检索结果-内蒙古大学图书馆

A Self-distillation Bi-atrial Segmentation Network for Cardiac MRI 15th

A Self-distillation Bi-atrial Segmentation Network for Card...

15th International Workshop on Statistical Atlases and Computational Models of the Heart, STACOM 2024, Held in Conjunction with MICCAI 2024

作者： Anwaar, Waqas Van, Manh The Hu, Jiongtong Chen, Zhurong Xue, Wufeng Ni, Dong National-Reginoal Key Technology Engineering Laboratory for Medical Ultrasound Guangdong Key Laboratory of Biomedical Measurements and Ultrasound Imaging School of Biomedical Engineering Shenzhen University Medical School Shenzhen University Shenzhen518060 China Marshall Laboratory of Biomedical Engineering Shenzhen University Shenzhen China Lab Shenzhen University Shenzhen China

ISBN: (纸本)9783031877551

Bi-atrial segmentation in late gadolinium-enhanced MRI (LGE-MRI) is an important step for diagnosing and treating atrial fibrillation. However, in real scenarios, this process is hugely impeded by varying appearance of the atrial shape, intensity variations and large inter- and intra-class distribution among volumes. In this paper, we propose a 3D-based self-distillation network for robustly segmenting both the left atrium, right atrium as well as their walls. Specifically, our network employs a 3D segmentation model to better explore the spatial dependencies information in input volumes. The model is equipped with an atrous spatial pyramid pooling module to better deal with variation in atrial shape and thin boundary details at different scales followed by a spatial and depth self-attention module to learn the long-range relationship between relevant information within volume. In addition, we apply a distillation training scheme to improve the robustness of the segmentation model for huge intensity variations among volumes. The experimental results show that our framework can produce a robust performance for bi-atrial segmentation and attain an average Dice of 83.3% and HD95 of 4.51 (pixels). © The Author(s), under exclusive license to Springer Nature Switzerland AG 2025.

关键词： Image segmentation

来源：评论

学校读者我要写书评

暂无评论

Thermally activated delayed phosphorescence triggered by charge separation state carrier storage in an organic scintillator

引用

National Science Review 2025年第5期12卷 225-233页

作者： Ruo-Yu Cao Yu-Bing Si Qi Yang Zi-Ying Gao Jia-Wang Yuan Yi Zhao Qiu-Chen Peng Kai Li Shuang-Quan Zang Ben Zhong Tang Tianjian Laboratory of Advanced Biomedical Sciences Henan Key Laboratory of Crystalline Molecular Functional Materials College of Chemistry Zhengzhou University State Key Laboratory of Physical Chemistry of Solid Surfaces i Ch EM Fujian Provincial Key Lab of Theoretical and Computational Chemistry and College of Chemistry and Chemical Engineering Xiamen University School of Science and Engineering Shenzhen Institute of Aggregate Science and Technology The Chinese University of Hong KongShenzhen(CUHK-Shenzhen)

Organic scintillators are among the most promising due to their inherent merits in terms of heavy metal–free constituents, synthesis designability, affordability of raw materials, and low usage costs. However,the limited X-ray excited luminescence(XEL) property of organic scintillators affects their application. To date, the main approaches for improving the XEL property of organic scintillators have focused on introducing heavy atoms to increase the absorbance of X-rays and establishing new luminescence pathways,such as thermally activated delayed fluorescence(TADF), to increase the exciton utilization efficiency. Even so, the XEL property of organic scintillators is not ideal compared with that of commercial inorganic scintillators. In this work, a highly stable charge separation(CS) state trap was introduced into the design of an organic scintillator. Combined with a unique thermally activated delayed phosphorescence(TADP)process, highly efficient capture and conversion of high-energy carriers are realized. As a result, the exciton generation efficiency dramatically increases, with an ultrahigh XEL intensity, and X-ray afterglow imaging at room temperature is achieved for the first time. This work provides a brand-new strategy for the design of high-performance organic scintillators.

