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Active Fault Diagnosis in Sampled-data systems

IFAC-PapersOnLine 2015年第21期48卷 883-888页

作者： Niemann, Henrik Poulsen, Niels Kjolstad Department of Electrical Engineering Automation and Control Technical University of Denmark Building 326 DK-2800 Kgs. Lyngby Denmark Dept. of Applied Mathematics and Computer Science Section for Dynamical Systems Technical University of Denmark DK-2800 Kgs. Lyngby Denmark

The focus in this paper is on active fault diagnosis (AFD) in closed-loop sampleddata systems. Applying the same AFD architecture as for continuous-time systems does not directly result in the same set of closed-loop matrix transfer functions. For continuous-time systems, the LFT (linear fractional transformation) structure in the connection between the parametric faults and the matrix transfer function (also known as the fault signature matrix) applied for AFD is not directly preserved for sampled-data system. As a consequence of this, the AFD methods cannot directly be applied for sampled-data systems. Two methods are considered in this paper to handle the fault signature matrix for sampled-data systems such that standard AFD methods can be applied. The first method is based on a discretization of the system such that the LFT structure is preserved resulting in the same LFT structure in the fault signature matrix as obtained for continuous-time systems. The other method is an approximation method, where the same structure is obtained for small parametric faults. © 2015

关键词： Continuous time systems

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Noise subtraction from KAGRA O3GK data using Independent Component Analysis

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Classical and Quantum Gravity 2023年第8期40卷 085015-085015页

作者： H Abe T Akutsu M Ando A Araya N Aritomi H Asada Y Aso S Bae Y Bae R Bajpai K Cannon Z Cao E Capocasa M Chan C Chen D Chen K Chen Y Chen C-Y Chiang Y-K Chu S Eguchi M Eisenmann Y Enomoto R Flaminio H K Fong Y Fujii Y Fujikawa Y Fujimoto I Fukunaga D Gao G-G Ge S Ha I P W Hadiputrawan S Haino W-B Han K Hasegawa K Hattori H Hayakawa K Hayama Y Himemoto N Hirata C Hirose T-C Ho B-H Hsieh H-F Hsieh C Hsiung H-Y Huang P Huang Y-C Huang Y-J Huang D C Y Hui S Ide K Inayoshi Y Inoue K Ito Y Itoh C Jeon H-B Jin K Jung P Jung K Kaihotsu T Kajita M Kakizaki M Kamiizumi N Kanda T Kato K Kawaguchi C Kim J Kim J C Kim Y-M Kim N Kimura T Kiyota Y Kobayashi K Kohri K Kokeyama A K H Kong N Koyama C Kozakai J Kume Y Kuromiya S Kuroyanagi K Kwak E Lee H W Lee R Lee M Leonardi K L Li P Li L C -C Lin C-Y Lin E T Lin F-K Lin F-L Lin H L Lin G C Liu L-W Luo M Ma’arif E Majorana Y Michimura N Mio O Miyakawa K Miyo S Miyoki Y Mori S Morisaki N Morisue Y Moriwaki K Nagano K Nakamura H Nakano M Nakano Y Nakayama T Narikawa L Naticchioni L Nguyen Quynh W-T Ni T Nishimoto A Nishizawa S Nozaki Y Obayashi W Ogaki J J Oh K Oh M Ohashi T Ohashi M Ohkawa H Ohta Y Okutani K Oohara S Oshino S Otabe K-C Pan A Parisi J Park F E Pe na Arellano S Saha Y Saito K Sakai T Sawada Y Sekiguchi L Shao Y Shikano H Shimizu K Shimode H Shinkai T Shishido A Shoda K Somiya I Song R Sugimoto J Suresh T Suzuki H Tagoshi H Takahashi R Takahashi S Takano H Takeda M Takeda K Tanaka T Tanaka S Tanioka A Taruya T Tomaru T Tomura L Trozzo T Tsang J-S Tsao S Tsuchida T Tsutsui D Tuyenbayev N Uchikata T Uchiyama A Ueda T Uehara K Ueno G Ueshima T Ushiba M H P M van Putten J Wang T Washimi C Wu H Wu T Yamada K Yamamoto T Yamamoto K Yamashita R Yamazaki Y Yang S Yeh J Yokoyama T Yokozawa T Yoshioka H Yuzurihara S Zeidler M Zhan H Zhang Y Zhao Z-H Zhu The KAGRA Collaboration Graduate School of Science Tokyo Institute of Technology Meguro-ku Tokyo 152-8551 Japan Gravitational Wave Science Project National Astronomical Observatory of Japan (NAOJ) Mitaka City Tokyo 181-8588 Japan Advanced Technology Center National Astronomical Observatory of Japan (NAOJ) Mitaka City Tokyo 181-8588 Japan Department of Physics The University of Tokyo Bunkyo-ku Tokyo 113-0033 Japan Research Center for the Early Universe (RESCEU) The University of Tokyo Bunkyo-ku Tokyo 113-0033 Japan Earthquake Research Institute The University of Tokyo Bunkyo-ku Tokyo 113-0032 Japan Department of Mathematics and Physics Gravitational Wave Science Project Hirosaki University Hirosaki City Aomori 036-8561 Japan Kamioka Branch National Astronomical Observatory of Japan (NAOJ) Kamioka-cho Hida City Gifu 506-1205 Japan The Graduate University for Advanced Studies (SOKENDAI) Mitaka City Tokyo 181-8588 Japan Korea Institute of Science and Technology Information (KISTI) Yuseong-gu Daejeon 34141 Republic of Korea National Institute for Mathematical Sciences Yuseong-gu Daejeon 34047 Republic of Korea School of High Energy Accelerator Science The Graduate University for Advanced Studies (SOKENDAI) Tsukuba City Ibaraki 305-0801 Japan Department of Astronomy Beijing Normal University Beijing 100875 People’s Republic of China Department of Applied Physics Fukuoka University Jonan Fukuoka City Fukuoka 814-0180 Japan Department of Physics Tamkang University Danshui Dist. New Taipei City 25137 Taiwan Department of Physics and Institute of Astronomy National Tsing Hua University Hsinchu 30013 Taiwan Department of Physics Center for High Energy and High Field Physics National Central University Zhongli District Taoyuan City 32001 Taiwan Department of Physics National Tsing Hua University Hsinchu 30013 Taiwan Institute of Physics Academia Sinica Nankang Taipei 11529 Taiwan Univ. Grenoble Alpes Laboratoire d’Annecy de Physique des Particules (LAPP) Université Savoie M

