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Parkes Pulsar Timing Array constraints on ultralight scalar-field dark matter

Physical Review D 2018年第10期98卷 102002-102002页

作者： Nataliya K. Porayko Xingjiang Zhu Yuri Levin Lam Hui George Hobbs Aleksandra Grudskaya Konstantin Postnov Matthew Bailes N. D. Ramesh Bhat William Coles Shi Dai James Dempsey Michael J. Keith Matthew Kerr Michael Kramer Paul D. Lasky Richard N. Manchester Stefan Osłowski Aditya Parthasarathy Vikram Ravi Daniel J. Reardon Pablo A. Rosado Christopher J. Russell Ryan M. Shannon Renée Spiewak Willem van Straten Lawrence Toomey Jingbo Wang Linqing Wen Xiaopeng You Max-Planck-Institut für Radioastronomie Auf dem Hügel 69 D-53121 Bonn Germany School of Physics and Astronomy Monash University Clayton VIC 3800 Australia School of Physics University of Western Australia Crawley WA 6009 Australia OzGrav: Australian Research Council Centre of Excellence for Gravitational Wave Discovery Hawthorn VIC 3122 Australia Center for Theoretical Physics Department of Physics Columbia University New York New York 10027 USA Center for Computational Astrophysics Flatiron Institute New York New York 10010 USA CSIRO Astronomy and Space Science P.O. Box 76 Epping NSW 1710 Australia Sternberg Astronomical Institute Lomonosov Moscow State University Universitetskii pr. 13 Moscow 119234 Russia Kazan Federal University Kremlevskaya 18 Kazan 420008 Russia Centre for Astrophysics and Supercomputing Swinburne University of Technology P.O. Box 218 Hawthorn VIC 3122 Australia International Centre for Radio Astronomy Research Curtin University Bentley WA 6102 Australia Department of Electrical and Computer Engineering University of California at San Diego La Jolla California 92093 USA CSIRO Information Management and Technology PO Box 225 Dickson ACT 2602 Australia Jodrell Bank Center for Astrophysics University of Manchester Manchester M13 9PL UK Space Science Division Naval Research Laboratory Washington DC 20375 USA Cahill Center for Astronomy and Astrophysics MC 249-17 California Institute of Technology Pasadena California 91125 USA CSIRO Scientific Computing Australian Technology Park Locked Bag 9013 Alexandria NSW 1435 Australia Institute for Radio Astronomy & Space Research Auckland University of Technology Private Bag 92006 Auckland 1142 New Zealand Xinjiang Astronomical Observatory Chinese Academy of Sciences 150 Science 1-Street Urumqi Xinjiang 830011 China School of Physical Science and Technology Southwest University Chongqing 400715 China

It is widely accepted that dark matter contributes about a quarter of the critical mass-energy density in our Universe. The nature of dark matter is currently unknown, with the mass of possible constituents spanning nearly one hundred orders of magnitude. The ultralight scalar field dark matter, consisting of extremely light bosons with m∼10−22 eV and often called “fuzzy” dark matter, provides intriguing solutions to some challenges at sub-Galactic scales for the standard cold dark matter model. As shown by Khmelnitsky and Rubakov, such a scalar field in the Galaxy would produce an oscillating gravitational potential with nanohertz frequencies, resulting in periodic variations in the times of arrival of radio pulses from pulsars. The Parkes Pulsar Timing Array (PPTA) has been monitoring 20 millisecond pulsars at two- to three-week intervals for more than a decade. In addition to the detection of nanohertz gravitational waves, PPTA offers the opportunity for direct searches for fuzzy dark matter in an astrophysically feasible range of masses. We analyze the latest PPTA data set which includes timing observations for 26 pulsars made between 2004 and 2016. We perform a search in this data set for evidence of ultralight dark matter in the Galaxy using Bayesian and Frequentist methods. No statistically significant detection has been made. We, therefore, place upper limits on the local dark matter density. Our limits, improving on previous searches by a factor of 2 to 5, constrain the dark matter density of ultralight bosons with m≤10−23 eV to be below 6 GeV cm−3 with 95% confidence in the Earth neighborhood. Finally, we discuss the prospect of probing the astrophysically favored mass range m≳10−22 eV with next-generation pulsar timing facilities.

