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作者： Xu, Shiyun Yang, Ying Department of Mechanics and Aerospace Engineering State Key Lab for Turbulence and Complex Systems Peking University Beijing 100871 China

ISBN: (纸本)9781424474264

In this study, the generalized synchronization of coupled periodically driven duffing oscillators is investigated through Linear Matrix Inequality (LMI) approaches. We first examine the complete synchronization between master-slave Duffing oscillators by converting it to the test of absolute stability of the corresponding error dynamics that possess a standard form of Lur'e system in nonlinear system theory. Anticipating synchronization between time-delayed oscillators is then explored. The obtained LMI condition is based on the delay-dependent stability of time-delay systems, and it allows one to predict the dynamic features of duffing oscillators using a copy of the same system that performs as a slave. Finally, we show the effectiveness of the proposed criteria through two numerical examples. © 2010 AACC.

关键词： Linear matrix inequalities

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Study on Hydrophobic Stability and Water dynamics around Hydrophobic Core in Near Folding trajectory of Trp-cage

Study on Hydrophobic Stability and Water dynamics around Hyd...

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第二届全国“跨学科蛋白质研究”学术讨论会

作者： Gao Meng Yao Xin-Qiu She Zhen-Su State Key Laboratory for Turbulence and Complex Systems and Department of Biomedical Engineering Pe State Key Laboratory for Turbulence and Complex Systems and Department of Biomedical Engineering Pe

Hydrophobic effect is the dominate force in protein *** 40 simulations around Trp-cage protein, we found that the water dynamic behavior companying with the protein folding events around the hydrophobic *** as small as Trp-cage hydrophobic core, there may be also have *** on protein configuration may induce big water density fluctuation and water dynamic effect back on stability of hydrophobic core in *** are particular long resident time and long life hydrogen bond between water and protein *** tight relevance shows that protein configurations have big effect on water dynamics *** will be possible to consider water dynamic effect from protein configuration in a new implicit model.

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Flight Control Using only Synthetic Jet Actuators in High-Angle-of-Attack 35

Flight Control Using only Synthetic Jet Actuators in High-An...

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第35届中国控制会议

作者： LI Chunzhi Yang Jianying State Key Laboratory for Turbulence and Complex Systems Department of Mechanics and Engineering Science College of Engineering Peking University National Key Laboratory of Science and Technology on Aerospace Intelligence Control

ISBN: (纸本)9781509009107

This paper proposes a novel airfoil active flow control method using only synthetic jet to achieve triple-channel flight attitude control at high angle of attack. It's a feasible and effective control method to solve the difficult problem of flight control at high attack angle when stall occurs. As a first step, we build a model of the aircraft, and derive the relationship between the synthetic-jet peak velocity and moments. Under these conditions, we design a controller to the system. A nonlinear integrated flight control and flow control system was developed and tested in simulations. Simulation results showed that the proposed control method, can effectively control the aircraft at high angle of attack.

关键词： synthetic jet flight control high angle of attack

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How Microbes Shape Their Communities? A Microbial Community Model Based on Functional Genes

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Genomics, Proteomics & Bioinformatics 2019年第1期17卷 91-105页

作者： Xiaoqing Jiang Xin Li Longshu Yang Chunhong Liu Qi Wang Weilai Chi Huaiqiu Zhu State Key Laboratory for Turbulence and Complex Systems Department of Biomedical Engineering College of Engineering Peking University Center for Quantitative Biology Peking University Peking University-Tsinghua University-National Institute of Biological Sciences Joint Biological (PTN) PhD Program and College of Life Sciences Peking University Center for Protein Science Peking University

Exploring the mechanisms of maintaining microbial community structure is important to understand biofilm development or microbiota dysbiosis. In this paper, we propose a functional gene-based composition prediction(FCP) model to predict the population structure composition within a microbial community. The model predicts the community composition well in both a low-complexity community as acid mine drainage(AMD) microbiota, and a complex community as human gut microbiota. Furthermore, we define community structure shaping(CSS) genes as functional genes crucial for shaping the microbial community. We have identified CSS genes in AMD and human gut microbiota samples with FCP model and find that CSS genes change with the conditions. Compared to essential genes for microbes, CSS genes are significantly enriched in the genes involved in mobile genetic elements, cell motility, and defense mechanisms, indicating that the functions of CSS genes are focused on communication and strategies in response to the environment factors. We further find that it is the minority, rather than the majority, which contributes to maintaining community structure. Compared to health control samples, we find that some functional genes associated with metabolism of amino acids, nucleotides, and lipopolysaccharide are more likely to be CSS genes in the disease group. CSS genes may help us to understand critical cellular processes and be useful in seeking addable gene circuitries to maintain artificial self-sustainable communities. Our study suggests that functional genes are important to the assembly of microbial communities.