During April 7–21 2020, KAGRA conducted its first scientific observation in conjunction with the GEO600 detector. The dominant noise sources during this run were found to be suspension control noise in the low-frequency range and acoustic noise in the mid-frequency range. In this study, we show that their contributions in the observational data can be reduced by a signal processing method called independent component analysis (ICA). The model of ICA is extended from that studied in the initial KAGRA data analysis to account for frequency dependence, while the linearity and stationarity of the coupling between the interferometer and the noise sources are still assumed. We identify optimal witness sensors in the application of ICA, leading to successful mitigation of these two dominant contributions. We also analyze the stability of the transfer functions for the entire two weeks of data to investigate the applicability of the proposed subtraction method in gravitational wave searches.

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Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

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Nature 2024年第8003期627卷 347-357页

作者： Ken Suzuki Konstantinos Hatzikotoulas Lorraine Southam Henry J Taylor Xianyong Yin Kim M Lorenz Ravi Mandla Alicia Huerta-Chagoya Giorgio E M Melloni Stavroula Kanoni Nigel W Rayner Ozvan Bocher Ana Luiza Arruda Kyuto Sonehara Shinichi Namba Simon S K Lee Michael H Preuss Lauren E Petty Philip Schroeder Brett Vanderwerff Mart Kals Fiona Bragg Kuang Lin Xiuqing Guo Weihua Zhang Jie Yao Young Jin Kim Mariaelisa Graff Fumihiko Takeuchi Jana Nano Amel Lamri Masahiro Nakatochi Sanghoon Moon Robert A Scott James P Cook Jung-Jin Lee Ian Pan Daniel Taliun Esteban J Parra Jin-Fang Chai Lawrence F Bielak Yasuharu Tabara Yang Hai Gudmar Thorleifsson Niels Grarup Tamar Sofer Matthias Wuttke Chloé Sarnowski Christian Gieger Darryl Nousome Stella Trompet Soo-Heon Kwak Jirong Long Meng Sun Lin Tong Wei-Min Chen Suraj S Nongmaithem Raymond Noordam Victor J Y Lim Claudia H T Tam Yoonjung Yoonie Joo Chien-Hsiun Chen Laura M Raffield Bram Peter Prins Aude Nicolas Lisa R Yanek Guanjie Chen Jennifer A Brody Edmond Kabagambe Ping An Anny H Xiang Hyeok Sun Choi Brian E Cade Jingyi Tan K Alaine Broadaway Alice Williamson Zoha Kamali Jinrui Cui Manonanthini Thangam Linda S Adair Adebowale Adeyemo Carlos A Aguilar-Salinas Tarunveer S Ahluwalia Sonia S Anand Alain Bertoni Jette Bork-Jensen Ivan Brandslund Thomas A Buchanan Charles F Burant Adam S Butterworth Mickaël Canouil Juliana C N Chan Li-Ching Chang Miao-Li Chee Ji Chen Shyh-Huei Chen Yuan-Tsong Chen Zhengming Chen Lee-Ming Chuang Mary Cushman John Danesh Swapan K Das H Janaka de Silva George Dedoussis Latchezar Dimitrov Ayo P Doumatey Shufa Du Qing Duan Kai-Uwe Eckardt Leslie S Emery Daniel S Evans Michele K Evans Krista Fischer James S Floyd Ian Ford Oscar H Franco Timothy M Frayling Barry I Freedman Pauline Genter Hertzel C Gerstein Vilmantas Giedraitis Clicerio González-Villalpando Maria Elena González-Villalpando Penny Gordon-Larsen Myron Gross Lindsay A Guare Sophie Hackinger Liisa Hakaste Sohee Han Andrew T Hattersley Christian Herder Momoko Horikoshi Annie-Green Howard Willa Centre for Genetics and Genomics Versus Arthritis Centre for Musculoskeletal Research Division of Musculoskeletal and Dermatological Sciences University of Manchester Manchester UK. Department of Diabetes and