关键词： Dark matter Neutron stars & pulsars Electromagnetic radiation astronomy Gravitational wave detection

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Toward the End-to-End Optimization of Particle Physics Instruments with Differentiable Programming: a White Paper

arXiv

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arXiv 2022年

作者： Dorigo, Tommaso Giammanco, Andrea Vischia, Pietro Aehle, Max Bawaj, Mateusz Boldyrev, Alexey de Castro Manzano, Pablo Derkach, Denis Donini, Julien Edelen, Auralee Fanzago, Federica Gauger, Nicolas R. Glaser, Christian Baydin, Atılım G. Heinrich, Lukas Keidel, Ralf Kieseler, Jan Krause, Claudius Lagrange, Maxime Lamparth, Max Layer, Lukas Maier, Gernot Nardi, Federico Pettersen, Helge E.S. Ramos, Alberto Ratnikov, Fedor Röhrich, Dieter de Austri, Roberto Ruiz del Árbol, Pablo Martínez Ruiz Savchenko, Oleg Simpson, Nathan Strong, Giles C. Taliercio, Angela Tosi, Mia Ustyuzhanin, Andrey Zaraket, Haitham Istituto Nazionale di Fisica Nucleare Sezione di Padova Italy Université Catholique de Louvain Belgium Scientific Computing Technische Universität Kaiserslautern Germany Università di Perugia INFN Sezione di Perugia Italy HSE University Russia Université Clermont Auvergne Laboratoire de Physique de Clermont CNRS IN2P3 France SLAC National Accelerator Laboratory United States Department of Physics and Astronomy Uppsala University Sweden Department of Computer Science University of Oxford United Kingdom Physik-Department Technische Universität München Germany Center for Technology and Transfer University of Applied Sciences Worms Germany CERN Switzerland NHETC Dept. of Physics and Astronomy Rutgers University United States Università di Napoli "Federico II" Italy Germany Università degli Studi di Padova Italy Department of Oncology and Medical Physics Haukeland University Hospital Norway Instituto de Física Corpuscular UV-CSIC Spain Department of Physics and Technology University of Bergen Norway Instituto de Física de Cantabria UC-CSIC Spain Lund University Sweden Multi-Disciplinary Physics Laboratory Optics and Fiber Optics Group Faculty of Sciences Lebanese University Lebanon Lebanon

The full optimization of the design and operation of instruments whose functioning relies on the interaction of radiation with matter is a superhuman task, given the large dimensionality of the space of possible choices for geometry, detection technology, materials, data-acquisition, and information-extraction techniques, and the interdependence of the related parameters. On the other hand, massive potential gains in performance over standard, "experience-driven" layouts are in principle within our reach if an objective function fully aligned with the final goals of the instrument is maximized by means of a systematic search of the configuration space. The stochastic nature of the involved quantum processes make the modeling of these systems an intractable problem from a classical statistics point of view, yet the construction of a fully differentiable pipeline and the use of deep learning techniques may allow the simultaneous optimization of all design parameters. In this document we lay down our plans for the design of a modular and versatile modeling tool for the end-to-end optimization of complex instruments for particle physics experiments as well as industrial and medical applications that share the detection of radiation as their basic ingredient. We consider a selected set of use cases to highlight the specific needs of different applications. Copyright © 2022, The Authors. All rights reserved.

关键词： Medical applications

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Parkes Pulsar Timing Array constraints on ultralight scalar-field dark matter

