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The evolutionary history of 2,658 cancers (vol 578, pg 122, 2020)

NATURE 2023年第7948期614卷 E42-E42页

作者： Gerstung, Moritz Jolly, Clemency Leshchiner, Ignaty Dentro, Stefan C. Gonzalez, Santiago Rosebrock, Daniel Mitchell, Thomas J. Rubanova, Yulia Anur, Pavana Yu, Kaixian Tarabichi, Maxime Deshwar, Amit Wintersinger, Jeff Kleinheinz, Kortine Vazquez-Garcia, Ignacio Haase, Kerstin Jerman, Lara Sengupta, Subhajit Macintyre, Geoff Malikic, Salem Donmez, Nilgun Livitz, Dimitri G. Cmero, Marek Demeulemeester, Jonas Schumacher, Steven Fan, Yu Yao, Xiaotong Lee, Juhee Schlesner, Matthias Boutros, Paul C. Bowtell, David D. Zhu, Hongtu Getz, Gad Imielinski, Marcin Beroukhim, Rameen Sahinalp, S. Cenk Ji, Yuan Peifer, Martin Markowetz, Florian Mustonen, Ville Yuan, Ke Wang, Wenyi Morris, Quaid D. Spellman, Paul T. Wedge, David C. Van Loo, Peter European Molecular Biology Laboratory European Bioinformatics Institute (EMBL-EBI) Cambridge UK European Molecular Biology Laboratory Genome Biology Unit Heidelberg Germany Wellcome Sanger Institute Cambridge UK Genome Biology Unit European Molecular Biology Laboratory (EMBL) Heidelberg Germany University of Ljubljana Ljubljana Slovenia The Francis Crick Institute London UK Big Data Institute University of Oxford Oxford UK Wellcome Sanger Institute Wellcome Genome Campus Hinxton UK Big Data Institute Li Ka Shing Centre University of Oxford Oxford UK University of Cambridge Cambridge UK Cambridge University Hospitals NHS Foundation Trust Cambridge UK Department of Applied Mathematics and Theoretical Physics Centre for Mathematical Sciences University of Cambridge Cambridge UK Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center New York NY USA Department of Statistics Columbia University New York NY USA Department of Haematology University of Cambridge Cambridge UK University of Leuven Leuven Belgium Broad Institute of MIT and Harvard Cambridge MA USA Center for Cancer Research Massachusetts General Hospital Charlestown MA USA Department of Pathology Massachusetts General Hospital Boston MA USA Harvard Medical School Boston MA USA Center for Cancer Research Massachusetts General Hospital Boston MA USA Dana-Farber Cancer Institute Boston MA USA Department of Medical Oncology Dana-Farber Cancer Institute Boston MA USA Department of Cancer Biology Dana-Farber Cancer Institute Boston MA USA Oxford NIHR Biomedical Research Centre Oxford UK Oxford NIHR Biomedical Research Centre University of Oxford Oxford UK University of Toronto Toronto Ontario Canada Vector Institute Toronto Ontario Canada Vector Institute Toronto ON Canada Department of Computer Science University of Toronto Toronto ON Canada Ontario Institute for Cancer Research Toronto Ontario Canada University of California Los Angeles

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Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

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Nature communications 2025年第1期16卷 4235-4235页