Metabolic Diseases Graduate School of Medicine University of Tokyo Tokyo Japan. Department of Statistical Genetics Osaka University Graduate School of Medicine Suita Japan. Institute of Translational Genomics Helmholtz Zentrum München German Research Center for Environmental Health Neuherberg Germany. konstantinos.hatzikotoulas@helmholtz-munich.de. Institute of Translational Genomics Helmholtz Zentrum München German Research Center for Environmental Health Neuherberg Germany. Center for Precision Health Research National Human Genome Research Institute National Institutes of Health Bethesda MD USA. British Heart Foundation Cardiovascular Epidemiology Unit Department of Public Health and Primary Care University of Cambridge Cambridge UK. Heart and Lung Research Institute University of Cambridge Cambridge UK. Department of Epidemiology School of Public Health Nanjing Medical University Nanjing China. Department of Biostatistics and Center for Statistical Genetics University of Michigan Ann Arbor MI USA. Corporal Michael J. Crescenz VA Medical Center Philadelphia PA USA. Department of Systems Pharmacology and Translational Therapeutics University of Pennsylvania Perelman School of Medicine Philadelphia PA USA. Department of Genetics University of Pennsylvania Perelman School of Medicine Philadelphia PA USA. Programs in Metabolism and Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge MA USA. Diabetes Unit and Center for Genomic Medicine Massachusetts General Hospital Boston MA USA. TIMI Study Group Division of Cardiovascular Medicine Brigham and Women's Hospital Harvard Medical School Boston MA USA. William Harvey Research Institute Barts and the London School of Medicine and Dentistry Queen Mary University of London L

Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes and molecular mechanisms that are often specific to cell type. Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases of T2D. We identify 1,289 independent association signals at genome-wide significance (P < 5 × 10) that map to 611 loci, of which 145 loci are, to our knowledge, previously unreported. We define eight non-overlapping clusters of T2D signals that are characterized by distinct profiles of cardiometabolic trait associations. These clusters are differentially enriched for cell-type-specific regions of open chromatin, including pancreatic islets, adipocytes, endothelial cells and enteroendocrine cells. We build cluster-specific partitioned polygenic scores in a further 279,552 individuals of diverse ancestry, including 30,288 cases of T2D, and test their association with T2D-related vascular outcomes. Cluster-specific partitioned polygenic scores are associated with coronary artery disease, peripheral artery disease and end-stage diabetic nephropathy across ancestry groups, highlighting the importance of obesity-related processes in the development of vascular outcomes. Our findings show the value of integrating multi-ancestry genome-wide association study data with single-cell epigenomics to disentangle the aetiological heterogeneity that drives the development and progression of T2D. This might offer a route to optimize global access to genetically informed diabetes care.

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Native diversity buffers against severity of non-native tree invasions ( vol 621,pg 773 , 2023 )

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NATURE 2023年第7982期622卷 E2-E2页

