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Non-invasive glucose sensing via the fingernail bed using THz radiation

Current Directions in Biomedical engineering 2023年第1期9卷 507-510页

作者： Jalali, Mandana Prokscha, Andreas Kaiser, Thomas Yan, Yijun Taro Svejda, Jan Erni, Daniel Kubiczek, Tobias Balzer, Jan Preu, Sascha General and Theoretical Electrical Engineering (ATE) Faculty of Engineering University of Duisburg-Essen Essen Duisburg Germany CENIDE-Center for Nanointegration Duisburg-Essen Duisburg D-47048 Germany Institute of Digital Signal Processing Faculty of Engineering University of Duisburg-Essen Duisburg D-47048 Germany Chair of Communication Systems Faculty of Engineering University of Duisburg-Essen Duisburg D-47048 Germany Terahertz Devices and Systems Institute of Microwave Engineering and Photonics Department of Electrical Engineering and Information Technology Technical University of Darmstadt Darmstadt D-64283 Germany

The possibility of establishing a novel technique for reliably accessing glycemic information in a non-invasive, easy to implement method at THz frequencies via the fingernail bed is investigated. The nail bed's major content is blood at its various glucose levels and is also partially protected from environmental conditions by the nail plate, making it a desirable platform for non-invasive glucose sensing. The study is based on a 2D computational electromagnetics (EM) model of the layered fingernail in COMSOL Multiphysics, where the required dielectric function (i.e. permittivity and conductivity) of the fingernail plate is measured using THz-Time-Domain-Spectroscopy (THz-TDS), and the glucose-dependend dielectric functions of the fingernail bed are taken from available experimental data in the literature. From this data a material model using a multipole Cole-Cole model is established for both, the nail plate and the nail bed, where the glucose content in the latter is varied from 3.0-19.0 mmol/l. A numerical analysis of the THz reflectometry at the fingernail in the frequency range of 0.1-2.0 THz revealed that the reflectance spectra are sensitive to the glucose content in the nail bed proving that accurate glucose sensing via the fingernail bed may become feasible around 0.2-0.4 THz. © 2023 the author(s), published by Walter de Gruyter Berlin/Boston.

关键词： Glucose

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Shannon-like Interpolation with Spectral Priors and Weighted Hilbert Spaces: Beyond the Nyquist Rate

arXiv

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arXiv 2024年

作者： Haldar, Justin P. Signal and Image Processing Institute Ming Hsieh Department of Electrical and Computer Engineering University of Southern California Los AngelesCA90089 United States

In this work, we draw connections between the classical Shannon interpolation of bandlimited deterministic signals and the literature on estimating continuous-time random processes from their samples (known in various communities under different names, such as Wiener-Kolmogorov filtering, Gaussian process regression, and kriging). This leads to the realization that Shannon interpolation can be interpreted as implicitly expecting that the unknown signal has uniform spectral density within its bandwidth. However, in many practical applications, we often expect more energy at some frequencies than at others. This leads us to propose novel Shannon-like interpolators that are optimal with respect to appropriately-constructed weighted Hilbert spaces, where weighting enables us to accommodate prior information about nonuniform spectral density. Although our new interpolants are derived for data obtained with any sampling rate, we observe that they are particularly useful for interpolating sub-Nyquist data. In addition to theory, we also discuss aspects of practical implementation and show illustrative examples to demonstrate the potential benefits of the approach. Copyright © 2024, The Authors. All rights reserved.

关键词： Wiener filtering

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Automatic extraction of lightweight and efficient neural network architecture of heavy convolutional architectures to predict microsatellite instability from hematoxylin and eosin histology in gastric cancer

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Neural Computing and Applications 2024年第25期36卷 15295-15321页

作者： Rostami, Habib Ashkpour, Maryam Behzadi-Khormouji, Hamed Mokhtari, Maral Khayati, Armin Keshavarz, Ahmad Talatian Azad, Saeed Tabesh, Yahya Computer Engineering Department Faculty of Intelligent Systems Engineering and Data Science Persian Gulf University Bushehr75168 Iran Artificial Intelligence and Intelligent Healthcare Lab Artificial Intelligence and Data Mining Research Group Faculty of Intelligent Systems Engineering and Data Science ICT Research Institute Persian Gulf University Bushehr75168 Iran Faculty of New Science and Technologies University of Tehran Tehran Iran Department of Computer Science Imec-IDLab University of Antwerp Sint-Pietersvliet 7 Antwerp2000 Belgium Shahid Faghihi Hospital Shiraz University of Medical Sciences Shiraz Iran Department of Computer Science Engineering and IT School of Electrical and Computer Engineering Shiraz University Shiraz Iran Electrical Engineering Department Faculty of Intelligent Systems Engineering and Data Science Persian Gulf University Bushehr75168 Iran IoT and Signal Processing Research Group Faculty of Intelligent Systems Engineering and Data Science ICT Research Institute Persian Gulf University Bushehr75168 Iran Department of Mathematical Sciences Sharif University of Technology Tehran Iran

