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Annexin A1 binds PDZ and LIM domain 7 to inhibit adipogenesis and prevent obesity

Signal Transduction and Targeted Therapy 2024年第9期9卷 4120-4136页

作者： Lu Fang Changjie Liu Zong-zhe Jiang Mengxiao Wang Kang Geng Yangkai Xu Yujie Zhu Yiwen Fu Jing Xue Wenxin Shan Qi Zhang Jie Chen Jiahong Chen Mingming Zhao Yuxuan Guo K.W.Michael Siu Y.Eugene Chen Yong Xu Donghui Liu Lemin Zheng The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine School of Basic Medical SciencesState Key Laboratory of Vascular Homeostasis and RemodelingNHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory PeptidesBeijing Key Laboratory of Cardiovascular Receptors ResearchHealth Science CenterPeking University100191 BeijingChina Department of Blood Transfusion Guangzhou First People’s HospitalSchool of MedicineSouth China University of TechnologyGuangzhou 510000 GuangdongChina Department of Endocrinology and Metabolism The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000 SichuanPR China Metabolic Vascular Disease Key Laboratory of Sichuan Province Luzhou 646000 SichuanChina Department of plastic and burns surgery The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000 SichuanPR China Beijing Tiantan Hospital China National Clinical Research Center for Neurological DiseasesAdvanced Innovation Center for Human Brain ProtectionCapital Medical University6 Tiantan XiliChongwen District100050 BeijingChina Department of Cardiology and Institute of Vascular Medicine Peking University Third Hospital/State Key Laboratory of Vascular Homeostasis and RemodelingPeking University/NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides/Beijing Key Laboratory of Cardiovascular Receptors Research/Research Unit of Medical Science Research Management/Basic and Clinical Research of Metabolic Cardiovascular DiseasesChinese Academy of Medical Sciences100191 BeijingChina Center for Mass Spectrometry Research and Clinical Application Shandong Public Health Clinical Center Affiliated to Shandong UniversityLishan Campus46 Lishan RoadJinanShandongChina Department of Chemistry and Biochemistry University of Windsor401 Sunset AvenueWindsorON N9B 3P4Canada Department of Internal Medicine University of Michigan Medical CenterAnn ArborMIUSA Department of Geriatrics National Key Clinical SpecialtyGuangzhou First People’s Ho

Obesity is a global issue that warrants the identification of more effective therapeutic targets and a better understanding of the pivotal molecular *** A1(ANXA1)is known to inhibit phospholipase A2,exhibiting anti-inflammatory ***,the specific effects of ANXA1 in obesity and the underlying mechanisms of action remain *** study reveals that ANXA1 levels are elevated in the adipose tissue of individuals with ***-body or adipocyte-specific ANXA1 deletion aggravates obesity and metabolic ***1 levels are higher in stromal vascular fractions(SVFs)than in mature *** investigation into the role of ANXA1 in SVFs reveals that ANXA1 overexpression induces lower numbers of mature adipocytes,while ANXA1-knockout SVFs exhibit the opposite *** suggests that ANXA1 plays an important role in ***,ANXA1 competes with MYC binding protein 2(MYCBP2)for interaction with PDZ and LIM domain 7(PDLIM7).This exposes the MYCBP2-binding site,allowing it to bind more readily to the SMAD family member 4(SMAD4)and promoting its ubiquitination and ***4 degradation downregulates peroxisome proliferator-activated receptor gamma(PPARγ)transcription and reduces *** with Ac2-26,an active peptide derived from ANXA1,inhibits both adipogenesis and obesity through the *** conclusion,the molecular mechanism of ANXA1 inhibiting adipogenesis was first uncovered in our study,which is a potential target for obesity prevention and treatment.

