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9th IEEE Smart World Congress, SWC 2023

作者： Yao, Jingwang Lv, Hui Xiao, Yijun Dalian University Key Laboratory of Advanced Design and Intelligent Computing Ministry of Education School of Software Engineering Dalian116622 China Northeastern University State Key Laboratory of Synthetical Automation for Process Industries Shenyang110004 China

ISBN: (纸本)9798350319804

Biochemical process control is often achieved through feedback control strategies for theoretical analysis and optimization of biochemical reaction processes. Here, the design improves the robustness of the biochemical process by taking advantage of the Smith prediction structure and internal mode control within the chemical reaction network theory framework to intervene against the time delays and perturbations present in the biochemical process. First, an IMC representation of Smith prediction is constructed using the presence of parameter rectification of the control method, and then an IMC-MSP control scheme is proposed. A first-order time-lag controlled object is established in the construction of the IMC-MSP control scheme. Besides, CRNs and kinetic representations are established based on the control structure to facilitate the evaluation of the control system performance. In this paper, CRNs representations of parabolic functions as signal inputs are defined for the first time and optimized for stepping signals to facilitate the design and study of biomolecular circuits. Notably, for the CRNs-based IMC-MSP control scheme, on the one hand, numerical simulation experiments are designed to verify the effectiveness of the whole scheme from multiple perspectives of time delays, external perturbations, and filter tuning parameters;on the other hand, using DNA strand displacement is reflected to verify the feasibility of the whole scheme. © 2023 IEEE.

关键词： Chemical reaction networks (CRNs) DNA strand displacement (DSD) Internal model control (IMC control) Smith predictor

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Performance Verification of State Feedback H∞ State Molecular Controller Via Chemical Reaction Networks 5

Performance Verification of State Feedback H∞ State Molecul...

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5th International Conference on Industrial Artificial Intelligence, IAI 2023

作者： Yao, Jingwang Wang, Xing'An Lv, Hui Li, Yang Zhang, Wujie Dalian University Key Laboratory of Advanced Design and Intelligent Computing Ministry of Education School of Software Engineering Dalian116622 China Dalian University College of Environmental and Chemical Engineering Dalian116622 China Dalian Chivy Biotechnology Co. Ltd Dalian116023 China Northeastern University State Key Laboratory of Synthetical Automation for Process Industries Shenyang110004 China

ISBN: (纸本)9798350325294

An important goal in synthetic biology is in the design and implementation of control strategies embedded in biochemical reaction systems to enable control of the process at the molecular level. The problem of set-point tracking and perturbation disturbances in the biochemical reaction process can be solved by a state feedback control strategy and a more stable and better dynamic performance of synthetic controllers. First, it is shown how a set of CRNs can provide state feedback to the biomolecular implementation of the H∞ controller. Then, to facilitate the modularity of biochemical process design, CRNs of trigonometric functions and repetitive sequence step signals are defined for the first time as input signals to the controller. Finally, numerical simulation experiments are designed to verify the effectiveness of the whole scheme from several perspectives, such as setpoint tracking and external perturbations. The results show that the state feedback H∞ molecular controller outperforms the conventional linear controller because it has a faster tracking response and better perturbation rejection performance. © 2023 IEEE.

关键词： Controllers

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Performance Verification of Smith Predictor Control Using IMC Scheme via Chemical Reaction Networks and DNA Strand Displacement Reaction

Performance Verification of Smith Predictor Control Using IM...

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Smart World Congress (SWC), IEEE

作者： Jingwang Yao Hui Lv Yijun Xiao Key Laboratory of Advanced Design and Intelligent Computing Ministry of Education School of Software Engineering Dalian University Dalian China State Key Laboratory of Synthetical Automation for Process Industries Northeastern University Shenyang China

