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SSRN 2023年

作者： Chelini, Gabriele Mirzapourdelavar, Hadi Durning, Peter Baidoe-Ansah, David O’Donovan, Sinead M. Klengel, Torsten Balasco, Luigi Berciu, Cristina Boyer-Boiteau, Anne Smith, Robert Ressler, Kerry J. Bozzi, Yuri Dityatev, Alexander Berretta, Sabina Translational Neuroscience Laboratory McLean Hospital BelmontMA United States Department of Psychiatry Harvard Medical School BostonMA United States DZNE Molecular Neuroplasticity Magdeburg Germany Cognitive Disorders Research Laboratory University of Toledo ToledoOH United States Translational Molecular Genomics Laboratory Mclean Hospital BelmontMA United States University Medical Center Göttingen Department of Psychiatry Göttingen Germany Center for Mind/Brain Science University of Trento Rovereto Italy Program in Neuroscience Harvard Medical School BostonMA United States Neurobiology of Fear Laboratory McLean Hospital BelmontMA United States CNR Neuroscience Institute Pisa Italy Medical Faculty Otto von Guericke University Magdeburg Germany Center for Behavioral Brain Sciences Otto von Guericke University Magdeburg Germany

Experience-dependent learning depends on synaptic plasticity. Recent findings show that effective integration of novel salient information requires coordinated processes of homo- and hetero- synaptic plasticity onto neighboring dendritic stretches. In this work, we hypothesized that activity-dependent remodeling of the peri-synaptic extracellular matrix contributes to this mechanism. We show that clusters of the peri-synaptic matrix, containing the 6-sulfated chondroitin sulfate proteoglycan versican ( Vcan-CSPG ), emerge in response to sensory stimuli, showing temporal and spatial coincidence with the dendritic spine plasticity. Moreover, the depletion of Vcan-CSPG in the CA1 hippocampal region was accompanied by impaired long-term potentiation and object location memory in adult mice. These findings show that a specific CSPG glycoform regulates the molecular mechanisms underlying induction and consolidation of synaptic plasticity, confirming that experience-dependent refinement of the brain extracellular matrix plays a critical role in learning and memory. © 2023, The Authors. All rights reserved.

关键词： Sulfur compounds

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Pediatric anxiety and daily fine particulate matter: A longitudinal study

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Psychiatry research Communications 2022年第4期2卷 100077页

作者： Vancil, Andrew Strawn, Jeffrey R. Rasnick, Erika Levine, Amir Schroeder, Heidi K. Specht, Ashley M. Turner, Ashley L. Ryan, Patrick H. Brokamp, Cole Cincinnati Children's Hospital Medical Center Division of Biostatistics and Epidemiology United States University of Cincinnati Anxiety Disorders Research Program Department of Psychiatry & Behavioral Neuroscience United States Department of Psychiatry College of Physicians and Surgeons Columbia University United States Division of Child and Adolescent Psychiatry New York State Psychiatric Institute United States University of Cincinnati College of Medicine Department of Pediatrics United States

Daily variations in ambient fine particulate matter (PM2.5) could contribute to the morbidity of anxiety disorders in children and adolescents, but has not yet been studied longitudinally at a daily level. We tested t...

Daily variations in ambient fine particulate matter (PM_2.5) could contribute to the morbidity of anxiety disorders in children and adolescents, but has not yet been studied longitudinally at a daily level. We tested this association using repeated weekly measures of anxiety symptom severity in a group of 23 adolescents with generalized anxiety disorder. After estimating ambient PM_2.5 concentrations using a validated model, we found that increased concentrations were significantly associated with increased anxiety symptom severity and frequency two, three, and four days later. PM_2.5 may be a novel, modifiable exposure that could inform population level interventions to decrease psychiatric morbidity. © 2022 The Authors

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Corrigendum to ’ The role of ultrasonic vocalizations in rat laryngological investigations’ [Physiology & Behavior volume 294 (2025) start page 1 –end page 10 /article number 114887]

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Physiology and Behavior 2025年 295卷 114907-114907页