关键词： organic scintillators afterglow charge separation thermally activated delayed phosphorescence X-ray afterglow imaging

来源：评论

学校读者我要写书评

暂无评论

Two-color emissive AIEgens with anti-Kasha property for dual-organelle imaging and phototherapy

引用

Science China Chemistry 2024年第5期67卷 1740-1752页

作者： Pu Chen Guogang Shan Qingli Nie Yuting Yan Pengfei Zhang Zujin Zhao Hai-Tao Feng Ben Zhong Tang AIE Research Center Shaanxi Key Laboratory of PhytochemistryCollege of Chemistry and Chemical EngineeringBaoji University of Arts and SciencesBaoji 721013China Institute of Functional Material Chemistry and National&Local United Engineering Lab for Power Battery Faculty of ChemistryNortheast Normal UniversityChangchun 130024China College of Chemistry&Materials Science Northwest UniversityXi’an 710127China Guangdong Key Laboratory of Nanomedicine CAS-HK Joint Lab of BiomaterialsCAS Key Laboratory of Biomedical Imaging Science and SystemShenzhen Engineering Laboratory of Nanomedicine and NanoformulationsCAS Key Lab for Health InformaticsShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China State Key Laboratory of Luminescent Materials and Devices Key Laboratory of Luminescence from Molecular Aggregates of Guangdong ProvinceSouth China University of TechnologyGuangzhou 510640China School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhen(CUHK-Shenzhen)Shenzhen 518172China

Despite the rapid development of probes for targeting single organelle, the construction of robust dual-organelle targeting probes with multicolor emission was rarely reported. Herein, two dual-emissive aggregation-induced emission luminogens(AIEgens)with donor-π-acceptor structures were designed and synthesized, namely QT-1 and QF-2. Both two AIEgens exhibited excitation wavelength-dependence defying the Kasha's rule, and could stain lipid droplets(LDs) and mitochondria in blue and red fluorescence, respectively. Moreover, thanks to the near-infrared emission and abundant reactive oxygen species(ROS) generation efficiency of QT-1, it was chosen as a photodynamic therapy agent to selectively kill cancer cells from normal cells. Upon light irradiation, an obvious decrease of mitochondrial membrane potential(MMP) and serious change of mitochondrial shape in cells were observed, which corresponded to the efficient inhibition of tumor growth in vivo. This work afforded a promising strategy for the construction of multicolor emission by tuning anti-Kasha behaviors and expanding their application in dualorganelle targeting-based phototheranostics.

关键词： aggregation-induced emission anti-Kasha luminescence fluorescent probe bioimaging photodynamic therapy

来源：评论

学校读者我要写书评

暂无评论

D-type neuropeptide decorated AIEgen/RENP hybrid nanoprobes with light-driven ROS generation ability for NIR-Ⅱ fluorescence imaging-guided through-skull photodynamic therapy of gliomas

Aggregate

引用

Aggregate 2024年第1期5卷 185-195页

作者： Xuelu He Yuan Luo Yanying Li Yuanbo Pan Ryan T.K.Kwok Lulu He Xiaolin Duan Pengfei Zhang Aiguo Wu Ben Zhong Tang Juan Li Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology Zhejiang International Cooperation Base of Biomedical Materials Technology and ApplicationChinese Academy of Sciences(CAS)Key Laboratory of Magnetic Materials and DevicesNingbo Cixi Institute of Biomedical EngineeringZhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingboP.R.China Guangdong Key Laboratory of Nanomedicine Shenzhen Engineering Laboratory of Nanomedicine and NanoformulationsCAS-HK Joint Lab for BiomaterialsResearch Laboratory for Biomedical Optics and Molecular ImagingShenzhen Key Laboratory for Molecular ImagingCAS Key Lab for Health InformaticsShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenP.R.China Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction and Institute for Advanced StudyThe Hong Kong University of Science and Technology(HKUST)KowloonP.R.China School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhenP.R.China

Glioma is one of the most common malignant tumors of the central nervous system,leading high mortality rates in ***-induced emission(AIE)photosensitizers-based photodynamic therapy(PDT)has emerged as a promising therapeutic strategy for least-invasive treatment of glioma,which involves local irradiation of the tumor using an external near-infrared(NIR)***,most AIE photosensitizers suffered from poorly penetration of the visible light excitation,bad spatiotemporal resolution in deep tissues and low efficient blood-brain barrier(BBB)crossing ability,which greatly limited the clinical practice of AIE photosensitizers for especially deep-seated brain tumor *** this work,we developed a multifunctional NIR-driven theranostic agent through hybrid of AIE photosensitizers TIND with rare-earth doping nanoparticles(RENPs)NaGdF4:Nd/Yb/Tm with up/down dual-mode conversion *** theranostic agent was further decorated with D-type neuropeptide DNPY for crossing BBB and targeting *** the 808-nm light irradiation,the down-conversion NIR-II luminescence could indicate the position glioma and the upconversion NIR-I luminescence could trigger the AIE photosensitizers producing reactive oxygen species to inhibit orthotopic glioma tumor growth in *** results demonstrate that the integration of Dtype neuropeptide,AIE photosensitizers and RENPs could be promising candidates for in vivo NIR-II fluorescence image-guided through-skull PDT treatments of brain tumors.