Biochemical process control is often achieved through feedback control strategies for theoretical analysis and optimization of biochemical reaction processes. Here, the design improves the robustness of the biochemical process by taking advantage of the Smith prediction structure and internal mode control within the chemical reaction network theory framework to intervene against the time delays and perturbations present in the biochemical process. First, an IMC representation of Smith prediction is constructed using the presence of parameter rectification of the control method, and then an IMC-MSP control scheme is proposed. A first-order time-lag controlled object is established in the construction of the IMC-MSP control scheme. Besides, CRNs and kinetic representations are established based on the control structure to facilitate the evaluation of the control system performance. In this paper, CRNs representations of parabolic functions as signal inputs are defined for the first time and optimized for stepping signals to facilitate the design and study of biomolecular circuits. Notably, for the CRNs-based IMC-MSP control scheme, on the one hand, numerical simulation experiments are designed to verify the effectiveness of the whole scheme from multiple perspectives of time delays, external perturbations, and filter tuning parameters; on the other hand, using DNA strand displacement is reflected to verify the feasibility of the whole scheme.

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Implementing a modified Smith predictor using chemical reaction networks and its application to protein translation 4

Implementing a modified Smith predictor using chemical react...

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4th International Conference on Industrial Artificial Intelligence, IAI 2022

作者： Xiao, Yijun Lv, Hui Wang, Xing'an School of Software Engineering Dalian University Key Laboratory of Advanced Design and Intelligent Computing Ministry of Education Liaoning Dalian116622 China Northeastern University State Key Laboratory of Synthetical Automation for Process Industries Liaoning Shenyang110004 China College of Environmental and Chemical Engineering Dalian University Liaoning Dalian116622 China Dalian Chivy Biotechnology Co. Ltd Liaoning Dalian116622 China

ISBN: (数字)9781665451208

ISBN: (纸本)9781665451208

In this article, a special attention is paid to the biochemical controller synthesis for time delay systems and try to implement the well-established Smith predictor approach in the context of biochemical systems. Then, chemical reaction networks (CRNs) are adopted to construct a modified Smith predictor scheme (integrating Smith predictor and feedback compensation controllers) for the first time. Taking a delayed protein translation model as the background, the CRNs-based proposed scheme has access to a method that can solve the effect of co-translated mRNA decay in protein translation. In addition, considering that the decay of mRNA affects mRNA stability and protein production, the co-translated mRNA degradation is treated as an interference input of the protein translation process. Our results show that the impact of a disturbance input (mRNA degradation) is restrained by the modified control strategy. The CRNs-based modified Smith predictor makes the protein translation process more robust and achieves protein output quickly and stably. © 2022 IEEE.

关键词： Time delay

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Performance Verification of State Feedback H∞ State Molecular Controller Via Chemical Reaction Networks

Performance Verification of State Feedback H∞ State Molecul...

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International Conference on Industrial Artificial Intelligence (IAI)

作者： Jingwang Yao Xing'An Wang Hui Lv Yang Li Wujie Zhang Key Laboratory of Advanced Design and Intelligent Computing Ministry of Education School of Software Engineering Dalian University Dalian China College of Environmental and Chemical Engineering Dalian University Dalian China Dalian Chivy Biotechnology Co. Ltd Dalian PR China State Key Laboratory of Synthetical Automation for Process Industries Northeastern University Shenyang China

An important goal in synthetic biology is in the design and implementation of control strategies embedded in biochemical reaction systems to enable control of the process at the molecular level. The problem of set-point tracking and perturbation disturbances in the biochemical reaction process can be solved by a state feedback control strategy and a more stable and better dynamic performance of synthetic controllers. First, it is shown how a set of CRNs can provide state feedback to the biomolecular implementation of the H ∞ controller. Then, to facilitate the modularity of biochemical process design, CRNs of trigonometric functions and repetitive sequence step signals are defined for the first time as input signals to the controller. Finally, numerical simulation experiments are designed to verify the effectiveness of the whole scheme from several perspectives, such as setpoint tracking and external perturbations. The results show that the state feedback H ∞ molecular controller outperforms the conventional linear controller because it has a faster tracking response and better perturbation rejection performance.