arXiv

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arXiv 2018年

作者： Porayko, Nataliya K. Zhu, Xingjiang Levin, Yuri Hui, Lam Hobbs, George Grudskaya, Aleksandra Postnov, Konstantin Bailes, Matthew Bhat, N.D. Ramesh Coles, William Dai, Shi Dempsey, James Keith, Michael J. Kerr, Matthew Kramer, Michael Lasky, Paul D. Manchester, Richard N. Oslowski, Stefan Parthasarathy, Aditya Ravi, Vikram Reardon, Daniel J. Rosado, Pablo A. Russell, Christopher J. Shannon, Ryan M. Spiewak, Renée van Straten, Willem Toomey, Lawrence Wang, Jingbo Wen, Linqing You, Xiaopeng Max-Planck-Institut für Radioastronomie Auf dem Hügel 69 BonnD-53121 Germany School of Physics and Astronomy Monash University ClaytonVIC3800 Australia School of Physics University of Western Australia CrawleyWA6009 Australia Australian Research Council Centre of Excellence for Gravitational Wave Discovery Center for Theoretical Physics Department of Physics Columbia University New YorkNY10027 United States Center for Computational Astrophysics Flatiron Institute New YorkNY10010 United States CSIRO Astronomy and Space Science P.O. Box 76 EppingNSW1710 Australia Sternberg Astronomical Institute Lomonosov Moscow State University Universitetskii pr. 13 Moscow119234 Russia Kazan Federal University Kremlevskaya 18 Kazan420008 Russia Centre for Astrophysics and Supercomputing Swinburne University of Technology P.O. Box 218 HawthornVIC3122 Australia International Centre for Radio Astronomy Research Curtin University BentleyWA6102 Australia Department of Electrical and Computer Engineering University of California at San Diego La JollaCA92093 United States CSIRO Information Management and Technology PO Box 225 DicksonACT2602 Australia Jodrell Bank Centre for Astrophysics University of Manchester ManchesterM13 9PL United Kingdom Space Science Division Naval Research Laboratory WashingtonDC20375 United States Cahill Center for Astronomy and Astrophysics California Institute of Technology MC 249-17 PasadenaCA91125 United States CSIRO Scientific Computing Australian Technology Park Locked Bag 9013 AlexandriaNSW1435 Australia Institute for Radio Astronomy & Space Research Auckland University of Technology Private Bag 92006 Auckland1142 New Zealand Xinjiang Astronomical Observatory Chinese Academy of Sciences 150 Science 1-Street Urumqi Xinjiang830011 China School of Physical Science and Technology Southwest University Chongqing400715 China

It is widely accepted that dark matter contributes about a quarter of the critical mass-energy density in our Universe. The nature of dark matter is currently unknown, with the mass of possible constituents spanning nearly one hundred orders of magnitude. The ultralight scalar field dark matter, consisting of extremely light bosons with m ∼ 10−22 eV and often called "fuzzy" dark matter, provides intriguing solutions to some challenges at sub-Galactic scales for the standard cold dark matter model. As shown by Khmelnitsky and Rubakov, such a scalar field in the Galaxy would produce an oscillating gravitational potential with nanohertz frequencies, resulting in periodic variations in the times of arrival of radio pulses from pulsars. The Parkes Pulsar Timing Array (PPTA) has been monitoring 20 millisecond pulsars at two to three weeks intervals for more than a decade. In addition to the detection of nanohertz gravitational waves, PPTA offers the opportunity for direct searches for fuzzy dark matter in an astrophysically feasible range of masses. We analyze the latest PPTA data set which includes timing observations for 26 pulsars made between 2004 and 2016. We perform a search in this data set for evidence of ultralight dark matter in the Galaxy using Bayesian and Frequentist methods. No statistically significant detection has been made. We, therefore, place upper limits on the local dark matter density. Our limits, improving on previous searches by a factor of 2 to 5, constrain the dark matter density of ultralight bosons with m ≤ 10−23 eV to be below 6 GeV cm−3 with 95% confidence in the Earth neighborhood. Finally, we discuss the prospect of probing the astrophysically favored mass range m & 10−22 eV with next-generation pulsar timing facilities. Copyright © 2018, The Authors. All rights reserved.

关键词： Timing circuits

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Combined effects of hydrometeorological hazards and urbanisation on dengue risk in Brazil: a spatiotemporal modelling study

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The Lancet Planetary Health 2021年第4期5卷 e209-e219页

作者： Lowe, Rachel Lee, Sophie A Brady, Oliver J Bastos, Leonardo Carrasco-Escobar, Gabriel de Castro Catão, Rafael Colón-González, Felipe J Barcellos, Christovam Carvalho, Marilia Sá Blangiardo, Marta Rue, Håvard Gasparrini, Antonio Centre for Mathematical Modelling of Infectious Diseases London School of Hygiene & Tropical Medicine London United Kingdom Centre on Climate Change and Planetary Health London School of Hygiene & Tropical Medicine London United Kingdom Department of Infectious Disease Epidemiology London School of Hygiene & Tropical Medicine London United Kingdom Department of Public Health Environments and Society London School of Hygiene & Tropical Medicine London United Kingdom Centre for Statistical Modelling London School of Hygiene & Tropical Medicine London United Kingdom Scientific Computing Program Oswaldo Cruz Foundation Rio de Janeiro Brazil Health Information and Communication Institute Oswaldo Cruz Foundation Rio de Janeiro Brazil Scripps Institution of Oceanography University of California San Diego San Diego CA United States Health Innovation Laboratory Institute of Tropical Medicine Alexander von Humboldt Universidad Peruana Cayetano Heredia Lima Peru Department of Geography Federal University of Espírito Santo Vitória Brazil MRC Centre for Environment and Health Department of Epidemiology and Biostatistics Imperial College London London United Kingdom Statistics Program Computer Electrical and Mathematical Sciences and Engineering Division King Abdullah University of Science and Technology Thuwal Saudi Arabia