作者： Cecilia Anza-Ramirez J. Jaime Miranda Benedetta Armocida Jorge César Correia Harriette Gillian Christine Van Spall David Beran Amirali Aali Kalkidan Hassen Abate Semagn Mekonnen Abate Cristiana Abbafati Mohsen Abbasi-Kangevari Zeinab Abbasi-Kangevari Zahra Aryan Sina Azadnajafabad Mohammadreza Azangou-Khyavy Seyyed-Hadi Ghamari Mohammad Keykhaei Javad Khanali Sara Momtazmanesh Fateme Montazeri Shayan Rahmani Mohammad-Mahdi Rashidi Nazila Rezaei Negar Rezaei Sahar Saeedi Moghaddam Hossein Hassanian-Moghaddam Ali-Asghar Kolahi Ali Nikoobar Hedayat Abbastabar Ahmed M. Abdel-Azeem Michael Abdelmasseh Juan Sanabria Sherief Abd-Elsalam Ahmed Abdelwahab Gholamreza Abdoli Mohammad Abdollahi Meriem Abdoun Deldar Morad Abdulah Abu Yousuf Md Abdullah Ame Mehadi Abdurehman Getachew Abebe Aidin Abedi Chirag P. Doshi Vida Abedi Hassan Abidi Richard Gyan Aboagye Hassan Abolhassani Nima Rezaei Lucas Guimarães Abreu Michael R. M. Abrigo Yonas Derso Abtew Hiwa Abubaker Ali Eman Abu-Gharbieh Hiba Jawdat Barqawi Rabih Halwani Maha Mohamed Saber-Ayad Iman M. Talaat Ahmed Abu-Zaid Manfred Mario Kokou Accrombessi Juan Manuel Acuna Denberu Eshetie Adane Tigist Demssew Adane Isaac Yeboah Addo Giovanni Addolorato Oluwafemi Atanda Adeagbo Victor Adekanmbi Miracle Ayomikun Adesina Isaac Iyinoluwa Olufadewa Olatunji O. Adetokunboh Daniel Adedayo Adeyinka Qorinah Estiningtyas Sakilah Adnani Aanuoluwapo Adeyimika Afolabi Olayinka Stephen Ilesanmi Muhammad Sohail Afzal Saira Afzal Gina Agarwal Prerna Agarwal Pradyumna Agasthi Anurag Agrawal Marcela Agudelo-Botero Adolfo Martinez-Valle Bright Opoku Ahinkorah Aqeel Ahmad Sajjad Ahmad Sohail Ahmad Tauseef Ahmad Ali Ahmadi Siamak Sabour Keivan Ahmadi Sanjay Basu Sepideh Ahmadi Ali Ahmed Shaun Wen Huey Lee Ayman Ahmed Haroon Ahmed Jivan Qasim Ahmed Gahin Abdulraheem Tayib Yahya Yahya Luai A. Ahmed Iffat Elbarazi Syed Mahboob Shah Janardhana P. Aithala Marjan Ajami Budi Aji Hossein Akbarialiabad Yibeltal Akelew Meisam Akhlaghdoust Elham Jamshidi Addis Aklilu Azene Tesfaye Melat Woldemariam Maxwell Ak CRONICAS Center of Excellence in Chronic Diseases Universidad Peruana Cayetano Heredia Lima Peru School of Medicine Universidad Peruana Cayetano Heredia Lima Peru Sydney School of Public Health Faculty of Medicine and Health University of Sydney Sydney NSW Australia Faculty of Epidemiology and Population Health London School of Hygiene & Tropical Medicine London UK Division of Tropical and Humanitarian Medicine University of Geneva Geneva Switzerland Department of Cardiovascular Endocrine-metabolic Diseases and Aging Istituto Superiore di Sanità Rome Italy Division of Endocrinology Diabetology Nutrition and Therapeutic Patient Education Department of Medicine Geneva University Hospitals Geneva Switzerland Department of Medicine and Department of Health Research Evidence and Impact McMaster University Hamilton ON Canada Research Institute of St. Joe’s Hamilton ON Canada Population Health Research Institute Hamilton Canada Geneva University Hospitals Geneva Switzerland Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran Department of Nutrition and Dietetics Jimma University Jimma Ethiopia Anesthesiology Department Dilla University Addis Ababa Ethiopia Department of Juridical and Economic Studies La Sapienza University Rome Italy Non-Communicable Diseases Research Center Tehran University of Medical Sciences Tehran Iran Social Determinants of Health Research Center Shahid Beheshti University of Medical Sciences Tehran Iran Brigham and Women’s Hospital Harvard University Boston MA USA Students’ Scientific Research Center (SSRC) Tehran University of Medical Sciences Tehran Iran School of Medicine Tehran University of Medical Sciences Tehran Iran School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran Endocrinology and Metabolism Research Institute Tehran University of Medical Sciences Tehran Iran Chapter of Addiction Medicine University of Sydney Sydney NSW Australia Advanced Diagnostic and Intervent

Chronic care manages long-term, progressive conditions, while acute care addresses short-term conditions. Chronic conditions increasingly strain health systems, which are often unprepared for these demands. This study examines the burden of conditions requiring acute versus chronic care, including sequelae. Conditions and sequelae from the Global Burden of Diseases Study 2019 were classified into acute or chronic care categories. Data were analysed by age, sex, and socio-demographic index, presenting total numbers and contributions to burden metrics such as Disability-Adjusted Life Years (DALYs), Years Lived with Disability (YLD), and Years of Life Lost (YLL). Approximately 68% of DALYs were attributed to chronic care, while 27% were due to acute care. Chronic care needs increased with age, representing 86% of YLDs and 71% of YLLs, and accounting for 93% of YLDs from sequelae. These findings highlight that chronic care needs far exceed acute care needs globally, necessitating health systems to adapt accordingly. © 2025. The Author(s).

