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Fabry–Perot interference optical fiber biosensor based on the ECF for label-free DNA detection

Applied Optics 2025年第9期64卷 2255-2260页

作者： Wang, Lina Li, Chong Cai, Jun Wu, Shenbing Dai, Mingxia Geng, Youfu Yi, Duo Li, Xuejin College of Electronic Engineering Huainan Normal University Huainan232038 China Shenzhen Key Laboratory of Sensor Technology Shenzhen University Shenzhen518060 China Shenzhen Key Laboratory of Advanced Thin Films and Applications College of Physics and Optoelectronic Engineering Shenzhen University Shenzhen518060 China School of Science and Engineering Chinese University of Hong Kong Shenzhen518172 China

A fiber-optic biosensor based on self-reference parallel Fabry–Perot interference (FPI) is proposed for label-free DNA detection. The parallel FPI is formed by fusing a section of exposed core fiber (ECF) in SMF and MMF. Adopting the air cavity of the ECF as a reference, a self-reference differential phase demodulation technique is designed to improve the stability and resolution of the demodulation system. By functionalizing the fiber surface, the sensor can efficiently capture complementary DNA (cDNA). In addition, the specific selection performance of the sensor is explored using non-complementary DNA (N-cDNA). The experimental results show that the sensor exhibits a good linear response in the concentration range of 1 to 5 µM, and the sensitivity reaches 5.53◦/µM. The detection concentration can be as low as 1 µM. The proposed fiber-optic DNA biosensor has good sensitivity and selectivity and has broad prospects in the fields of biomedical diagnostics, environmental monitoring, and food safety detection. © 2025 Optica Publishing Group. All rights, including for text and data mining (TDM), Artificial Intelligence (AI) training, and similar technologies, are reserved.

关键词： Optical fibers

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Ultra-low frequency magnetic energy focusing for highly effective wireless powering of deep-tissue implantable electronic devices

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National Science Review 2024年第5期11卷 272-290页

作者： Yuanyuan Li Zhipeng Chen Yuxin Liu Zijian Liu Tong Wu Yuanxi Zhang Lelun Peng Xinshuo Huang Shuang Huang Xudong Lin Xi Xie Lelun Jiang Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument School of Biomedical EngineeringShenzhen Campus of Sun Yat-Sen University School of Mechanical and Electrical Engineering Guangzhou University State Key Laboratory of Optoelectronic Materials and Technologies Guangdong Province Key Laboratory of Display Material and Technology School of Electronics and Information Technology Sun Yat-Sen University

The limited lifespan of batteries is a challenge in the application of implantable electronic devices. Existing wireless power technologies such as ultrasound, near-infrared light and magnetic fields cannot charge devices implanted in deep tissues, resulting in energy attenuation through tissues and thermal ***, an ultra-low frequency magnetic energy focusing(ULFMEF) methodology was developed for the highly effective wireless powering of deep-tissue implantable devices. A portable transmitter was used to output the low-frequency magnetic field(<50 Hz), which remotely drives the synchronous rotation of a magnetic core integrated within the pellet-like implantable device, generating an internal rotating magnetic field to induce wireless electricity on the coupled coils of the device. The ULFMEF can achieve energy transfer across thick tissues(up to 20 cm) with excellent transferred power(4–15 mW) and non-heat effects in tissues, which is remarkably superior to existing wireless powering technologies. The ULFMEF is demonstrated to wirelessly power implantable micro-LED devices for optogenetic neuromodulation, and wirelessly charged an implantable battery for programmable electrical stimulation on the sciatic nerve. It also bypassed thick and tough protective shells to power the implanted devices. The ULFMEF thus offers a highly advanced methodology for the generation of wireless powered biodevices.

关键词： ultra-low frequency transcutaneous energy transmission electromagnetic generator implantable electronic device deep tissue

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Research on liquid pipeline blockage based on quasi-distributed FBG 4

Research on liquid pipeline blockage based on quasi-distribu...

