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Optical Imaging Technology: A Useful Tool to Identify Remission in Cushing Disease After Surgery (vol 51, pg 120, 2019)

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HORMONE AND METABOLIC RESEARCH 2019年第2期51卷 E1-E1页

作者： Afshari, Ali Keil, Margaret Lyssikatos, Charalampos Section on Analytical and Functional Biophotonics Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) National Institutes of Health (NIH) Bethesda Maryland USA Section on Endocrinology and Genetics Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) National Institutes of Health (NIH) Bethesda Maryland USA Section on Endocrinology and Genetics Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) National Institutes of Health (NIH) Bethesda Maryland USA Section on Endocrinology and Genetics Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) National Institutes of Health (NIH) Bethesda Maryland USA Service of Endocrinology and Nutrition Hospital Universitario Central de Asturias Instituto Universitario de Oncología del Principado de Asturias Universidad de Oviedo Oviedo Spain Section on Analytical and Functional Biophotonics Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) National Institutes of Health (NIH) Bethesda Maryland USA Section on Analytical and Functional Biophotonics Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) National Institutes of Health (NIH) Bethesda Maryland USA Section on Analytical and Functional Biophotonics Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) National Institutes of Health (NIH) Bethesda Maryland USA Section on Signal Processing & Instrumentation Computational Biosciences and Engineering Laboratory Office of Intramural Research (OIR) Center for Information Technology (CIT) National Institutes of Health (NIH) Bethesda Maryland USA Section on Analytical and Functional Biophotonics Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) National Institutes of Health (NIH) Bethesda Maryland USA Assistant Professor of Biomedical Engineering Colle

We recently reported the use of optical imaging technology to quantify facial plethora in endogenous Cushing syndrome (CS). In the present study, we studied a larger cohort of patients with Cushing disease (CD) and examined water content fraction as well as blood volume fraction as bio-optic markers for determining the efficacy of this methodology as a predictor of lasting remission after surgery for CS. We imaged 49 patients before and after transsphenoidal surgery (TSS) for Cushing disease (CD); 22 patients were also seen at 3-6 months, and 13 patients 12 months post-operatively. On all patients, we used multi-spectral imaging (MSI) to evaluate hemodynamic distributions as well as water content at a specific area of the face. We found a decrease in blood volume fraction after vs. before surgical treatment in the tested facial area in 37 of the 40 patients, as determined with biochemical markers (p<0.001). All patients that were followed up for up to 12 months showed the same decrease from preoperative values and they remained in remission from CD. We conclude that MSI can be used for the evaluation of remission from CD, at least in the immediate post-operative period and up to one year after surgery. The use of this technology can supplement biochemical and other testing for the evaluation of the various treatment modalities available for patients with CD.

关键词： cushing disease optical imaging technology bio-optic marker facial plethora serum cortisol water content volume

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Near Infra-Red Spectroscopy (NIRS) in urea cycle disorders and typically developing children

Near Infra-Red Spectroscopy (NIRS) in urea cycle disorders a...

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Optics and the Brain, BRAIN 2018

作者： Chowdhry, Fatima Gropman, Andrea Anderson, Afrouz Dashestani, Hadis Gandjbakhche, Amir Section on Analytical and Functional Biophotonics National Institute of Child Health and Human Development National Institutes of Health BethesdaMD United States National Human Genome Research Institute National Institutes of Health BethesdaMD United States Children's National Medical Center Department of Neurology WashingtonDC United States Department of Computer Science and Electrical Engineering University of Maryland Baltimore County BaltimoreMD United States

To test whether NIRS can be used to monitor cognitive brain function and detect markers for differentiation of neurocognitive variance in children with urea cycle disorders as compared to typically developing children... 详细信息

ISBN: (纸本)9781943580415

关键词： Metabolism

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Importance of left dorsolateral prefrontal cortex in moral judgment using functional near-infrared spectroscopy

Importance of left dorsolateral prefrontal cortex in moral j...

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Clinical and Translational biophotonics, TRANSLATIONAL 2018

作者： Dashtestani, Hadis Zaragoza, Rachel Kermanian, Riley Knutson, Kristine M. Halem, Milton Chowdhry, Fatima Karamzadeh, Nader Shahni Anderson, Afrouz A. Claude Boccara, A. Gandjbakhche, Amir Section on Analytical and Functional Biophotonics National Institute of Child Health and Human Development National Institutes of Health BethesdaMD United States Department of Computer Science and Electrical Engineering University of Maryland Baltimore County BaltimoreMD United States Brain Neurology Unit National Institute of Neurological Disorders and Stroke National Institutes of Health BethesdaMD United States Institut Langevin ESPCI Paris PSL Research University Paris France

We used fNIRS to investigate the neural processes of moral judgment (MJ). Left dorsolateral PFC was significantly more activated during impersonal MJ (less emotional) in nonutilitarian decisions. © OSA 2018.