作者： Shembel, Adrianna C. Johnson, Aaron M. Ciucci, Michelle R. Lunaris, Charlie Lenell Morrison, Robert A. Rudisch, Denis Michael School of Behavioral and Brain Sciences University of Texas at Dallas Dallas TX United States Department of Otolaryngology-Head and Neck Voice Center University of Texas Southwestern Medical Center Dallas TX United States Department of Otolaryngology—Head and Neck Surgery NYU Voice Center NYU Langone Health New York NY United States Department of Surgery Division of Otolaryngology-Head & Neck Surgery UW School of Medicine and Public Health University of Wisconsin-Madison Madison WI United States Department of Communication Sciences and Disorders University of Wisconsin-Madison Madison WI United States Neuroscience Training Program University of Wisconsin-Madison Madison WI United States Communication Sciences and Disorders University of Northern Colorado Greeley CO United States Institute for Clinical and Translational Research UW School of Medicine and Public Health University of Wisconsin-Madison Madison WI United States

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Cell-type-specific and inflammatory DNA methylation patterns associated with PTSD

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Brain, Behavior, and Immunity 2025年 128卷 540-548页

作者： Smith, Alicia K. Katrinli, Seyma Maihofer, Adam X. Aiello, Allison E. Baker, Dewleen G. Boks, Marco P. Brick, Leslie A. Chen, Chia-Yen Dalvie, Shareefa Fani, Negar Fortier, Catherine B. Gelernter, Joel Geuze, Elbert Gillespie, Charles F. Hayes, Jasmeet P. Hong, Suzi Kessler, Ronald C. King, Anthony P. Koen, Nastassja Koenen, Karestan C. Liberzon, Israel Linnstaedt, Sarah D. McLean, Samuel A. Michopoulos, Vasiliki Milberg, William P. Miller, Mark W. Mufford, Mary S. Nugent, Nicole R. Orcutt, Holly K. Powers, Abigail Rauch, Sheila A.M. Ressler, Kerry J. Risbrough, Victoria B. Rutten, Bart P.F. Smoller, Jordan W. Stein, Dan J. Stein, Murray B. Ursano, Robert J. Verfaellie, Mieke H. Vermetten, Eric Vinkers, Christiaan H. Wani, Agaz H. WareVinkers, Erin B. Wildman, Derek E. Wolf, Erika J. Zhao, Ying Logue, Mark W. Nievergelt, Caroline M. Uddin, Monica Zannas, Anthony S. Emory University Department of Gynecology and Obstetrics Atlanta GA United States Emory University Department of Human Genetics Atlanta GA United States Emory University Department of Psychiatry and Behavioral Sciences Atlanta GA United States University of California San Diego Department of Psychiatry La Jolla CA United States Veterans Affairs San Diego Healthcare System Center of Excellence for Stress and Mental Health San Diego CA United States Veterans Affairs San Diego Healthcare System Research Service San Diego CA United States Columbia University Robert N Butler Columbia Aging Center Department of Epidemiology New York NY United States Amsterdam UMC Department of Psychiatry NH Amsterdam Netherlands Dimence Specialised Mental Health Mood Disorders OV Deventer Netherlands University Medical Center Utrecht Department Psychiatry UT Utrecht Netherlands Alpert Medical School of Brown University Department of Psychiatry and Human Behavior Providence RI United States Biogen Inc. Translational Medicine Cambridge MA United States University of Cape Town Division of Human Genetics Western Province Cape Town South Africa Harvard Medical School Department of Psychiatry Boston MA United States VA Boston Healthcare System Geriatric Research Education and Clinical Center (GRECC) Boston MA United States VA Boston Healthcare System Translational Research Center for Traumatic Brain Injury and Stress Disorders (TRACTS) Boston MA United States VA Connecticut Healthcare Center Psychiatry Service West Haven CT United States Yale University School of Medicine Departments of Psychiatry Genetics and Neuroscience New Haven CT United States Netherlands Ministry of Defence Brain Research and Innovation Centre UT Utrecht Netherlands UMC Utrecht Brain Center Rudolf Magnus Department of Psychiatry UT Utrecht Netherlands The Ohio State University Department of Psychology Columbus OH United States University of California San Diego Herbert Wertheim Sch