作者： Delavaux, Camille S. Crowther, Thomas W. Zohner, Constantin M. Robmann, Niamh M. Lauber, Thomas van den Hoogen, Johan Kuebbing, Sara Liang, Jingjing de-Miguel, Sergio Nabuurs, Gert-Jan Reich, Peter B. Abegg, Meinrad Yao, Yves C. Adou Alberti, Giorgio Zambrano, Angelica M. Almeyda Alvarado, Braulio Vilchez Alvarez-Davila, Esteban Alvarez-Loayza, Patricia Alves, Luciana F. Ammer, Christian Anton-Fernandez, Clara Araujo-Murakami, Alejandro Arroyo, Luzmila Avitabile, Valerio Aymard, Gerardo A. Baker, Timothy R. Balazy, Radomir Banki, Olaf Barroso, Jorcely G. Bastian, Meredith L. Bastin, Jean-Francois Birigazzi, Luca Birnbaum, Philippe Bitariho, Robert Boeckx, Pascal Bongers, Frans Bouriaud, Olivier Brancalion, Pedro H. S. Brandl, Susanne Brienen, Roel Broadbent, Eben N. Bruelheide, Helge Bussotti, Filippo Gatti, Roberto Cazzolla Cesar, Ricardo G. Cesljar, Goran Chazdon, Robin Chen, Han Y. H. Chisholm, Chelsea Cho, Hyunkook Cienciala, Emil Clark, Connie Clark, David Colletta, Gabriel D. Coomes, David A. Valverde, Fernando Cornejo Corral-Rivas, Jose J. Crim, Philip M. Cumming, Jonathan R. Dayanandan, Selvadurai de Gasper, Andre L. Decuyper, Mathieu Derroire, Geraldine DeVries, Ben Djordjevic, Ilija Dolezal, Jiri Dourdain, Aurelie Obiang, Nestor Laurier Engone Enquist, Brian J. Eyre, Teresa J. Fandohan, Adande Belarmain Fayle, Tom M. Feldpausch, Ted R. Ferreira, Leandro V. Fischer, Markus Fletcher, Christine Frizzera, Lorenzo Gamarra, Javier G. P. Gianelle, Damiano Glick, Henry B. Harris, David J. Hector, Andrew Hemp, Andreas Hengeveld, Geerten Herault, Bruno Herbohn, John L. Herold, Martin Hillers, Annika Coronado, Euridice N. Honorio Hui, Cang Ibanez, Thomas T. Amaral, Ieda Imai, Nobuo Jagodzinski, Andrzej M. Jaroszewicz, Bogdan Johannsen, Vivian Kvist Joly, Carlos A. Jucker, Tommaso Jung, Ilbin Karminov, Viktor Kartawinata, Kuswata Kearsley, Elizabeth Kenfack, David Kennard, Deborah K. Kepfer-Rojas, Sebastian Keppel, Gunnar Khan, Mohammed Latif Killeen, Timothy J. Kim, Hyun Seok Kitayama, Kanehiro Kohl, Michael Korju Institute of Integrative Biology ETH Zurich (Swiss Federal Institute of Technology) Zurich Switzerland Department of Genetics Evolution and Environment University College London London UK The Forest School at The Yale School of the Environment Yale University New Haven CT USA Department of Forestry and Natural Resources Purdue University West Lafayette IN USA Department of Agriculture Forestry and Bioresources Seoul National University Seoul South Korea Department of Crop and Forest Sciences University of Lleida Lleida Spain Joint Research Unit CTFC–AGROTECNIO–CERCA Solsona Spain Wageningen University and Research Wageningen The Netherlands World Agroforestry (ICRAF) Nairobi Kenya Department of Forest Resources University of Minnesota St Paul MN USA Hawkesbury Institute for the Environment Western Sydney University Penrith New South Wales Australia Institute for Global Change Biology and School for Environment and Sustainability University of Michigan Ann Arbor MI USA Swiss Federal Institute for Forest Snow and Landscape Research WSL Birmensdorf Switzerland UFR Biosciences University Félix Houphouët-Boigny Abidjan Côte d’Ivoire Department of Agricultural Food Environmental and Animal Sciences University of Udine Udine Italy Faculty of Science and Technology Free University of Bolzano Bolzano Italy Spatial Ecology and Conservation Laboratory Department of Tourism Recreation and Sport Management University of Florida Gainesville FL USA Forestry School Tecnológico de Costa Rica TEC Cartago Costa Rica Fundacion ConVida Universidad Nacional Abierta y a Distancia UNAD Medellin Colombia Field Museum of Natural Histiory Chicago IL USA Center for Tropical Research Institute of the Environment and Sustainability UCLA Los Angeles CA USA Silviculture and Forest Ecology of the Temperate Zones University of Göttingen Göttingen Germany Division of Forest and Forest Resources Norwegian Institute of Bioeconomy Research (NIBIO) Ås Norway Museo de Hi

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Global investments in pandemic preparedness and COVID-19: development assistance and domestic spending on health between 1990 and 2026

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The Lancet Global Health 2023年第3期11卷 e385-e413页

