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检索条件"机构=Signature Research Program in Neuroscience and Behavioral Disorders"
89 条 记 录,以下是11-20 订阅
排序:
Effects of the KCNQ (Kv7) Channel Opener Ezogabine on Resting-State Functional Connectivity of Striatal Brain Reward Regions, Depression, and Anhedonia in Major Depressive Disorder: Results From a Randomized Controlled Trial
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Biological Psychiatry 2025年
作者: Chowdhury, Avijit Boukezzi, Sarah Costi, Sara Hameed, Sara Jacob, Yael Salas, Ramiro Iosifescu, Dan V. Han, Ming-Hu Swann, Alan Mathew, Sanjay J. Morris, Laurel Murrough, James W. Depression and Anxiety Center for Discovery and Treatment Department of Psychiatry Icahn School of Medicine at Mount Sinai New York New York United States Psychopharmacology and Emotion Research Laboratory Department of Psychiatry Warneford Hospital University of Oxford Oxford United Kingdom Warneford Hospital Oxford Health NHS Foundation Trust Oxford United Kingdom Mood and Anxiety Disorders Program Menninger Department of Psychiatry and Behavioral Sciences Baylor College of Medicine Houston Texas United States Michael E. DeBakey VA Medical Center Houston Texas United States Menninger Clinic Houston Texas United States Department of Psychiatry New York University School of Medicine New York New York United States Nathan Kline Institute for Psychiatric Research Orangeburg NY United States Brain Cognition and Brain Disease Institute Shenzhen Institute of Advanced Technology Shenzhen China Faculty of Life and Health Sciences Shenzhen University of Advanced Technology Shenzhen China Department of Pharmacological Sciences Icahn School of Medicine at Mount Sinai New York New York United States Nash Family Department of Neuroscience Icahn School of Medicine at Mount Sinai New York New York United States VISN 2 Mental Illness Research Education and Clinical Center James J. Peters VA Medical Center Bronx NY United States
Background: Major depressive disorder (MDD) is a leading cause of disability worldwide, with available treatments often showing limited efficacy. Recent research suggests that targeting specific subtypes of depression... 详细信息
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Atlas of Gray Matter Volume Differences Across Psychiatric Conditions: A Systematic Review With a Novel Meta-Analysis That Considers Co-Occurring disorders
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Biological Psychiatry 2025年
作者: Fortea, Lydia Ortuño, Maria De Prisco, Michele Oliva, Vincenzo Albajes-Eizagirre, Anton Fortea, Adriana Madero, Santiago Solanes, Aleix Vilajosana, Enric Yao, Yuanwei Del Fabro, Lorenzo Solé, Eduard Verdolini, Norma Farré-Colomés, Alvar Serra-Blasco, Maria Picó-Pérez, Maria Lukito, Steve Wise, Toby Carlisi, Christina Arnone, Danilo Kempton, Matthew J. Hauson, Alexander Omar Wollman, Scott Soriano-Mas, Carles Rubia, Katya Norman, Luke Fusar-Poli, Paolo Mataix-Cols, David Valentí, Marc Via, Esther Cardoner, Narcis Solmi, Marco Zhang, Jintao Pan, Pinglei Shin, Jae Il Fullana, Miquel A. Vieta, Eduard Radua, Joaquim Institut d'Investigacions Biomèdiques August Pi I Sunyer Barcelona Spain Department of Medicine University of Barcelona Institute of Neuroscience Barcelona Spain Centro de Investigación Biomédica en Red de Salud Mental Instituto de Salud Carlos III Madrid Spain Bipolar and Depressive Disorders Unit Hospital Clínic Barcelona Spain Department of Biomedical and Neuromotor Sciences University of Bologna Bologna Italy Psychiatric and Psychology Service Hospital Clínic Barcelona Spain Schizophrenia Unit Hospital Clínic Barcelona Spain Department of Psychology The University of Hong Kong Hong Kong Department of Systems Neuroscience University Medical Center Hamburg-Eppendorf Hamburg Germany Department of Pathophysiology and Transplantation University of Milan Milan Italy Local Health Unit Umbria 1 Department of Mental Health Mental Health Center of Perugia Perugia Italy Department of Addictive Behaviour and Addiction Medicine Central Institute of Mental Health Medical Faculty of Mannheim Heidelberg University Mannheim Germany eHealth ICOnnecta't Program and Psycho-Oncology Service Institut Català d'Oncologia L'Hospitalet de