关键词： obesity prevention elevated

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A polyphenol-modified chitosan hybrid hydrogel with enhanced antimicrobial and antioxidant activities for rapid healing of diabetic wounds

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Nano Research 2023年第1期16卷 905-916页

作者： Zejun Xu Guiting Liu Li Zheng Jun Wu The State Key Laboratory of Polymer Materials Engineering Polymer Research Institute of Sichuan UniversityChengdu 610065China Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-Sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration Life Science InstitutesGuangxi Medical UniversityNanning 530021China Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry Guangxi Medical UniversityNanning 530021China Bioscience and Biomedical Engineering Thrust The Hong Kong University of Science and Technology(Guangzhou)Guangzhou 511400China Division of Life Science The Hong Kong University of Science and TechnologyHong Kong 999077China

High oxidative stress injury and bacterial infection are the main challenges that impair wound healing in diabetic ***,a hydrogel with enhanced antimicrobial and antioxidant properties was developed for rapid healing of diabetic *** this study,chitosan methacrylate-gallic acid(CSMA-GA)polymer with antioxidant activity,antimicrobial activity,and ultraviolet(UV)-triggered gelling properties was developed as a hydrogel ***,amphiphilic Pluronic F127 molecules were used to load hydrophobic chlorhexidine drug molecules to obtain F127/chlorhexidine nanoparticle(NP)with strong antibacterial ***,F127/chlorhexidine NPs were encapsulated in CSMA-GA hydrogel to further enhance its antibacterial *** hybrid hydrogel platform(CSMA-GA/F127/chlorhexidine(CMGFC))exhibited high antibacterial efficiency(>99.9%)and strong reactive oxygen species(ROS)scavenging ability(>80.0%),which effectively protected cells from external oxidative stress(upregulated superoxide dismutase(SOD)and glutathione/oxidized glutathione disulfide(GSH/GSSG)levels and downregulated malondialdehyde(MDA)levels).Moreover,in vivo results proved that the CMGFC hydrogel significantly reduced inflammatory responses(downregulated interleukin-6(IL-6)and upregulated interleukin-10(IL-10)levels),promoted angiogenesis(upregulated vascular endothelial growth factor(VEGF)and platelet endothelial cell adhesion molecule-1(CD 31)levels),and wound healing(enhanced collagen deposition and tissue remodelling).Overall,the CMGFC hydrogel with enhanced antimicrobial and antioxidant properties demonstrated significant potential to enhance diabetic wound healing.

关键词： antimicrobial antioxidant diabetic wound hydrogel

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Using T-shaped Metal Structure for Far-end Crosstalk Mitigation in PCIe5 High-speed Connectors

Using T-shaped Metal Structure for Far-end Crosstalk Mitigat...

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Progress in Electromagnetic Research Symposium (PIERS)

作者： Haoxin Luo Haoran Li Yuyu Zhu Lanqing Yang Xin Cao Qiang-Ming Cai Longjian Zhou Jun Fan School of Information Engineering Southwest University of Science and Technology Mianyang China Robot Technology Used for Special Environment Key Laboratory of Sichuan Province Mianyang China Tianfu Institute of Research and Innovation Southwest University of Science and Technology (SWUST-TIRI) China

ISBN: (数字)9798350375909

ISBN: (纸本)9798350375916

With the increase in data transmission rates, reducing far-end crosstalk (FEXT) has become a critical challenge in the design of high-speed connectors. In this paper, we develop an efficient crosstalk mitigation approach by designing T-shaped metal structure to increase the mutual capacitance between differential pairs. The PCIe 5.0 connector was simulated by three-dimensional electromagnetic simulation software HFSS. The simulated results show the achieved FEXT can maintain under −50.0 dB from dc to 20 GHz, and, in comparison with the initial connector, over 10 dB reduction in FEXT is achieved within the 0–20 GHz frequency range. Besides, the time-domain results are also provided to indicate a significant suppression of crosstalk amplitude on the end with higher crosstalk in the differential pair, thereby balancing the crosstalk difference between the difference pairs and reducing overall differential crosstalk. Moreover, a thorough examination of the influence of manufacturing errors on crosstalk suppression was conducted. Therefore, this technology with T-shaped metal structure is a promising candidate to address FEXT challenges in high-speed connectors of PCIe 5.0, which contribute to the enhancement of signal quality and reliability in modern communication systems.

关键词： Connectors Prevention and mitigation Frequency-domain analysis Crosstalk Metals Capacitance Software

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Using Coaxial Ground Full-touch Structure to Reduce Far-end Crosstalk in PCIe5 High-speed Connectors

Using Coaxial Ground Full-touch Structure to Reduce Far-end ...