Cancers have emerged as a significant concern due to their impact on public health and society. The examination and interpretation of tissue sections stained with Hematoxylin and Eosin (H&E) play a crucial role in disease assessment, particularly in cases like gastric cancer. Microsatellite instability (MSI) is suggested to contribute to the carcinogenesis of specific gastrointestinal tumors. However, due to the nonspecific morphology observed in H&E-stained tissue sections, MSI determination often requires costly evaluations through various molecular studies and immunohistochemistry methods in specialized molecular pathology laboratories. Despite the high cost, international guidelines recommend MSI testing for gastrointestinal cancers. Thus, there is a pressing need for a new diagnostic modality with lower costs and widespread applicability for MSI detection. This study aims to detect MSI directly from H&E histology slides in gastric cancer, providing a cost-effective alternative. The performance of well-known deep convolutional neural networks (DCNNs) and a proposed architecture are compared. Medical image datasets are typically smaller than benchmark datasets like imageNet, necessitating the use of off-the-shelf DCNN architectures developed for large datasets through techniques such as transfer learning. Designing an architecture proportional to a custom dataset can be tedious and may not yield desirable results. In this work, we propose an automatic method to extract a lightweight and efficient architecture from a given heavy architecture (e.g., well-known off-the-shelf DCNNs) proportional to a specific dataset. To predict MSI instability, we extracted the MicroNet architecture from the Xception network using the proposed method and compared its performance with other well-known architectures. The models were trained using tiles extracted from whole-slide images, and two evaluation strategies, tile-based and whole-slide image (WSI)-based, were employed and comp

关键词： Network architecture

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Deeper Bidirectional Neural Networks with Generalized Non-Vanishing Hidden Neurons

Deeper Bidirectional Neural Networks with Generalized Non-Va...

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International Conference on Machine Learning and Applications (ICMLA)

作者： Olaoluwa Adigun Bart Kosko Department of Electrical and Computer Engineering Signal and Image Processing Institute Los Angeles California

The new NoVa hidden neurons have outperformed ReLU hidden neurons in deep classifiers on some large image test sets. The NoVa or nonvanishing logistic neuron additively perturbs the sigmoidal activation function so that its derivative is not zero. This helps avoid or delay the problem of vanishing gradients. We here extend the NoVa to the generalized perturbed logistic neuron and compare it to ReLU and several other hidden neurons on large image test sets that include CIFAR-100 and Caltech-256. Generalized NoVa classifiers allow deeper networks with better classification on the large datasets. This deep benefit holds for ordinary unidirectional backpropagation. It also holds for the more efficient bidirectional backpropagation that trains in both the forward and backward directions.

关键词： Backpropagation Training Neurons Machine learning Delays Biological neural networks Logistics

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Machine learning predicts long-term mortality after acute myocardial infarction using systolic time intervals and routinely collected clinical data

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Intelligent Medicine 2024年第3期4卷 170-176页

作者： Bijan Roudini Boshra Khajehpiri Hamid Abrishami Moghaddam Mohamad Forouzanfar Department of Systems Engineering School of Advanced TechnologyUniversity of QuebecMontrealCanada Machine Vision and Medical Image Processing(MVMIP)Laboratory Faculty of Electrical and Computer EngineeringK.N.Toosi University of TechnologyTehranIran Research Center of the Montreal University Institute of Geriatrics MontrealCanada