Background: Epigenetic modifications, including DNA methylation (DNAm), can change in response to traumatic stress exposure, and may help to distinguish between individuals with and without PTSD. Here, we examine the DNAm patterns specific to immune cell types and inflammation in those with PTSD. Methods: This study includes 3,277 participants from 11 cohorts participating in the Psychiatric Genomics Consortium (PGC) PTSD Epigenetics Workgroup. DNAm was assayed from blood with the MethylationEPIC BeadChip. A standardized QC pipeline was applied and used to impute cell composition. Within each cohort, we identified cell-type-specific DNAm patterns associated with PTSD, controlling for sex (if applicable), age, and ancestry. Meta-analyses were performed from summary statistics. Results: PTSD cases had lower proportions of B cells and NK cells as well as higher proportions of neutrophils when compared to trauma-exposed controls. Overall, we identified 96 PTSD-associated CpGs across six types of immune cells. Most of these differences were identified in B cells, with 95 % exhibiting lower methylation levels in those with PTSD. Interestingly, the PTSD-associated CpGs annotated to a gene in B cells were enriched in a recent GWAS of PTSD (p < 0.0001). Conclusions: This study identifies novel PTSD-associated CpGs in individual immune cell types and supports the role of immune dysregulation and inflammation in PTSD. © 2025 The Author(s)

关键词： B-cells CRP DNA methylation EWAS Immune Inflammation PTSD Trauma

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Neural signatures of emotional biases predict clinical outcomes in difficult-to-treat depression

Research directions. Depression

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research directions. Depression 2024年 1卷 e21页

作者： Diede Fennema Gareth J Barker Owen O'Daly Beata R Godlewska Ewan Carr Kimberley Goldsmith Allan H Young Jorge Moll Roland Zahn Centre of Affective Disorders Institute of Psychiatry Psychology & Neuroscience King's College London London UK. Department of Neuroimaging Institute of Psychiatry Psychology & Neuroscience King's College London London UK. Psychopharmacology Research Unit University Department of Psychiatry University of Oxford Oxford UK. Oxford Health NHS Foundation Trust Warneford Hospital Oxford UK. Department of Biostatistics and Health Informatics Institute of Psychiatry Psychology & Neuroscience King's College London London UK. National Service for Affective Disorders South London and Maudsley NHS Foundation Trust London UK. Cognitive and Behavioral Neuroscience Unit D'Or Institute for Research and Education (IDOR) Pioneer Science Program Rio de Janeiro Brazil.

Background:Neural predictors underlying variability in depression outcomes are poorly understood. Functional MRI measures of subgenual cortex connectivity, self-blaming and negative perceptual biases have shown prognostic potential in treatment-naïve, medication-free and fully remitting forms of major depressive disorder (MDD). However, their role in more chronic, difficult-to-treat forms of MDD is unknown. Methods:Forty-five participants (n = 38 meeting minimum data quality thresholds) fulfilled criteria for difficult-to-treat MDD. Clinical outcome was determined by computing percentage change at follow-up from baseline (four months) on the self-reported Quick Inventory of Depressive Symptomatology (16-item). Baseline measures included self-blame-selective connectivity of the right superior anterior temporal lobe with an Brodmann Area 25 region-of-interest, blood-oxygen-level-dependent bilateral amygdala activation for subliminal sad vs happy faces, and resting-state connectivity of the subgenual cortex with an defined ventrolateral prefrontal cortex/insula region-of-interest. Findings:A linear regression model showed that baseline severity of depressive symptoms explained 3% of the variance in outcomes at follow-up ([3,34] = .33, = .81). In contrast, our three pre-registered neural measures combined, explained 32% of the variance in clinical outcomes ([4,33] = 3.86, .01). Conclusion:These findings corroborate the pathophysiological relevance of neural signatures of emotional biases and their potential as predictors of outcomes in difficult-to-treat depression.