Background: Temperature and rainfall patterns are known to influence seasonal patterns of dengue transmission. However, the effect of severe drought and extremely wet conditions on the timing and intensity of dengue epidemics is poorly understood. In this study, we aimed to quantify the non-linear and delayed effects of extreme hydrometeorological hazards on dengue risk by level of urbanisation in Brazil using a spatiotemporal model. Methods: We combined distributed lag non-linear models with a spatiotemporal Bayesian hierarchical model framework to determine the exposure-lag-response association between the relative risk (RR) of dengue and a drought severity index. We fit the model to monthly dengue case data for the 558 microregions of Brazil between January, 2001, and January, 2019, accounting for unobserved confounding factors, spatial autocorrelation, seasonality, and interannual variability. We assessed the variation in RR by level of urbanisation through an interaction between the drought severity index and urbanisation. We also assessed the effect of hydrometeorological hazards on dengue risk in areas with a high frequency of water supply shortages. Findings: The dataset included 12 895 293 dengue cases reported between 2001 and 2019 in Brazil. Overall, the risk of dengue increased between 0–3 months after extremely wet conditions (maximum RR at 1 month lag 1·56 [95% CI 1·41–1·73]) and 3–5 months after drought conditions (maximum RR at 4 months lag 1·43 [1·22–1·67]). Including a linear interaction between the drought severity index and level of urbanisation improved the model fit and showed the risk of dengue was higher in more rural areas than highly urbanised areas during extremely wet conditions (maximum RR 1·77 [1·32–2·37] at 0 months lag vs maximum RR 1·58 [1·39–1·81] at 2 months lag), but higher in highly urbanised areas than rural areas after extreme drought (maximum RR 1·60 [1·33–1·92] vs 1·15 [1·08–1·22], both at 4 months lag). We also found the den

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Advances in space quantum communications

arXiv

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arXiv 2021年

作者： Sidhu, Jasminder S. Joshi, Siddarth K. Gündogan, Mustafa Brougham, Thomas Lowndes, David Mazzarella, Luca Krutzik, Markus Mohapatra, Sonali Dequal, Daniele Vallone, Giuseppe Villoresi, Paolo Ling, Alexander Jennewein, Thomas Mohageg, Makan Rarity, John Fuentes, Ivette Pirandola, Stefano Oi, Daniel K.L. SUPA Department of Physics University of Strathclyde 107 Rottenrow GlasgowG4 0NG United Kingdom Quantum Engineering Technology Labs H. H. Wills Physics Laboratory Department of Electrical and Electronic Engineering University of Bristol Merchant Venturers Building Woodland Road BristolBS8 1UB United Kingdom Institüt für Physik Humboldt-Universität zu Berlin Newtonstr. 15 Berlin12489 Germany Jet Propulsion Laboratory California Institute of Technology United States Scientific Research Unit Agenzia Spaziale Italiana Matera Italy Dipartimento di Ingegneria dell'Informazione Università degli Studi di Padova Padova35131 Italy Dipartimento di Fisica e Astronomia Università degli Studi di Padova Padova35131 Italy Centre for Quantum Technologies National University of Singapore S15-02-10 3 Science Drive 2 Singapore117543 Singapore Department of Physics 2 Science Drive 3 Blk S12 Level 2 Singapore117551 Singapore Institute for Quantum Computing University of Waterloo WaterlooONN2L 3G1 Canada Department of Physics and Astronomy University of Waterloo WaterlooONN2L 3G1 Canada School of Physics and Astronomy University of Southampton SouthamptonSO17 1BJ United Kingdom Department of Computer Science University of York YorkYO10 5GH United Kingdom Craft Prospect Ltd. Suite 4A Fairfield 1048 Govan Road GlasgowG51 4XS United Kingdom