Background Precise estimation of current and future comorbidities of patients with cardiovascular disease is an important factor in prioritizing continuous physiological monitoring and new *** learning(ML)models have shown satisfactory performance in short-term mortality prediction in patients with heart disease,whereas their utility in long-term predictions is *** study aimed to investigate the performance of tree-based ML models on long-term mortality prediction and effect of two recently introduced biomarkers on long-term *** This study used publicly available data from the Collaboration Center of Health Information Appli-cation at the Ministry of Health and Welfare,Taiwan,*** collected data were from patients admitted to the cardiac care unit for acute myocardial infarction(AMI)between November 2003 and September *** collected and analyzed mortality data up to December *** records were used to gather demo-graphic and clinical data,including age,gender,body mass index,percutaneous coronary intervention status,and comorbidities such as hypertension,dyslipidemia,ST-segment elevation myocardial infarction,and non-ST-segment elevation myocardial *** the data,collected from 139 patients with AMI,from medical and demographic records as well as two recently introduced biomarkers,brachial pre-ejection period(bPEP)and brachial ejection time(bET),we investigated the performance of advanced ensemble tree-based ML algorithms(random forest,AdaBoost,and XGBoost)to predict all-cause mortality within 14 years.A nested cross-validation was performed to evaluate and compare the performance of our developed models precisely with that of the conventional logistic regression(LR)as the baseline *** The developed ML models achieved significantly better performance compared to the baseline LR(C-Statistic,0.80 for random forest,0.79 for AdaBoost,and 0.78 for XGBoost,vs.0.77 for LR)(PRF<0.001,PAdaBoost<0.001,a

关键词： Electrocardiogram Predication Mortality prediction Machine learning

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Extended Version of "New Theory and Faster Computations for Subspace-Based Sensitivity Map Estimation in Multichannel MRI"

arXiv

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arXiv 2023年

作者： Lobos, Rodrigo A. Chan, Chin-Cheng Haldar, Justin P. The Signal and Image Processing Institute Ming Hsieh Department of Electrical and Computer Engineering University of Southern California Los AngelesCA90089 United States

This is an unabridged version of a journal manuscript that has been submitted for publication [1]. (Due to length restrictions, we were forced to remove substantial amounts of content from the version that was submitted to the journal, including more detailed theoretical explanations, additional figures, and a more comprehensive bibliography. This content remains intact in this version of the document). Sensitivity map estimation is important in many multichannel MRI applications. Subspace-based sensitivity map estimation methods like ESPIRiT are popular and perform well, though can be computationally expensive and their theoretical principles can be nontrivial to understand. In the first part of this work, we present a novel theoretical derivation of subspace-based sensitivity map estimation based on a linear-predictability/structured low-rank modeling perspective. This results in an estimation approach that is equivalent to ESPIRiT, but with distinct theory that may be more intuitive for some readers. In the second part of this work, we propose and evaluate a set of computational acceleration approaches (collectively known as PISCO) that can enable substantial improvements in computation time (up to ∼100× in the examples we show) and memory for subspace-based sensitivity map estimation. Copyright © 2023, The Authors. All rights reserved.

关键词： Magnetic resonance imaging

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An Efficient Algorithm for Spatial-Spectral Partial Volume Compartment Mapping with Applications to Multicomponent Diffusion and Relaxation MRI

arXiv

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arXiv 2024年

作者： Liu, Yunsong Mandal, Debdut Liao, Congyu Setsompop, Kawin Haldar, Justin P. Signal and Image Processing Institute Ming Hsieh Department of Electrical and Computer Engineering University of Southern California Los AngelesCA90089 United States Departments of Radiology and Electrical Engineering Stanford University StanfordCA94305 United States

We introduce a new algorithm to solve a regularized spatial-spectral image estimation problem. Our approach is based on the linearized alternating directions method of multipliers (LADMM), which is a variation of the popular ADMM algorithm. Although LADMM has existed for some time, it has not been very widely used in the computational imaging literature. This is in part because there are many possible ways of mapping LADMM to a specific optimization problem, and it is nontrivial to find a computationally efficient implementation out of the many competing alternatives. We believe that our proposed implementation represents the first application of LADMM to the type of optimization problem considered in this work (involving a linear-mixture forward model, spatial regularization, and nonnegativity constraints). We evaluate our algorithm in a variety of multiparametric MRI partial volume mapping scenarios (diffusion-relaxation, relaxation-relaxation, relaxometry, and fingerprinting), where we consistently observe substantial (∼3×-50×) speed improvements. We expect this to reduce barriers to using spatially-regularized partial volume compartment mapping methods. Further, the considerable improvements we observed also suggest the potential value of considering LADMM for a broader set of computational imaging problems. Copyright © 2024, The Authors. All rights reserved.