关键词： depression difficult-to-treat fMRI prediction prognosis

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Association of Spousal Separation and Widowhood with Incident Dementia: The Atherosclerosis Risk in Communities (ARIC) Neurocognitive Study (NCS)

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Alzheimer's & Dementia 2022年第S11期18卷

作者： Jiaxin Xie James R. Pike Keenan A Walker Kevin J Sullivan B Gwen Windham Rebecca F Gottesman National Institute of Neurological Disorders and Stroke Intramural Research Program Bethesda MD USA University of North Carolina Chapel Hill NC USA Laboratory of Behavioral Neuroscience National Institute on Aging Intramural Research Program Baltimore MD USA University of Mississippi Medical Center Jackson MS USA

Background Community-based investigations suggest that being unmarried in mid- to late-life increases dementia risk. However, these studies rarely distinguish the cause of unmarried status (i.e., whether divorced, widowed, or never married). We prospectively examined spousal separation/loss and dementia incidence in the ARIC study. Method 14,922 participants reported marital status and were dementia-free at baseline (Visit 3, 1993-95; mean age 59.6, SD 5.8). They were followed through 2019 with annual follow-up surveys of marital status (never married [n = 390], married [n = 7,314], divorced/separated [n = 1,512], widowed [n = 5,706]). Widowed or divorced/separated participants were asked when this event occurred. Dementia cases were adjudicated through in-person evaluations, informant interviews, and phone assessments from Visit 5 onward, and pre- and post-Visit 5 hospitalization codes and death certificates. We investigated the association between being widowed and being divorced/separated (both as time-varying variables) with dementia (excluding dementia in the first year after widowhood event) using Cox proportional hazards models, adjusted for demographics, APOEε4, and vascular risk factors. Results 2,931 dementia cases were identified. Demographic- and APOEε4-adjusted hazard ratio (HR) (95% CI) for dementia was 1.11 (1.02-1.21) in participants who were widowed compared to those who were not widowed, when time-varying widowhood status was considered. ( Table 1 ). This association was no longer significant when the model was further adjusted for time-variant covariates (e.g., vascular risk factors, occupation, health insurance status). A similar pattern was seen for number of times widowed, where results were suggestive of elevated dementia risk in minimally adjusted but not more fully adjusted models. Compared to participants who were neither widowed nor separated, participants who were widowed had a higher unadjusted HR (95% CI) for dementia, HR = 1.78 (1.65-1

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Author Correction: Kalium channelrhodopsins effectively inhibit neurons

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Nature communications 2024年第1期15卷 6088页

作者： Stanislav Ott Sangyu Xu Nicole Lee Ivan Hong Jonathan Anns Danesha Devini Suresh Zhiyi Zhang Xianyuan Zhang Raihanah Harion Weiying Ye Vaishnavi Chandramouli Suresh Jesuthasan Yasunori Saheki Adam Claridge-Chang Program in Neuroscience and Behavioral Disorders Duke-NUS Medical School Singapore Singapore. Institute for Molecular and Cell Biology A*STAR Agency for Science Technology and Research Singapore Singapore. School of Biological Sciences and Institute for Life Sciences University of Southampton Southampton UK. Lee Kong Chian School of Medicine Nanyang Technological University Singapore Singapore. Department of Pharmacy National University of Singapore Singapore Singapore. Program in Neuroscience and Behavioral Disorders Duke-NUS Medical School Singapore Singapore. claridge-chang.adam@duke-nus.edu.sg. Institute for Molecular and Cell Biology A*STAR Agency for Science Technology and Research Singapore Singapore. claridge-chang.adam@duke-nus.edu.sg. Department of Physiology National University of Singapore Singapore Singapore. claridge-chang.adam@duke-nus.edu.sg.

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Consensus framework for conducting phase I/II clinical trials for children, adolescents, and young adults with pediatric low-grade glioma: Guidelines established by the International Pediatric Low-Grade Glioma Coalition Clinical Trial Working Group (Dec, 10.1093/neuonc/noad227, 2023)

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NEURO-ONCOLOGY 2024年第5期26卷 984-984页