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Progress in Electromagnetic Research Symposium (PIERS)

作者： Yuhui Liu Lanqing Yang Qiang-Ming Cai Xin Cao Longjian Zhou Haoran Li Haoxin Luo Yuyu Zhu Jun Fan School of Information Engineering Southwest University of Science and Technology Mianyang China Robot Technology Used for Special Environment Key Laboratory of Sichuan Province Mianyang China Tianfu Institute of Research and Innovation Southwest University of Science and Technology (SWUST-TIRI) China

ISBN: (数字)9798350375909

ISBN: (纸本)9798350375916

With the continuous increase of data transmission speed, the problem of far-end crosstalk (FEXT) of high-speed connectors has gradually become a significant challenge that restricts the performance of communication systems. This paper proposes a full-contact return path design to mitigate the FEXT. By improving the return path distance, the stripping of the ground layer of the coaxial line is directly connected with the metal spacer in the hollow of the full-contact connection. Thus, the current return path flows between the coaxial and the metal spacer, which shortens the return path of high-frequency current. At the same time, to the entire coaxial conductive layer as the ground, FEXT can be further reduced by expanding the grounding area to constrain the signal. Simulations with the commercial software HFSS show the FEXT decreases by 6 dB from DC to 20 GHz compared to a return path design without complete contact. Besides, the time domain results are also simulated. Compared with the return path design without complete contact, the coaxial ground full-touch structure reduces peaks in FEXT voltage compared to the return path design. Therefore, it can be demonstrated that the coaxial ground full-touch structure can be adopted to mitigate the FEXT in high-speed connectors, further improving the signal quality and reliability in modern communication systems.

关键词： Connectors Grounding Simulation Crosstalk Metals Voltage Software

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Accurate RLC Extraction for Stripline Structures Using 2D-FEM

Accurate RLC Extraction for Stripline Structures Using 2D-FE...

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Progress in Electromagnetic Research Symposium (PIERS)

作者： Chenxi Liu Xiaoping Li Quan Deng Qiang-Ming Cai Xin Cao Longjian Zhou Yuyu Zhu Jun Fan School of Information Engineering Southwest University of Science and Technology Mianyang China Robot Technology Used for Special Environment Key Laboratory of Sichuan Province Mianyang China Tianfu Institute of Research and Innovation Southwest University of Science and Technology (SWUST-TIRI) China

ISBN: (数字)9798350375909

ISBN: (纸本)9798350375916

In this paper, a two-dimensional finite element method (2D-FEM) is presented to extract the per-unit-length RLC for the stripline. Because the current propagates in the same direction in the three-dimensional stripline structures, the RLC extraction can be converted to a two-dimensional problem, i.e., calculating the per-unit-length RLC. In this 2D-FEM, in order to extract R and L, considering the influence of skin effect on current distribution, a frequency factor was introduced into the vector Poisson’s equation, the Lagrange interpolation functions defined in triangular elements are adopted to discretize the magnetic vector potential, which can ensure the continuity of the solutions on both sides of these elements. After introducing the Dirichlet boundary condition on the boundary of the central conductor of the stripline and the boundary of the metal grounding plate, the matrix equation is obtained. Using Gaussian elimination method to obtain an accurate solution of vector magnetic potential, and obtaining the per-unit-length R and L of the stripline through post-processing. In order to extract C, the unknowns of the Poisson equation are scalar potentials, and the solution method is consistent with the methods of R and L. Moreover, numerical results are provided to demonstrate the accuracy and efficiency of this proposed 2D-FEM method. The RLC was calculated using EM-software, and compared with 2D-FEM at 1GHz, the error was less than 3%. When calculating the RLC of a structure with the same current distribution in a certain direction, compared to three-dimensional finite element, two-dimensional finite element has lower order, fewer number of basis functions, occupies less memory, and has higher computational efficiency.