作者： Micah, Angela E. Bhangdia, Kayleigh Cogswell, Ian E. Lasher, Dylan Lidral-Porter, Brendan Maddison, Emilie R. Nguyen, Trang Nhu Ngoc Patel, Nishali Pedroza, Paola Solorio, Juan Stutzman, Hayley Tsakalos, Golsum Wang, Yifeng Warriner, Wesley Zhao, Yingxi Zlavog, Bianca S. Abbafati, Cristiana Abbas, Jaffar Abbasi-Kangevari, Mohsen Abbasi-Kangevari, Zeinab Abdelmasseh, Michael Abdulah, Deldar Morad Abedi, Aidin Abegaz, Kedir Hussein Abhilash, E.S. Aboagye, Richard Gyan Abolhassani, Hassan Abrigo, Michael R.M. Abubaker Ali, Hiwa Abu-Gharbieh, Eman Adem, Mohammed Hussien Afzal, Muhammad Sohail Ahmadi, Ali Ahmed, Haroon Ahmed Rashid, Tarik Aji, Budi Akbarialiabad, Hossein Akelew, Yibeltal Al Hamad, Hanadi Alam, Khurshid Alanezi, Fahad Mashhour Alanzi, Turki M. Al-Hanawi, Mohammed Khaled Alhassan, Robert Kaba Aljunid, Syed Mohamed Almustanyir, Sami Al-Raddadi, Rajaa M. Alvis-Guzman, Nelson Alvis-Zakzuk, Nelson J. Amare, Azmeraw T. Ameyaw, Edward Kwabena Amini-Rarani, Mostafa Amu, Hubert Ancuceanu, Robert Andrei, Tudorel Anwar, Sumadi Lukman Appiah, Francis Aqeel, Muhammad Arabloo, Jalal Arab-Zozani, Morteza Aravkin, Aleksandr Y. Aremu, Olatunde Aruleba, Raphael Taiwo Athari, Seyyed Shamsadin Avila-Burgos, Leticia Ayanore, Martin Amogre Azari, Samad Baig, Atif Amin Bantie, Abere Tilahun Barrow, Amadou Baskaran, Pritish Basu, Sanjay Batiha, Abdul-Monim Mohammad Baune, Bernhard T. Berezvai, Zombor Bhardwaj, Nikha Bhardwaj, Pankaj Bhaskar, Sonu Boachie, Micheal Kofi Bodolica, Virginia Botelho, João Silva Botelho Braithwaite, Dejana Breitborde, Nicholas J.K. Busse, Reinhard Cahuana-Hurtado, Lucero Catalá-López, Ferrán Chansa, Collins Charan, Jaykaran Chattu, Vijay Kumar Chen, Simiao Chukwu, Isaac Sunday Dadras, Omid Dandona, Lalit Dandona, Rakhi Dargahi, Abdollah Debela, Sisay Abebe Denova-Gutiérrez, Edgar Desye, Belay Dharmaratne, Samath Dhamminda Diao, Nancy Doan, Linh Phuong Dodangeh, Milad dos Santos, Wendel Mombaque Doshmangir, Leila Dube, John Eini, Ebrahim El Sayed Zaki, Maysaa El Tantawi, Maha Enyew, Daniel Berhanie Institute for Health Metrics and Evaluation University of Washington Seattle WA United States Department of Applied Mathematics University of Washington Seattle WA United States Department of Health Metrics Sciences School of Medicine University of Washington Seattle WA United States Nuffield Department of Medicine University of Oxford Oxford United Kingdom Department of Juridical and Economic Studies La Sapienza University Rome Italy Antai College of Economics Shanghai Jiao Tong University Shanghai China Non-communicable Diseases Research Center Tehran University of Medical Sciences Tehran Iran Research Center for Immunodeficiencies Tehran University of Medical Sciences Tehran Iran Multiple Sclerosis Research Center Tehran University of Medical Sciences Tehran Iran Children’s Medical Center Tehran University of Medical Sciences Tehran Iran Department of Epidemiology and Biostatistics Tehran University of Medical Sciences Tehran Iran Tehran Heart Center Tehran University of Medical Sciences Tehran Iran Faculty of Medicine Tehran University of Medical Sciences Tehran Iran National Institute for Health Research Tehran University of Medical Sciences Tehran Iran Department of Pharmacology Tehran University of Medical Sciences Tehran Iran Department of Cardiology Tehran University of Medical Sciences Tehran Iran Sina Trauma and Surgery Research Center Tehran University of Medical Sciences Tehran Iran Digestive Diseases Research Institute Tehran University of Medical Sciences Tehran Iran Department of Neurology Tehran University of Medical Sciences Tehran Iran Social Determinants of Health Research Center Shahid Beheshti University of Medical Sciences Tehran Iran Department of Epidemiology Shahid Beheshti University of Medical Sciences Tehran Iran Department of Health Economics and Statistics Shahid Beheshti University of Medical Sciences Tehran Iran Department of Neurosurgery Shahid Beheshti University of Medical Sciences Tehran Iran Ophthalmic R

