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Fabry–Perot interference optical fiber biosensor based on the ECF for label-free DNA detection

Applied Optics 2025年第9期64卷 2255-2260页

作者： Wang, Lina Li, Chong Cai, Jun Wu, Shenbing Dai, Mingxia Geng, Youfu Yi, Duo Li, Xuejin College of Electronic Engineering Huainan Normal University Huainan232038 China Shenzhen Key Laboratory of Sensor Technology Shenzhen University Shenzhen518060 China Shenzhen Key Laboratory of Advanced Thin Films and Applications College of Physics and Optoelectronic Engineering Shenzhen University Shenzhen518060 China School of Science and Engineering Chinese University of Hong Kong Shenzhen518172 China

A fiber-optic biosensor based on self-reference parallel Fabry–Perot interference (FPI) is proposed for label-free DNA detection. The parallel FPI is formed by fusing a section of exposed core fiber (ECF) in SMF and MMF. Adopting the air cavity of the ECF as a reference, a self-reference differential phase demodulation technique is designed to improve the stability and resolution of the demodulation system. By functionalizing the fiber surface, the sensor can efficiently capture complementary DNA (cDNA). In addition, the specific selection performance of the sensor is explored using non-complementary DNA (N-cDNA). The experimental results show that the sensor exhibits a good linear response in the concentration range of 1 to 5 µM, and the sensitivity reaches 5.53◦/µM. The detection concentration can be as low as 1 µM. The proposed fiber-optic DNA biosensor has good sensitivity and selectivity and has broad prospects in the fields of biomedical diagnostics, environmental monitoring, and food safety detection. © 2025 Optica Publishing Group. All rights, including for text and data mining (TDM), Artificial Intelligence (AI) training, and similar technologies, are reserved.

关键词： Optical fibers

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Research on liquid pipeline blockage based on quasi-distributed FBG 4

Research on liquid pipeline blockage based on quasi-distribu...

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4th International Computational Imaging Conference, CITA 2024

作者： Zhou, Xinghong Li, Dongqing Yi, Duo Geng, Youfu Li, Xuejin College of Physics and Optoelectronic Engineering Shenzhen Key Laboratory of Sensor Technology Shenzhen University Shenzhen China School of Science Chinese University of HongKong Shenzhen518172 China

ISBN: (纸本)9781510688834

The blockage of liquid pipelines greatly affects the safe operation of pipelines, while it is rarely discussed in the previous studies. In this paper, the Fiber Bragg Grating (FBG) sensor is used to monitor the blockage state of liquid pipeline system, and the wavelength shift characteristics of FBG under different degrees of front blockage and rear blockage are discussed. The experimental results have shown that the liquid flow velocity is affected when the inner liquid pipeline is blocked, and the wavelength shifts of different FBGs show the significant differences. Specifically speaking, when the pipeline is blocked, the FBG sensor before and after the blockage point will show the opposite wavelength shifts. The FBG center wavelength shows the red-shift when it located before the blockage point, while the blue-shift occurs when it located after the blockage point. The wavelength shift range is closely related to the relative position between the FBG and the blockage point. Besides, the wavelength shift of FBG caused by rear blockage is significantly greater than that of the front blockage. Based on the above results, an effective method to detect the pipeline blockage can be summarized. These research results provide important theoretical support and technical guidance for real-time monitoring of pipeline health status and prevention of pipeline blockage. © 2025 SPIE.

关键词： Fiber Bragg gratings

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Frequency band feature extraction analysis of pipeline leakage in fiber optic DAS system 4

Frequency band feature extraction analysis of pipeline leaka...

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4th International Computational Imaging Conference, CITA 2024

作者： Li, Dongqing Zhou, Xinghong Yi, Duo Geng, Youfu Li, Xuejin College of Physics and Optoelectronic Engineering Shenzhen Key Laboratory of Sensor Technology Shenzhen University Shenzhen China School of Science and Engineering Chinese University of HongKong Shenzhen518172 China

ISBN: (纸本)9781510688834

Real-time and early detection of pipeline leakage is extremely important in the oil/gas reservoir monitoring. When compared with the traditional sensors, the fiber optic distributed acoustic sensing (DAS) technology exhibits significant advantages due to its high sensitivity, high dynamic range, and excellent detection performance over long distances. However, challenges still remain in liquid pipeline scenarios such as oil and nuclear coolant, the leakage signals from smaller holes are easily submerged by the water flow noise, and it can be also easily confused by the environmental interference. In our study, we conduct the frequency band feature extraction analysis of pipeline leakage signals, and we proposed two effective feature parameters, i.e., short-time band power (STFBP) and short-time band standard deviation (STFSD) to quantitatively distinguish both the leakage signal and non-leakage signal in fiber optic DAS system. The experimental results show that, for a 4-mm leakage hole, the proposed two feature parameters demonstrate high signal-to-noise ratios (4.65 dB, 2.55 dB) and low error rates (9.36%, 4.77%), which effectively enhances the detection accuracy and reliability of pipeline leakage. © 2025 SPIE.