关键词： Accuracy Transmission line matrix methods Poisson equations Stripline Metals Current distribution Vectors

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RFNet: Toward High-Quality Object Detection in Aerial Images 4

RFNet: Toward High-Quality Object Detection in Aerial Images

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4th International Conference on Computer Information Science and Artificial Intelligence, CISAI 2021

作者： Tang, Hui Wu, Jing Southwest University of Science and Technology School of Information Engineering Mianyang China Robot Technology Used for Special Environment Key Laboratory of Sichuan Province Southwest University of Science and Technology Mianyang China

ISBN: (纸本)9781665406925

Due to the object overlap and multi-scale transformation problems in aerial image detection, the detection system has false and missed detections. In this paper, we propose feature Re-Fusion Network, named RFNet. Specifically, the recurses multi-layer feature maps into a pyramid network, cross fusion of upper and lower features to enhancing information flow. Next, we introduced a lightweight module that connects feature semantic information for fusion to improve the feature fusion ability. Finally, we optimized the parameters of attention mechanism block to adapt to aerial images detection. We equipped it to the modern detector Cascade R-CNN on the VisDrone dataset, which improved the mean Average Precision(mAP) by 1.1%, increased middle-size object detection accuracy by 2.1%, and increased the accuracy of the truck class by 2.4%. © 2021 IEEE.

关键词： Object detection

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Improving Muscat Wine Quality with Innovative Fermentation Strategies Using Schizosaccharomyces Pombe Derived from Fermented Grains of Sauce-Flavor Baijiu

SSRN

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SSRN 2024年

作者： Zhang, Cuiying Lyu, Xiaotong Li, Wenxuan Li, Furong Zhou, Yifei Zhou, Meiyi Wei, Chunhui Lin, Liangcai Li, Xin State Key Laboratory of Food Nutrition and Safety Key Laboratory of Industrial Fermentation Microbiology Ministry of Education Tianjin Key Laboratory of Industrial Microbiology College of Biotechnology Tianjin University of Science and Technology Tianjin300457 China Guizhou Guotai Liquor Group Co. Ltd. Renhuai564500 China Liquor Making Biological Technology Application of Key Laboratory of Sichuan Province China

This study investigates innovative approaches to improve the quality and aroma characteristics of Muscat wine production by substituting the conventional Saccharomyces cerevisiae yeast with an efficient fermentation strain of Schizosaccharomyces pombe. The typical use of S. cerevisiae in Muscat wine often leads to uniformity and prolonged processing times, necessitating subsequent malolactic fermentation to degrade excessive malic acid. The study advocates for the replacement of S. cerevisiae with a specific S. pombe strain, Sp-410, isolated from the fermented grains of Sauce-Flavor Baijiu, a Chinese spirit. Muscat wine fermented with the S. pombe strain demonstrates decreased malic acid levels, offering a potential alternative to malolactic fermentation. However, exclusive S. pombe fermentation may result in an overproduction of acetic acid metabolites, leading to a monotonous taste. In response, the study proposes a mixed fermentation approach, combining the S. pombe strain with a Saccharomyces uvarum strain and a non-Saccharomyces yeast, Torulaspora delbrueckii. The optimized mixed fermentation strategies (M:SP+TD and M60SP+TD) involve specific proportions and intervals of inoculation, aiming to enhance the quality and aroma complexity of Muscat wine. In conclusion, this research contributes to advancing the production of high-quality Muscat wines, utilizing S. pombe as the primary yeast strain and implementing mixed fermentation methodologies. © 2024, The Authors. All rights reserved.

关键词： Fermentation

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Advancing cancer diagnosis and prognostication through deep learning mastery in breast, colon, and lung histopathology with ResoMergeNet

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Computers in Biology and Medicine 2025年 185卷 109494-109494页

作者： Ejiyi, Chukwuebuka Joseph Qin, Zhen Agbesi, Victor K. Yi, Ding Atwereboannah, Abena A. Chikwendu, Ijeoma A. Bamisile, Oluwatoyosi F. Bakanina Kissanga, Grace-Mercure Bamisile, Olusola O. College of Nuclear Technology and Automation Engineering & Sichuan Industrial Internet Intelligent Monitoring and Application Engineering Research Center Chengdu University of Technology Sichuan Chengdu China Network and Data Security Key Laboratory of Sichuan Province University of Electronic Science and Technology of China Sichuan Chengdu China School of Computer Science and Engineering University of Electronic Science and Technology of China Chengdu China School of Information and Communication Engineering University of Electronic Science and Technology of China Chengdu China School of Life Science University of Electronic Science and Technology of China Chengdu China

