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Minimally invasive technology for continuous glucosemonitoring

Bio-Design and Manufacturing 2022年第1期5卷 9-13页

作者： Xinshuo Huang Jingbo Yang Shuang Huang Hui-jiuan Chen Xi Xie State Key Laboratory of Optoelectronic Materials and Technologies Guangdong Province Key Laboratory of Display Material and TechnologySchool of Electronics and Information TechnologySun Yat-Sen UniversityGuangzhou 510006China Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument School of Biomedical EngineeringShenzhen Campus of Sun Yat-Sen UniversityShenzhen 518107China

Introduction Despite the numerous breakthroughs made in medical and biomedical technologies,biosensing underneath the skin without any associated pain still sounds like a dream yet to be *** invasive biosensors refer to functional or electronic sensors that can contact the interior environment of living organisms and their biological tissues,while the connected bulk devices remain on the surface of the biological objects[1].Minimally invasive biosensors are currently a key research area because they can not only meet the increasing technical demands to precisely detect biological activities inside biological objects,but also provide an ideal platform to externally incorporate complicated functionalities and electronic integration[2].The current development level of minimally invasive sensing still necessitates solving the constraints and bottlenecks in the three aspects of functionalities,sensitivity and biocompatibility[3].In this perspective,we select minimally invasive sensors as a representative research object with the aim to solve the limitations of current diabetes diagnosis and treatment approaches.

关键词： breakthrough interior diagnosis

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Janus hydrogel/electrospun-membrane dressing enhancing wound healing in rats

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Biomedical Engineering Communications 2024年第2期3卷 17-25页

作者： Zi-Rui Zhu Jia-Na Huang Jin-Ze Li Hao Cao Zhao-Yi Lin Yan Li School of Biomedical Engineering Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument Sun Yat-sen UniversityGuangzhou 510006China

Background:Excessive exudate secreted from chronic wounds often leads to overhydration and *** a variety of dressings are currently available in clinical applications,they frequently fail to provide multifunction to promote chronic wound *** dressings with a Janus structure,featuring distinct properties on each side,are potential to improve wound ***:Composite dressings with a Janus structure were fabricated,comprising freeze-dried polycaprolactone(PCL)electrospun membrane and alginate-based *** PCL fibrous membrane provided air permeability,while the hydrogel loaded with Deferoxamine,composed of alginate and poly(N-isopropylacrylamide)(PNIPAM),exhibited hygroscopic *** inclusion of PNIPAM imparted ***:The hydrogel(thickness of 2.778±0.082 mm)exhibited a robust adhesion to the fiber membrane(thickness of 0.261±0.041 mm).For ANDC(Alginate-PNIPAM hydrogel with Deferoxamine/PCL membrane)samples,the water vapor transmission rate(WVTR)was measured to be 3364.80±23.23 g∙m−2∙day−1 and the swelling ratio at 2 h was determined to be 1179±125%.The thermo-responsivity of ANDC samples manifested in an increased swelling rate,escalating from 797±189%at 37°C to 1132±147%at 4°*** elastic modulus was assessed for lyophilized and rehydrated ANDC *** theωof the rheometer rotor was decreased from 10 rad/s to 0.1 rad/s,the lyophilized dressing exhibited a decrease from 2.65±0.01 MPa to 1.80±0.90 MPa,while the rehydrated dressing demonstrated an increase from 133.65±55.68 Pa to 264.23±141.71 *** pro-healing properties of the dressings were evaluated using full-thickness skin defect model on SD rats,and a circular wound of diameter 10 mm healed completely by day ***:The dressings not only protected the wound and absorbed excess exudate,but also demonstrated nondestructive peelability upon cooling,providing a novel approach for accelerating wound healing and management.

关键词： Janus structure composite dressing wound healing

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Employing pH-responsive RNA triplex to control CRISPR/Cas9-mediated gene manipulation in mammalian cells

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Chinese Chemical Letters 2024年第9期35卷 219-222页

作者： Yan Liu Yang Wang Jiayi Zhu Xuxian Su Xudong Lin Liang Xu Xiwen Xing Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument School of Biomedical EngineeringShenzhen Campus of Sun Yat-sen UniversitySun Yat-sen UniversityShenzhen 518107China MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of ChemistrySun Yat-sen UniversityGuangzhou 510275China Department of Cardiology the first people’s hospital of FoshanFoshan 528000China Department of Biotechnology College of Life Science and TechnologyJinan UniversityGuangzhou 510632China

The clustered regularly interspersed short palindromic repeats/CRISPR-associated protein 9(CRISPR/Cas9)system is an RNA-guided platform for highly efficient and specific genome targeting in diverse organisms,which has been exploited for various applications in gene *** with the constantly active CRISPR/Cas9 function,conditional control of its activity can improve the performance of the system with reduced side effects and high spatiotemporal *** pH-responsive triplex RNA was successful used in CRISPR-derived RNA/trans-activating crRNA(crRNA/tracrRNA)of CRISPR/Cas9,thus affecting RNA/dead Cas9(dCas9)complex to target DNA in vitro and in *** design of triplex RNA opens a new window towards the broad involvement of eukaryotic cells for conditional control of CRISPR/Cas9function.?2024 Published by Elsevier *** behalf of Chinese Chemical Society and Institute of Materia Medica,Chinese Academy of Medical Sciences.

