The phenomenon of cracks on the surface of buildings is widespread. The existence of cracks affects the normal use of buildings, shortening the service life, seriously damaging the structure of buildings, resulting in...
The phenomenon of cracks on the surface of buildings is widespread. The existence of cracks affects the normal use of buildings, shortening the service life, seriously damaging the structure of buildings, resulting in safety accidents. Therefore, regular detection and reinforcement of cracks on the surface of buildings is a necessary link to ensure safety. At present, the detection of building surface cracks is mainly carried out by manpower with means of equipment assisted. However, there are some problems in manpower detection, such as high manpower consumption, low *** paper presents a method of detecting and inspecting cracks on building surface based on image processing technology in machine vision, which includes image gray transformation, image denoising etc. Curve fitting and least square method are used to obtain crack parameters, so as to improve the inspecting efficiency and realize the automation of building surface inspection.
The paper deals with two nonlinear elliptic equations with (p, q)-Laplacian and the Dirichlet-Neumann-Dirichlet (DND) boundary conditions, and Dirichlet-Neumann-Neumann (DNN) boundary conditions, respectively. Under m...
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Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes and molecular mechanisms that are often specific to cell type. Here, to characterize the genetic contribution...
Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes and molecular mechanisms that are often specific to cell type. Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases of T2D. We identify 1,289 independent association signals at genome-wide significance (P < 5 × 10) that map to 611 loci, of which 145 loci are, to our knowledge, previously unreported. We define eight non-overlapping clusters of T2D signals that are characterized by distinct profiles of cardiometabolic trait associations. These clusters are differentially enriched for cell-type-specific regions of open chromatin, including pancreatic islets, adipocytes, endothelial cells and enteroendocrine cells. We build cluster-specific partitioned polygenic scores in a further 279,552 individuals of diverse ancestry, including 30,288 cases of T2D, and test their association with T2D-related vascular outcomes. Cluster-specific partitioned polygenic scores are associated with coronary artery disease, peripheral artery disease and end-stage diabetic nephropathy across ancestry groups, highlighting the importance of obesity-related processes in the development of vascular outcomes. Our findings show the value of integrating multi-ancestry genome-wide association study data with single-cell epigenomics to disentangle the aetiological heterogeneity that drives the development and progression of T2D. This might offer a route to optimize global access to genetically informed diabetes care.
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