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Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

Nature 2024年第8003期627卷 347-357页

作者： Ken Suzuki Konstantinos Hatzikotoulas Lorraine Southam Henry J Taylor Xianyong Yin Kim M Lorenz Ravi Mandla Alicia Huerta-Chagoya Giorgio E M Melloni Stavroula Kanoni Nigel W Rayner Ozvan Bocher Ana Luiza Arruda Kyuto Sonehara Shinichi Namba Simon S K Lee Michael H Preuss Lauren E Petty Philip Schroeder Brett Vanderwerff Mart Kals Fiona Bragg Kuang Lin Xiuqing Guo Weihua Zhang Jie Yao Young Jin Kim Mariaelisa Graff Fumihiko Takeuchi Jana Nano Amel Lamri Masahiro Nakatochi Sanghoon Moon Robert A Scott James P Cook Jung-Jin Lee Ian Pan Daniel Taliun Esteban J Parra Jin-Fang Chai Lawrence F Bielak Yasuharu Tabara Yang Hai Gudmar Thorleifsson Niels Grarup Tamar Sofer Matthias Wuttke Chloé Sarnowski Christian Gieger Darryl Nousome Stella Trompet Soo-Heon Kwak Jirong Long Meng Sun Lin Tong Wei-Min Chen Suraj S Nongmaithem Raymond Noordam Victor J Y Lim Claudia H T Tam Yoonjung Yoonie Joo Chien-Hsiun Chen Laura M Raffield Bram Peter Prins Aude Nicolas Lisa R Yanek Guanjie Chen Jennifer A Brody Edmond Kabagambe Ping An Anny H Xiang Hyeok Sun Choi Brian E Cade Jingyi Tan K Alaine Broadaway Alice Williamson Zoha Kamali Jinrui Cui Manonanthini Thangam Linda S Adair Adebowale Adeyemo Carlos A Aguilar-Salinas Tarunveer S Ahluwalia Sonia S Anand Alain Bertoni Jette Bork-Jensen Ivan Brandslund Thomas A Buchanan Charles F Burant Adam S Butterworth Mickaël Canouil Juliana C N Chan Li-Ching Chang Miao-Li Chee Ji Chen Shyh-Huei Chen Yuan-Tsong Chen Zhengming Chen Lee-Ming Chuang Mary Cushman John Danesh Swapan K Das H Janaka de Silva George Dedoussis Latchezar Dimitrov Ayo P Doumatey Shufa Du Qing Duan Kai-Uwe Eckardt Leslie S Emery Daniel S Evans Michele K Evans Krista Fischer James S Floyd Ian Ford Oscar H Franco Timothy M Frayling Barry I Freedman Pauline Genter Hertzel C Gerstein Vilmantas Giedraitis Clicerio González-Villalpando Maria Elena González-Villalpando Penny Gordon-Larsen Myron Gross Lindsay A Guare Sophie Hackinger Liisa Hakaste Sohee Han Andrew T Hattersley Christian Herder Momoko Horikoshi Annie-Green Howard Willa Centre for Genetics and Genomics Versus Arthritis Centre for Musculoskeletal Research Division of Musculoskeletal and Dermatological Sciences University of Manchester Manchester UK. Department of Diabetes and Metabolic Diseases Graduate School of Medicine University of Tokyo Tokyo Japan. Department of Statistical Genetics Osaka University Graduate School of Medicine Suita Japan. Institute of Translational Genomics Helmholtz Zentrum München German Research Center for Environmental Health Neuherberg Germany. konstantinos.hatzikotoulas@helmholtz-munich.de. Institute of Translational Genomics Helmholtz Zentrum München German Research Center for Environmental Health Neuherberg Germany. Center for Precision Health Research National Human Genome Research Institute National Institutes of Health Bethesda MD USA. British Heart Foundation Cardiovascular Epidemiology Unit Department of Public Health and Primary Care University of Cambridge Cambridge UK. Heart and Lung Research Institute University of Cambridge Cambridge UK. Department of Epidemiology School of Public Health Nanjing Medical University Nanjing China. Department of Biostatistics and Center for Statistical Genetics University of Michigan Ann Arbor MI USA. Corporal Michael J. Crescenz VA Medical Center Philadelphia PA USA. Department of Systems Pharmacology and Translational Therapeutics University of Pennsylvania Perelman School of Medicine Philadelphia PA USA. Department of Genetics University of Pennsylvania Perelman School of Medicine Philadelphia PA USA. Programs in Metabolism and Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge MA USA. Diabetes Unit and Center for Genomic Medicine Massachusetts General Hospital Boston MA USA. TIMI Study Group Division of Cardiovascular Medicine Brigham and Women's Hospital Harvard Medical School Boston MA USA. William Harvey Research Institute Barts and the London School of Medicine and Dentistry Queen Mary University of London L

Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes and molecular mechanisms that are often specific to cell type. Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases of T2D. We identify 1,289 independent association signals at genome-wide significance (P < 5 × 10) that map to 611 loci, of which 145 loci are, to our knowledge, previously unreported. We define eight non-overlapping clusters of T2D signals that are characterized by distinct profiles of cardiometabolic trait associations. These clusters are differentially enriched for cell-type-specific regions of open chromatin, including pancreatic islets, adipocytes, endothelial cells and enteroendocrine cells. We build cluster-specific partitioned polygenic scores in a further 279,552 individuals of diverse ancestry, including 30,288 cases of T2D, and test their association with T2D-related vascular outcomes. Cluster-specific partitioned polygenic scores are associated with coronary artery disease, peripheral artery disease and end-stage diabetic nephropathy across ancestry groups, highlighting the importance of obesity-related processes in the development of vascular outcomes. Our findings show the value of integrating multi-ancestry genome-wide association study data with single-cell epigenomics to disentangle the aetiological heterogeneity that drives the development and progression of T2D. This might offer a route to optimize global access to genetically informed diabetes care.

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Nonnegative Edge Consensus of Networked Linear systems

Nonnegative Edge Consensus of Networked Linear Systems

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第35届中国控制会议

作者： Xiaoling Wang Housheng Su Xiaofan Wang Guanrong Chen Department of Automation Shanghai Jiaotong Universityand Key Laboratory of System Control and Information ProcessingMinistry of Education of China School of Automation Image Processing and Intelligent Control Key Laboratory of Education Ministry of ChinaHuazhong University of Science and Technology Department of Electronic Engineering City University of Hong Kong

ISBN: (纸本)9781509009107

In this paper,nonnegative edge consensus of systems steered by general linear dynamics on directed network is *** the new approach,one first endows dynamics to each directed edge and then designs a distributed edge consensus protocol guiding all edges to reach a common *** the help of line graph theory,it is proved that strongly connected network can ensure reaching nonnegative edge consensus,if the initial conditions of all edges are *** simulations are provided to verify the theoretical results.

关键词： Networked system Nonnegative edge consensus Distributed algorithm Line graph

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An overview of coordinated control for multi-agent systems subject to input saturation

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Perspectives in Science 2016年 7卷 133-139页

作者： Xiaoling Wang Housheng Su Xiaofan Wang Guanrong Chen Department of Automation Shanghai Jiao Tong University and Key Laboratory of System Control and Information Processing Ministry of Education of China Shanghai 200240 China School of Automation Image Processing and Intelligent Control Key Laboratory of Education Ministry of China Huazhong University of Science and Technology Wuhan 430074 China Department of Electronic Engineering City University of Hong Kong Hong Kong China

Coordinated control of multi-agent systems has widespread application in engineering such as unmanned aerial vehicles and unmanned ground vehicles. Due to the fact that input saturation can lead a control system to deterioration and instability, a lot of efforts have been devoted to investigating this subject of great importance. The present article offers a survey of recent developments on coordinated control of multi-agents systems subject to input saturation. Some preliminaries about graph theory, stability theory and input saturation are first provided, followed by some important results in the area, which are categorized into semi-global and global coordinated controls. Future research topics are finally discussed.

关键词： Multi-agent system Coordinated control Consensus tracking Input saturation Low-and-high-gain feedback

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Architectural distortion recognition based on a subclass technique and the sparse representation classifier

Architectural distortion recognition based on a subclass tec...

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International Congress on Image and Signal processing, BioMedical Engineering and Informatics (CISP-BMEI)

作者： Xiaoming Liu Leilei Zhai Ting Zhu Zhou Yang School of Automation Huazhong University of Science and Technology Wuhan China Hubei Province Key Laboratory of Intelligent Information Processing and Real-time Industrial System Wuhan China Key Laboratory of Image Processing and Intelligent Control of Education Ministry of China Wuhan China College of Computer Science and Technology Wuhan University of Science and Technology Wuhan China

ISBN: (纸本)9781509037117

Architectural distortion is the third most common sign of breast cancer in mammograms. The accurate recognition is important for computer aided diagnosis of breast cancer. However, due to the subtle symptom and complex structures in the mammogram images, it is difficult to recognize whether a region of interest (ROI) is truly an architectural distortion. In this paper, we proposed a new method for architectural distortion recognition. In the proposed method, several texture features are extracted for each region of interest, including features from GLCM matrix, spiculated related features, entropy features, etc. Feature selection is obtained by a sub-classes clustering based multi-task learning method (SMTL), which can utilize the discriminative label information and reflect the multi-clustering characteristic of the data samples. Finally, the powerful sparse representation based classifier is used for the classification of AD or non-AD. The proposed method has been tested on DDSM dataset and compared with several other methods, the experimental results showed the effectiveness of the proposed method.