关键词： Metagenomics Dynamics model Community structure Acid mine drainage Human gut microbiota

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On nonlinear observer parameterizations and its application to fault detection 9

On nonlinear observer parameterizations and its application ...

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9th IFAC Symposium on Fault Detection, Supervision and Safety for Technical Processes, SAFEPROCESS 2015

作者： Li, Liniin Ding, Steven X. Yang, Ying Zhang, Yong Dominic, Shane Institute for Automatic Control and Complex Systems Faculty of Engineering University of Duisburg-Essen Duisburg47057 Germany State Key Lab for Turbulence and Complex Systems Department of Mechanics and Engineering Science College of Engineering Peking University Beijing100871 China

This paper investigates observer parameterizations and its application to observerbased fault detection for nonlinear systems. With the aid of coprime factorization techniques, the observer parameterization forms are first derived in terms of input-to-output approach and state space representation. To further implement the methodology, one design scheme is proposed for the so-called affine nonlinear systems. Then, the application of the proposed observer parameterization form to observer-based fault detection is studied. In the end, a numerical example is given to demonstrate the efficiency of our proposed scheme. © 2015, IFAC (International Federation of Automatic Control) Hosting by Elsevier Ltd. All rights reserved.

关键词： Fault detection

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Fully distributed consensus of second-order multi-agent systems using adaptive event-based control

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Science China(Information Sciences) 2018年第12期61卷 199-201页

作者： Wei ZHU Qianghui ZHOU DANDan WANG Gang FENG Key Lab of Intelligent Analysis and Decision on Complex Systems Chongqing University of Posts and Telecommunications Key Lab of Industrial Internet of Things & Networked Control Ministry of EducationChongqing University of Posts and Telecommunications Department of Mechanical and Biomedical Engineering City University of Hong Kong

Dear editor,In recent years, the distributed consensus of multiagent systems (MASs) has attracted compelling attention because of its potential applications in many fields such as sensor networks, unmanned aerial vehicle (UAV) formation flying, and multiple signals tracking. The central task in the distributed consensus of MASs is to design distributed control protocols to achieve the consensus

关键词： In MAS Fully distributed consensus of second-order multi-agent systems using adaptive event-based control

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Decipher the single-cell level responses to chemotherapy in pancreatic ductal adenocarcinoma by a cross-time context graph model

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Cancer Letters 2025年 626卷 217751-217751页

作者： Li, Xinqi Liu, Yueze Zhou, Feihan Guo, Wenbo Chen, Guangyu Tao, Jinxin Huang, Jingmin Qiu, Jiangdong Chen, Hao Ren, Bo You, Lei Shi, Yanan Yang, Gang Zhang, Taiping Gu, Jin Zhao, Yupei MOE Key Lab of Bioinformatics BNRIST Bioinformatics Division Department of Automation & Institute for Precision Medicine Tsinghua University Beijing China Department of General Surgery State Key Laboratory of Complex Severe Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Breast Surgery The Affiliated Hospital of Guizhou Medical University Guizhou Medical University Guiyang China Biomedical Engineering Facility of National Infrastructures for Translational Medicine Peking Union Medical College Hospital Beijing China Clinical Immunology Center Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China