ISBN: (纸本)9781943580415

关键词： Infrared devices

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Normative database of judgment of complexity task with functional near infrared spectroscopy-application for TBI

Normative database of judgment of complexity task with funct...

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Digital Holography and Three-Dimensional Imaging, DH 2012

作者： Amyot, Franck Zimmermann, Trelawny Riley, Jason Kainerstorfer, Jana M. Chernomordik, Victor Najafizadeh, Laleh Wassermann, Eric M. Gandjbakhche, Amir H. National Institutes of Health Eunice Kennedy Shriver National-Institute of Child Health and Human Development Program on Pediatric Imaging and Tissue Sciences Section on Analytical and Functional Biophotonics 9 south Drive Bethesda MD 20892 United States National Institutes of Health National Institute of Neurological Disorders and stroke Behavioral Neurology Unit Bethesda MD United States

We construct a normative database for a simple cognitive test which can be useful in evaluating cognitive disability such as mild traumatic brain injury. Our results with fNIRS show activation from the medial frontopo... 详细信息

ISBN: (纸本)9781557529428

关键词： Infrared devices

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Handheld near infra red imaging device for hemorrhage detection

Handheld near infra red imaging device for hemorrhage detect...

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Biomedical Optics, BIOMED 2012

作者： Riley, Jason D. Amyot, Franck Pohida, Tom Pursley, Randall Ardeshipour, Yasaman Kainerstorfer, Jana M. Najafizadeh, Laleh Chernomordik, Victor Smith, Paul Smirniotopoulos, James Wassermann, Eric M. Gandjbakhche, Amir H. Section on Functional and Analytical Biophotonics Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Bethesda MD 20892 United States Behavioral Neurology Unit National Institute of Neurological Disorders and Stroke National Institutes of Health Bethesda MD 20892 United States Center for Neuroscience and Regenerative Medicine Henry Jackson Foundation 725 Twinbrook Parkway Rockville MD 20852 United States Imaging and Diagnostics Center for Neuroscience Regenerative Medicine Uniformed Services University 4301 Jones Bridge Road Bethesda MD 20814 United States Signal Processing and Instrumentation Section Division of Computational Bioscience Center for Information Technology National Institutes of Health Bethesda MD 20892 United States Biomedical Instrumentation and Multiscale Imaging Section Laboratory of Cellular Imaging and Macromolecular Biophysics National Institute of Biomedical Imaging and Bioengineering National Institutes of Health Bethesda MD 20892 United States

We present a Near-infra red handheld device for imaging subsurface hemorrhage such as hematomas. The device uses novel motion-based measurement techniques to detect inclusions in real-time. We present phantom studies ... 详细信息

ISBN: (纸本)9781557529428

关键词： Diffuse optical tomography Imaging techniques Infrared imaging Near infrared radiation Phantom studies Position sensing equipment Infrared imaging (110.3080) Medical and biological imaging (170.3880)

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Fast optical signal in the prefrontal cortex correlates with EEG

Fast optical signal in the prefrontal cortex correlates with...

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12th Mediterranean Conference on Medical and Biological Engineering and Computing, MEDICON 2010

作者： Medvedev, A.V. Kainerstorfer, J.M. Borisov, S.V. Vanmeter, J. Center for Functional and Molecular Imaging Georgetown University Medical Center Preclinical Science Bldg LM-14 3900 Reservoir Rd NW Washington DC United States Dept. of Physics University of Vienna Vienna Austria Section on Analytical and Functional Biophotonics PPITS NICHD National Institutes of Health Bethesda MD United States Department of Neurology Brain Imaging Center Goethe University Frankfurt Germany

ISBN: (纸本)9783642130380

Near-infrared spectroscopy (NIRS) is a developing technology which provides a cost-effective imaging tool for noninvasive functional brain imaging complementary to more traditional fMRI and PET techniques. An attractive feature of NIRS is that it can potentially measure both brain hemodynamics (slow signal) and neuronal activity (fast optical signal, FOS). FOS is presumed to be generated by changes in light scatter as a result of electrophysiological activity at neuronal membranes. Because of its relatively low signal-to-noise ratio (SNR) it is still debatable how reliable is FOS measured from the human scalp. We recorded FOS in combination with high density EEG and compared the temporal profiles of both signals during a Go-NoGo task (fast presentation of visual scenes with animals as targets) from 11 right-handed subjects. Optical probes were placed bilaterally over the prefrontal areas. Cardiac and movement artifacts were removed using Independent Component Analysis (ICA). Independent components of FOS and EEG were correlated pairwise over all trials. Correlation coefficient in the best correlated FOS-EEG pairs reached 0.1 and was highly significant (p -8). Several typical components of event-related optical signal (EROS) could be identified within the grand average response, which were similar to the ERP components. The most robust and stable optical response developed at t = 200-300 ms as a negative wave due to a decrease in signal amplitude ('optical N200', oN200). oN200 also showed a significant difference between targets and nontargets. EROS was well localized and greater in the right hemisphere in the majority of subjects. We demonstrate for the first time significant correlation between electrical and optical signals recorded from the scalp and that at least some FOS components 'reflect' electrical brain processes directly. Compared to EEG, FOS is better localized and therefore can aid in localization and cortical mapping of cognitive processes. © 2010 Inte