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4th International Computational Imaging Conference, CITA 2024

作者： Zhou, Xinghong Li, Dongqing Yi, Duo Geng, Youfu Li, Xuejin College of Physics and Optoelectronic Engineering Shenzhen Key Laboratory of Sensor Technology Shenzhen University Shenzhen China School of Science Chinese University of HongKong Shenzhen518172 China

ISBN: (纸本)9781510688834

The blockage of liquid pipelines greatly affects the safe operation of pipelines, while it is rarely discussed in the previous studies. In this paper, the Fiber Bragg Grating (FBG) sensor is used to monitor the blockage state of liquid pipeline system, and the wavelength shift characteristics of FBG under different degrees of front blockage and rear blockage are discussed. The experimental results have shown that the liquid flow velocity is affected when the inner liquid pipeline is blocked, and the wavelength shifts of different FBGs show the significant differences. Specifically speaking, when the pipeline is blocked, the FBG sensor before and after the blockage point will show the opposite wavelength shifts. The FBG center wavelength shows the red-shift when it located before the blockage point, while the blue-shift occurs when it located after the blockage point. The wavelength shift range is closely related to the relative position between the FBG and the blockage point. Besides, the wavelength shift of FBG caused by rear blockage is significantly greater than that of the front blockage. Based on the above results, an effective method to detect the pipeline blockage can be summarized. These research results provide important theoretical support and technical guidance for real-time monitoring of pipeline health status and prevention of pipeline blockage. © 2025 SPIE.

关键词： Fiber Bragg gratings

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Frequency band feature extraction analysis of pipeline leakage in fiber optic DAS system 4

Frequency band feature extraction analysis of pipeline leaka...

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4th International Computational Imaging Conference, CITA 2024

作者： Li, Dongqing Zhou, Xinghong Yi, Duo Geng, Youfu Li, Xuejin College of Physics and Optoelectronic Engineering Shenzhen Key Laboratory of Sensor Technology Shenzhen University Shenzhen China School of Science and Engineering Chinese University of HongKong Shenzhen518172 China

ISBN: (纸本)9781510688834

Real-time and early detection of pipeline leakage is extremely important in the oil/gas reservoir monitoring. When compared with the traditional sensors, the fiber optic distributed acoustic sensing (DAS) technology exhibits significant advantages due to its high sensitivity, high dynamic range, and excellent detection performance over long distances. However, challenges still remain in liquid pipeline scenarios such as oil and nuclear coolant, the leakage signals from smaller holes are easily submerged by the water flow noise, and it can be also easily confused by the environmental interference. In our study, we conduct the frequency band feature extraction analysis of pipeline leakage signals, and we proposed two effective feature parameters, i.e., short-time band power (STFBP) and short-time band standard deviation (STFSD) to quantitatively distinguish both the leakage signal and non-leakage signal in fiber optic DAS system. The experimental results show that, for a 4-mm leakage hole, the proposed two feature parameters demonstrate high signal-to-noise ratios (4.65 dB, 2.55 dB) and low error rates (9.36%, 4.77%), which effectively enhances the detection accuracy and reliability of pipeline leakage. © 2025 SPIE.

关键词： Petroleum reservoir evaluation

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Research on transient response optimization of fiber optic seismic sensor targeting oil and gas field exploration 4

Research on transient response optimization of fiber optic s...

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4th International Computational Imaging Conference, CITA 2024

作者： Tang, Guitao Li, Dongqing Zhou, Xinghong Yi, Duo Liu, Fei College of Physics and Optoelectronic Engineering Shenzhen Key Laboratory of Sensor Technology Shenzhen University Shenzhen518060 China School of Computer and Communication Engineering University of Science and Technology Beijing Beijing100083 China

ISBN: (纸本)9781510688834

The current research relating to the fiber optic seismic sensor (FOSS) mainly focuses on optimizing its steady-state characteristic parameters including sensitivity, cross-sensitivity and operating bandwidth etc., while there are few studies on its transient response characteristics. In this study, we discuss the transient response improvement of the FOSS in both laboratory platform and oilfield. In the laboratory platform, the ball-falling process is used to simulate the perforation shot signal during down-hole seismic monitoring, and the transient response between the FOSS and the commercial piezoelectric sensor has been compared in both time and frequency domain. Besides, two different types of balls (steel and cotton) are used to verify the transient response performance of the presented FOSS when retrieving different types of signals. The experimental results demonstrate that correlation coefficients as high as 90% are obtained within the frequency range 0~3000 Hz for two ball-falling processes. Finally, the presented FOSS has been used for detecting the perforation shot signal in the oilfield, the comparative analyses based on the key parameters including taking off time and attenuation constant also confirm the transient response optimization of the presented sensor, which is beneficial to improve the acquisition accuracy of seismic signal. © 2025 SPIE.