关键词： aggregation-induced emission D-type neuropeptide glioma photodynamic therapy rare-earth doping nanoparticles

来源：评论

学校读者我要写书评

暂无评论

Aggregation-induced emission (AIE) luminescent materials boosting optical storage into the new era of petabit-level capacity

Aggregate

引用

Aggregate 2024年第3期5卷 1-3页

作者： Siwei Zhang Pengfei Zhang Ben Zhong Tang Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionThe Hong Kong University of Science and TechnologyHong KongChina Guangdong Key Laboratory of Nanomedicine CAS-HK Joint Lab of BiomaterialsCAS Key Laboratory of Biomedical Imaging Science and SystemShenzhen Engineering Laboratory of Nanomedicine and NanoformulationsCAS Key Lab for Health InformaticsShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdongChina School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhen(CUHK-Shenzhen)ShenzhenGuangdongChina

The recording of information stands as the most significant milestone in human ***,the recording and storage of information have undergone a technological evolution from paintings to carvings,scribing,and *** invention of optical compact discs(CDs)was one of the major landmarks in digital information *** the past half-century,scientists have endeavored to enhance optical storage capacity by improving both optical systems and optical storage materials,as shown in Scheme *** terms of commercial products,the storage capacity has increased from 700 MB(CDs)to 27 GB(Blu-ray discs)by optimizing the optical system based on the same optical storage medium(polycarbonate).To surpass the conventional optical diffraction limit,the optical systems have evolved from traditional lasers to nonlinear two-photon absorption(TPA)and stimulated emission depletion(STED),which has minified the laser spot size from microns to approximately tens of nanometers,marking a remarkable achievement.

关键词： aggregation-induced emission optical storage super disk

来源：评论

学校读者我要写书评

暂无评论

Long-Chain Gemini Surfactant-Assisted Blade Coating Enables Large-Area Carbon-Based Perovskite Solar Modules with Record Performance

引用

Nano-Micro Letters 2023年第10期15卷 463-477页

作者： Yumin Ren Kai Zhang Zedong Lin Xiaozhen Wei Man Xu Xianzhen Huang Haining Chen Shihe Yang Guangdong Provincial Key Lab of Nano‑Micro Material Research School of Chemical Biology and BiotechnologyShenzhen Graduate SchoolPeking UniversityShenzhen 518055People’s Republic of China Shenzhen Bay Laboratory Institute of Biomedical EngineeringShenzhen 518107GuangdongPeople’s Republic of China School of Materials Science and Engineering Beihang UniversityBeijing 100191People’s Republic of China

Carbon-based perovskite solar cells show great potential owing to their low-cost production and superior stability in ambient ***,scaling up to high-efficiency carbon-based solar modules hinges on reliable deposition of uniform defect-free perovskite films over large areas,which is an unsettled but urgent *** this work,a long-chain gemini surfactant is introduced into perovskite precursor ink to enforce self-assembly into a network structure,considerably enhancing the coverage and smoothness of the perovskite *** long gemini surfactant plays a distinctively synergistic role in perovskite film construction,crystallization kinetics modulation and defect passivation,leading to a certified record power conversion efficiency of 15.46%with Voc of 1.13 V and Jsc of 22.92 mA cm^(-2)for this type of ***,all of the functional layers of the module are printed through a simple and high-speed(300 cm min^(-1))blade coating strategy in ambient *** results mark a significant step toward the commercialization of all-printable carbon-based perovskite solar modules.