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Publisher Correction: A genome-wide association analysis reveals new pathogenic pathways in gout

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Nature genetics 2024年第11期56卷 2577页

作者： Tanya J Major Riku Takei Hirotaka Matsuo Megan P Leask Nicholas A Sumpter Ruth K Topless Yuya Shirai Wei Wang Murray J Cadzow Amanda J Phipps-Green Zhiqiang Li Aichang Ji Marilyn E Merriman Emily Morice Eric E Kelley Wen-Hua Wei Sally P A McCormick Matthew J Bixley Richard J Reynolds Kenneth G Saag Tayaza Fadason Evgenia Golovina Justin M O'Sullivan Lisa K Stamp Nicola Dalbeth Abhishek Abhishek Michael Doherty Edward Roddy Lennart T H Jacobsson Meliha C Kapetanovic Olle Melander Mariano Andrés Fernando Pérez-Ruiz Rosa J Torres Timothy Radstake Timothy L Jansen Matthijs Janssen Leo A B Joosten Ruiqi Liu Orsolya I Gaal Tania O Crişan Simona Rednic Fina Kurreeman Tom W J Huizinga René Toes Frédéric Lioté Pascal Richette Thomas Bardin Hang Korng Ea Tristan Pascart Geraldine M McCarthy Laura Helbert Blanka Stibůrková Anne-K Tausche Till Uhlig Véronique Vitart Thibaud S Boutin Caroline Hayward Philip L Riches Stuart H Ralston Archie Campbell Thomas M MacDonald Akiyoshi Nakayama Tappei Takada Masahiro Nakatochi Seiko Shimizu Yusuke Kawamura Yu Toyoda Hirofumi Nakaoka Ken Yamamoto Keitaro Matsuo Nariyoshi Shinomiya Kimiyoshi Ichida Chaeyoung Lee Linda A Bradbury Matthew A Brown Philip C Robinson Russell R C Buchanan Catherine L Hill Susan Lester Malcolm D Smith Maureen Rischmueller Hyon K Choi Eli A Stahl Jeff N Miner Daniel H Solomon Jing Cui Kathleen M Giacomini Deanna J Brackman Eric M Jorgenson Hongbo Liu Katalin Susztak Suyash Shringarpure Alexander So Yukinori Okada Changgui Li Yongyong Shi Tony R Merriman Department of Biochemistry University of Otago Dunedin New Zealand. Division of Clinical Immunology and Rheumatology University of Alabama at Birmingham Birmingham AL USA. Department of Integrative Physiology and Bio-Nano Medicine National Defense Medical College Saitama Japan. Department of Biomedical Information Management National Defense Medical College Research Institute National Defense Medical College Saitama Japan. Department of Statistical Genetics Osaka University Graduate School of Medicine Osaka Japan. Genomics R&D 23andMe Inc Sunnyvale CA USA. The Biomedical Sciences Institute and The Affiliated Hospital of Qingdao University Qingdao University Qingdao Shandong China. Shandong Provincial Key Laboratory of Metabolic Diseases Shandong Provincial Clinical Research Center for Immune Diseases and Gout the Affiliated Hospital of Qingdao University Qingdao Shandong China. The Institute of Metabolic Diseases Qingdao University Qingdao Shandong China. Department of Physiology and Pharmacology West Virginia University Morgantown WV USA. Department of Women's and Children's Health University of Otago Dunedin New Zealand. Liggins Institute University of Auckland Auckland New Zealand. MRC Lifecourse Epidemiology Unit University of Southampton Southampton United Kingdom. Singapore Institute for Clinical Sciences Agency for Science Technology and Research Singapore Singapore. Australian Parkinsons Mission Garvan Institute of Medical Research Sydney New South Wales Australia. Department of Medicine University of Otago Christchurch Christchurch New Zealand. Department of Medicine University of Auckland Auckland New Zealand. Academic Rheumatology School of Medicine University of Nottingham Nottingham United Kingdom. School of Medicine Keele University Keele Staffordshire United Kingdom. Haywood Academic Rheumatology Centre Midlands Partnership University NHS Foundation Trust Stoke-on-Trent UK. Department of Rheumatology and Inflammation Research