关键词： Gas industry

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Digital PCR-free technologies for absolute quantitation of nucleic acids at single-molecule level

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Chinese Chemical Letters 2025年第2期36卷 90-98页

作者： Xinyi Luo Ke Wang Yingying Xue Xiaobao Cao Jianhua Zhou Jiasi Wang Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument School of Biomedical EngineeringShenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China School of Biomedical Engineering Sun Yat-sen UniversityGuangzhou 510275China Guangzhou National Laboratory Guangzhou International Bio IslandGuangzhou 510005China

Ultrasensitive detection of nucleic acids is of great significance for precision *** polymerase chain reaction(dPCR)is the most sensitive method but requires sophisticated and expensive instruments and a long reaction *** PCR-free technologies,which mean the digital assay not relying on thermal cycling to amplify the signal for quantitative detection of nucleic acids at the singlemolecule level,include the digital isothermal amplification techniques(d IATs)and the digital clustered regularly interspaced short palindromic repeats(CRISPR)*** combine the advantages of d PCR and IATs,which could be fast and simple,enabling absolute quantification of nucleic acids at a single-molecule level with minimum instrument,representing the next-generation molecular diagnostic ***,we systematically summarized the strategies and applications of various dIATs,including the digital loop-mediated isothermal amplification(dLAMP),the digital recombinase polymerase amplification(dRPA),the digital rolling circle amplification(dRCA),the digital nucleic acid sequencebased amplification(d NASBA)and the digital multiple displacement amplification(d MDA),and evaluated the pros and cons of each *** emerging digital CRISPR technologies,including the detection mechanism of CRISPR and the various strategies for signal amplification,are also introduced comprehensively in this *** current challenges as well as the future perspectives of the digital PCR-free technology were discussed.

关键词： Digital bioassay Isothermal amplification Nucleic acid detection Digital CRISPR Cas Absolute quantification

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A lateral-immobilization zebrafish microfluidic chip-based system for in vivo real-time evaluation of antithrombotic agents

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Chinese Chemical Letters 2024年第3期35卷 312-315页

作者： Lijuan He Hongxia Du Yi Yang Zhihua Guan Jinjin Li Honglin Li Xudong Lin Lili Zhu Shanghai Key Laboratory of New Drug Design School of PharmacyEast China University of Science&TechnologyShanghai 200237China Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument School of Biomedical EngineeringShenzhen Campus of Sun Yat-sen UniversityShenzhen 518000China Innovation Center for AI and Drug Discovery East China Normal UniversityShanghai 200062China

Thrombosis remains a major global health concern mainly characterized by high rates of morbidity and *** models serve as an indispensable tool to understand the underlying pathogenesis of thrombosis and assess the efficacy of novel antithrombotic ***,zebrafish has emerged as a valuable model organism for thrombosis ***,the traditional method of studying zebrafish thrombosis requires a laborious and time-consuming procedure,including anesthesia and manual immobilization of *** this study,based on hydrodynamic force,a lateral-immobilization zebrafish microfluidic chip(LIZMC)was designed to evaluate the cardiovascular system of multiple larvae within a single microscope field of ***,coupling with microscope imaging,real-time monitoring of the peripheral blood circulation in the tail of phenylhydrazine(PHZ)-induced zebrafish thrombosis was ***,the reliability of LIZMC for in vivo evaluation of antithrombotic agents in zebrafish was verified using ***,this novel LIZMC-based system can be used for in vivo zebrafish thrombosis studies and rapid screening of antithrombotic agents.

关键词： Microfluidic chip Zebrafish Thrombosis In vivo evaluation Real-time monitor

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A Review of Nano/Micro/Milli Needles Fabrications for Biomedical Engineering

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Chinese Journal of Mechanical Engineering 2022年第3期35卷 51-79页

作者： Bin Liu Xin Yi Ying Zheng Zhishan Yuan Jingbo Yang Jian Yang Xiao Yu Lelun Jiang Chengyong Wang Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instruments School of Biomedical EngineeringShenzhen Campus of Sun Yatsen UniversityShenzhen 518107China Guangdong Provincial Key Laboratory of Minimally Invasive Surgical Instruments and Manufacturing Technology School of Electromechanical EngineeringGuangdong University of TechnologyGuangzhou 510006China

Needles,as some of the most widely used medical devices,have been effectively applied in human disease prevention,diagnosis,treatment,and *** 1D needle can easily penetrate cells/organs by generating highly localized stress with their sharp tips to achieve bioliquid sampling,biosensing,drug delivery,surgery,and other such *** this review,we provide an overview of multiscale needle fabrication techniques and their biomedical *** are classified as nanoneedles,microneedles and millineedles based on the needle diameter,and their fabrication techniques are *** bridge the inside and outside of cells,achieving intracellular electrical recording,biochemical sensing,and drug *** penetrate the stratum corneum layer to detect biomarkers/bioelectricity in interstitial fluid and deliver drugs through the skin into the human circulatory ***,including puncture,syringe,acupuncture and suture needles,are ***,conclusions and future perspectives for next-generation nano/micro/milli needles are discussed.