Concerted efforts are underway to establish an infrastructure for a global quantum internet to realise a spectrum of quantum technologies. This will enable more precise sensors, secure communications, and faster data processing. Quantum communications are a front-runner with quantum networks already implemented in several metropolitan areas. A number of recent proposals have modelled the use of space segments to overcome range limitations of purely terrestrial networks. Rapid progress in the design of quantum devices have enabled their deployment in space for in-orbit demonstrations. We review developments in this emerging area of space-based quantum technologies and provide a roadmap of key milestones towards a complete, global quantum networked landscape. Small satellites hold increasing promise to provide a cost effective coverage required to realised the quantum internet. We review the state of art in small satellite missions and collate the most current in-field demonstrations of quantum cryptography. We summarise important challenges in space quantum technologies that must be overcome and recent efforts to mitigate their effects. A perspective on future developments that would improve the performance of space quantum communications is included. We conclude with a discussion on fundamental physics experiments that could take advantage of a global, space-based quantum network. Copyright © 2021, The Authors. All rights reserved.

关键词： Quantum cryptography

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Fractal descriptors for discrimination of microscopy images of plant leaves

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Journal of Physics: Conference Series 2014年第1期490卷

作者： N R Silva J B Florindo M C Gómez R M Kolb O M Bruno Institute of Mathematics and Computer Science University of SãO Paulo (USP) Avenida Trabalhador são-carlense 400 13566-590 SãO Carlos SãO Paulo Brazil Scientific Computing Group SãO Carlos Institute of Physics University of SãO Paulo (USP) cx 369 13560-970 SãO Carlos SãO Paulo Brazil Department of Physics Faculty of Biochemistry and Biological Sciences National University of Littoral S3000ZAA Santa Fe Argentina Department of Biological Sciences Faculty of Sciences and Letters Universidade Estadual Paulista Júlio de Mesquita Filho UNESP. Av. Dom Antônio 2100 19806-900 Assis Brazil

This study proposes the application of fractal descriptors method to the discrimination of microscopy images of plant leaves. Fractal descriptors have demonstrated to be a powerful discriminative method in image analysis, mainly for the discrimination of natural objects. In fact, these descriptors express the spatial arrangement of pixels inside the texture under different scales and such arrangements are directly related to physical properties inherent to the material depicted in the image. Here, we employ the Bouligand-Minkowski descriptors. These are obtained by the dilation of a surface mapping the gray-level texture. The classification of the microscopy images is performed by the well-known Support Vector Machine (SVM) method and we compare the success rate with other literature texture analysis methods. The proposed method achieved a correctness rate of 89%, while the second best solution, the Co-occurrence descriptors, yielded only 78%. This clear advantage of fractal descriptors demonstrates the potential of such approach in the analysis of the plant microscopy images.

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Big Data: Prospects and Challenges

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Vikalpa 2015年第1期40卷 74 - 96页

作者： Janakiraman Moorthy Rangin Lahiri Neelanjan Biswas Dipyaman Sanyal Jayanthi Ranjan Krishnadas Nanath Pulak Ghosh (Coordinator) Director and Professor of Marketing at the Institute of Management Technology Dubai. Earlier he was Professor of Marketing at the IIM Calcutta and IIM Lucknow. He received his PhD from IIM Ahmedabad. His recent research papers were published in the leading scholarly ournals such as Marketing Science British Food Journal Journal of Information Technology Case and Application Research Journal of Database Marketing & Customer Strategy Management. He has wide experience in the banking and investment industry. He was earlier the Global Research and Project Director of the Institute for Customer Relationship Management Atlanta USA. He was the Convener of the prestigious CAT Exam 2011. e-mail: Practice Director leading Atos India's CRM practice while supporting Strategic Business Development for North American Market. With an experience of more than 15 years Rangin has worked extensively as a Business Consultant in Information Technology (Sales Automation Marketing & Service Management area) Customer Data Management and CRM Analytics. e-mail: Business Consultant at Atos with extensive experience in Business Analysis Risk Management Analytics Business Development Presales Solution Ideation on Enterprise Data Management Enterprise Reference Data and Master Data Management area. e-mail: founder and CEO of dono consulting a boutique quantitative analytics and investment research firm. He has worked for leading financial firms in New York and India including Dow Jones Blackstone Sorin Capital (VP Quantitative Modeling) and Thomson Reuters (Head of Real Estate Analytics). A CFA charter holder and Commonwealth Scholar Deep has an MS (Applied Economics) from University of Texas Dallas and an MA (Economics) from Jadavpur University e-mail: Professor in the Information Systems Group of the Institute of Management Technology Ghaziabad. Her PhD is in the field of data mining from Jamia Millia Islamia Central University India. She has published five edited books. She is serving on the editorial b

