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Nanotechnology for diagnosis and therapy of theumatoid arthritis:Evolution towards theranostic approaches

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Chinese Chemical Letters 2021年第1期32卷 66-86页

作者： Junkai Zhao Xuan Chen Kwun-Hei Ho Chao Cai Cheuk-Wing Li Mo Yang Changqing Yi Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument School of Biomedical EngineeringSun Yat-sen UniversityShenzhen 518107China Department of Biomedical Engineering the Hong Kong Polytechnic UniversityHong KongChina School of Science and Technology Nottingham Trent UniversityClifton LaneNottinghamNG118NSUnited Kingdom

Rheumatoid arthritis(RA),as a chronic autoimmune disease,damages the bone and cartilage of patients,and even leads to ***,the diagnosis and treatment of RA is particularly ***,due to the complexity of RA,it is difficult to make effective early diagnosis of RA,which is detrimental to RA ***,long-term intake of anti-RA drugs can also cause damage to patients' *** emergence of nanotechnology provides the new train of thoughts for the diagnosis and treatment of *** the combination of diagnosis and therapy is an ideal method to solve the problem of disease management of RA *** this review,we summarize the mechanism and microenvironment of RA,discuss the commonly used diagnostic techniques and therapeutic drugs for RA,and review their advantages and *** nanotherapy strategies such as drug-carrying nanoparticles,PTT,PDT are listed,and their applications in RA treatment are also *** addition,multimodal imaging,combined therapy and responsive diagnosis and treatment are also summarized as important *** last,we also review typical nanocarriers that can be used in the integration of diagnosis and therapy,and discussed their potential applications in RA theranostics.

关键词： Rheumatoid arthritis Diagnosis Therapy Theranostics Nanomedicine

Digital Crispr/Cas12a-Based Platform for Precise Quantification of Telomerase Activity

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SSRN 2023年

作者： Luo, Xinyi Wan, Yunzhu Wang, Ke Wei, Qidong Chen, Lei Zhou, Jianhua Wang, Jiasi Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument School of Biomedical Engineering Shenzhen Campus of Sun Yat-sen University Shenzhen518107 China School of Biomedical Engineering Sun Yat-sen University Guangzhou510275 China

Precise quantification of telomerase activity is of great significance for telomerase-based early cancer diagnosis, as well as the effective inhibition and screening of prodrugs. Telomeric repeat amplification protocol (TRAP) has been most widely used for assessing telomerase activity, which is limited by false-positive results, complicated operations, and long detection times. Herein, we develop a droplet digital hyperbranched amplification enhanced CRISPR/Cas12a-based telomerase detection platform (ddHECTelo). By combining with the droplet digital platform and hyperbranched amplification, the ddHECTelo allows precise quantification of telomerase activity with single-molecule sensitivity. A polydisperse droplets digital system was employed, so that the reaction mixtures could be partitioned into picoliter-scale polydisperse droplets in several seconds to avoid the pre-amplification, without the need for a sophisticated microfluidic chip. This is the first digital isothermal platform for sensitive and precise quantification of telomerase activity, which shows great potential in telomerase-based early cancer diagnosis. It could also be used to analyze the telomerase activity in fundamental biomedical research. © 2023, The Authors. All rights reserved.

关键词： Drops

Adaptive Stimulation Profiles Adjustment of Functional Electrical Stimulation for Foot Drop Based on Iterative Learning Control

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Adaptive Stimulation Profiles Adjustment of Functional Elect...

International Conference on Advanced Robotics and Mechatronics (ICARM)

作者： You Li Qinlian Yang Peng Fang Rong Song School of Biomedical Engineering Shenzhen Campus of Sun Yat-sen University Shenzhen Guangdong China Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument Sun Vat-Sen University Guangzhou Guangdong China Research Center for Neural Engineering Shenzhen Institutes of Advanced Technology (SIAT) Chinese Academy of Sciences (CAS) Shenzhen Guangdong China