关键词： Feature extraction Distortion Entropy Training Mammography Delta-sigma modulation Breast cancer

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A sub-pixel SAR and optical image registration method 66

A sub-pixel SAR and optical image registration method

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66th International Astronautical Congress 2015: Space - The Gateway for Mankind's Future, IAC 2015

作者： Zhang, Hanmo Lu, Shan You, Hongjian Shanghai Key Laboratory of Aerospace Intelligent Control Technology Shanghai Aerospace Control Technology Institution China Key Laboratory of Geo-Spatial Information Processing and Application System Technology Institute of Electronics Chinese Academy of Sciences Beijing China

ISBN: (纸本)9781510818934

Automatic image registration method is important because data amount acquired and processed is increasingly heavy. For SAR and optical sensor images, it is important to align the same object shown in different images from multi sensors. Considering extracting and matching features in SAR and optical images, a template registration strategy is proposed in this paper. A particular similarity measurement which is robust in matching remote sensing images of general sceneries is hardly to construct. Being the invertible and essential tendency nowadays in the field of earth observation, high pixel-resolution images can offer much more information of the ground. Thus subpixel image registration methods have been researched, among which can successfully achieve 1/50 pixel level accuracy in matching homologous sensor image. This paper firstly investigated the performance of 2D Gaussian fitting for low correlated synthetic images and real satellite images acquired by Radat SAT-2, COSMO and TerraSAR-X satellites. Three algorithms for subpixel locating have been utilized with consideration of the low correlated coefficient peak and corrupted shape of neighbourhood around it. The results show 2D Gaussian fitting is the most efficient on noisy coefficient maps. Then a subpixel image registration method for SAR and optical images is proposed. Normalized gradient correlation (NGC) algorithm is used to solve the problem of different intensity property at first, and by combining 2D Gaussian fitting to relocate matched points at a subpixel level accuracy. Experiment results have shown that the proposed method has enough capabilities in handling differences between images from multi-sensors. The proposed approach has been found to be simple and efficient in implementation with a low computation load. And the most important performance is the results presented here have achieved matching accuracy within 1 pixel.

关键词： Image registration

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A Sophisticated RMPC Design for LPV systems based on the mixed multi-step feedback control 34

A Sophisticated RMPC Design for LPV Systems based on the mix...

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第三十四届中国控制会议

作者： ZHENG Pengyuan LI Dewei XI Yugeng LI Xiaoli College of Automation Engineering Shanghai University of Electric PowerShanghai Engineering Research Center of Intelligent Management and Control for Power Process Department of Automation Shanghai Jiao Tong UniversityKey Laboratory of System Control and Information Processing Ministry of Education School of Information Science and Technology Donghua University

ISBN: (纸本)9781467374439

This paper studies a sophisticated robust model predictive control(RMPC) design for linear parameter varying(LPV)systems with the varying parameter unmeasurable. Based on a mixed multi-step feedback control, a sophisticated control design which utilizes both multi-step control sets and parameter-dependent feedback control is developed to introduce more freedom and thus reduces the conservativeness. The proposed method achieves good control performance with guaranteed robust and stability properties, which is verified by simulation examples.

关键词： Linear parameter varying systems,Robust model predictive control,Parameter-dependent feedback control,Mixed multi-step feedback control,Linear matrix inequalities

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Data-Based Health State Analysis for the Axle of High Speed Train

Data-Based Health State Analysis for the Axle of High Speed ...