关键词： Long-chain gemini surfactant Blade-coating Capillary number Carbon-based perovskite photovoltaics All-printable module

来源：评论

学校读者我要写书评

暂无评论

Palladium-free chemoselective probe for in vivo fluorescence imaging of carbon monoxide

引用

Chinese Chemical Letters 2024年第9期35卷 223-226页

作者： Gongcheng Ma Qihang Ding Yuding Zhang Yue Wang Jingjing Xiang Mingle Li Qi Zhao Saipeng Huang Ping Gong Jong Seung Kim Guangdong Key Laboratory of Nanomedicine Shenzhen Engineering Laboratory of Nanomedicine and NanoformulationsCAS-HK Joint Lab for BiomaterialsResearch Laboratory for Biomedical Optics and Molecular ImagingShenzhen Key Laboratory for Molecular ImagingCAS Key Lab for Health InformaticsShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China Department of Chemistry Korea UniversitySeoul 02841South Korea School of Chemical Engineering Northwest UniversityXi’an 710069China Cancer Center Institute of Translational MedicineFaculty of Health SciencesUniversity of MacaoMacao 999078China State Key Laboratory of Fine Chemicals College of Materials Science and EngineeringShenzhen UniversityShenzhen 518060China

Carbon monoxide(CO)is a vital intracellular gas messenger known for its cytoprotective and homeostatic *** plays a pivotal role in a myriad of biological ***,the precise detection of CO is of paramount importance in unraveling the intricacies of pathological mechanisms and advancing the development of disease *** herein introduce NFCOP,a state-of-the-art near-infrared(NIR)turn-on fluorescence(FL)probe that has been meticulously designed for highly sensitive,swift and selective imaging of *** NFCOP response occurred rapidly with CO,within just 10 s,and the calculated detection limit for CO was determined to be 0.32μmol/*** investigations conducted at the cellular level and in vivo demonstrated that NFCOP possesses high sensitivity and selectivity for imaging CO.

关键词： Palladium-free Chemoselective probe Fluorescence imaging Carbon monoxide Near-infrared

来源：评论

学校读者我要写书评

暂无评论

Enzymes immobilized in wood-derived cellulose scaffold for constructing a novel modular bioreactor

引用

Green Chemical engineering 2023年第1期4卷 39-48页

作者： Zhihong Zhang Mengchen Jin Guiru Chen Jiandu Lei Luying Wang Jun Ge Beijing Key Laboratory of Lignocellulosic Chemistry Beijing Forestry UniversityBeijing100083China Key Lab for Industrial Biocatalysis Ministry of EducationDepartment of Chemical EngineeringTsinghua UniversityBeijing100084China MOE Engineering Research Center of Forestry Biomass Materials and Bioenergy Beijing Forestry UniversityBeijing100083China Institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate SchoolShenzhen518055China Institute of Biomedical Health Technology and Engineering Shenzhen Bay LaboratoryShenzhen518107China

Modular bioreactors can provide a flexible platform for constructing complex multi-step pathways,which may be a solution for maximizing reactions and overcoming the complexity of multi-enzyme ***,we selected wood-derived cellulose scaffold as a support for enzyme immobilization and constructed the modular *** scaffold was prepared after removing lignin from wood,followed by citric acid functionalization and the addition of glutaraldehyde finally allowed the cross-linking of *** enzymes,horseradish peroxidase(HRP),glucose oxidase(GOD),and catalase(CAT),were separately immobilized,resulting in the immobilized enzyme amount to over 40 mg/*** introduction of carboxyl groups from citric acid facilitated the rapid enzyme adsorption on the support surface and immobilized enzymes possess~65%expressed *** bioreactors were constructed by using the immobilized *** the immobilized HRP module,reactor showed desired catalytic performance with the phenol degradation rate of>90%.Also,a pH regulation can occur in the bioreactors for preserving enzyme activities and neutralizing acid *** the GOD/CAT modular bioreactor,the cascade reaction with adjusting pH values can achieve a 95%yield of sodium gluconate and exhibit a favorable reusability of 5 operation cycles.

关键词： Wood Immobilized enzyme Citric acid Modular bioreactor Cascade reaction

来源：评论

学校读者我要写书评

暂无评论

D-π-D molecular layer electronically bridges the NiO_(x) hole transport layer and the perovskite layer towards high performance photovoltaics

引用

Journal of Energy Chemistry 2022年第4期31卷 797-804页

作者： Rongguo Xu Xiuwen Xu Ruixi Luo Yu Li Gaopeng Wang Tongfa Liu Ning Cai Shihe Yang Guangdong Provincial Key Lab of Nano-Micro Materials Research School of Chemical Biology and BiotechnologyShenzhen Graduate SchoolPeking UniversityShenzhen 518055GuangdongChina School of Chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhou 510006GuangdongChina Institute of Biomedical Engineering Shenzhen Bay LaboratoryShenzhen 518107GuangdongChina