Cancer, a global health threat, demands effective diagnostic solutions to combat its impact on public health, particularly for breast, colon, and lung cancers. Early and accurate diagnosis is essential for successful treatment, prompting the rise of Computer-Aided Diagnosis Systems as reliable and cost-effective tools. Histopathology, renowned for its precision in cancer imaging, has become pivotal in the diagnostic landscape of breast, colon, and lung cancers. However, while deep learning models have been widely explored in this domain, they often face challenges in generalizing to diverse clinical settings and in efficiently capturing both local and global feature representations, particularly for multi-class tasks. This underscores the need for models that can reduce biases, improve diagnostic accuracy, and minimize error susceptibility in cancer classification tasks. To this end, we introduce ResoMergeNet (RMN), an advanced deep-learning model designed for both multi-class and binary cancer classification using histopathological images of breast, colon, and lung. ResoMergeNet integrates the Resboost mechanism which enhances feature representation, and the ConvmergeNet mechanism which optimizes feature extraction, leading to improved diagnostic accuracy. Comparative evaluations against state-of-the-art models show ResoMergeNet's superior performance. Validated on the LC-25000 and BreakHis (400× and 40× magnifications) datasets, ResoMergeNet demonstrates outstanding performance, achieving perfect scores of 100 % in accuracy, sensitivity, precision, and F1 score for binary classification. For multi-class classification with five classes from the LC25000 dataset, it maintains an impressive 99.96 % across all performance metrics. When applied to the BreakHis dataset, ResoMergeNet achieved 99.87 % accuracy, 99.75 % sensitivity, 99.78 % precision, and 99.77 % F1 score at 400× magnification. At 40× magnification, it still delivered robust results with 98.85 % accuracy,

关键词： Lung cancer

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An VIE-PEEC Method for Circuit Parameters Extraction from Complex Packaging Structures

An VIE-PEEC Method for Circuit Parameters Extraction from Co...

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International Applied Computational Electromagnetics Society Symposium (ACES)

作者： Yu Tang Qiang-Ming Cai Ce-Ming Zhou Feng Guo Xin Cao Longjian Zhou Yuyu Zhu Jun Fan School of Information Engineering Southwest University of Science and Technology Mianyang China Tianfu Institute of Research and Innovation Southwest University of Science and Technology (SWUST-TIRI) Robot Technology Used for Special Environment Key Laboratory of Sichuan Province Mianyang Sichuan China

In this paper, a partial element equivalent circuit (PEEC) model based on SWG basis function is proposed for electromagnetic simulation of conductor-dielectric composite Alternating Current(AC) circuits. This method discretizes structures of interest through tetrahedral elements for geometric modeling. Then, the quasi-static moment method (MoM) solution of the volume electric field integral equation (EFIE) is derived, and the equivalent RLC circuit network is obtained by the PEEC method. Finally, import the network into the PARDISO for calculation. A numerical example is given to prove the accuracy and efficiency of the method.

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Constitutive Model and Plate Forging Ability of 5052 Aluminum Alloy Under Different Temperatures 13th

Constitutive Model and Plate Forging Ability of 5052 Aluminu...

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13th International Conference on the technology of Plasticity, ICTP 2021

作者： Li, Yantao Dong, Wenzheng Lin, Qiquan Wang, Zhigang Key Laboratory of Robot and Application Technology of Hunan Province Xiangtan University Xiangtan China State Key Laboratory of Materials Processing and Die and Mould Technology Huazhong University of Science and Technology Wuhan China Department of Mechanical and System Engineering Gifu University Gifu Japan

ISBN: (纸本)9783030753801

The hot tensile deformation behavior of 5052 aluminum alloy is investigated by uniaxial tensile tests with the temperature range of 523–723 K and strain rate range of 0.001–0.1 s−1. The constitutive equation is established based on the Arrhenius-type equation and Zener–Hollomon parameters, which are applied to numerical simulation for solid boss forming by plate forging process. As a result, the flow stresses obtained from the constitutive equation are consistent with the experiments, and the proposed constitutive equation is succeeded to predict the deformation behavior in the plate forging process. The best forming temperature for boss solid forming is 673 K based on the boss forming ability analysis. © 2021, The Minerals, Metals & Materials Society.

关键词： Constitutive equations

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