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Author Correction: Genomic footprints of activated telomere maintenance mechanisms in cancer (Dec, 10.1038/s41467-019-13824-9, 2022)

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NATURE COMMUNICATIONS 2022年第1期13卷 1页

作者： Sieverling, Lina Hong, Chen Koser, Sandra D. Ginsbach, Philip Kleinheinz, Kortine Hutter, Barbara Braun, Delia M. Cortes-Ciriano, Isidro Xi, Ruibin Kabbe, Rolf Park, Peter J. Eils, Roland Schlesner, Matthias Brors, Benedikt Rippe, Karsten Jones, David T. W. Feuerbach, Lars Division of Applied Bioinformatics German Cancer Research Center (DKFZ) 69120 Heidelberg Germany Faculty of Biosciences Heidelberg University 69120 Heidelberg Germany Division of Applied Bioinformatics German Cancer Research Center (DKFZ) Heidelberg Germany Faculty of Biosciences Heidelberg University Heidelberg Germany German Cancer Consortium (DKTK) Heidelberg Germany National Center for Tumor Diseases (NCT) Heidelberg Heidelberg Germany German Cancer Consortium (DKTK) German Cancer Research Center (DKFZ) Heidelberg Germany Wellcome Sanger Institute Wellcome Genome Campus Hinxton Cambridge CB10 1SA UK Korea Advanced Institute of Science and Technology Daejeon 34141 South Korea Wellcome Sanger Institute Wellcome Genome Campus Hinxton UK Korea Advanced Institute of Science and Technology Daejeon South Korea Division of Chromatin Networks German Cancer Research Center (DKFZ) and BioQuant 69120 Heidelberg Germany Division of Theoretical Bioinformatics German Cancer Research Center (DKFZ) 69120 Heidelberg Germany Department for Bioinformatics and Functional Genomics Institute for Pharmacy and Molecular Biotechnology (IPMB) and BioQuant 69120 Heidelberg Germany Division of Theoretical Bioinformatics German Cancer Research Center (DKFZ) Heidelberg Germany Institute of Pharmacy and Molecular Biotechnology and BioQuant Heidelberg University Heidelberg Germany Heidelberg University Heidelberg Germany New BIH Digital Health Center Berlin Institute of Health (BIH) and Charité - Universitätsmedizin Berlin Berlin Germany Heidelberg Center for Personalized Oncology (DKFZ-HIPO) German Cancer Research Center (DKFZ) Heidelberg Germany Department of Biomedical Informatics Harvard Medical School Boston MA USA Ludwig Center at Harvard Medical School Boston MA USA Department of Biomedical Informatics Harvard Medical School Boston Massachusetts 02115 USA Ludwig Center at Harvard Medical School Boston Massachusetts 02115 USA Broad Institute of MIT and Harvard

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PKCδ null mutations in a mouse model of osteoarthritis alter osteoarthritic pain independently of joint pathology by augmenting NGF/TrkA-induced axonal outgrowth

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Annals of the Rheumatic Diseases 2016年第12期75卷 2133-2141页

作者： Kc, Ranjan Li, Xin Kroin, Jeffrey S. Liu, Zhiqiang Chen, Di Xiao, Guozhi Levine, Brett Li, Jinyuan Hamilton, John L. Van Wijnen, Andre J. Piel, Margaret Shelly, Daniel A. Brass, Dovrat Kolb, Ela Im, Hee-Jeong Department of Biochemistry Rush University Medical Center Cohn Research BD 516 1735 W. Harrison Chicago 60612 IL United States Department of Anesthesiology Rush University Medical Center Chicago IL United States Department of Biology Shenzhen Key Laboratory of Cell Microenvironment South University of Science and Technology of China Shenzhen China Department of Orthopedic Surgery Rush University Medical Center Chicago IL United States Departments of Orthopedic Surgery and Biochemistry and Molecular Biology Mayo Clinic Rochester MN United States Novozymes Biopharma US Franklinton NC United States Alomone Labs Ltd Jerusalem Israel Department of Internal Medicine Section of Rheumatology Rush University Medical Center Chicago IL United States Department of Bioengineering University of Illinois at Chicago IL United States Jesse Brown Veterans Affairs Medical Center at Chicago IL United States