关键词： Petroleum reservoir evaluation

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Research on transient response optimization of fiber optic seismic sensor targeting oil and gas field exploration 4

Research on transient response optimization of fiber optic s...

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4th International Computational Imaging Conference, CITA 2024

作者： Tang, Guitao Li, Dongqing Zhou, Xinghong Yi, Duo Liu, Fei College of Physics and Optoelectronic Engineering Shenzhen Key Laboratory of Sensor Technology Shenzhen University Shenzhen518060 China School of Computer and Communication Engineering University of Science and Technology Beijing Beijing100083 China

ISBN: (纸本)9781510688834

The current research relating to the fiber optic seismic sensor (FOSS) mainly focuses on optimizing its steady-state characteristic parameters including sensitivity, cross-sensitivity and operating bandwidth etc., while there are few studies on its transient response characteristics. In this study, we discuss the transient response improvement of the FOSS in both laboratory platform and oilfield. In the laboratory platform, the ball-falling process is used to simulate the perforation shot signal during down-hole seismic monitoring, and the transient response between the FOSS and the commercial piezoelectric sensor has been compared in both time and frequency domain. Besides, two different types of balls (steel and cotton) are used to verify the transient response performance of the presented FOSS when retrieving different types of signals. The experimental results demonstrate that correlation coefficients as high as 90% are obtained within the frequency range 0~3000 Hz for two ball-falling processes. Finally, the presented FOSS has been used for detecting the perforation shot signal in the oilfield, the comparative analyses based on the key parameters including taking off time and attenuation constant also confirm the transient response optimization of the presented sensor, which is beneficial to improve the acquisition accuracy of seismic signal. © 2025 SPIE.

关键词： Gas industry

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Digital PCR-free technologies for absolute quantitation of nucleic acids at single-molecule level

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Chinese Chemical Letters 2025年第2期36卷 90-98页

作者： Xinyi Luo Ke Wang Yingying Xue Xiaobao Cao Jianhua Zhou Jiasi Wang Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument School of Biomedical EngineeringShenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China School of Biomedical Engineering Sun Yat-sen UniversityGuangzhou 510275China Guangzhou National Laboratory Guangzhou International Bio IslandGuangzhou 510005China

Ultrasensitive detection of nucleic acids is of great significance for precision *** polymerase chain reaction(dPCR)is the most sensitive method but requires sophisticated and expensive instruments and a long reaction *** PCR-free technologies,which mean the digital assay not relying on thermal cycling to amplify the signal for quantitative detection of nucleic acids at the singlemolecule level,include the digital isothermal amplification techniques(d IATs)and the digital clustered regularly interspaced short palindromic repeats(CRISPR)*** combine the advantages of d PCR and IATs,which could be fast and simple,enabling absolute quantification of nucleic acids at a single-molecule level with minimum instrument,representing the next-generation molecular diagnostic ***,we systematically summarized the strategies and applications of various dIATs,including the digital loop-mediated isothermal amplification(dLAMP),the digital recombinase polymerase amplification(dRPA),the digital rolling circle amplification(dRCA),the digital nucleic acid sequencebased amplification(d NASBA)and the digital multiple displacement amplification(d MDA),and evaluated the pros and cons of each *** emerging digital CRISPR technologies,including the detection mechanism of CRISPR and the various strategies for signal amplification,are also introduced comprehensively in this *** current challenges as well as the future perspectives of the digital PCR-free technology were discussed.