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Using entropy-driven amplifier circuit response to build nonlinear model under the influence of Lévy jump

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BMC bioinformatics 2022年第SUPPL 12期22卷 437页

作者： Hao Fu Hui Lv Qiang Zhang Key Laboratory of Advanced Design and Intelligent Computing Ministry of Education School of Software Engineering Dalian University Dalian 116622 China. Key Laboratory of Advanced Design and Intelligent Computing Ministry of Education School of Software Engineering Dalian University Dalian 116622 China. lh8481@***. State Key Laboratory of Synthetical Automation for Process Industries Northeastern University Shenyang 110004 China. lh8481@***. Key Laboratory of Advanced Design and Intelligent Computing Ministry of Education School of Software Engineering Dalian University Dalian 116622 China. zhangq@***. School of Computer Science and Technology Dalian University of Technology Dalian 116024 China. zhangq@***.

BACKGROUND:Bioinformatics is a subject produced by the combination of life science and computer science. It mainly uses computer technology to study the laws of biological systems. The design and realization of DNA circuit reaction is one of the important contents of bioinformatics. RESULTS:In this paper, nonlinear dynamic system model with Lévy jump based on entropy-driven amplifier (EDA) circuit response is studied. Firstly, nonlinear biochemical reaction system model is established based on EDA circuit response. Considering the influence of disturbance factors on the system, nonlinear biochemical reaction system with Lévy jump is built. Secondly, in order to prove that the constructed system conforms to the actual meaning, the existence and uniqueness of the system solution is analyzed. Next, the sufficient conditions for the end and continuation of EDA circuit reaction are certified. Finally, the correctness of the theoretical results is proved by numerical simulation, and the reactivity of THTSignal in EDA circuit under different noise intensity is verified. CONCLUSIONS:In EDA circuit reaction, the intensity of external noise has a significant impact on the system. The end of EDA circuit reaction is closely related to the intensity of Lévy noise, and Lévy jump has a significant impact on the nature of biochemical reaction system.

关键词： Entropy-driven amplifier Lyapunov function Lévy jump Nonlinear system model

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Dynamic forecasting and optimal scheduling of by-product gases in integrated iron and steel works

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Journal of Iron and Steel Research International 2019年第5期26卷 529-546页

作者： Qi Zhang Hui Li Jia-lin Ma Hua-yan Xu Bo-yang Yu Gang Wang Shan Jiang State Environmental Protection Key Laboratory of Eco-Industry Northeastern University Shenyang 110819 Liaoning China State Key Laboratory of Hybrid Process Industry Automation Systems and Equipment Technology Automation Research and Design Institute of Metallurgical Industry Beijing 100072 China Software College Northeastern University Shenyang 110169 Liaoning China Shougang Jingtang United Iron & Steel Co. Ltd. Tangshan 063200 Hebei China China United Engineering Company Hangzhou 310052 Zhejiang China

The by-product gases, which are generated in ironmaking, coking and steel making processes, can be used as fuel for the metallurgical processes and on-site power plants. However, if the supply and demand of by-product gases are imbalanced, gas flaring may occur, leading to energy wastage and environmental pollution. Therefore, optimal scheduling of by-product gases is important in iron and steel works. A BP_LSSVM model, which combines back-propagation (BP) neural network and least squares support vector machine (LSSVM), and an improved mixed integer linear programming model were proposed to forecast the surplus gases and allocate them optimally. To maximize energy utilization, the stability of gas holders and boilers was considered and a concise heuristic procedure was proposed to assign penalties for boilers and gas holders. Moreover, the optimal level of gas holder was studied to enhance the stability of the gas system. Compared to the manual operation, the optimal results showed that the electricity generated by the power plant increased by 2.93% in normal condition and by 22.2% in overhaul condition. The proposed model minimizes the total cost by optimizing the boiler load with less adjustment frequency and the stability of gas holders and can be used as a guidance in dynamic forecasting and optimal scheduling of by-product gases in integrated iron and steel works.

