Tropical disease is one of the infectious diseases that affect Indonesia. Many people die because of tropical diseases, such as dengue hemorrhagic fever (DHF), chikungunya, leprosy, lymphatic, and filariasis. The Indo...
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The rapid advancement of immersive technologies has propelled the development of the Metaverse, where the convergence of virtual and physical realities necessitates the generation of high-quality, photorealistic image...
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This study analyzed interactions between Twitter users in conversations regarding Indonesia's state-owned vaccine manufacturer 'Biofarma' in 2021. The primary objective of this study is to identify Key Opi...
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multidisciplinary collaboration between public health, system engineering, and UX is able to generate a solution in healthcare problem like stunting. The principle of Agile UX gathers requirements to generate an appli...
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A sugarcane yield of one plantation area depends on several independent variables. Practically it is challenging to predict accurately by using conventional methods. This study aims to develop a decision model based o...
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ISBN:
(数字)9798331519643
ISBN:
(纸本)9798331519650
A sugarcane yield of one plantation area depends on several independent variables. Practically it is challenging to predict accurately by using conventional methods. This study aims to develop a decision model based on a combination of fuzzy logic and object-oriented methods to predict sugarcane yield. The research is conducted in four main stages, employing object-oriented methods for model design and fuzzy logic for model construction. Object and activity diagrams are used for the object-oriented model design. The fuzzy membership functions employed are a combination of trapezoidal and triangular shapes. The resulting decision model can simulate 2,225 data from plantation areas in Indonesia. Based on the 10 examples of plantation area data in Indonesia, plantation number one obtained the largest sugarcane yield, which was 4.79%, with a similarity value of 0.90 (when compared to manual calculations as its ground truth). This similarity value is a higher value when compared to the average similarity value, which is 0.89.
Quantifying the effect of mutations in the BRCA1 gene is useful for understanding their clinical consequences on breast cancer. Machine learning models can be applied to predict the landscape of protein variant effect...
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Quantifying the effect of mutations in the BRCA1 gene is useful for understanding their clinical consequences on breast cancer. Machine learning models can be applied to predict the landscape of protein variant effects that might not be always accessible by experiments. In this work, we propose a simple semi-supervised learning method using a Gaussian mixture model to predict ∼90% of the unlabeled missense variants of the BRCA1 gene collected from the ClinVar database. High-quality embeddings are used as a feature of the protein sequences, extracted using the latest pre-trained transformer-based language protein model. A statistical test show that the protein embeddings are effective and robust for predicting pathogenicity. Further, the lower representations of the features are then fed into the semi-supervised model. The prediction performance of the model only for the labeled testing data achieves an AUC score and an accuracy of 79.27% and 71.58%, respectively. Using our defined pathogenic probability score, we find that ∼94% of variants in our unlabeled dataset are well-separated into either benign or pathogenic classes according to that scoring. Our scores obtain a moderate Spearman rank correlation with the results of established unsupervised variant effect models. Finally, our approach can potentially be developed for more accurate and biologically reliable predictions of the variant effects.
This study is related to a system that enables elderly people to communicate interactively with young people who use existing message exchange services by simply speaking to an avatar on a tablet PC, without having to...
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Regulatory compliance in the pharmaceutical industry entails navigating through complex and voluminous guidelines, often requiring significant human resources. To address these challenges, our study introduces a chatb...
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In this digital era, we are exposed to a large amount of data. This includes biological data, which stores information about living organisms, including Deoxyribonucleic acid (DNA), genes, and proteins. With the devel...
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This paper employs Topological data Analysis (TDA) to detect extreme events (EEs) in the stock market at a continental level. Previous approaches, which analyzed stock indices separately, could not detect EEs for mult...
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