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International Conference on Computational Intelligence and Security

作者： Guo Xie Minying Ye Xinhong Hei Jinwei Zhao Fucai Qian Xi'an University of Technology Xi'an China Shaanxi Key Laboratory of Complex System Control and Intelligent Information Processing Xi'an China

Taking into account that the present popular methods, such as the judgement of the axle failure based on temperature threshold, and the early warning of axle based on real-time temperature analysis, cannot analyze the changing of performance trends, a health state analysis method for the axle of high-speed train based on long-term temperature monitoring data is proposed in this paper, which including the following main steps: (1) Preprocessing of the original data to correct the singular zero value and complement the missing values, (2) Smoothing of the processed data in order to automatically extract the beginning and end points of every temperature rising stage of axles, (3) Establishment of the calculation method of temperature rising rate, and evaluating the health sate of axles based on the temperature rising rate. Finally, the proposed method is validated based on the data from a test line, the results demonstrate the effectiveness and practicability of the method.

关键词： Axles Temperature distribution Aging Safety Data mining Fault diagnosis Monitoring

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Robust fault tolerant manoeuvring and rudder control of marine vehicles with state saturation

Robust fault tolerant manoeuvring and rudder control of mari...

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IEEE International Conference on Industrial Technology (ICIT)

作者： Xiaozheng Jin Qiuhong Liu Yu Kang Jiahu Qin School of Electrical Engineering and Automation HeFei University of Technology HeFei AnHui China Research Institute of Intelligent Control and Systems Harbin Institute of Technology Harbin China Department of Automation University of Science and Technology of China Hefei China Key Laboratory of Technology in Geo-Spatial Information Processing and Application System Chinese Academy of Sciences Beijing China

ISBN: (纸本)9781467380768

In this paper, the problem of rudder-roll damping control for a class of cruise keeping ships subject to both actuator fault and state saturation is investigated. A manoeuvring and rudder control model of marine vessels is firstly reviewed based on the existing literature. Actuator faults which including partial loss of rudder effectiveness and actuator-bias faults are considered in the model. Then a switching control strategy is developed to compensate for the actuator faults and to guarantee the stability of the rudder-roll damping control system. Moreover, some relationship regarding state saturation bounds, actuator fault limits and control parameters are analyzed in this paper. Finally, simulation results are given to illustrate the proposed procedures and their effectiveness.

关键词： Actuators Vehicles Damping Mathematical model Marine vehicles Vehicle dynamics

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Research on speed and tension multivariable system of reversible cold strip mill based on ILQ theory

Research on speed and tension multivariable system of revers...

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International Conference on Machine Learning and Cybernetics (ICMLC)

作者： Gang Zheng Xiao-Li Chao Zhe Yang Fu-Caiqian Shaanxi Key Laboratory of Complex System Control and Intelligent Information Processing Xi'an University of Technology Xi'an China Xi'an University of Technology Xi'an Shaanxi CN

ISBN: (纸本)9781467372220

For the speed and tension system of reversing cold strip mill with multivariable, uncertainties and strong coupling, a new method of inverse linear quadratic (ILQ) is proposed. Firstly, a relatively complete mathematical model for the speed and tension multivariable coupling system is established by using the mechanism modeling method. Then according to the state-space expression of the controlled system and aspirations closed-loop poles, optimal feedback matrix is obtained by ILQ method. Instead of choosing the weighted matrix simplifies the design process, and the asymptotic behavior of the system is robust. Simulation results show the effectiveness of this method.

关键词： Reversible cold strip mill Speed and tension multivariable control system inverse linear quadratic (ILQ) pole-assignment cold strip Cold strip mills pole assignment design process multiple input multiple output systems tension speed Aspirations (Psychology) system behavior asymptotic behavior

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Cover Feature: Ultrasensitive, Sustainable, and Selective Electrochemical Hydrazine Detection by ALD-Developed Two-Dimensional WO3(ChemElectroChem 2/2018)

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ChemElectroChem 2017年第2期5卷

作者： Zihan Wei Zhenyin Hai Mohammad Karbalaei Akbari Prof. Jie Hu Lachlan Hyde Prof. Stephen Depuydt Prof. Francis Verpoort Prof. Serge Zhuiykov Ghent University Global Campus Department of Applied Analytical & Physical Chemistry 119 Songdomunhwa-ro Yeonsu-gu Incheon South Korea Micro and Nano System Research Center Key Lab of Advanced Transducers and Intelligent Control System (Ministry of Education) & College of Information Engineering Taiyuan University of Technology Taiyuan 030024 Shanxi PR China Factory of the Future Swinburne University of Technology Hawthorn Australia National Research Tomsk Polytechnic University Lenin Avenue 30 634050 Tomsk Russian Federation Laboratory of Organometallics Catalysis and Ordered Materials State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Center for Chemical and Material Engineering Wuhan University of Technology Wuhan P.R. China

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