关键词： Iron and steel works Back-propagation neural network Least squares support vector machine Mixed integer linear programming Dynamic forecasting Optimal scheduling

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Backward inference in Bayesian networks for distributed systems management

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Journal of Network and Systems Management 2005年第4期13卷 409-427页

作者： Ding, Jianguo Krämer, Bernd Bai, Yingcai Chen, Hansheng Software Engineering Institute East China Normal University Shanghai 200062 China Department of Electrical Engineering and Information Engineering FernUniversität Hagen Germany Department of Computer Science and Engineering Shanghai Jiao Tong University Shanghai China East-china Institute of Computer Technology Shanghai China IEEE FernUniversität Hagen Germany International Society for Process and Design Sciences Shanghai Jiao Tong University China Shanghai Engineering Center of GOLDEN Network Shanghai Computer Open System Association East-China Institute of Computer Technology

The growing complexity of distributed systems in terms of hardware components, operating system, communication and application software and the huge amount of dependencies among them have caused an increase in demand for distributed management systems. An efficient distributed management system needs to work effectively even in face of incomplete management information, uncertain situations, and dynamic changes. In this paper, Bayesian networks are proposed to model dependencies between managed objects in distributed systems. The strongest dependency route (SDR) algorithm is developed for backward inference in Bayesian networks. The SDR algorithm can track the strongest causes and trace the strongest routes between particular effects and its causes, the strongest dependency of causes can be also achieved by the algorithm. Thus, the backward inference provides an efficient mechanism in fault locating, and is beneficial for performance management. © 2005 Springer Science+Business Media, Inc.

关键词： Computer networks

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design and Implementation of Distributed Numerical Control in Flexible Manufacturing System

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Journal of Donghua University(English Edition) 2004年第1期21卷 1-6页

作者：周炳海余传猛奚立峰曹永上 School of Mechanical Engineering Shanghai Jiaotong University Shanghai 200030 School of Mechanical Engineering Shanghai University of Engineering Science Shanghai 200336 School of Mechanical Engineering Shanghai Jiaotong University Shanghai 200030 School of Mechanical Engineering Shanghai University of Engineering Science Shanghai 200336o monitor control and manage the work process of computer numerical control machine tools in a flexible manufacturing system (FMS) effectively the distributed numerical coutrol (distributed-NC) software should be innovated with the characteristics of modularization and reconfiguration. In this paper firstly distributed-NC functions in the FMS environment are described. Then we present a design and development method of the real time distributed-NC that is on the basis of the re-coufigurable software and hardware platform and with an object-oriented model concept. Finally to verify the proposed method the distributed-NC software has been implemented in VC++ 6.0 and has been tested in connection with the different physical flexible manufacturing shops.

To monitor, control and manage the work process of computer numerical control machine tools in a flexible manufacturing system (FMS) effectively, the distributed numerical coutrol (distributed-NC) software should be innovated with the characteristics of modularization and reconfiguration. In this paper, firstly, distributed-NC functions in the FMS environment are described. Then, we present a design and development method of the real time distributed-NC that is on the basis of the re-coufigurable software and hardware platform and with an object-oriented model concept. Finally, to verify the proposed method, the distributed-NC software has been implemented in VC++ 6.0 and has been tested in connection with the different physical flexible manufacturing shops.

关键词： flexible manufacturing system distributed numerical control communication protocol computer numerical control.

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Recipe-driven batch processes: event handling in hybrid system simulation

Recipe-driven batch processes: event handling in hybrid syst...

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IEEE International Symposium on Computer Aided Control System design (CACSD)

作者： M. Fritz A. Liefeldt S. Engell Software Design and Management GmbH and Company KG Ratingen Germany Germany Process Control Laboratory Department of Chemical Engineering University of Dortmund Dortmund Germany

This paper describes the integration of different simulation methods for batch processes under one single user interface and based upon one core model. We discuss two different simulation concepts with respect to event detection and handling of hybrid systems, especially of recipe-driven batch processes. The notation of event handling is central to both approaches. Examples are given to demonstrate that discrete-event simulation of hybrid systems can produce results which are equivalent to those from continuous simulation and under which conditions it fails.

关键词： Discrete event simulation process control Computational modeling Chemical processes Laboratories Event detection User interfaces Batch production systems software packages software design

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