Objectives: A key clinical paradox in osteoarthritis (OA), a prevalent age-related joint disorder characterised by cartilage degeneration and debilitating pain, is that the severity of joint pain does not strictly correlate with radiographic and histological defects in joint tissues. Here, we determined whether protein kinase Cδ (PKCδ), a key mediator of cartilage degeneration, is critical to the mechanism by which OA develops from an asymptomatic joint-degenerative condition to a painful disease. Methods: OA was induced in 10-week-old PKCδ null (PKCδ^-/-) and wild-type mice by destabilisation of the medial meniscus (DMM) followed by comprehensive examination of the histology, molecular pathways and knee-pain-related-behaviours in mice, and comparisons with human biopsies. Results: In the DMM model, the loss of PKCδ expression prevented cartilage degeneration but exacerbated OA-associated hyperalgesia. Cartilage preservation corresponded with reduced levels of inflammatory cytokines and of cartilage-degrading enzymes in the joints of PKCδ-deficient DMM mice. Hyperalgesia was associated with stimulation of nerve growth factor (NGF) by fibroblast-like synovial cells and with increased synovial angiogenesis. Results: from tissue specimens of patients with symptomatic OA strikingly resembled our findings from the OA animal model. In PKCδ null mice, increases in sensory neuron distribution in knee OA synovium and activation of the NGF-tropomyosin receptor kinase (TrkA) axis in innervating dorsal root ganglia were highly correlated with knee OA hyperalgesia. Conclusions: Increased distribution of synovial sensory neurons in the joints, and augmentation of NGF/TrkA signalling, causes OA hyperalgesia independently of cartilage preservation. © 2016 Published by the BMJ Publishing Group Limited.

关键词： Chondrocytes Fibroblasts Knee Osteoarthritis Synovitis

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Comparison of Microbial Growth on Fish Waste Peptones from Different Hydrolysis Methods

Comparison of Microbial Growth on Fish Waste Peptones from D...

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2015 5th International Conference on Biomedical Engineering and technology

作者： Nurdiyana Husin Siti Mazlina Mustapa Kamal Ling Tau Chuan Nurul Fadzni Muhammad Norhani Jusoh Section of Bioengineering Technology Universiti Kuala Lumpur Malaysian Institute of Chemical and Bioengineering Technology (Uni KL MICET) Dept. of Process and Food Engineering Faculty of Engineering Universiti Putra Malaysia Institute of Biological Sciences Faculty of Science Building University of Malaya

This study utilized mixture of sardine and mackerel wastes from fish processing industry for peptone recovery. The recovered peptones from different methods of hydrolysis（alkaline and enzymatic） were supplied as nitrogen sources for microbial growth. Peptone performance in microbial growth was found to be affected by hydrolysis method. Saccharomyces cerevisiae growth using peptone from enzymatic（Alcalase enzyme） was superior compared to its growth using other types of peptone. The same trend was observed for Bacillus subtilis growth. Hydrolysis process played important roles in producing peptone with high protein content and degree of hydrolysis, which contributed to better performance of the fish waste peptone in microbial growth. In conclusion, peptones produced from the mixture of sardine and mackerel waste are potentially viable to replace existing commercial peptone as microbial cultivation media.

关键词： Alcalase enzyme fish waste peptone degree of hydrolysis

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Author Correction: Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers

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Scientific data 2021年第1期8卷 242页