关键词： Digital bioassay Isothermal amplification Nucleic acid detection Digital CRISPR Cas Absolute quantification

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Fully automated in vivo screening system for multi-organ imaging and pharmaceutical evaluation

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Microsystems & Nanoengineering 2025年第1期11卷 301-311页

作者： Junhan Duan Guanming Lin Kangjian Jiao Xiaohui Hong Xudong Lin Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument School of Biomedical EngineeringShenzhen Campus of Sun Yat-Sen University518000 ShenzhenChina

Advancements in screening technologies employing small organisms have enabled deep profiling of compounds in ***,current strategies for phenotyping of behaving animals,such as zebrafish,typically involve tedious ***,we develop and validate a fully automated in vivo screening system(AISS)that integrates microfluidic technology and computer-vision-based control methods to enable rapid evaluation of biological responses of non-anesthetized zebrafish to molecular *** precise fluidic control,the AISS allows automatic loading,encapsulation,transportation and immobilization of single-larva in droplets for multi-organ imaging and chemical gradients generation inaccessible in previous *** this platform,we examine the cardiac sensitivity of an antipsychotic drug with multiple concentration gradients,and reveal dramatic diversity and complexity in the accurate chemical regulation of cardiac functions in *** proposed system expands the arsenal of tools available for in vivo screening and facilitates comprehensive profiling of pharmaceuticals.

关键词： small organisms automated vivo screening system screening technologies microfluidic technology deep profiling compounds precise flui evaluation biological responses automated vivo screening system aiss

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A review for design,mechanism,fabrication,and application of magnetically responsive microstructured functional surface

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International Journal of Extreme Manufacturing 2025年第1期7卷 96-128页

作者： Jian Wang Xingyi Song Chaochao Wang Yumei Zhou Ri Chen Yong Yang Bin Liu Yihao Zheng Hui Li Wei Zhou Lelun Jiang Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument School of Biomedical EngineeringShenzhen Campus of Sun Yat-sen UniversityShenzhen 518107People’s Republic of China School of Mechatronic Engineering Guangdong Polytechnic Normal UniversityGuangzhou 510665People’s Republic of China School of Mechanical and Electrical Engineering Guangdong Polytechnic of Industry and CommerceGuangzhou 510550People’s Republic of China Mechanical&Materials Engineering Department Worcester Polytechnic InstituteWorcesterMA 01609United States of America Guangdong Provincial Key Laboratory of Micro/Nano Optomechatronics Engineering College of Mechatronics and Control EngineeringShenzhen UniversityShenzhen 518060People’s Republic of China Pen-Tung Sah Institute of Micro-Nano Science and Technology Xiamen UniversityXiamen 361005People’s Republic of China

Magnetically responsive microstructured functional surface(MRMFS),capable of dynamically and reversibly switching the surface topography under magnetic actuation,provides a wireless,noninvasive,and instantaneous way to accurately control the microscale engineered *** the last decade,many studies have been conducted to design and optimize MRMFSs for diverse applications,and significant progress has been *** review comprehensively presents recent advancements and the potential prospects in *** first classify MRMFSs into one-dimensional linear array MRMFSs,two-dimensional planar array MRMFSs,and dynamic self-assembly MRMFSs based on their ***,an overview of three deformation mechanisms,including magnetically actuated bending deformation,magnetically driven rotational deformation,and magnetically induced self-assembly deformation,are *** main fabrication strategies employed to create MRMFSs are summarized,including replica molding,magnetization-induced self-assembly,laser cutting,and ferrofluid-infused ***,the applications of MRMFS in droplet manipulation,solid transport,information encryption,light manipulation,triboelectric nanogenerators,and soft robotics are ***,the challenges that limit the practical applications of MRMFSs are discussed,and the future development of MRMFSs is proposed.

关键词： functional surfaces microstructures magnetic actuation manipulation

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EAVFormer: an end-to-end audio and visual emotion recognition network based on transformers

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Multimedia Systems 2025年第3期31卷 1-22页

作者： Liu, Haoran Sun, Zijian Li, Haibin Li, Yaqian Zhang, Wenming Song, Tao School of Information Science and Engineering Yanshan University Qinhuangdao066004 China The Key Laboratory for Special Fiber and Fiber Sensor of Hebei Province Yanshan University Qinhuangdao066004 China Key Lab of Industrial Computer Control Engineering of Hebei Province Yanshan University Qinhuangdao066004 China Shenzhen Research Institute of Yanshan University Shenzhen518057 China Key Lab of Measurement Technology & Instrumentation of Hebei Province School of Electrical Engineering Yanshan University Qinhuangdao066004 China