Llobregat Spain Psycho-oncology and Digital Health Group Health Services Research in Cancer Institut d'Investigació Biomèdica de Bellvitge L'Hospitalet del Llobregat Spain Live and Health Sciences Research Institute University of Minho Braga Portugal ICVS/3B's PT Government Associate Laboratory Guimarães Braga Portugal Departamento de Psicología Básica Universitat Jaume I Castelló de la Plana Spain Department of Child and Adolescent Psychiatry Institute of Psychology Psychiatry and Neuroscience King's College London London United Kingdom Department of Neuroimaging Institute of Psychiatry Psychology & Neurosciences King's College London London United Kingdom Division of Psychology and Language Sciences University College London London United Kingdom Centre for Affective Disorders Psychological Medicine King's College London Londo
Background: Regional gray matter volume (GMV) differences between individuals with mental disorders and comparison participants may be confounded by co-occurring disorders. To disentangle disorder-specific GMV correla... 详细信息
来源: 评论
Depth-targeted intracortical microstroke by two-photon photothrombosis in rodent brain
Depth-targeted intracortical microstroke by two-photon photo...
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Clinical and Translational Biophotonics, Translational 2022
作者: Fukuda, Masahiro Matsumura, Takayoshi Suda, Toshio Hirase, Hajime International Research Center for Medical Sciences Kumamoto University 2-2-1 Honjo Chuo-ku Kumamoto860-0811 Japan Signature Program in Neuroscience and Behavioral Disorders Duke-NUS Medical School 8 college Road Singapore169857 Singapore Division of Inflammation Research Center for Molecular Medicine Jichi Medical University 3311-1 Yakushiji Tochigi Shimotsuke329-0498 Japan Cancer Science Institute of Singapore National University of Singapore 14 Medical Drive #12-01 Singapore117599 Singapore Center for Translational Neuromedicine Faculty of Health and Life Sciences University of Copenhagen Blegdamsvej 3B Copenhagen N2200 Denmark
We have developed depth-targeted Photothrombosis (DTPT) technique that can target a single vessel in the cortical parenchyma by two-photon excitation. Rose Bengal-mediated DTPT could be induced at 720 nm scanning with... 详细信息
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Studying neurological disorders using induced pluripotent stem cells and optogenetics
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Neural Regeneration research 2015年 第11期10卷 1720-1722页
作者: Eunice W.M.Chin Eyleen L.K.Goh Program in Neuroscience and Behavioral Disorders Duke-NUS Graduate Medical School Singapore NUS Graduate School for Integrative Singapore Sciences and Engineering National University of Singapore Department of Physiology Yong Loo Lin School of Medicine National University of Singapore KK Research Center KK Women’s and Children’s HospitalSingapore
Neurological disorders are amongst the most widely studied human ***,they are also one of the most poorly *** most of these disorders are polygenic,genotype still plays an important role in their *** example,in schizo... 详细信息
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Erratum to: Mitochondrial CHCHD-Containing Proteins: Physiologic Functions and Link with Neurodegenerative Diseases
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Molecular neurobiology 2017年 第7期54卷 5547-5549页
作者: Zhi-Dong Zhou Wuan-Ting Saw Eng-King Tan National Neuroscience Institute of Singapore 11 Jalan Tan Tock Seng Singapore 308433 Singapore. Zhidong_zhou@nni.com.sg. Signature Research Program in Neuroscience and Behavioural Disorders Duke-NUS Graduate Medical School Singapore 8 College Road Singapore 169857 Singapore. Zhidong_zhou@nni.com.sg. National Neuroscience Institute of Singapore 11 Jalan Tan Tock Seng Singapore 308433 Singapore. National Neuroscience Institute of Singapore 11 Jalan Tan Tock Seng Singapore 308433 Singapore. Tan.eng.king@sgh.com.sg. Signature Research Program in Neuroscience and Behavioural Disorders Duke-NUS Graduate Medical School Singapore 8 College Road Singapore 169857 Singapore. Tan.eng.king@sgh.com.sg. Department of Neurology Singapore General Hospital Outram Road Singapore 169608 Singapore. Tan.eng.king@sgh.com.sg.