作者： Julien Cohen-Adad Eva Alonso-Ortiz Mihael Abramovic Carina Arneitz Nicole Atcheson Laura Barlow Robert L Barry Markus Barth Marco Battiston Christian Büchel Matthew Budde Virginie Callot Anna J E Combes Benjamin De Leener Maxime Descoteaux Paulo Loureiro de Sousa Marek Dostál Julien Doyon Adam Dvorak Falk Eippert Karla R Epperson Kevin S Epperson Patrick Freund Jürgen Finsterbusch Alexandru Foias Michela Fratini Issei Fukunaga Claudia A M Gandini Wheeler-Kingshott Giancarlo Germani Guillaume Gilbert Federico Giove Charley Gros Francesco Grussu Akifumi Hagiwara Pierre-Gilles Henry Tomáš Horák Masaaki Hori James Joers Kouhei Kamiya Haleh Karbasforoushan Miloš Keřkovský Ali Khatibi Joo-Won Kim Nawal Kinany Hagen H Kitzler Shannon Kolind Yazhuo Kong Petr Kudlička Paul Kuntke Nyoman D Kurniawan Slawomir Kusmia René Labounek Maria Marcella Laganà Cornelia Laule Christine S Law Christophe Lenglet Tobias Leutritz Yaou Liu Sara Llufriu Sean Mackey Eloy Martinez-Heras Loan Mattera Igor Nestrasil Kristin P O'Grady Nico Papinutto Daniel Papp Deborah Pareto Todd B Parrish Anna Pichiecchio Ferran Prados Àlex Rovira Marc J Ruitenberg Rebecca S Samson Giovanni Savini Maryam Seif Alan C Seifert Alex K Smith Seth A Smith Zachary A Smith Elisabeth Solana Y Suzuki George Tackley Alexandra Tinnermann Jan Valošek Dimitri Van De Ville Marios C Yiannakas Kenneth A Weber Ii Nikolaus Weiskopf Richard G Wise Patrik O Wyss Junqian Xu NeuroPoly Lab Institute of Biomedical Engineering Polytechnique Montreal Montreal QC Canada. jcohen@polymtl.ca. Functional Neuroimaging Unit CRIUGM Université de Montréal Montreal QC Canada. jcohen@polymtl.ca. Mila - Quebec AI Institute Montreal QC Canada. jcohen@polymtl.ca. NeuroPoly Lab Institute of Biomedical Engineering Polytechnique Montreal Montreal QC Canada. Department of Radiology Swiss Paraplegic Centre Nottwil Switzerland. Centre for Advanced Imaging The University of Queensland Brisbane Australia. Department of Radiology University of British Columbia Vancouver BC Canada. Athinoula A. Martinos Center for Biomedical Imaging Department of Radiology Massachusetts General Hospital Charlestown MA USA. Department of Radiology Harvard Medical School Boston MA USA. Harvard-Massachusetts Institute of Technology Health Sciences & Technology Cambridge MA USA. School of Information Technology and Electrical Engineering The University of Queensland Brisbane Australia. NMR Research Unit Queen Square MS Centre UCL Queen Square Institute of Neurology Faculty of Brain Sciences University College London London UK. Department of Systems Neuroscience University Medical Center Hamburg-Eppendorf Hamburg Germany. Department of Neurosurgery Medical College of Wisconsin Milwaukee WI USA. Aix-Marseille Univ CNRS CRMBM Marseille France. APHM Hopital Universitaire Timone CEMEREM Marseille France. Vanderbilt University Institute of Imaging Science Vanderbilt University Medical Center Nashville TN USA. Department of Computer and Software Engineering Polytechnique Montreal Montreal Canada. CHU Sainte-Justine Research Centre Montreal QC Canada. Centre de Recherche CHUS CIMS Sherbrooke Canada. Sherbrooke Connectivity Imaging Lab (SCIL) Computer Science department Université de Sherbrooke Sherbrooke Canada. Université de Strasbourg CNRS ICube Strasbourg France. UHB - University Hospital Brno and Masaryk University Department of Radiology and Nuclear

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Designing and Performance Evaluation of Biochar Production in a Top-Lit Updraft Up-scaled Gasifier

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Journal of Sustainable Bioenergy Systems 2015年第2期5卷 41-55页

作者： Hussein Kisiki Nsamba Sarah E. Hale Gerard Cornelissen Robert Thomas Bachmann Malaysian Institute of Chemical and Bioengineering Technology (MICET) Universiti Kuala Lumpur Kuala Lumpur Malaysia Section of Industrial Chemistry Department of Chemistry Makerere University Kampala Uganda Invention Plus Limited Kampala Uganda Norwegian Geotechnical Institute (NGI) Oslo Norway

