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Medical Imaging 2023: Physics of Medical Imaging

作者： Li, Wangyang Hao, Wenqing Li, Ruijing Liu, Tianshuai Rong, Junyan Zhang, Wenli Lu, Hongbing Department of Biomedical Engineering Fourth Military Medical University Xi'an710032 China School of Life Science & Technology Xidian University Xi'an China Shaanxi Provincial Key Laboratory of Bioelectromagnetic Detection and Intelligent Perception Xi'an China

ISBN: (纸本)9781510660311

X-ray excited shortwave infrared (X-SWIR) imaging attracts much attention because of its advantages in optical deep imaging. However, the X-ray used for X-SWIR imaging brings risk of radiation to organism. How to better realize the synergistic optimization of X-ray dose and luminous efficiency with proper X-ray excitations is especially important for further application. To indicate the effects of X-ray excitation voltage on the X-SWIR light efficiency, the paper builds up an evaluating method, considering the variation of both X-SWIR intensity and X-ray dose along with the X-ray excitation voltages. Based on the method, the X-SWIR intensity and X-ray dose with different X-ray voltages are tested. By calculating the X-SWIR luminescence intensity with unit absorption dose at different X-ray voltages, the influence of X-ray energy on luminous efficiency is revealed. Results show that the dose efficiency of the probe is related to the X-ray energy, and it is the highest under 30-40 kV X-ray excitation (average energy of 10-20 keV). The conclusion is that the proposed evaluating method is feasible for assessing the luminescence efficiency and providing a reference for the practical application of X-ray luminescent nanoprobes. It helps understanding the X-ray luminescence theory, optimizing the X-ray excitation, reducing the X-ray dose while maintaining the X-SWIR luminescence intensity, which is meaningful for practical application of X-SWIR imaging in vivo. © COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.

关键词： Luminescence

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Dual-weighted frequency difference magnetic induction tomography for acute intracranial hemorrhage detection 6

Dual-weighted frequency difference magnetic induction tomogr...

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6th International Conference on Biological Information and Biomedical Engineering, BIBE 2022

作者： Zhang, Tao Liu, Xuechao Ye, Jian’an Tian, Xiang Feng, Zili Zhang, Weirui Liu, Ruigang Xu, Canhua Department of Biomedical Engineering The Fourth Military Medical University China Shaanxi Key Laboratory for Bioelectromagnetic Detection and Intelligent Perception China Drug and Instrument Supervision and Inspection Station Xining Joint Logistics Support Center China

ISBN: (纸本)9783800759651

Multi-frequency magnetic induction tomography (mfMIT) is considered a promising technique for the early detection of intracranial hemorrhage. However, the lack of practical and stable algorithms has limited the use of mfMIT in clinical application research. In this study, we developed a dual-weighted frequency difference (DWFD) algorithm to address the limitations of the conventional weighted frequency difference method. This method does not require a priori information about the electrical conductivity of each tissue in the brain and only requires MIT measurements at three excitation frequencies to reconstruct an image of the hemorrhagic target. The performance of the proposed algorithm was verified using a three-dimensional head simulation model with an actual anatomical structure and comparing it with that of the conventional method. The results of the simulation experiments revealed that the DWFD algorithm can extract the hemorrhage tissue information and reconstruct low-noise images in a complex brain model with multiple tissue backgrounds. Through this method, the influence of non-homogeneous tissues in the head, which is observed in the conventional method, is eliminated;thus, the method can be used in further experiments. The DWFD method can facilitate the use of mfMIT in clinical studies for the rapid detection of intracranial hemorrhage. © VDE VERLAG GMBH.