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Perspectives for self-driving labs in synthetic biology

arXiv

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arXiv 2022年

作者： Martin, Hector Garcia Radivojevic, Tijana Zucker, Jeremy Bouchard, Kristofer Sustarich, Jess Peisert, Sean Arnold, Dan Hillson, Nathan Babnigg, Gyorgy Marti, Jose Manuel Mungall, Christopher J. Beckham, Gregg T. Waldburger, Lucas Carothers, James Sundaram, ShivShankar Agarwal, Deb Simmons, Blake A. Backman, Tyler Banerjee, Deepanwita Tanjore, Deepti Ramakrishnan, Lavanya Singh, Anup Lawrence Berkeley National Laboratory Biological Systems and Engineering Division BerkeleyCA United States Department of Energy Agile BioFoundry EmeryvilleCA United States Joint BioEnergy Institute EmeryvilleCA United States BCAM Basque Center for Applied Mathematics Bilbao Spain Lawrence Berkeley National Laboratory Scientific Data Division BerkeleyCA United States Helen Wills Neuroscience Institute Redwood Center for Theoretical Neuroscience BerkeleyCA United States Lawrence Berkeley National Laboratory Energy Storage and Distributed Resources Division BerkeleyCA United States University of California Davis Department of Computer Science DavisCA United States Global Security Computing Applications Division Lawrence Livermore National Laboratory LivermoreCA United States Engineering Directorate Lawrence Livermore National Laboratory LivermoreCA United States Center for Bioengineering Lawrence Livermore National Laboratory LivermoreCA United States Department of Chemical Engineering Molecular Engineering & Sciences Institute Center for Synthetic Biology University of Washington SeattleWA United States Biosciences Division Argonne National Laboratory ArgonneIL United States Advanced Biofuels and Bioproducts Process Development Unit Lawrence Berkeley National Laboratory BerkeleyCA United States Biomaterials and Biomanufacturing Division Sandia National Laboratories LivermoreCA United States Earth and Biological Sciences Division Pacific Northwest National Laboratories RichlandWA United States Resources and Enabling Sciences Center National Renewable Energy Laboratory GoldenCO80401 United States Department of Bioengineering University of California BerkeleyCA United States

Self-driving labs (SDLs) combine fully automated experiments with artificial intelligence (AI) that decides the next set of experiments. Taken to their ultimate expression, SDLs could usher a new paradigm of scientific research, where the world is probed, interpreted, and explained by machines for human benefit. While there are functioning SDLs in the fields of chemistry and materials science, we contend that synthetic biology provides a unique opportunity since the genome provides a single target for affecting the incredibly wide repertoire of biological cell behavior. However, the level of investment required for the creation of biological SDLs is only warranted if directed towards solving difficult and enabling biological questions. Here, we discuss challenges and opportunities in creating SDLs for synthetic biology. © 2022, CC BY.

关键词： Synthetic biology

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The Healthgrid White Paper 3

The Healthgrid White Paper

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3rd Annual Conference of the Healthgrid Association, Healthgrid 2005