作者： Mueller, Sabine Fangusaro, Jason Thomas, Arzu Onar Jacques, Thomas S. Bandopadhayay, Pratiti de Blank, Peter Packer, Roger J. Fouladi, Maryam van Meeteren, Antoinette Schouten Jones, David Perry, Arie Nakano, Yoshiko Hargrave, Darren Riedl, David Robinson, Nathan J. Partanen, Marita Fisher, Michael J. Witt, Olaf Department of Neurology Neurological Surgery and Pediatrics University of California San Francisco San Francisco California USA Department of Pediatrics University Children’s Hospital University of Zurich Zürich Switzerland Department of Hematology and Oncology Children’s Healthcare of Atlanta and Emory University Atlanta Georgia USA Department of Biostatistics St Jude Children’s Research Hospital Memphis Tennessee USA UCL Great Ormond Street Institute of Child Health and Histopathology Department Developmental Biology and Cancer Programme Great Ormond Street Hospital for Children NHS Foundation Trust London UK Dana-Farber/Boston Children’s Cancer and Blood Disorders Center Boston Massachusetts USA Department of Pediatrics Harvard Medical School Boston Massachusetts USA Broad Institute of MIT and Harvard Cambridge Massachusetts USA Department of Pediatrics University of Cincinnati Medical Center and Cincinnati Children’s Hospital Medical Center Cincinnati Ohio USA Brain Tumor Institute Washington DC USA Gilbert Family Neurofibromatosis Institute Washington DC USA Center for Neuroscience and Behavioral Medicine Children’s National Hospital Washington District of Columbia USA Pediatric Brain Tumor Program Division of Hematology Oncology and Bone Marrow Transplant Nationwide Children’s Hospital Columbus Ohio USA Princess Màxima Center for Pediatric Oncology Department of Neuro-oncology Utrecht The Netherlands Hopp Children’s Cancer Center Heidelberg (KiTZ) Heidelberg Germany Departments of Pathology and Neurological Surgery University of California San Francisco San Francisco California USA Division of Haematology/Oncology Hospital for Sick Children Toronto Canada Department of Paediatric Oncology Great Ormond Street Hospital for Children NHS Foundation Trust London UK Department of Psychiatry Psychotherapy Psychosomatics and Medical Psychology University Hospital of Psychiatry II Medical University of Innsbruck Innsbruck Austria Ludwig Boltzma

Within the last few decades, we have witnessed tremendous advancements in the study of pediatric low-grade gliomas (pLGG), leading to a much-improved understanding of their molecular underpinnings. Consequently, we have achieved successful milestones in developing and implementing targeted therapeutic agents for treating these tumors. However, the community continues to face many unknowns when it comes to the most effective clinical implementation of these novel targeted inhibitors or combinations thereof. Questions encompassing optimal dosing strategies, treatment duration, methods for assessing clinical efficacy, and the identification of predictive biomarkers remain unresolved. Here, we offer the consensus of the international pLGG coalition (iPLGGc) clinical trial working group on these important topics and comment on clinical trial design and endpoint rationale. Throughout, we seek to standardize the global approach to early clinical trials (phase I and II) for pLGG, leading to more consistently interpretable results as well as enhancing the pace of novel therapy development and encouraging an increased focus on functional endpoints as well and quality of life for children faced with this disease.

关键词： Low grade glioma Consensus recommendation Early phase clinical trial

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Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information (vol 91, pg 626, 2022)

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BIOLOGICAL PSYCHIATRY 2022年第7期91卷 690-690页

作者： Maihofer, Adam X. Vinkers, Christiaan H. Department of Psychiatry University of California San Diego La Jolla California Department of Family Medicine and Public Health University of California San Diego La Jolla California Center of Excellence for Stress and Mental Health Veterans Affairs Healthcare System San Diego California. Electronic address: amaihofer@health.ucsd.edu. Department of Epidemiology Harvard T.H. Chan School of Public Health Boston Massachusetts Department of Psychiatry Massachusetts General Hospital Boston Massachusetts. Social Genetic and Developmental Psychiatry Centre Institute of Psychiatry Psychology and Neuroscience King's College London London United Kingdom National Institute of Health Research Maudsley Biomedical Research Centre King's College London London United Kingdom. Department of Psychiatry Harvard Medical School Boston Massachusetts Stanley Center for Psychiatric Research Broad Institute of MIT and Harvard Cambridge Massachusetts Center of Excellence in Depression and Anxiety Disorders Belmont Massachusetts. Department of Epidemiology Harvard T.H. Chan School of Public Health Boston Massachusetts Stanley Center for Psychiatric Research Broad Institute of MIT and Harvard Cambridge Massachusetts. Department of Psychiatry University of California San Diego La Jolla California Center of Excellence for Stress and Mental Health Veterans Affairs Healthcare System San Diego California Research Service Veterans Affairs Healthcare System San Diego California. Duke Molecular Physiology Institute Duke University School of Medicine Durham North Carolina. Department of Psychiatry Veterans Affairs Connecticut Healthcare System West Haven Connecticut Department of Psychiatry Yale University School of Medicine New Haven Connecticut. Department of Epidemiology Harvard T.H. Chan School of Public Health Boston Massachusetts Department of Epidemiology Columbia University Mailman School of Public Health New York. Division of Mental Health Atlanta Veterans Affairs Medical Center