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Consensus guidelines for assessing eligibility of pathogenic DNA variants for antisense oligonucleotide treatments
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American Journal of Human Genetics 2025年 第5期112卷 975-983页
作者: Cheerie, David Meserve, Margaret M. Beijer, Danique Kaiwar, Charu Newton, Logan Taylor Tavares, Ana Lisa Verran, Aubrie Soucy Sherrill, Emma Leonard, Stefanie Sanders, Stephan J. Blake, Emily Elkhateeb, Nour Gandhi, Aastha Liang, Nicole S.Y. Morgan, Jack T. Verwillow, Anna Verheijen, Jan Giles, Andrew Williams, Sean Chopra, Maya Croft, Laura Dafsari, Hormos Salimi Davidson, Alice E. Friedman, Jennifer Gregor, Anne Haque, Bushra Lechner, Rosan Montgomery, Kylie-Ann Ryten, Mina Schober, Emil Siegel, Gabriele Sullivan, Patricia J. Whittle, Ella F. Zardetto, Bianca Yu, Timothy W. Synofzik, Matthis Aartsma-Rus, Annemieke Costain, Gregory Lauffer, Marlen C. Program in Genetics & Genome Biology SickKids Research Institute Toronto M5G 0A4 ON Canada Department of Molecular Genetics University of Toronto Toronto M5S 1A8 ON Canada Division of Genetics and Genomics Boston Children's Hospital Boston 02115 MA United States Division of Translational Genomics of Neurodegenerative Diseases Hertie Institute for Clinical Brain Research and Center of Neurology University of Tübingen Tübingen 72076 Germany German Center of Neurodegenerative Diseases (DZNE) Tübingen 72076 Germany Clinical Molecular Geneticist Department of Pathology and Laboratory Medicine Precision Diagnostics Laboratory Children's Hospital Colorado Aurora 80045 CO United States Genomics England London E14 5AB United Kingdom Department of Clinical Genetics Cambridge University Hospitals NHS Foundation Trust Cambridge Cambridgeshire CB2 0QQ United Kingdom N=1 Collaborative 7 Carole Place Somerville 02143 MA United States Institute of Developmental and Regenerative Medicine Department of Pediatrics University of Oxford Oxford OX3 7TY United Kingdom Department of Psychiatry and Behavioral Sciences UCSF Weill Institute for Neurosciences University of California San Francisco San Francisco 94158 CA United States New York Genome Center New York 10013 NY United States Department of Quantitative Health Sciences Mayo Clinic Rochester 55902 MN United States Division of Clinical & Metabolic Genetics Hospital for Sick Children Toronto M5G 1X8 ON Canada Department of Genetic Counselling Hospital for Sick Children Toronto M5G 1X8 ON Canada Dutch Center for RNA Therapeutics Department of Human Genetics Leiden University Medical Center Leiden 2333 ZA Netherlands Center for Genomic Medicine Massachusetts General Hospital 55 Fruit Street Boston 02114 MA United States Department of Pathology University of Utah School of Medicine Salt Lake City 84112 UT United States ARUP Laboratories Salt Lake City 84108 UT United States Ambry Genetics 1 E
Of the around 7,000 known rare diseases worldwide, disease-modifying treatments are available for fewer than 5%, leaving millions of individuals without specialized therapeutic strategies. In recent years, antisense o... 详细信息
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Dissecting the Thermodynamics of Branched Peptides-Lipopolysaccharide Interactions
Dissecting the Thermodynamics of Branched Peptides-Lipopolys...