作者： Breton, Vincent Dean, Kevin Solomonides, Tony Aloisio, Giovanni Benkner, Siegfried Bilofsky, Howard Blanquer, Ignacio Brady, Michael Cannataro, Mario Chouvarda, Ioanna Claerhout, Brecht De Moor, Georges De Neve, Wilfried De Wagter, Carlos Fiore, Sandro Hassan, Kinda Heeren, Germaine Hernández, Vicente Herveg, Jean A.M. Hofmann, Martin Jones, Chris Koutkias, Vassilios Lloyd, Sharon Lonsdale, Guy Alonso, Victoria L. Maglaveras, Nicos Maigne, Lydia Malousi, Andigoni Martín-Sánchez, Fernando McClatchey, Richard Medico, Enzo Miguet, Serge Mirto, Maria Montagnat, Johan Nørager1, Sofie Nozaki, Kazunori Oliveira, Ilídio Castro Pennec, Xavier Poullet, Yves Merino, Juan Pedro Sánchez Strizh, Irina G. Taillet, Michel Tristram, Clive Tverdokhlebov, Nikolay Veltri, Pierangelo Ziegler, René CNRS-IN2P3 LPC Campus des Cézeaux AubiereCedex63177 France Internet Business Solutions Group Cisco Systems 9 New Square Bedfont Lakes Middlesex FelthamTW14 8HA United Kingdom University of the West of England Bristol CEMS Coldharbour Lane BristolBS6 6TH United Kingdom Center for Advanced Computational Technologies ISUFI Dept. of Innovation Engineering University of Lecce Via per Monteroni Lecce73100 Italy Institute of Scientific Computing University of Vienna Nordbergstrasse 15 ViennaA-1090 Austria University of Pennsylvania School of Engineering and Applied Science Computer and Information Science Center for Bioinformatics 1416 Blockley Hall 423 Guardian Drive PhiladelphiaPA19104-6021 United States Universidad Politecnica de Valencia Camino de Vera/n Valencia46022 Spain FRS FREng Dept. of Engineering Science Oxford University Parks Road OxfordOX1 3PJ United Kingdom Magna Graecia University of Catanzaro School of Bioinformatics and Biomedical Engineering Campus di Germaneto Viale Europa Germaneto Catanzaro88100 Italy Aristotle University The Medical School Lab of Medical Informatics Box 323 Thessaloniki54124 Greece Custodix NV Verlorenbroodstraat 120 Bus 14 MerelbekeB-9820 Belgium Research in Advanced Medical Informatics and Telematics UZ Gent 5K3 De Pintelaan 185 GentB9000 Belgium Department of Radiotherapy Ghent University Hospital Building P7 De Pintelaan 185 GentB-9000 Belgium Laboratoire LIRIS Université Lumière Lyon 2 Campus Porte des Alpes 5 avenue Pierre Mendès France Bron69676 France av. E.Mounierlaan 83 Brussels1200 Belgium Faculté de Droit de Namur - FUNDP Centre de Recherches Informatiques & Droit 5 rempart de la Vierge Namur5000 Belgium Schloss Birlinghoven Sankt Augustin53754 Germany CERN Geneva 231211 Switzerland Oxford University Computing Laboratory Wolfson Building OxfordOX1 3QD United Kingdom C&C Research Laboratories NEC Europe Ltd. Rathausallee 10 Sankt AugustinD-53757 Germany Medic

ISBN: (纸本)158603510X

Over the last four years, a community of researchers working on Grid and High Performance computing technologies started discussing the barriers and opportunities that grid technologies must face and exploit for the development of health-related applications. This interest lead to the first Healthgrid conference, held in Lyon, France, on January 16th–17th, 2003, with the focus of creating increased awareness about the possibilities and advantages linked to the deployment of grid technologies in health, ultimately targeting the creation of a European/international grid infrastructure for health. The topics of this conference converged with the position of the eHealth division of the European Commission, whose mandate from the Lisbon Meeting was "To develop an intelligent environment that enables ubiquitous management of citizens’ health status, and to assist health professionals in coping with some major challenges, risk management and the integration into clinical practice of advances in health knowledge." In this context "Health" involves not only clinical procedures but covers the whole range of information from molecular level (genetic and proteomic information) over cells and tissues, to the individual and finally the population level (social healthcare). Grid technology offers the opportunity to create a common working backbone for all different members of this large "health family" and will hopefully lead to an increased awareness and interoperability among disciplines. The first HealthGrid conference led to the creation of the Healthgrid association, a non-profit research association legally incorporated in France but formed from the broad community of European researchers and institutions sharing expertise in health grids. After the second Healthgrid conference, held in Clermont-Ferrand on January 29th–30th, 2004, the need for a "white paper" on the current status and prospective of health grids was raised. Over fifty experts from different areas of grid tec

关键词： Health risks

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Harmonized-Multinational qEEG norms (HarMNqEEG)

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NEUROIMAGE 2022年 256卷 119190-119190页