Functional electrical stimulation (FES) offers an effective approach for foot drop (FD) correction by artificially contracting the tibialis anterior (TA) muscle. The majority of current FES systems employ predetermined stimulation parameters and stimulation profiles, which cannot improve gait performances well considering significant time-variance and individuality of muscle response dynamics under electrical stimulation. To mitigate these challenges, this article proposes a model-based closed-loop control scheme to achieve adaptive adjustment of stimulation intensity profiles using Norm-optimal iterative learning control (NOILC). Firstly, a dynamic model for ankle joint utilizing a Hammerstein structure for subject-specific is developed, as well as the parameters identification. Then, a closed-loop controller based on NOILC is designed to allow tracking of desired trajectory of ankle joint angle for foot drop correction according to FES-induced foot motion. Finally, computer simulation tests are performed and verify that the proposed control method can achieve a good tracking performance through adaptive modulation of stimulation intensity profile, and it is consistent with the physiological characteristics of foot motion.

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Mechanoluminescent hybrids from a natural resource for energy-related applications

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InfoMat 2021年第11期3卷 1272-1284页

作者： Chunfeng Wang Ronghua Ma Dengfeng Peng Xianhu Liu Jing Li Boru Jin Aixian Shan Yu Fu Lin Dong Wenchao Gao Zhong Lin Wang Caofeng Pan Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhenChina CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro-nano Energy and SensorBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijingChina Key Laboratory of Materials Processing and Mold(Ministry of Education) Henan Key Laboratory of Diamond Optoelectronic Materials and DevicesKey Laboratory of Material PhysicsMinistry of EducationSchool of Physics and MicroelectronicsZhengzhou UniversityZhengzhouChina Beijing Advanced Innovation Center for Materials Genome Engineering Beijing Key Laboratory for Magneto-Photoelectrical Composite and Interface ScienceSchool of Mathematics and PhysicsUniversity of Science and Technology BeijingBeijingChina Department of Civil Engineering Monash UniversityClaytonAustralia

Mechanoluminescent(ML)materials that directly convert mechanical energy into photon emission have emerged as promising candidates for various *** the recent advances in the development of both novel and conventional ML materials,the limited access to ML materials that simultaneously have the attributes of high brightness,low cost,self-recovery,and stability,and the lack of appropriate designs for constructing ML devices represent significant challenges that remain to be addressed to boost the practical application of ML ***,ML hybrids derived from a natural source,waste eggshell,with the aforementioned attributes are *** introduction of the eggshell not only enables the preparation of the hybrid in a simple and cost-effective manner but also contributes to the homochromatism(red,green,or blue emission),high brightness,and robustness of the resultant ML *** significant properties of the ML hybrids,together with the proposed structural design,such as porosity or core–shell structure,could expedite a series of mechanic-optical applications,including the self-luminous shoes for the conversion of human motions into light and light generators that efficiently harvest water wave *** fascinating properties,versatile designs,and the efficient protocol of“turning waste into treasure”of the ML hybrids represent significant advances in ML materials,promising a leap to the practical applications of this flouring material family.

关键词： blue energy harvesting eggshell waste mechanoluminescent hybrids smart sensing

The Stability of Sno2 And In2o3 Gas sensors to Water Under Temperature Modulation Mode

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SSRN 2023年

作者： Si, Renjun Li, Yan Tian, Jie Tan, Changshu Chen, Shaofeng Lei, Ming Guo, Xin Zhang, Shunping State Key Laboratory of Material Processing and Die &Mould Technology Department of Materials Science and Engineering Huazhong University of Science and Technology Wuhan430074 China Shenzhen Power Supply Co. Ltd Shenzhen518000 China Nanomaterial and Smart Sensor Research Laboratory Department of Materials Science and Engineering Huazhong University of Science and Technology Luo-Yu Road 1037 Hubei Wuhan430074 China State Key Laboratory of Material Processing and Die & Mould Technology China