关键词： Nanoneedles Microneedles Millineedles Fabrication methods Biomedical Engineering

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Semi-implantable device based on multiplexed microfilament electrode cluster for continuous monitoring of physiological ions

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Bio-Design and Manufacturing 2024年第1期7卷 88-103页

作者： Shuang Huang Shantao Zheng Mengyi He Chuanjie Yao Xinshuo Huang Zhengjie Liu Qiangqiang Ouyang Jing Liu Feifei Wu Hang Gao Xi Xie Hui-jiuan Chen State Key Laboratory of Optoelectronic Materials and Technologies Guangdong Province Key Laboratory of Display Material and TechnologySchool of Electronics and Information TechnologySun Yat-Sen UniversityGuangzhou 510006China Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument School of Biomedical EngineeringSun Yat-Sen UniversityShenzhen 518107China The First Affiliated Hospital of Sun Yat-Sen University Guangzhou 510080China Pazhou Lab Guangzhou 510335China Institute of Microelectronics of the Chinese Academy of Sciences Beijing 100029China

Modern medicine is increasingly interested in advanced sensors to detect and analyze biochemical *** sensors based on potentiometric methods are a promising platform for monitoring physiological ions in biological *** semi-implantable devices are mainly based on single-parameter *** semi-implantable electrodes for multiparameter sensing have more restrictions on the electrode size due to biocompatibility considerations,but reducing the electrode surface area could potentially limit electrode *** study developed a semi-implantable device system comprising a multiplexed microfilament electrode cluster(MMEC)and a printed circuit board for real-time monitoring of intra-tissue K^(+),Ca^(2+),and Na^(+)*** electrode surface area was less important for the potentiometric sensing mechanism,suggesting the feasibility of using a tiny fiber-like electrode for potentiometric *** MMEC device exhibited a broad linear response(K^(+):2–32 mmol/L;Ca^(2+):0.5–4 mmol/L;Na^(+):10–160 mmol/L),high sensitivity(about 20–45 mV/decade),temporal stability(>2weeks),and good selectivity(>80%)for the above *** vitro detection and in vivo subcutaneous and brain experiment results showed that the MMEC system exhibits good multi-ion monitoring performance in several complex *** work provides a platform for the continuous real-time monitoring of ion fluctuations in different situations and has implications for developing smart sensors to monitor human health.

关键词： Multiplexed microfilament electrode cluster Physiological ion sensing Subcutaneous and brain experiment Wearable platform for multi-ion detection Continuous real-time monitoring system

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Minimally invasive technology for continuous glucosemonitoring

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Bio-Design and Manufacturing 2022年第1期5卷 9-13页

作者： Xinshuo Huang Jingbo Yang Shuang Huang Hui-jiuan Chen Xi Xie State Key Laboratory of Optoelectronic Materials and Technologies Guangdong Province Key Laboratory of Display Material and TechnologySchool of Electronics and Information TechnologySun Yat-Sen UniversityGuangzhou 510006China Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument School of Biomedical EngineeringShenzhen Campus of Sun Yat-Sen UniversityShenzhen 518107China

Introduction Despite the numerous breakthroughs made in medical and biomedical technologies,biosensing underneath the skin without any associated pain still sounds like a dream yet to be *** invasive biosensors refer to functional or electronic sensors that can contact the interior environment of living organisms and their biological tissues,while the connected bulk devices remain on the surface of the biological objects[1].Minimally invasive biosensors are currently a key research area because they can not only meet the increasing technical demands to precisely detect biological activities inside biological objects,but also provide an ideal platform to externally incorporate complicated functionalities and electronic integration[2].The current development level of minimally invasive sensing still necessitates solving the constraints and bottlenecks in the three aspects of functionalities,sensitivity and biocompatibility[3].In this perspective,we select minimally invasive sensors as a representative research object with the aim to solve the limitations of current diabetes diagnosis and treatment approaches.

关键词： breakthrough interior diagnosis

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