinburgh Western General Hospital Edinburgh EH4 2XU UK. BrainWorkup LLC Los Angeles 90033 CA USA. Department of Psychiatry and Behavioral Sciences Keck School of Medicine University of Southern California Los Angeles 90033 CA USA. Social Genetic and Developmental Psychiatry Centre Institute of Psychiatry Psychology & Neuroscience King's College London De Crespigny Park Denmark Hill London SE5 8AF UK. Research Centre of Applied and Preventive Cardiovascular Medicine University of Turku Turku 20520 Finland. Department of Internal Medicine Satakunta Central Hospital Pori 28100 Finland. Centre for Global Health Research Usher Institute of Population Health Sciences and Informatics University of Edinburgh Teviot Place Edinburgh EH8 9AG Scotland. Max Planck Institute for Molecular Genetics Berlin 14195 Germany. Cardiovascular Health Research Unit Department of Medicine University of Washington Seattle 98101 Washington USA. Department of Psychiatry Icahn School of Medicine at Mount Sinai New York 10029 NY USA. Mental Illness Research Education and Clinical Center (VISN 3) James J. Peters VA Medical Center Bronx 10468 NY USA. Department of Psychiatry Brigham and Women's Hospital Harvard Medical School Boston 02115 MA USA. NORMENT K.G. Jebsen Centre for Psychosis Research Department of Clinical Science University of Bergen Bergen 5021 Norway. Dr. Einar Martens Research Group for Biological Psychiatry Center for Medical Genetics and Molecular Medicine Haukeland University Hospital Bergen 5020 Norway. Center for Psychiatric Neuroscience Feinstein Institute for Medical Resea

Christina M. Lill, who contributed to analysis of data, was inadvertently omitted from the author list in the originally published version of this article. This has now been corrected in both the PDF and HTML versions...

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