Gemcitabine is commonly used for pancreatic ductal adenocarcinoma (PDAC), one of the most lethal cancer types. However, the drug resistance is a critical challenge for improving the PDAC chemotherapy. Here, we applied single-cell RNA sequencing (scRNA-seq) on PDAC patient-derived xenograft (PDX) models to study the complex cellular responses related to the gemcitabine resistances. To reconstruct dynamic tumor cell responses from these static scRNA-seq snapshots, we proposed scConGraph, a scalable bi-layer graph model that can efficiently integrate cross-time context information. Based on scConGraph, we observed that stemness and endoplasmic reticulum stress contribute to intrinsic resistance. As for acquired resistance, cancer cells may resist or evade gemcitabine treatment by activating the cell cycle, entering quiescence, or inducing epithelial-mesenchymal transition. Notably, GDF15 exhibited recurrent and significant upregulations among acquired-resistance cell subpopulations. Experimental validation confirmed that inhibiting GDF15 sensitizes tumor cells to gemcitabine, suggesting a potential target for gemcitabine-induced chemoresistance. © 2025 Elsevier B.V.

关键词： Chemoresistance Intratumor heterogeneity Pancreatic ductal adenocarcinoma Single-cell RNA sequencing

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The Robust Roll Control Using only Synthetic Jet Actuators in High-Angle-of-Attack Flight

The Robust Roll Control Using only Synthetic Jet Actuators i...

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第三十四届中国控制会议

作者： LI Chunzhi Yang Jianying LIU Yifan State Key Laboratory for Turbulence and Complex Systems Department of Mechanics and Engineering ScienceCollege of EngineeringPeking University National Key Laboratory of Science and Technology on Aerospace Intelligence Control

ISBN: (纸本)9781467374439

By taking NACA0015 airfoil as an example, we study synthetic jets' effect on the aerodynamic performance, then propose the ideas and concrete methods of using synthetic jet to flight roll control at high angle of attack, which replaces the traditional aileron completely. According to the influence by the peak velocity, frequency, layout position, exit angles of synthetic jets and the angle of attack on lift, the optimal parameter combination was obtained. Based on the optimal parameter combination we provided a scheme that uses peak velocity of synthetic jet as the input. We also designed a synthetic jet controller for flight roll control at high angle of attack, which adopts the Robust LQR method to realize the stability control of roll(57.3 deg) at high angle of attack(18 deg). The simulation shows that the proposed control method has good control performance, and it overcomes the difficulty of using traditional aileron for flight roll control at high angle of attack.

关键词： synthetic jet,roll control,high angle of attack

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A new criterion for synchronization in deterministic underdamped ratchets

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IFAC Proceedings Volumes 2008年第2期41卷 15125-15130页

作者： Pingli Lu Ying Yang Lin Huang State Key Lab for Turbulence and Complex Systems Department of Mechanics and Aerospace Engineering Peking University Beijing 100871 China

This paper deals with the synchronization for deterministic underdamped ratchets. Using the technique derived from pendulum-like nonlinear analytic theory and Kalman-Yakubovich-Popov(KYP) lemma, simple linear matrix inequality (LMI) formulations are established to guarantee the stable synchronization between two periodically driven identical deterministic, underdamped ratchets. With this new efficient criterion, the direction of transporting particles can be controlled and the distance among particles also can be fixed on some values in order to separate them. Finally, simulation results verified the applicability and validity of the proposed approach.

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A class of uncertain pendulum-like systems with several nonlinearities

A class of uncertain pendulum-like systems with several nonl...

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2007 American Control Conference, ACC

作者： Lu, Pingli Yang, Ying Huang, Lin Department of Mechanics and Aerospace Technology College of Engineering Peking University Beijing 100871 China State Key Lab. for Turbulence and Complex Systems Department of Mechanics and Aerospace Technology Peking University Beijing 100871 China

ISBN: (纸本)1424409888

This paper considers the existence of cycles of the second kind in uncertain pendulum-like systems with several nonlinearities. Based on Kalman-Yakubovich-Popov (KYP) lemma, which establishes the equivalence between frequency domain inequalities(FDIs) and linear matrix inequalities(LMIs), LMI conditions guaranteeing the existence of cycles of the second kind for such nonlinear systems under parameter uncertainties are established. In virtue of the results, an interesting conclusion is reached that synthesis problem ensuring the existence of cycles of the second kind for such uncertain nonlinear system can be converted into synthesis problem for a system without uncertainties. A practical example about synchronous machine demonstrates the validity of the present approach. © 2007 IEEE.

关键词： Linear matrix inequalities

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