Background: The COVID-19 pandemic highlighted gaps in health surveillance systems, disease prevention, and treatment globally. Among the many factors that might have led to these gaps is the issue of the financing of national health systems, especially in low-income and middle-income countries (LMICs), as well as a robust global system for pandemic preparedness. We aimed to provide a comparative assessment of global health spending at the onset of the pandemic;characterise the amount of development assistance for pandemic preparedness and response disbursed in the first 2 years of the COVID-19 pandemic;and examine expectations for future health spending and put into context the expected need for investment in pandemic preparedness. Methods: In this analysis of global health spending between 1990 and 2021, and prediction from 2021 to 2026, we estimated four sources of health spending: development assistance for health (DAH), government spending, out-of-pocket spending, and prepaid private spending across 204 countries and territories. We used the Organisation for Economic Co-operation and Development (OECD)'s Creditor Reporting System (CRS) and the WHO Global Health Expenditure Database (GHED) to estimate spending. We estimated development assistance for general health, COVID-19 response, and pandemic preparedness and response using a keyword search. Health spending estimates were combined with estimates of resources needed for pandemic prevention and preparedness to analyse future health spending patterns, relative to need. Findings: In 2019, at the onset of the COVID-19 pandemic, US$9·2 trillion (95% uncertainty interval [UI] 9·1–9·3) was spent on health worldwide. We found great disparities in the amount of resources devoted to health, with high-income countries spending $7·3 trillion (95% UI 7·2–7·4) in 2019;293·7 times the $24·8 billion (95% UI 24·3–25·3) spent by low-income countries in 2019. That same year, $43·1 billion in development assistance was provided

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The competitive nature of STAT complex formation drives phenotype switching of T cells

arXiv

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arXiv 2017年

作者： Sadreev, Ildar I. Chen, Michael Z.Q. Umezawa, Yoshinori Biktashev, Vadim N. Kemper, Claudia Salakhieva, Diana V. Welsh, Gavin I. Kotov, Nikolay V. Centre for Systems Dynamics and Control College of Engineering Mathematics and Physical Sciences University of Exeter Harrison Building North Park Road ExeterEX4 4QF United Kingdom Section of Experimental Haematology Leeds Institute of Cancer and Pathology University of Leeds Leeds United Kingdom Department of Mechanical Engineering University of Hong Kong Pokfulam Road Hong Kong Department of Dermatology Jikei University School of Medicine 3-25-8 Nishishimbashi Minato-ku Tokyo105-8461 Japan Division of Transplantation Immunology and Mucosal Biology MRC Centre for Transplantation King's College London Guy's Hospital LondonSE1 9RT United Kingdom Federal University 18 Kremlyovskaya St. Kazan420008 Russia Bristol Renal School of Clinical Sciences University of Bristol Dorothy Hodgkin Building Whitson Street BristolBS1 3NY United Kingdom Biophysics & Bionics Lab Institute of Physics Kazan Federal University Kazan420008 Russia

Signal transducers and activators of transcription (STATs) are key molecular determinants of T cell fate and effector function. A number of inflammatory diseases are characterized by an altered balance of T cell phenotypes and cytokine secretion. STATs, therefore, represent viable therapeutic targets in numerous pathologies. However, the underlying mechanisms of how the same STAT proteins regulate both the development of different T cell phenotypes and their plasticity during changes in extracellular conditions remain unclear. In this study, we investigated the STAT mediated regulation of T cell phenotype formation and plasticity using mathematical modeling and experimental data for intracellular STAT signaling proteins. The close fit of our model predictions to the experimental data allows us to propose a potential mechanism for T cell switching. According to this mechanism, T cell phenotype switching is due to the relative redistribution of STAT dimer complexes caused by the extracellular cytokine-dependent STAT competition effects. The developed model predicts that the balance between the intracellular STAT species defines the amount of the produced cytokines and thereby T cell phenotypes. The model predictions are consistent with the experimentally observed IFN-γ to IL-10 switching that regulates human Th1/Tr1 responses. The proposed model is applicable to a number of STAT signaling circuits. Copyright © 2017, The Authors. All rights reserved.