关键词： Independent component analysis

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"Seeing" electroencephalogram through the skull: Imaging prefrontal cortex with fast optical signal

"Seeing" electroencephalogram through the skull: Imaging pre...

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作者： Medvedev, Andrei V. Kainerstorfer, Jana M. Borisov, Sergey V. Gandjbakhche, Amir H. Georgetown University Medical Center Center for Functional and Molecular Imaging Preclinical Science Building LM 143900 Reservoir Road NW Washington DC 20057 United States University of Vienna Department of Physics Vienna Austria Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Section on Analytical and Functional Biophotonics Program on Pediatric Imaging and Tissue Sciences Bethesda MD 20892 United States Department of Neurology and Brain Imaging Center Goethe University Frankfurt Germany

Near-infrared spectroscopy is a novel imaging technique potentially sensitive to both brain hemodynamics (slow signal) and neuronal activity (fast optical signal, FOS). The big challenge of measuring FOS noninvasively lies in the presumably low signal-to-noise ratio. Thus, detectability of the FOS has been controversially discussed. We present reliable detection of FOS from 11 individuals concurrently with electroencephalogram (EEG) during a Go-NoGo task. Probes were placed bilaterally over prefrontal cortex. Independent component analysis (ICA) was used for artifact removal. Correlation coefficient in the best correlated FOS-EEG ICA pairs was highly significant (p 8), and event-related optical signal (EROS) was found in all subjects. Several EROS components were similar to the event-related potential (ERP) components. The most robust "optical N200" at t = 225 ms coincided with the N200 ERP;both signals showed significant difference between targets and nontargets, and their timing correlated with subject's reaction time. Correlation between FOS and EEG even in single trials provides further evidence that at least some FOS components "reflect" electrical brain processes directly. The data provide evidence for the early involvement of prefrontal cortex in rapid object recognition. EROS is highly localized and can provide cost-effective imaging tools for cortical mapping of cognitive processes. © 2010 Society of Photo-Optical Instrumentation Engineers.

关键词： Electroencephalography

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Modern Trends in Imaging IX: biophotonics Techniques for Structural and functional Imaging,In Vivo

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analytical Cellular Pathology 2000年第1期35卷

作者： Yasaman Ardeshirpour Amir H. Gandjbakhche Laleh Najafizadeh Section on Functional and Analytical Biophotonics Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Bethesda MD USAnih.gov Center for Neuroscience and Regenerative Medicine Henry M. Jackson Foundation Rockville MD ***

In vivo optical imaging is being conducted in a variety of medical applications, including optical breast cancer imaging, functional brain imaging, endoscopy, exercise medicine, and monitoring the photodynamic therapy and progress of neoadjuvant chemotherapy. In the past three decades, in vivo diffuse optical breast cancer imaging has shown promising results in cancer detection, and monitoring the progress of neoadjuvant chemotherapy. The use of near infrared spectroscopy for functional brain imaging has been growing rapidly. In fluorescence imaging, the difference between autofluorescence of cancer lesions compared to normal tissues were used in endoscopy to distinguish malignant lesions from normal tissue or inflammation and in determining the boarders of cancer lesions in surgery. Recent advances in drugs targeting specific tumor receptors, such as AntiBodies (MAB), has created a new demand for developing non-invasive in vivo imaging techniques for detection of cancer biomarkers, and for monitoring their down regulations during therapy. Targeted treatments, combined with new imaging techniques, are expected to potentially result in new imaging and treatment paradigms in cancer therapy. Similar approaches can potentially be applied for the characterization of other disease-related biomarkers. In this chapter, we provide a review of diffuse optical and fluorescence imaging techniques with their application in functional brain imaging and cancer diagnosis.

关键词： Diffuse optical imaging near infrared spectroscopy functional brain imaging fluorescence imaging targeted fluorescent probe Affibody cancer treatment cancer diagnostics human epidermal growth factor receptor 2

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