作者： Li, Min Wang, Ying Lopez-Naranjo, Carlos Hu, Shiang Reyes, Ronaldo Cesar Garcia Paz-Linares, Deirel Areces-Gonzalez, Ariosky Hamid, Aini Ismafairus Abd Evans, Alan C. Savostyanov, Alexander N. Calzada-Reyes, Ana Villringer, Arno Tobon-Quintero, Carlos A. Garcia-Agustin, Daysi Yao, Dezhong Dong, Li Aubert-Vazquez, Eduardo Reza, Faruque Razzaq, Fuleah Abdul Omar, Hazim Abdullah, Jafri Malin Galler, Janina R. Ochoa-Gomez, John F. Prichep, Leslie S. Galan-Garcia, Lidice Morales-Chacon, Lilia Valdes-Sosa, Mitchell J. Trondle, Marius Zulkifly, Mohd Faizal Mohd Rahman, Muhammad Riddha Bin Abdul Milakhina, Natalya S. Langer, Nicolas Rudych, Pavel Koenig, Thomas Virues-Alba, Trinidad A. Lei, Xu Bringas-Vega, Maria L. Bosch-Bayard, Jorge F. Valdes-Sosa, Pedro Antonio [a]The Clinical Hospital of Chengdu Brain Science Institute MOE Key Lab for Neuroinformation School of Life Science and Technology University of Electronic Science and Technology of China Chengdu China [b]Cuban Center for Neurocience La Habana Cuba [c]McGill Centre for Integrative Neuroscience Ludmer Centre for Neuroinformatics and Mental Health Montreal Neurological Institute Canada [d]Department of Neurosciences School of Medical Sciences Universiti Sains Malaysia Universiti Sains Malaysia Health Campus Kota Bharu Kelantan 16150 Malaysia [e]Brain and Behaviour Cluster School of Medical Sciences Universiti Sains Malaysia Health Campus Kota Bharu Kelantan 16150 Malaysia [f]Hospital Universiti Sains Malaysia Universiti Sains Malaysia Health Campus Kota Bharu Kelantan 16150 Malaysia [g]Humanitarian Institute Novosibirsk State University Novosibirsk 630090 Russia [h]Laboratory of Psychophysiology of Individual Differences Federal State Budgetary Scientific Institution Scientific Research Institute of Neurosciences and Medicine Novosibirsk 630117 Russia [i]Laboratory of Psychological Genetics at the Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences Novosibirsk 630090 Russia [j]University of Pinar del Río “Hermanos Saiz Montes de Oca” Pinar del Río Cuba [k]Department of Neurology Max Planck Institute for Human Cognitive and Brain Sciences Leipzig Germany [l]Department of Cognitive Neurology University Hospital Leipzig Leipzig Germany [m]Center for Stroke Research Charité-Universitätsmedizin Berlin Berlin Germany [n]Grupo Neuropsicología y Conducta - GRUNECO Faculty of Medicine Universidad de Antioquia Colombia [o]Research Department Institución Prestadora de Servicios de Salud IPS Universitaria Colombia [p]The Cuban center aging longevity and health Havana Cuba [q]Research Unit of NeuroInformation Chinese Academy of Medical Sciences Chengdu 2019RU035 China [r]School of Electrical Engineering Zhengzhou University Zhengzhou 4500

This paper extends frequency domain quantitative electroencephalography (qEEG) methods pursuing higher sensitivity to detect Brain Developmental Disorders. Prior qEEG work lacked integration of cross-spectral information omitting important functional connectivity descriptors. Lack of geographical diversity precluded accounting for site-specific variance, increasing qEEG nuisance variance. We ameliorate these weaknesses. (i) Create lifespan Riemannian multinational qEEG norms for cross-spectral tensors. These norms result from the HarMNqEEG project fostered by the Global Brain Consortium. We calculate the norms with data from 9 countries, 12 devices, and 14 studies, including 1564 subjects. Instead of raw data, only anonymized metadata and EEG cross spectral tensors were shared. After visual and automatic quality control, developmental equations for the mean and standard deviation of qEEG traditional and Riemannian DPs were calculated using additive mixed-effects models. We demonstrate qEEG "batch effects " and provide methods to calculate harmonized z-scores. (ii) We also show that harmonized Riemannian norms produce z-scores with increased diagnostic accuracy predicting brain dysfunction produced by malnutrition in the first year of life and detecting COVID induced brain dysfunction. (iii) We offer open code and data to calculate different individual z-scores from the HarMNqEEG dataset. These results contribute to developing bias-free, low-cost neuroimaging technologies applicable in various health settings.

关键词： Quantitative EEG EEG cross-spectrum Riemannian geometry Batch effects Z-score Harmonization Malnutrition Covid induced brain dysfunction Developmental Brain Chart

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