关键词： RNA triplex pH-responsive CRISPR/Cas9 Gene manipulation Eukaryotic cells

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Flexible high-resolution micro-LED display device with integrations of transparent,conductive,and highly elastic hydrogel

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Nano Research 2023年第9期16卷 11893-11899页

作者： Jiangwen Wang Jianan Niu Wei Sha Xinhuan Dai Tianci Huang Qilin Hua Yong Long Junfeng Xiao Weiguo Hu CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro-nano Energy and SensorBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 101400China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049China Center on Nanoenergy Research School of Physical Science and TechnologyGuangxi UniversityNanning 530004China School of Electronic Communication Technology Shenzhen Institute of Information Technology Shenzhen 518172China

Computer vision techniques are real-time,immersive,and perceptual human-computer interaction *** display effect,dynamic surface flexibility,and safe bio-adhesion are essential for various human–computer interaction applications,such as metaverse interfaces,skin-like sensors,and optoelectronic medical ***,realizing the flexible matching of inorganic optoelectronic devices and organisms remains a grand challenge for current display ***,we proposed a novel strategy by combining the optoelectronic advantages of inorganic micro light emitting diode(micro-LED)display and the extraordinary mechanical/biological compatibility of organic materials to overcome this challenge.A highly elastic(greater than 2000%strain),highly transparent(94%visible light transmittance),biocompatible conductive hydrogel composite electrode layer was *** the first time,we realized the on-chip electrical interconnection of 4900 LED units to form a blue-green light display patch with high resolution(264 PPI),low power consumption(4.4 mW)and adaptive surface *** work demonstrates an integrated scheme and potential applications of flexible high-resolution microdisplays,such as wearable fullcolor micro-LED smart curved display devices and conformable biomedical monitoring systems.

关键词： flexible InGaN/GaN micro light emitting diode(micro-LED) hydrogel

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Early and Sensitive Detection of Pathogens for Public Health and Biosafety:An Example of Surveillance and Genotyping of SARS-CoV-2 in Sewage Water by Cas12a-Facilitated Portable Plasmonic Biosensor

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Research 2024年第2期2023卷 259-272页

作者： Tianzhong Li Yuzhi Chen Zhi Chen Yuan Hao Minyi Liang Yingxia Liu Guanyong Ou Huanian Zhang Yuxuan Tang Yabing Hao Swelm Wageh Omar AAl-Hartomy Abul Kalam Bin Zhang Xin Shi Xuejin Li Han Zhang College of Physics and Optoelectronic Engineering Institute of Translational MedicineDepartment of OtolaryngologyShenzhen Second People's HospitalFirst Affiliated Hospital of Shenzhen UniversityHealth Science CenterShenzhen UniversityShenzhen 518060China Shenzhen Key Laboratory of Sensor Technology Shenzhen 518060China The Sixth Affiliated Hospital of Guangzhou Medical University Qingyuan People's HospitalQingyuan 511518China Shenzhen Key Laboratory of Pathogen and Immunity National Clinical Research Center for Infectious DiseaseState Key Discipline of Infectious DiseaseShenzhen Third People's HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyShenzhen 518112China School of Medicine Southern University of Science and TechnologyShenzhen 518055China School of Physics and Optoelectronic Engineering Shandong University of TechnologyZibo 255049China Department of Physics Faculty of ScienceKing Abdulaziz University Jeddah 21589Saudi Arabia Research Center for Advanced Materials Science(RCAMS) King Khalid UniversityP.0.Box 9004Abha 61413Saudi Arabia Department of Chemistry College of ScienceKing Khalid UniversityP.0.Box9004Abha 61413 Saudi Arabia Health Sciences Institute China Medical UniversityShenyang 110000China The Chinese University of Hong Kong Shenzhen 518060China

Infectious diseases severely threaten public health and global *** addition to transmission through the air,pathogenic microorganisms have also been detected in environmental liquid samples,such as sewage *** biochemical detection methodologies are time-consuming and cost-ineffective,and their detection limits hinder early *** the present study,ultrafine plasmonic fiber probes with a diameter of 125μm are fabricated for clustered regularly interspaced short palindromic repeats/CRISPR-associated protein(CRISPR/Cas)-12a-mediated sensing of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Single-stranded DNA exposed on the fiber surface is trans-cleaved by the Cas12a enzyme to release gold nanoparticles that are immobilized onto the fiber surface,causing a sharp reduction in the surface plasmon resonance(SPR)*** proposed fiber probe is virus-specific with the limit of detection of~2,300 copies/ml,and genomic copy numbers can be reflected as shifts in wavelengths.A total of 21 sewage water samples have been examined,and the data obtained are consistent with those of quantitative polymerase chain reaction(qPCR).In addition,the Omicron variant and its mutation sites have been fast detected using S gene-specific *** study provides an accurate and convenient approach for the real-time surveillance of microbial contamination in sewage water.

