As a new class of xenogenous nanoparticle, quantum dots （QDs） possess the potential to co-exist with Cu^2＋ in human liver. The combined toxicity is thus concerned. Considering QDs and Cu^2＋ are known ROS （reactiv...
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As a new class of xenogenous nanoparticle, quantum dots （QDs） possess the potential to co-exist with Cu^2＋ in human liver. The combined toxicity is thus concerned. Considering QDs and Cu^2＋ are known ROS （reactive oxygen species） inducer, we investigated the combined oxidative stress and corresponding protective strategy using human hepatic L02 cells. The results demonstrated that the presence of a small amount of MPA-CdTe QDs （2 μg/mL） in a Cu^2＋ solution （2.5-20 μg/mL） resulted in a higher toxicity with up to 8-fold cell viability decrease, which was accompanied by cell morphology changes. The combined toxicity was then confirmed as ROS associated oxidative stress with up to 300% and 35% increase of the intracellular ROS level and glutathione S-transferase （GST） activity, respectively. N-acetylcysteine （NAC） can also provide almost complete protection against the induced toxicity. Therefore, the ROS associated oxidant injury might be responsible for the QDs-Cu^2＋/Cu^2＋ induced toxicity and could be balanced through cytoprotective antioxidant enzyme GST.
Titanium dioxide (TiO2) nanoparticles possess the potential to coexist with Copper (Cu2+) in soil. The individual and combined toxicity of these two chemicals was evaluated using the bacterium Bacillus subtilis, a kno...
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