关键词： T-cells

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Active fault diagnosis in sampled-data systems 9

Active fault diagnosis in sampled-data systems

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9th IFAC Symposium on Fault Detection, Supervision and Safety for Technical Processes, SAFEPROCESS 2015

作者： Niemann, Henrik Poulsen, Niels Kjølstad Department of Electrical Engineering Automation and Control Technical University of Denmark Building 326 Kgs. LyngbyDK-2800 Denmark Dept. of Applied Mathematics and Computer Science Section for Dynamical Systems Technical University of Denmark Kgs. LyngbyDK-2800 Denmark

关键词： Continuous time systems

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Evaluation of the fine fraction content using electrical logging method

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AIJ Journal of Technology and Design 2015年第48期21卷 557-562页

作者： Gao, Yuanhao Fujii, Mamoru Mochida, Yasuhide Takechi, Kotaro Adachi, Yukio Graduate School of Earth and Environmental Science Course of Earth and Environmental Science Tokai Univ. Japan Dept. of Architecture and Building Engineering Tokai Univ. Japan Dept. of Architecture and Urban Design Ritsumeikan Univ. Japan Ground Analysis Section Japan Home Shield Co. Ltd. Japan Control Systems Division Nitto Seiko Co. Ltd. Japan

SWS test is widely used as a research method to evaluate the residential sites. Advantage of SWS test is possible to evaluate the bearing capacity of residential sites. On the other hand, a disadvantage of SWS test is to determine soil and groundwater level. Suppose that if it is possible incorporate the determination method of the soil by electrical resistivity using SWS test holes, a lot of information will be gained. As an ideal way, the electrical logging method by the electrode to the SWS test hole, is effective. Based on the above background, it was cleared that the evaluation of fine fraction content of soil was possible by electrical resistivity from the laboratory test. And the estimation equation was completed. In this study, field experiments of the six sites were performed to confirm the accuracy of the estimation equation from the laboratory test.

关键词： Soils

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Bus Priority System Using Radio Frequency Identification (RFID) Detection in Singapore

Bus Priority System Using Radio Frequency Identification (RF...

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2015年南京第十四届亚太智能交通论坛

作者： Tatsuya Higuchi Lincoln Tan Musthafa Ibrahim Joanne Cheong Traffic Control Systems Engineering Section Electronic Control Technology Department ICT Solution He Traffic Control & Transportation Division Mitsubishi Heavy Industries Engine System Asia Pie LtdSin Intelligent Transport Systems Development Land Transport AuthoritySingapore City219428Singapore

Making public transport a choice mode is one of the three key strategic thrusts listed in Land Transport Master Plan (LTMP) *** achieve that, it is important to make the public transport system attractive for use by the *** of such application identified is to provide signal priority for busses at traffic light *** scan and assessment of various detection technologies have indicated that RFID is the appropriate, open standards and economical technology for the bus *** is a wireless non-contact system that uses radio-frequency electromagnetic fields to transfer data from a tag attached to an object, for the purposes of automatic identification and *** tags has been widely used in various industries, including transportation for payment services such as for transit fares, highway tolls and parking fares, as well as in the areas of vehicle identification and access control in many *** the cost of RFID tags has decreased significantly over time, its detection capability has also improved to allow longer range *** this, a concerted initiative between the local authorities and the industry to conduct a technical trial for traffic light priority for buses using radio frequency identification technology (RFID) was executed at selected test locations in *** paper discusses on the technical trial conducted to assess the accuracy and reliability of Bus Priority System using RFID in providing traffic light priority for buses in Singapore.

关键词： ITS signal priority technical trial radio frequency identification

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Radiative Cooling of the Thermally Isolated System in KAGRA Gravitational Wave Telescope

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Journal of Physics: Conference Series 2021年第1期1857卷