关键词： fiber consuming hinder

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FRET-based fiber-optic fluorescent biosensor for the detection of alpha-fetoprotein 4

FRET-based fiber-optic fluorescent biosensor for the detecti...

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4th International Conference on sensors and Information technology, ICSI 2024

作者： Qi, Shiya Li, Xuejin Chen, Yuzhi College of Physics and Optoelectronic Engineering Shenzhen University No.3688 Nanhai Avenue Guangdong Shenzhen518060 China Shenzhen Key Laboratory of Sensor Technology No.3688 Nanhai Avenue Guangdong Shenzhen518060 China Shenzhen Engineering Laboratory for Optical Fiber Sensors and Networks No.3688 Nanhai Avenue Guangdong Shenzhen518060 China The Chinese University of HongKong Guangdong Shenzhen518071 China

ISBN: (数字)9781510678699

ISBN: (纸本)9781510678682

This article reports the development of a novel sensor based on fiber-optic fluorescence biosensing technology for detecting alpha-fetoprotein (AFP), a key biomarker for liver cancer screening. The sensor utilizes the fluorescence resonance energy transfer (FRET) effect and constructs a fluorescence immunoassay system on the surface of the optical fiber, using the sandwich method with dual antibodies. This approach leverages the immune response to quench the fluorescent microspheres with the Gold nanoparticles (AuNPs). By precisely quantifying the difference in light intensity before and after quenching, it establishes a direct correlation between the reduced light intensity and AFP concentration. The sensor boasts a broad detection range of 10-10, 000 ng/mL and offers advantages such as compact size, affordability, and ease of operation, thus presenting a promising new method for AFP detection. Extensive experimental tests have been conducted to confirm the sensor's performance, demonstrating its high sensitivity and reliability under laboratory conditions. This research provides an innovative tool and method for liver cancer-related research and clinical applications, which is expected to promote further development in the field of liver cancer diagnosis. © 2024 SPIE.

关键词： Forster resonance energy transfer

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Fiber Optic Refractive Index sensor Based on U-Tapered Structure 3

Fiber Optic Refractive Index Sensor Based on U-Tapered Struc...

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3rd International Conference on Optics and Machine Vision, ICOMV 2024

作者： Wang, Jinfeng Chen, Xinghong Li, Xuejin Chen, Yuzhi School of Physics and Optoelectronic Engineering Shenzhen University No.3688 Nanhai Avenue Guangdong Shenzhen518060 China Shenzhen Key Laboratory of Sensor Technology No.3688 Nanhai Avenue Guangdong Shenzhen518060 China Shenzhen Engineering Laboratory for Optical Fiber Sensors and Networks No.3688 Nanhai Avenue Guangdong Shenzhen518060 China The Chinese University of Hong Kong Guangdong Shenzhen518071 China

ISBN: (纸本)9781510680319

In this paper, an inserted U-tapered fiber optic probe is proposed, which has the characteristics of simple structure, small size, easy to manufacture, easy to store, and can realize the detection of parameters in small space. In this work, firstly, we optimize the parameters of the linear taper sensor from the theoretical simulation and experiment, and then prepare the linear taper sensor structure into a U-tapered fiber optic probe according to the optimized parameters, and explore the influence of different U-tapered curvature radius on the interference spectrum. According to the research results, when the curvature radius of the U-tapered fiber optic probe is 1. 75 mm, the sensor has a good response to refractive index (RI), and the RI sensitivity is 386. 23 nm/RIU, the linear responsivity is 0. 998, and the measured temperature sensitivity is -0. 04 nm/℃, and the response to temperature is not significant. This work provides a feasible method for the future development of RI detection in narrow space. © 2024 SPIE.