Temperature modulation technology has been extensively used in metal oxide semiconductor (MOS) gas sensors, especially based on micro-hotplate sensor structure. Temperature modulation technique not only improves the selectivity, but also enables the sensor to exhibit a highly active surface due to the effect of oxygen accumulation, thereby increasing the sensitivity. However, when the MOS sensor is in a state of high surface activity, the corresponding hydroxide may be formed with water, which affects the gas sensing performance and stability of the sensor. This paper mainly studies the stability of SnO2 and In2O3 gas sensors during storage process after temperature modulation test. The results show that SnO2 stability is good but In2O3 stability is poor. The deactivation mechanism was discussed with infrared spectroscopy results. The formation of In(OH)3 was confirmed by high resolution transmission electron microscope, which further confirmed the above conclusion. It indicates that after temperature modulation, the gas sensitive materials stored in atmospheric environment (20℃, 40%-60%RH) would generate hydroxides. When temperature modulation was carried out again (100-400℃), Sn(OH)4 would decompose into SnO2, thus maintaining stability. The decomposition temperature of In(OH)3 is around 600℃. So that In(OH)3 would not decompose into In2O3, which would lead to poor stability. © 2023, The Authors. All rights reserved.

关键词： Oxygen

Halide perovskite single crystals for resistive switching

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Science Bulletin 2022年第10期67卷 1018-1021页

作者： Shuaipeng Ge Long-Biao Huang Caofeng Pan Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro-nano Energy and SensorBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 101400China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049China

As one of the most promising nonvolatile memory,resistive switching random-access memory(ReRAM)has exhibited great application potential for information storage and artificial synapses in computing and neuromorphic systems,and has shown great advantages including low power consumption,high integration density,simple device structure,and fast switching speed.

关键词： artificial computing 转换特性

Multifunctional and Structural Magnetic Nanobranches for High-Efficiency Biological Detection

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SSRN 2024年

作者： Hu, Wenxu Dong, Yongliang Ge, Tianxin Liu, Si-Yang Guo, Jianhe Wang, Liqiu Yi, Changqing Han, Xing Daia, Zong School of Biomedical Engineering Shenzhen Campus of Sun Yat-sen University Sun Yat-sen University No.66 Gongchang Road Guangming District Guangdong Shenzhen518107 China The Hong Kong Polytechnic University Hong Kong999077 Hong Kong Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument China

Microfluidics is a powerful tool to integrate biological detection/chemical synthesis processes into a centimeter-size chip with microscale channels for fast and sample-saving detections and reactions. While bringing benefits, the microscale channels make it difficult to mix high-viscosity liquid samples and reagents, hindering the further improvement of the rapidity, reliability, sensitivity, and accuracy of biological detections based on microfluidics. The nanorotors can be vital for mixing enhancement in microfluidic chips and specific binding as biomacromolecule carriers. Still, the development of low-cost, mass-producible, and particular-shaped nanorotor fabrication methods has been desired but difficult. Here, we introduce low-cost multifunctional and structural magnetic nanobranches to improve mixing efficiency inside microfluidic chips and serve as biomolecular carriers. The nanobranches were fabricated by associating magnetic-field-induced Fe3O4 nanoparticle alignment with self-polymerized dopamine. The nanobranches combine the functionalities of mixers and antibody carriers, being mass-producible, biocompatible, and recyclable. The required mixing time by nanobranches can be as half as that by nanochains, and the reaction for Enzyme-Linked Immunosorbent Assay (ELISA) can be enhanced, promoting sensitivity improvement (~1.8 times higher than that of nanochains), the limit of detection reduction (6.20, 13.7, and 61.2 pg mL-1 for nanobranches, nanochains, and commercial ELISA kit, respectively), and linear range expansion. It is promising that the fabricated magnetic nanobranches would be a multifunctional tool for high-sensitivity biosensing. © 2024, The Authors. All rights reserved.