The Original Belonio Rice Husk Gasifier (OBRHG), initially of height of 0.6 m, diameter of 0.15 m and thickness of 0.025 m was tested for biochar production through air gasification of rice husk (RH) and the design was upscaled to height of 1.65 m, diameter of 0.85 m and thickness of 0.16 m. A total of 27 experiments were conducted to monitor the gasifier performance and the system can operate with the centrifugal blower operating at a power input of 155 W and a maximum flow rate of 1450 m3/hr regulated according to the air requirement. Building the UBRHG is simple and inexpensive to fabricate and with the fairly satisfactory performance and ease of construction along with the convenience of operation, the UBRHG with RH as feed would find abundant avenues of applications in a rural setting for biochar production alongside thermal, mechanical and electrical energy delivery.

关键词： Biochar Equivalence Ratio Yield Upscale Belonio Rice Husk Gasifier

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Sustainable Technologies for Small-Scale Biochar Production—A Review

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Journal of Sustainable Bioenergy Systems 2015年第1期5卷 10-31页

Charcoal has found enormous application in both agriculture (AKA biochar) and other sectors. Despite its potential benefits, small scale technologies relevant for its production remain a challenge. Technologies striking a balance between user friendliness, energy efficiency, ease of adaptation and limited emissions could easily be integrated into the local community for the sustainable production of biochar answering both technical and socio-economic aspects. These technologies can be customized to recover the produced heat alongside biochar and the producer gas. The purpose of this work is to review the state of the art in small scale technologies, their associated risks and challenges as well as research gaps for future work. Factors affecting biochar production have been discussed and temperature is known to heavily influence the biomass to biochar conversion process. Based on the reviewed work, there is a need to develop and promote sustainable and efficient technologies that can be integrated into biochar production systems. There is also further need to develop portable, economically viable technologies that could be integrated into the biochar production process without compromising the quality of produced biochar. Such technologies at midscale level can be channeled into conventional small scale farmer use in order that the farmers can process their own biochar.

关键词： Biochar Technologies Small Scale Sustainable Farmers

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26th Annual Computational Neuroscience Meeting (CNS*2017) of the Organization for Computational Neuroscience Antwerp, Belgium, July 15-20, 2017

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BMC NEUROSCIENCE 2017年第SUPPL 1期18卷 59-59页

作者： [Anonymous] Indiana University Purdue University Indianapolis Indianapolis IN 46032 USA Stark Neurosciences Research Institute Indiana University School of Medicine Indianapolis IN 46032 USA Department of Mathematics East Carolina University Greenville NC 27858 USA Jülich Supercomputing Centre Forschungszentrum Jülich 52425 Jülich Germany Future Systems Swiss National Supercomputing Centre 8092 Zurich Switzerland User Engagement and Support Swiss National Supercomputing Centre 6900 Lugano Switzerland Institut de Neurosciences des Systèmes Aix Marseille Univ 13005 Marseille France Simulation Lab Neuroscience Forschungszentrum Jülich Jülich Germany Department of Experimental Psychology Ghent University 9000 Ghent Belgium Donders Center for Cognitive Neuroimaging Radboud University 6525HR Nijmegen The Netherlands Department of Electrical Computer and Energy Engineering University of Colorado Boulder CO 80309 USA Department of Neurosurgery Johns Hopkins School of Medicine Baltimore MD 21287 USA Department of Neurology Johns Hopkins School of Medicine Baltimore MD 21287 USA Department of Otolaryngology Johns Hopkins School of Medicine Baltimore MD 21287 USA INSERM U968 Paris France Sorbonne Universités UPMC University Paris 06 UMR_S 968 Institut de la Vision Paris France CNRS UMR_7210 Paris France Department of Computer Architecture and Technology University of Granada (CITIC) Granada Spain Sorbonne Universités UPMC Univ Paris 06 INSERM CNRS Institut de la Vision Paris France Department of Adaptive Machine Systems Osaka University Osaka Japan Department of Computer Science University of Cergy-Pontoise Cergy-Pontoise France Department of Physics and Astronomy College of Charleston Charleston SC 29424 USA School of Physics Faculty of Science University of Sydney Sydney NSW 2006 Australia Center of Excellence for Integrative Brain Function Australian Research Council Sydney Australia Max Planck Institute for Human Cognitive and Brain Sciences Saxony Lei

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