关键词： Refractive index

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SPR-based fiber optic biosensor for the detection of HER2

SPR-based fiber optic biosensor for the detection of HER2

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2024 International Conference on Optoelectronic Information and Optical Engineering, OIOE 2024

作者： Liang, Minyi Li, Xuejin Chen, Yuzhi College of Physics and Optoelectronic Engineering Shenzhen University No.3688 Nanhai Avenue Guangdong Shenzhen518060 China Shenzhen Key Laboratory of Sensor Technology No.3688 Nanhai Avenue Guangdong Shenzhen518060 China Shenzhen Engineering Laboratory for Optical Fiber Sensors and Networks No.3688 Nanhai Avenue Guangdong Shenzhen518060 China The Chinese University of Hong Kong Guangdong Shenzhen518071 China

ISBN: (数字)9781510680470

ISBN: (纸本)9781510680463

Breast cancer is currently the most prevalent cancer among women, and the level of HER2 is one of the important indicators of breast cancer prognosis. In this paper, we propose a fiber-optic biosensor based on surface plasmon resonance (SPR) for rapid and direct detection of HER2 protein using patient plasma. The method utilizes the difference in resonance wavelength shift before and after immunoassay to achieve quantitative detection of HER2 protein. To simplify the bio-modification step and improve the detection efficiency, we used protein G in a one-step reaction with 2-iminothiolane to generate a thiol functional group to form a self-assembled layer on the gold surface of the sensor. We optimized the strategy of immobilizing coating antibody on the sensor surface as well as the antibody concentration, which significantly improved the sensitivity of the biosensor to 0.20666 nm/(μg/mL), a 2.5-fold increase compared to the non-optimized case. Our protocol was able to specifically detect HER2 protein under label-free conditions with a minimum concentration of 1 μg/mL. This study provides an innovative tool and methodology for breast cancer-related research and clinical applications and is expected to promote further development in the field of breast cancer diagnosis. © 2024 SPIE.

关键词： Surface plasmon resonance

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Exploring Affective Peripheral Patterns Based on Body Surface Potentials with Covariance

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IEEE Transactions on Affective Computing 2024年第2期16卷 986-998页

作者： Wu, Wei Pi, Yao Zhang, Xianbin Xu, Lin Wu, Wanqing Sun Yat-sen University School of Biomedical Engineering Shenzhen518107 China General Hospital of the Southern Theatre Command of the Chinese People's Liberation Army Department of Geriatric Cardiology Guangzhou510010 China Southern Medical University School of Clinical Medicine Guangzhou510010 China Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument Shenzhen518107 China

Affective patterns based on physiological signals reflect bodily changes linked to specific emotional states. Previous studies on the cardiac electrical signal, a key peripheral physiological signal, were limited by the measurement density of single-lead ECG signal, focusing solely on temporal pattern analysis but ignoring topographic pattern analysis that can reflect the body's emotional response. Our research advances affective peripheral pattern studies by innovatively using body surface potentials to comprehensively monitor cardiac electrical activity with increased measurement density. To tackle the challenge of extracting spatial and temporal features from multi-channel body surface potentials, we establish a dynamic correlation among these diverse channel signals through covariance matrices. Our hypothesis is that the dynamic inter-channel relationship provides a valuable source of insights into emotional clues. Experimental results demonstrate that the extracted spatial and temporal features effectively capture topographic and temporal patterns from cardiac electrical signals, and achieve excellent performance in classification tasks simultaneously. Our finding reveals affective patterns based on body surface potentials for the first time, offering novel insights into affective peripheral patterns analysis. © 2010-2012 IEEE.

关键词： Covariance matrix

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An integrative review on the applications of 3D printing in the field of in vitro diagnostics

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Chinese Chemical Letters 2022年第5期33卷 2231-2242页

作者： Jian Yang Yanxiang Cheng Xia Gong Shengzhu Yi Cheuk-Wing Li Lelun Jiang Changqing Yi Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument School of Biomedical EngineeringSun Yat-sen UniversityShenzhen 518107China Research Institute of Sun Yat-sen University in Shenzhen Shenzhen 518057China School of Science and Technology Nottingham Trent UniversityClifton LaneNottingham NG118NSUnited Kingdom

Biomedicine is one of the fastest growing areas of additive ***,in the field of in vitro diagnostics(IVD),contributions of 3D printing include i)rapid prototyping and iterative IVD proof-of-concept designing ranging from materials,devices to system integration;ii)conceptual design simpli-fication and improved practicality of IVD products;iii)shifting the IVD applications from centralized labs to point-of-care testing(POCT).In this review,the latest developments of 3D printing and its advantages in IVD applications are summarized.A series of 3D-printed objects for IVD applications,including single-function modules,multi-function devices which integrate several single-function modules for specific an-alytical applications such as sample pre-treatment and chemo-/bio-sensing,and all-in-one systems which integrate multi-function devices and the instrument operating them,are analyzed from the perspective of functional *** current and potential commercial applications of 3D-printed objects in the IVD field are *** features of 3D printing,especially rapid prototyping and low start-up,en-able the easy fabrication of bespoke modules,devices and systems for a range of analytical applications,and broadens the commercial IVD prospects.

关键词： 3D printing In vitro diagnostics Portable sensing device Point-of-care testing Stereolithography(SLA) Digital light projection(DLP) Fused deposition modeling(FDM)

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