关键词： Microfluidic chips

rADSC-loaded tubular units composed of multilayer electrospun membranes promoted bone regeneration of critical-sized skull defects

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材料展望（英文）

材料展望（英文） 2024年第3期3卷 189-205页

作者： Huamin Jiang Zhaoyi Lin Jinze Li Ting Song Hongyun Zang Pengwen Li Jiarun Li Wenyi Hou Jianhua Zhou Yan Li School of Biomedical Engineering Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107People's Republic of China Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument Sun Yat-sen UniversityGuangzhou 510006People's Republic of China Hospital of Stomatology Guangdong Provincial Key Laboratory of StomatologyInstitute of Stomatological ResearchGuanghua School of StomatologySun Yat-sen UniversityGuangzhou 510062People's Republic of China The Third Affiliated Hospital of Sun Yat-sen University Guangzhou 510630People's Republic of China

Adipose-derived stem cells(ADSCs)have considerable potential tor bone ***,their performance is limited by a lack of scaffolds that adequately mimic the hierarchical structure of bone to promote proliferation and osteogenic differentiation of *** this study,nanofiber membranes composed of polycaprolactone,poly(lactide-co-glycolide),and hydroxyapatite(HAp)were prepared via electrospinning,and the membranes curled after responding to temperature stimuli in an aqueous *** electron microscopy and scanning electron microscopy observations indicated that needle-like HAp nanoparticles with an average diameter of 57±39 nm and a length-diameter ratio of 7.4±1.56 were entrapped in the nanofiber matrix and did not affect the surface morphology of *** cutting and deformation,the nanofibers changed from straight to bent,and the diameters increased;they were 1105±200 nm for BPLG85-H and 1120±199 nm for ***,tubular units with a single layer(BPLG-H(1.5))or multiple layers(BPLG-H(3.5))were obtained by controlling the initial shape and size of the *** on the concave surface of BPLG-H(3.5)proliferated faster and exhibited better osteogenic activity than those on the convex side of BPLG-H(3.5)and both surfaces of BPLG-H(1.5),which was correlated with the higher expressions of vascular endothelial growth factor and bone morphogenetic protein ***,rADSCs on both units maintained osteogenic activity after storage at-80 ℃ for 20 *** rat skull defect(diameter of 8 mm)models,rADSC-loaded BPLG-H(3.5)units fixed using gelatin hydrogel(ADSC@BHM)exhibited 84.1±6.6％BV/TV after implantation for 12 weeks,which was 155.6％higher than that of the Blank group.H&E and Masson's staining results demonstrated that there was more bone regeneration at the defect center of ADSC@BHM than in the BHM and Blank *** conclusion,rADSC-loaded BPLG-H(3.5)with an osteon-mimic structure provides a potential strategy to repair

关键词： adipose-derived stem cells electrospinning composite fiber bone regeneration

Development of Smartphone-Controlled and Microneedle-Based Wearable Continuous Glucose Monitoring System for Home-Care Diabetes Management

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SSRN 2022年

作者： Yang, Jian Gong, Xia Chen, Shuijin Zheng, Ying Chen, Zhipeng Xie, Xi Yi, Changqing Jiang, Lelun Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument School of Biomedical Engineering Sun Yat-Sen University Shenzhen Campus Shenzhen518107 China Research Institute of Sun Yat-Sen University in Shenzhen Shenzhen518057 China State Key Laboratory of Optoelectronic Materials and Technologies School of Electronics and Information Technology Sun Yat-Sen University Guangzhou510006 China

Continuous glucose monitoring (CGM) can mini-invasively track blood glucose fluctuation and reduce the risk of hyperglycemia and hypoglycemia, which is in great demand for diabetes management. However, cost-effective manufacture of CGM systems with continuously improved convenience and performance is still the persistent goal. Herein, we developed a smartphone-controlled and microneedle (MN)-based wearable CGM system for long-term glucose monitoring. The CGM system modified with a sandwich-type enzyme immobilization strategy can satisfy the clinical requirement of interstitial fluid (ISF) glucose monitoring for 14 days with a mean absolute relative difference of 10.2 % and a cost of less than $15, which correlated well with the commercial glucometer and FDA-approved CGM system FreeStyle Libre(Abbott Inc., Illinois, USA). The self-developed CGM system is demonstrated to accurately monitor glucose fluctuations and provide abundant clinical information. It is better to find the cause of individual blood glucose changes and beneficial for the guide of precise glucose control. On the whole, the intelligently wearable CGM system may provide an alternative solution for home-care diabetes management. © 2022, The Authors. All rights reserved.

关键词： Smartphones