作者： T. Akutsu M. Ando K. Arai Y. Arai S. Araki A. Araya N. Aritomi Y. Aso S.-W. Bae Y.-B. Bae L. Baiotti R. Bajpai M. A. Barton K. Cannon E. Capocasa M.-L. Chan C.-S. Chen K.-H. Chen Y.-R. Chen H.-Y. Chu Y.-K. Chu S. Eguchi Y. Enomoto R. Flaminio Y. Fujii M. Fukunaga M. Fukushima G.-G. Ge A. Hagiwara S. Haino K. Hasegawa H. Hayakawa K. Hayama Y. Himemoto Y. Hiranuma N. Hirata E. Hirose Z. Hong B.-H. Hsieh G.-Z. Huang P.-W. Huang Y.-J. Huang B. Ikenoue S. Imam K. Inayoshi Y. Inoue K. Ioka Y. Itoh K. Izumi K. Jung P. Jung T. Kajita M. Kamiizumi N. Kanda G.-W. Kang K. Kawaguchi N. Kawai T. Kawasaki C. Kim J. Kim W. Kim Y.-M. Kim N. Kimura N. Kita H. Kitazawa Y. Kojima K. Kokeyama K. Komori A. K. H. Kong K. Kotake C. Kozakai R. Kozu R. Kumar J. Kume C.-M. Kuo H.-S. Kuo S. Kuroyanagi K. Kusayanagi K. Kwak H.-K. Lee H.-W. Lee R.-K. Lee M. Leonardi C.-Y. Lin F.-L. Lin L. C.-C. Lin G.-C. Liu L.-W. Luo M. Marchio Y. Michimura N. Mio O. Miyakawa A. Miyamoto Y. Miyazaki K. Miyo S. Miyoki S. Morisaki Y. Moriwaki K. Nagano S. Nagano K. Nakamura H. Nakano M. Nakano R. Nakashima T. Narikawa R. Negishi W.-T. Ni A. Nishizawa Y. Obuchi W. Ogaki J. J. Oh S.-H. Oh M. Ohashi N. Ohishi M. Ohkawa K. Okutomi K. Oohara C.-P. Ooi S. Oshino K.-C. Pan H.-F. Pang J. Park F. E. Peiia Arellano I. Pinto N. Sago S. Saito Y. Saito K. Sakai Y. Sakai Y. Sakuno S. Sato T. Sato T. Sawada T. Sekiguchi Y. Sekiguchi S. Shibagaki R. Shimizu T. Shimoda K. Shimode H. Shinkai T. Shishido A. Shoda K. Somiya E. J. Son H. Sotani R. Sugimoto T. Suzuki H. Tagoshi H. Takahashi R. Takahashi A. Takamori S. Takano H. Takeda M. Takeda H. Tanaka K. Tanaka T. Tanaka S. Tanioka E. N. Tapia San Martin S. Telada T. Tomaru Y. Tomigami T. Tomura F. Travasso L. Trozzo T. T. L. Tsang K. Tsubono S. Tsuchida T. Tsuzuki D. Tuyenbayev N. Uchikata T. Uchiyama A. Ueda T. Uehara K. Ueno G. Ueshima F. Uraguchi T. Ushiba M. H. P. M. van Putten H. Vocca J. Wang C.-M. Wu H.-C. Wu S.-R. Wu W.-R. Xu T. Yamada K. Yamamoto T. Yamamoto K. Yokogawa J. Yokoyama T. Yokozawa T. Yoshioka H. Yuzurihar National Astronomical Observatory of Japan (NAOJ) 2-21-1 Osawa Mitaka-City Tokyo 181-8588 Japan Research Center for the Early Universe (RESCEU) The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-0033 Japan Department of Physics The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-0033 Japan Institute for Cosmic Ray Research (ICRR) The University of Tokyo 5-1-5 Kashiwa-no-Ha Kashiwa-City Chiba 277-8582Japan Accelerator Laboratory High Energy Accelerator Research Organization (KEK) 1-1 OhoTsukuba-City Ibaraki 305-0801 Japan Earthquake Research Institute The University of Tokyo 1-1-1Yayoi Bunkyo-ku Tokyo 113-0032Japan Kamioka Branch National Astronomical Observatory of Japan (NAOJ) 238 Higashi-Mozumi Kamioka-cho Hida-City Gifu Pref. Japan The Graduate University for Advanced Studies (SOKENDAI) 2-21-1 Osawa Mitaka-City Tokyo 181-8588 Japan Korea Institute of Science and Technology Information (KISTI) 245 Daehak-ro Yuseong-gu Daejeon 34141 South Korea National Institute for Mathematical Sciences 70 Yuseong-daero 1689 beon-gil Yuseong-gu Daejeon 34047 South Korea Graduate School of Science Osaka University 1-1 Machikaneyama-cho Toyonaka-City Osaka560-0043 Japan School of High Energy Accelerator Science The Graduate University for Advanced Studies (SOKENDAI) 1-1 Oho Tsukuba-City Ibaraki 305-0801 Japan Institute for Gravitational Research University of Glasgow Kelvin Building G12 8QQ UK Department of Applied Physics Fukuoka University Fukuoka Jonan Nanakuma 814-0180 Japan Department of Physics Tamkang university No.151 Yingzhuan Rd. Danshui Dist. New Taipei-City 25137 Taiwan Department of Physics the Center for High Energy and High Field Physics National Central University No. 300 Zhongda Road Zhongyi District Taiyuan-City 320 Taiwan Institute of Astronomy National Tsing Hua University No. 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan Department of Physics National Tsing Hua University No. 101 Section 2

Radiative cooling of the thermally isolated system is investigated in KAGRA gravitational wave telescope. KAGRA is a laser interferometer-based detector and main mirrors constituting optical cavities are cool down to 20K to reduce noises caused by the thermal fluctuation. The mirror is suspended with the multi-stage pendulum to isolate any vibration. Therefore, this mirror suspension system has few heat links to reduce vibration injection. Thus, this system is mainly cooled down with thermal radiation. In order to understand the process of radiative cooling of the mirror, we analyzed cooling curve based on mass and specific heat. As a result, it was newly found that a cryogenic part called 'cryogenic duct-shield' seems to have large contribution in the beginning of the mirror cooling. This finding will help to design new cooling system for the next generation cryogenic gravitational wave detector.

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