关键词： Tissue

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BERT: Accelerating Vital Signs Measurement for Bioradar with An Efficient Recursive Technique

arXiv

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arXiv 2024年

作者： Tang, Chengyao Dai, Yongpeng Li, Zhi Song, Yongping Liang, Fulai Jin, Tian The College of Electronic Science and Technology National University of Defense Technology Changsha410073 China The Shaanxi Key Laboratory for Bioelectromagnetic Detection and Intelligent Perception School of Military Biomedical Engineering Air Force Medical University Xi’an710032 China

Recent years have witnessed the great advance of bioradar system in smart sensing of vital signs (VS) for human healthcare monitoring. As an important part of VS sensing process, VS measurement aims to capture the chest wall micromotion induced by the human respiratory and cardiac activities. Unfortunately, the existing VS measurement methods using bioradar have encountered bottlenecks in making a tradeoff between time cost and measurement accuracy. To break this bottleneck, this letter proposes an efficient recursive technique (BERT) heuristically, based on the observation that the features of bioradar VS meet the conditions of Markov model. Extensive experimental results validate that BERT measurement yields lower time costs, competitive estimates of heart rate, breathing rate, and heart rate variability. Our BERT method is promising us a new and superior option to measure VS for bioradar. This work seeks not only to solve the current issue of how to accelerate VS measurement with an acceptable accuracy, but also to inspire creative new ideas that spur further advances in this promising field in the future. © 2024, CC BY-NC-SA.

关键词： Heart

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Temperature Characteristics of the Conductivity of Human Cerebrospinal Fluid at 10 Hz-100 MHz 10th

Temperature Characteristics of the Conductivity of Human Cer...

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10th Frontier Academic Forum of Electrical Engineering, FAFEE 2022

作者： Wang, Weice Guo, Jie Li, Weichen Bai, Siyuan Li, Kun Wang, Yu Xu, Canhua Shi, Xuetao Department of Biomedical Engineering Air Force Medical University Xi'an710032 China Shaanxi Provincial Key Laboratory of Bioelectromagnetic Detection and Intelligent Perception Xi'an710032 China Institute of Medical Research Northwestern Polytechnical University Xi'an710072 China School of Life Sciences Northwest University Xi'an710127 China Faculty of Electrical and Control Engineering Liaoning Technical University Huludao125000 China

ISBN: (纸本)9789819934034

The temperature characteristics of the conductivity of the cerebrospinal fluid (CSF) are important in the fields of biological effect research, and electromagnetic protection of electromagnetic fields. In this study, the temperature control tank was used for temperature control (17-37 ℃), and the four/two electrode data integration method was used to measure its dielectric parameters (10 Hz-100 MHz). The results showed that the conductivity didn't not change significantly with frequency and the temperature coefficient of conductivity of cerebrospinal fluid remained basically unchanged in the whole frequency range, being 1.591-1.612%/℃. The temperature coefficient could lay a foundation for the calculation of brain specific absorption rate, the study of frequency and temperature dependence of brain dielectric properties. © Beijing Paike Culture Commu. Co., Ltd. 2023.

关键词： Cerebrospinal fluid

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BERT: Remote Sensing of Vital Signs for Bioradar with An Efficient Recursive Technique

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IEEE Internet of Things Journal 2025年

作者： Tang, Chengyao Dai, Yongpeng Li, Zhi Song, Yongping Liang, Fulai Jin, Tian National University of Defense Technology College of Electronic Science and Technology Changsha410073 China Army Engineering University of PLA College of Communication NCO Nanjing210007 China Air Force Medical University Shaanxi Key Laboratory for Bioelectromagnetic Detection and Intelligent Perception School of Military Biomedical Engineering Xi’an710032 China