Audio-visual emotion recognition, integrating information from various sources, enhances the comprehensive understanding and analysis of human emotions. However, existing methods in this field primarily focus on feature fusion, often overlooking the equally crucial stage of feature extraction. Typically, these methods employ pre-trained models to extract features during the initial phase, complicating modality-specific feature extraction and increasing system complexity and coordination challenges, which hinder effective audio-visual feature fusion. To address these issues, we propose an end-to-end audio-visual emotion recognition model, EAVFormer. For the audio modality, we input raw audio signals along with a mix of mel spectrograms and Mel Frequency Cepstral Coefficients (MFCCs), employing a hierarchical transformer technique that facilitates both shallow local and deep global feature extraction to fully harness complementary acoustic information, significantly enhancing the acoustic modality’s contribution. For the visual modality, we input raw video frames and employ a hierarchical transformer feature extraction method that integrates three-dimensional convolution and spatio-temporal self-attention mechanisms to address spatial and temporal redundancies and dependencies, thereby enhancing the expression of dynamic visual information. In the modal fusion stage, we construct dual-modality representations and encode inter-modal information while preserving modality-specific and meaningful intra-modal features. Testing on three popular datasets RAVDESS, CREMA-D, and CMU-MOSEI demonstrates that EAVFormer surpasses existing state-of-the-art methods in audio-visual emotion recognition accuracy, achieving rates of 95.17%, 86.13%, and 78.22%, respectively. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2025.

关键词： Image coding

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Enhanced phase transformation in BiFeO3 thin films via synergistic pressure and electric field modulation

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Journal of Applied Physics 2025年第18期137卷

作者： Long, Jiemei Yang, Yan Dong, Yangda Bin, Shuping Zhang, Yuan Tan, Congbing Wang, Jinbin Song, Hongjia Zhong, Xiangli School of Materials Science and Engineering Xiangtan University Hunan Xiangtan411105 China Department of Materials Science and Engineering Southern University of Science and Technology Guangdong Shenzhen518055 China Hunan Provincial Key Laboratory of Intelligent Sensors and Advanced Sensor Materials School of Physics and Electronics Hunan University of Science and Technology Hunan Xiangtan411201 China

In complex multi-field application environments, enhancing the rhombohedral/tetragonal (R/T) phase transition in BiFeO3 (BFO) thin films and making more appearances of R/T morphotropic phase boundaries (MPBs) play a key role in improving the physical properties, such as ferroelectric, piezoelectric, and dielectric, and so on. Therefore, it is particularly important to study the R/T phase transition behavior of the BFO thin films under multi-field conditions. In this paper, the behavior of R/T phase transition in BFO thin films under synergistic modulation of pressure and electric fields is investigated by scanning probe microscopy. Under the condition of pressure-positive voltage synergistic regulation, achieving an R/T MPB with a volume fraction of 35.1% merely requires 3 V, which is lower than the one under a single positive voltage. Under the condition of pressure-negative voltage synergistic regulation, the relationship between the pressure and the voltage is mutual restraint and counterbalance. Under the pressure of above 1.3 μN, the decrease in volume fraction of MPBs is only 1/2 of the one without pressure when the negative voltage is increased from −6 to −10 V. This work provides new ideas and strategies for researching high-performance ferroelectric, piezoelectric, and dielectric devices, holding significant theoretical importance in BFO thin films in complex multi-field application environments. © 2025 Author(s).

关键词： Ferroelectric devices

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High-performance temperature sensor via Mach-Zehnder interferometer based on exposed-core microstructured fiber combined with PDMS

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Optical Fiber technology 2025年 93卷

作者： XingHong Zhou Duo Yi DongQing Li XingHong Chen YouFu Geng XueJin Li College of Physics and Optoelectronic Engineering Shenzhen Key Laboratory of Sensor Technology Shenzhen University Shenzhen 518060 China School of Science Chinese University of Hong Kong Shenzhen 518060 China

This study proposes a fiber optic temperature sensor based on an exposed-core fiber (ECF) combined with polydimethylsiloxane (PDMS). Owing to the unique structure design of ECF and the high-performance of PDMS, a triple interference effect occurs within the device. Then, by employing the interrogation techniques including fast Fourier transform (FFT) and band-pass filtering, mixed interference spectra can be effectively separated in the spatial domain, and each of them can be individually applied for temperature measurement. The experimental results demonstrate that high-sensitivity (8.2 nm/℃) or large-range (160 ℃) temperature measurements can be realized based on the separated interference spectra. Such an excellent performance is significantly enhanced over previously reported fiber temperature sensors. More importantly, different from the traditional methods by cascading two different sensing elements, high-sensitivity and large-range temperature measurement is achieved within a single sensor structure, significantly reducing the volume and complexity of the sensing device.

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