Nickel oxide (NiO_(x)) has significant cost and stability advantages over poly[bis (4-phenyl)(2,4,6-trimethyl phenyl)amine](PTAA) for inverted p-i-n perovskite solar cells (PSCs),but the poor NiO_(x)/perovskite contact stemming from some reactive species at the interface led to suboptimal device *** solve this problem,we take a multiple donor molecule approach,using 3,3’-(4,8-bis(hexylthio)benzo[1,2-b:4,5-b’]dithiophene-2,6-diyl)bis(10-(6-bromohexyl)-10H-phenoxazine)(BDT-POZ) as an example,to modify the NiO_(x)/perovskite *** primary goal was to reduce the under-coordinated Ni^(≥3+) cations via electron transfer from the donor molecules to NiO_(x),thus mitigating the detrimental reactions between perovskite and NiO_(x).Equally importantly,the hole extraction at the interface was greatly enhanced after the organic donor modification,since the hydrophobic species atop NiO_(x) not only enabled pinhole-free crystallization of the perovskite but also properly tuned the interfacial energy level ***,the PSCs with NiO_(x)/BDT-POZ HTL achieved a high power conversion efficiency (PCE) up to 20.16%,which compared excellently with that of the non-modified devices (17.83%).This work provides a new strategy to tackle the exacting issues that have so far impeded the development of NiO_(x) based PSCs.

关键词： Perovskite solar cells NiO_(x)modification Hole transport Energy level alignment High performance

来源：评论

学校读者我要写书评

暂无评论

Borosilicate bioactive glass synergizing low-dose antibiotic loaded implants to combat bacteria through ATP disruption and oxidative stress to sequentially achieve osseointegration

引用

Bioactive Materials 2025年第2期44卷 184-204页

作者： Mengke Fan Youliang Ren Yanbin Zhu Hao Zhang Shuaijie Li Chunyu Liu Hongzhi Lv Lei Chu Zhiyong Hou Yingze Zhang Haobo Pan Xu Cui Wei Chen Department of Orthopaedic Surgery the Hebei Medical University Third Hospital Orthopaedic Research Institution of Hebei ProvinceNHC Key Laboratory of Intelligent Orthopaedic EquipmentEngineering Research Center of Orthopedic Minimally Invasive Intelligent Equipment of Ministry of EducationKey Laboratory of Biomechanics of Hebei ProvinceNo.139 Ziqiang RoadShijiazhuang050051PR China Shenzhen Key Laboratory of Marine Biomedical Materials CAS-HK Joint Lab of BiomaterialsThe Key Laboratory of Biomedical Imaging Science and SystemShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen518055PR China Department of Orthopaedics Second Affiliated Hospital of Chongqing Medical University76 Linjiang RoadYuzhong DistinctChongqing400010PR China Department of Orthopaedics Guizhou Provincial People’s HospitalGuiyang550000PR China Shenzhen Healthemes Biotechnology Co. Ltd.ShenzhenPR China

Bone infection is a catastrophe in clinical *** being the standard therapy for osteomyelitis,antibiotic-loaded polymethyl methacrylate(PMMA)cement has low efficiency against bacteria in ***,high-dose antibiotic-loaded implants carry risks of bacterial resistance,tissue toxicity,and impairment of local tissue *** incorporating borosilicate bioactive glass(BSG)into low-dose gentamicin sulfate(GS)-loaded PMMA cement,an intelligent strategy that synergistically eradicates bacteria and sequen-tially promotes osseointegration,was *** showed that BSG did not compromises the handling properties of the cement,but actually endowed it with an ionic and alkaline microenvironment,thereby damaging the integrity of bacterial cell walls and membranes,inhibiting ATP synthesis by disrupting the res-piratory chain in cell membranes and glycogen metabolism,and elevating reactive oxygen species(ROS)levels by weakening antioxidant components(peroxisomes and carotenoids).These antibacterial characteristics of BSG synergistically reinforced the effectiveness of GS,which was far below the actual clinical dosage,achieving efficient bacterial killing and biofilm clearance by binding to the 30S subunit of ***,the released GS and the ionic and alkaline microenvironment from the implants fostered the osteogenic activity of hBMSCs in vitro and coordinately enhanced osseointegration in ***,this study underscores that BSG incorporation offers a promising strategy for reducing antibiotic dosage while simultaneously enhancing the antibacterial activity and osteogenesis of *** approach holds potential for resolving the conflict be-tween bacterial resistance and bone infection.

关键词： Staphylococcus aureus Biofilm Osteomyelitis Borosilicate bioactive glass Polymethyl methacrylate

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：