关键词： Mapping

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Bayesian Rule Ontologies For XAI Classification and Regression

Bayesian Rule Ontologies For XAI Classification and Regressi...

引用

International Conference on Machine Learning and Applications (ICMLA)

作者： Akash Kumar Panda Bart Kosko Department of Electrical and Computer Engineering Signal and Image Processing Institute University of Southern California Los Angeles California

A random foam defines a modular rule-based ontology after sampling from a neural or other input-output system. A random foam combines several rule-based systems and averages the systems. It gives a Bayesian posterior over the subsystems. It also gives separate Bayesian posteriors over the rules of each subsystem. The shape of the rules controls how well the random-foam ontology performs in classification and regression. We found that a heterogenous ontology that mixes different rule shapes can perform better than a homogenous ontology based on a single Gaussian or other rule type. Random foams are also universal function approximators. So they can train on a neural black box and act as its explainable proxy system. We prove this uniform approximation theorem for the important case of bump-function random foams with throughput combination. Random foams also measure their output’s uncertainty through the conditional variance. Bump function rules performed better than Cauchy rules at classification while Cauchy rules performed better at regression. Gaussian rules performed best in both classification and regression. A homogeneous Gaussian random foam that trained on a 96.7% accurate neural classifier was itself 95.96% accurate on the MNIST data set. A heterogeneous random foam with two-thirds Gaussian rules and one-third Laplacian rules did better than did the all-Gaussian foam ontology.

关键词： Uncertainty Laplace equations Shape Measurement uncertainty Machine learning Ontologies Aerospace electronics

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Enhancing Fault Diagnosis of Uncertain Grid-Connected Photovoltaic systems using Deep GRU-based Bayesian optimization

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IFAC-PapersOnLine 2024年第4期58卷 449-454页

作者： Zahra Yahyaoui Mansour Hajji Majdi Mansouri Abdelmalek Kouadri Kais Bouzrara Hazem Nounou Research Unit Advanced Materials and Nanotechnologies Higher Institute of Applied Sciences and Technology of Kasserine Kairouan University Kasserine 1200 Tunisia Electrical and Computer Engineering Program Texas A&M University at Qatar Doha Qatar Signals and Systems Laboratory Institute of Electrical and Electronics Engineering University M Hamed Bougara of Boumerdes Boumerdes Algeria Laboratory of Automatic Signal and Image Processing National Engineering School of Monastir Tunisia

The efficacy of photovoltaic systems is significantly impacted by electrical production losses attributed to faults. Ensuring the rapid and cost-effective restoration of system efficiency necessitates robust fault detection and diagnosis (FDD) procedures. This study introduces a novel interval-gated recurrent unit (I-GRU) based Bayesian optimization framework for FDD in grid-connected photovoltaic (GCPV) systems. The utilization of an interval-valued representation is proposed to address uncertainties inherent in the systems, the GRU is employed for fault classification, while the Bayesian algorithm optimizes its hyperparameters. Addressing uncertainties through the proposed approach enhances monitoring capabilities, mitigating computational and storage costs associated with sensor uncertainties. The effectiveness of the proposed approach for FDD in GCPV systems is demonstrated using experimental application.

关键词： Bayesian optimization fault detection fault diagnosis gated recurrent units grid-connected PV systems interval-data representation uncertainties

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Segmentation of Retina Vessels in 2D OCT-Reconstructed Fundus images with 3D UNet

Segmentation of Retina Vessels in 2D OCT-Reconstructed Fundu...

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signal processing Algorithms, Architectures, Arrangements and Applications (SPA)

作者： Tomasz Marciniak Agnieszka Stankiewicz Przemysław Zaradzki Department of Control Robotics and Electrical Engineering Division of Electronic Systems and Signal Processing Institute of Automatic Control and Robotics Poznan University of Technology Poznan Poland

This paper presents an analysis of the effectiveness of blood vessel segmentation in human retinal images. The segmentation process was carried out for three-dimensional optical coherence tomography (OCT) scans using the author’s publicly available CAVRI-C database. A 3D version of the U-Net artificial neural network was used. Various dimensions of the input blocks were investigated to determine their influence on the segmentation process. The effectiveness of the proposed solutions was evaluated using various metrics and the results obtained were compared with the 2D solution, also based on neural networks. The use of the proposed solutions allowed us to improve the segmentation even by 15% (in the case of the F1-score).

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