Recursive techniques have demonstrated excellent computational efficiency in classic remote sensing tasks but are rarely applied in emerging remote sensing tasks in the IoT field, such as bioradar-based remote sensing of vital signs (VS). As a fundamental but important problem, VS sensing lacks an effective state model, making it difficult to implement using recursive techniques for a bioradar system. However, this paper presents an efficient recursive technique (BERT) that benefits remote VS sensing and accelerates computational speed with bioradar. Specifically, the recursive technique is derived from an efficient Markov state model based on the features of bioradar VS and is significantly helpful for algorithm implementation. This technique fills the recursive application gap in the VS sensing task and motivates further exploration of its rationale. Thanks to the strong capability of the recursive technique in computation, the proposed BERT requires less time and demonstrates greater accuracy compared to other methods in simulation results. We further conduct extensive experiments on two real datasets — one comprising 50 children and the other involving 30 adults across various scenarios, and the results show that the BERT algorithm significantly accelerates computation speed, reducing processing time by nearly 41% compared to the state-of-the-art algorithm, while maintaining superior estimation accuracy. Furthermore, this work also offers a fresh perspective on interpreting remote VS sensing for bioradar. © 2014 IEEE.

关键词： Markov processes

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Radiation-Based Multi-Modal Therapy Combining with Immunotherapy to Develop a Vaccine-Like Effective Treatment for Triple-Negative Breast Cancer

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Breast Cancer: Targets and Therapy 2025年 17卷 483-496页

作者： Mengyan Dai Zuhong Tian Fanyuan Xu Bang Yao Hongxia Liang Dongyan Li Jiangang Wang Junyan Rong Tianshuai Liu Haili Tang Hongbing Lu Wenli Zhang The College of Life Sciences Northwest University Xi’an City 710069 People’s Republic of China School of Biomedical Engineering Shaanxi Provincial Key Laboratory of Bioelectromagnetic Detection and Intelligent Perception The Fourth Military Medical University Xi’an Shaanxi 710032 People’s Republic of China State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and Xijing Hospital of Digestive Diseases Fourth Military Medical University Xi’an 710032 People’s Republic of China School of Materials Science and Engineering Shaanxi University of Science and Technology Xi’an Shaanxi 710021 People’s Republic of China Department of General Surgery The Second Affiliated Hospital of the Fourth Military Medical University Xi’an 710038 People’s Republic of China

BackgroundTriple-negative breast cancer (TNBC) is an aggressive malignancy with high metastasis and recurrence rates. Current treatments like chemotherapy and immunotherapy face challenges due to chemotherapy side effects, limited immunotherapy applicability, and TNBC’s immunosuppressive *** achieve a more effective treatment for TNBC, a novel therapeutic strategy has been developed, which uses X-ray excited photodynamic therapy (X-PDT) to activate the tumor immune microenvironment following with the immunotherapy of *** on the 4T1 tumor mouse model, this study initially investigated the regulatory effects of X-PDT on the tumor immune microenvironment. Subsequently, the therapeutic efficacy of combining X-PDT with Anti-CTLA4 was evaluated for its inhibitory effects on primary, metastatic, and recurrent tumors. The underlying mechanisms were further elucidated through comprehensive techniques including flow cytometry, ELISA, and immunofluorescence *** synergistic strategy can effectively ablate the primary tumor while inhibiting metastasis and preventing recurrence like a vaccine. It enhances intratumoural dendritic cells (DCs) maturation (from 25.7% to 58.3%,P< 0.05) and immune T cell infiltration activating a strong anti-tumor immune response. The anti-tumor efficacy of synergistic therapy is enhanced by 2.5 times comparing with immunotherapy alone, while the tumor metastasis has been inhibited significantly. The maturation level of mature dendritic cells was increased from 26.7% to 86.3% (P< 0.01). The intratumoural CD8+/CD4+T cells were increased from 0.51% and 1.54% to 15.4% and 23.1% (P< 0.0001), respectively. The synergistic therapy exerts a powerful vaccine-like long-term immune memory function to prevent tumor recurrence with the elevated level of effector memory T (Tem) cells (from 12.8% to 33.3%,P< 0.05).ConclusionBased on the 4T1 mouse model, developed an effective vaccine-like therapeutic strategy c

关键词： combination therapies cancer vaccine X-ray excited photodynamic therapy immunotherapy nanodrugs

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