BACKGROUND: Posttraumatic stress disorder (PTSD) is heritable and a potential consequence of exposure to traumatic stress. Evidence suggests that a quantitative approach to PTSD phenotype measurement and incorporation of lifetime trauma exposure (LTE) information could enhance the discovery power of PTSD genome-wide association studies (GWASs). METHODS: A GWAS on PTSD symptoms was performed in 51 cohorts followed by a fixed-effects meta-analysis (N = 182,199 European ancestry participants). A GWAS of LTE burden was performed in the UK Biobank cohort (N = 132,988). Genetic correlations were evaluated with linkage disequilibrium score regression. Multivariate analysis was performed using Multi-Trait Analysis of GWAS. Functional mapping and annotation of leading loci was performed with FUMA. Replication was evaluated using the Million Veteran program GWAS of PTSD total symptoms. RESULTS: GWASs of PTSD symptoms and LTE burden identified 5 and 6 independent genome-wide significant loci, respectively. There was a 72% genetic correlation between PTSD and LTE. PTSD and LTE showed largely similar patterns of genetic correlation with other traits, albeit with some distinctions. Adjusting PTSD for LTE reduced PTSD heritability by 31%. Multivariate analysis of PTSD and LTE increased the effective sample size of the PTSD GWAS by 20% and identified 4 additional loci. Four of these 9 PTSD loci were independently replicated in the Million Veteran program. CONCLUSIONS: Through using a quantitative trait measure of PTSD, we identified novel risk loci not previously identified using prior case-control analyses. PTSD and LTE have a high genetic overlap that can be leveraged to increase discovery power through multivariate methods.

关键词： GWAS Genetics Heritability PTSD PheWAS Trauma

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A consensus protocol for functional connectivity analysis in the rat brain (vol 26, pg 673, 2023)

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NATURE neuroscience 2023年第6期26卷 1127-1128页