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第十三届中国国际多肽大会
作者: Rajamani Lakshminarayanan Muruganandham Nandhakumar Eunice Goh Tze Leng Liu Shouping Roger W Beuerman Singapore Eye Research Institute The Academia20 College RoadDiscovery Tower Level 6Singapore 169856 Neuroscience & Behavioral Disorders Program Duke-NUS Graduate Medical School8 College RoadSingapore 169857 Singapore Eye Research InstituteThe Academia20 College RoadDiscovery Tower Level 6Singapore 169856
The outer membrane of Gram-negative bacteria is composed of an asymmetric bilayer of lipopolysaccharide(LPS)and *** presence of LPS in the outer membrane in Gram-negative pathogens provides a formidable barrier for ot... 详细信息
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Sudden unexpected death in bipolar disorder
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Journal of affective disorders 2017年 223卷 8-9页
作者: Fulvio A Scorza Rodrigo B Mansur Raphael O Cerqueira Beny Lafer Flavio Kapczinski Roger S McIntyre Elisa Brietzke Laboratory of Neuroscience Department of Neurology and Neurosurgery Federal University of São Paulo São Paulo SP Brazil. Mood Disorders Psychopharmacology Unit University Health Network Toronto ON Canada. Research Group in Molecular and Behavioral Neuroscience of Bipolar Disorder Universidade Federal de São Paulo (Unifesp) São Paulo SP Brazil. Bipolar Disorders Program (PROMAN) Institute of Psychiatry Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (USP) São Paulo SP Brazil. McMaster University Hamilton ON Canada. Mood Disorders Psychopharmacology Unit University Health Network Toronto ON Canada Brain and Cognition Research Foundation Toronto ON Canada. Research Group in Molecular and Behavioral Neuroscience of Bipolar Disorder Universidade Federal de São Paulo (Unifesp) São Paulo SP Brazil. Electronic address: elisabrietzke@***.
Highlights • Evidence indicates that patients with mental illnesses have an increased incidence of sudden death. • Individuals with BD are disproportionately more affected for risk factors for sudden death. • Individu...
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Analysis of sleep spindles in children with Asperger’s syndrome
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Sleep Science 2023年 第3期14卷 201-206页
作者: Rodolfo Cebreros-Paniagua Fructuoso Ayala-Guerrero Erik Leonardo Mateos-Salgado Christopher Isaac Villamar-Flores Carlos Alberto Gutiérrez-Chávez Ulises Jiménez-Correa National Autonomous University of Mexico Psychology Faculty - Mexico City - Mexico. Autonomous University of the State of Mexico Psychology Faculty - Toluca - State of Mexico - Mexico. National Autonomous University of Mexico Sleep Disorders Clinic Medicine Faculty Research Division - Mexico City - Mexico. National Autonomous University of Mexico Postgraduate Program in Behavioral Neuroscience Psychology Faculty - Mexico City - Mexico.