作者： Grandjean, Joanes Desrosiers-Gregoire, Gabriel Anckaerts, Cynthia Angeles-Valdez, Diego Ayad, Fadi Barriere, David A. Blockx, Ines Bortel, Aleksandra Broadwater, Margaret Cardoso, Beatriz M. Celestine, Marina Chavez-Negrete, Jorge E. Choi, Sangcheon Christiaen, Emma Clavijo, Perrin Colon-Perez, Luis Cramer, Samuel Daniele, Tolomeo Dempsey, Elaine Diao, Yujian Doelemeyer, Arno Dopfel, David Dvorakova, Lenka Falfan-Melgoza, Claudia Fernandes, Francisca F. Fowler, Caitlin F. Fuentes-Ibanez, Antonio Garin, Clement M. Gelderman, Eveline Golden, Carla E. M. Guo, Chao C. G. Henckens, Marloes J. A. G. Hennessy, Lauren A. Herman, Peter Hofwijks, Nita Horien, Corey Ionescu, Tudor M. Jones, Jolyon Kaesser, Johannes Kim, Eugene Lambers, Henriette Lazari, Alberto Lee, Sung-Ho Lillywhite, Amanda Liu, Yikang Liu, Yanyan Y. Lopez-Castro, Alejandra Lopez-Gil, Xavier Ma, Zilu MacNicol, Eilidh Madularu, Dan Mandino, Francesca Marciano, Sabina McAuslan, Matthew J. McCunn, Patrick McIntosh, Alison Meng, Xianzong Meyer-Baese, Lisa Missault, Stephan Moro, Federico Naessens, Daphne M. P. Nava-Gomez, Laura J. Nonaka, Hiroi Ortiz, Juan J. Paasonen, Jaakko Peeters, Lore M. Pereira, Mickael Perez, Pablo D. Pompilus, Marjory Prior, Malcolm Rakhmatullin, Rustam Reimann, Henning M. Reinwald, Jonathan Del Rio, Rodrigo Triana Rivera-Olvera, Alejandro Ruiz-Perez, Daniel Russo, Gabriele Rutten, Tobias J. Ryoke, Rie Sack, Markus Salvan, Piergiorgio Sanganahalli, Basavaraju G. Schroeter, Aileen Seewoo, Bhedita J. Selingue, Erwan Seuwen, Aline Shi, Bowen Sirmpilatze, Nikoloz Smith, Joanna A. B. Smith, Corrie Sobczak, Filip Stenroos, Petteri J. Straathof, Milou Strobelt, Sandra Sumiyoshi, Akira Takahashi, Kengo Torres-Garcia, Maria E. Tudela, Raul van den Berg, Monica van der Marel, Kajo van Hout, Aran T. B. Vertullo, Roberta Vidal, Benjamin Vrooman, Roel M. Wang, Victora X. Wank, Isabel Watson, David J. G. Yin, Ting Zhang, Yongzhi Zurbruegg, Stefan Achard, Sophie Alcauter, Sarael Auer, Dorothee P. Barbier, Emmanuel L. Baudewig, Juergen Beckmann, Chri Donders Institute for Brain Behaviour and Cognition Radboud University Nijmegen The Netherlands Department for Medical Imaging Radboud University Medical Center Nijmegen The Netherlands Cerebral Imaging Centre Douglas Mental Health University Institute Verdun QC Canada Integrated Program in Neuroscience McGill University Montreal QC Canada Bio-imaging Lab University of Antwerp Antwerp Belgium µNEURO Research Centre of Excellence University of Antwerp Antwerp Belgium Instituto de Neurobiología Universidad Nacional Autónoma de México Campus Juriquilla Querétaro Mexico Biological and Biomedical Engineering McGill University Montreal QC Canada McConnell Brain Imaging Centre McGill University Montreal QC Canada Montreal Neurological Institute McGill University Montreal QC Canada UMR INRAE/CNRS 7247 Physiologie des Comportements et de la Reproduction Physiologie de la reproduction et des comportements Centre de recherche INRAE de Nouzilly Tours France Department of Neurology and Neurosurgery McGill University Montreal QC Canada Center for Animal MRI University of North Carolina at Chapel Hill Chapel Hill NC USA Department of Neurology University of North Carolina at Chapel Hill Chapel Hill NC USA Biomedical Research Imaging Center University of North Carolina at Chapel Hill Chapel Hill NC USA Preclinical MRI Champalimaud Research Champalimaud Centre for the Unknown Lisbon Portugal Laboratoire des Maladies Neurodégénératives Molecular Imaging Research Center (MIRCen) Université Paris-Saclay Commissariat à l’Énergie Atomique et aux Énergies Alternatives (CEA) CNRS Fontenay-aux-Roses France Departamento de Neurobiología Conductual y Cognitiva Instituto de Neurobiología Universidad Nacional Autónoma de México Campus Juriquilla Querétaro México Translational Neuroimaging and Neural Control Group High-Field Magnetic Resonance Max Planck Institute for Biological Cybernetics Tuebingen Germany Graduate Training Centre of Neuroscience International Max

Task-free functional connectivity in animal models provides an experimental framework to examine connectivity phenomena under controlled conditions and allows for comparisons with data modalities collected under invasive or terminal procedures. Currently, animal acquisitions are performed with varying protocols and analyses that hamper result comparison and integration. Here we introduce StandardRat, a consensus rat functional magnetic resonance imaging acquisition protocol tested across 20 centers. To develop this protocol with optimized acquisition and processing parameters, we initially aggregated 65 functional imaging datasets acquired from rats across 46 centers. We developed a reproducible pipeline for analyzing rat data acquired with diverse protocols and determined experimental and processing parameters associated with the robust detection of functional connectivity across centers. We show that the standardized protocol enhances biologically plausible functional connectivity patterns relative to previous acquisitions. The protocol and processing pipeline described here is openly shared with the neuroimaging community to promote interoperability and cooperation toward tackling the most important challenges in neuroscience.

关键词： Databases Neural circuits

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