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Biallelic pathogenic variants in TRMT1 disrupt tRNA modification and induce a neurodevelopmental disorder
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American Journal of Human Genetics 2025年 第5期112卷 1117-1138页
作者: Efthymiou, Stephanie Leo, Cailyn P. Deng, Chenghong Lin, Sheng-Jia Maroofian, Reza Lin, Renee Karagoz, Irem Zhang, Kejia Kaiyrzhanov, Rauan Scardamaglia, Annarita Owrang, Daniel Turchetti, Valentina Jahnke, Friederike Huang, Kevin Petree, Cassidy Derrick, Anna V. Rees, Mark I. Alvi, Javeria Raza Sultan, Tipu Li, Chumei Jacquemont, Marie-Line Tran-Mau-Them, Frederic Valenzuela-Palafoll, Maria Sidlow, Rich Yoon, Grace Morrow, Michelle M. Carere, Deanna Alexis Fleischer, Julie Gerkes, Erica H. Phornphutkul, Chanika Isidor, Bertrand Rivier-Ringenbach, Clotilde Philippe, Christophe Kurul, Semra Hiz Soydemir, Didem Kara, Bulent Sunnetci-Akkoyunlu, Deniz Bothe, Viktoria Platzer, Konrad Wieczorek, Dagmar Koch-Hogrebe, Margarete Rahner, Nils Thuresson, Ann-Charlotte Matsson, Hans Frykholm, Carina Bozdoğan, Sevcan Tuğ Bisgin, Atil Chatron, Nicolas Lesca, Gaetan Cabet, Sara Tümer, Zeynep Hjortshøj, Tina D. Rønde, Gitte Marquardt, Thorsten Reunert, Janine Afzal, Erum Zamani, Mina Azizimalamiri, Reza Galehdari, Hamid Nourbakhsh, Pardis Chamanrou, Niloofar Chung, Seo-Kyung Suri, Mohnish Benke, Paul J. Zaki, Maha S. Gleeson, Joseph G. Calame, Daniel G. Pehlivan, Davut Yilmaz, Halil I. Gezdirici, Alper Rad, Aboulfazl Abumansour, Iman Sabri Oprea, Gabriela Bereketoğlu, Muhammed Burak Banneau, Guillaume Julia, Sophie Zeighami, Jawaher Ashoori, Saeed Shariati, Gholamreza Sedaghat, Alireza Sabri, Alihossein Hamid, Mohammad Parvas, Sahere Tajudin, Tajul Arifin Abdullah, Uzma Baig, Shahid Mahmood Chung, Wendy K. Glazunova, Olga O. Sabine, Sigaudy Cheema, Huma Arshad Zifarelli, Giovanni Bauer, Peter Sidpra, Jai Mankad, Kshitij Vona, Barbara Fry, Andrew E. Varshney, Gaurav K. Houlden, Henry Fu, Dragony Department of Neuromuscular disorders UCL Queen Square Institute of Neurology London WC1N 3BG United Kingdom Department of Biology Center for RNA Biology University of Rochester Rochester NY United States Genes & Human Disease Research Program Oklahoma Medical Research Foundation Oklahoma City 73104 OK United States Institute for Auditory Neuroscience and Inner Ear Lab University Medical Center Göttingen Robert-Koch-Str. 40 Göttingen 37075 Germany Institute of Human Genetics University Medical Center Göttingen Heinrich-Düker-Weg 12 Göttingen 37073 Germany Neurology Research Group Institute of Life Science Swansea University Medical School Swansea University Swansea SA2 8PP United Kingdom Faculty of Medicine & Health Camperdown University of Sydney Sydney NSW Australia Department of Pediatric Neurology Institute of Child Health Children's Hospital Lahore 54590 Pakistan McMaster University 1280 Main St W Hamilton L8S 4L8 ON Canada Unité de Génétique Médicale et Centre de Référence Anomalies du Développement et Syndromes Malformatifs CHU de la Réunion Saint-Pierre France Unité Fonctionnelle Innovation en Diagnostic Génomique des maladies rares CHU Dijon Bourgogne Dijon France INSERM UMR1231 GAD Dijon F-21000 France Department of Clinical and Molecular Genetics Vall d'Hebron University Hospital and Medicine Genetics Group Vall d'Hebron Research Institute Barcelona Spain Department of Medical Genetics and Metabolism Valley Children's Hospital Madera CA United States Hospital for Sick Children Toronto ON Canada University of Toronto Toronto ON Canada GeneDx LLC Gaithersburg 20877 MD United States Department of Pediatrics Southern Illinois University School of Medicine Springfield IL United States Department of Medical Genetics University of Groningen and University Medical Center Groningen Department of Genetics Groningen Netherlands Division of Human Genetics Department of Pediatrics Warren Alpert Medical School of Brown University Ha
The post-transcriptional modification of tRNAs plays a crucial role in tRNA structure and function. Pathogenic variants in tRNA-modification enzymes have been implicated in a wide range of human neurodevelopmental and... 详细信息
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