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A novel pH-responsive berberine-loaded attapulgite microsphere for IBD therapy via the regulation of gut immunity and flora

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International Journal of Pharmaceutics 2025年 679卷 125705页

作者： Gong, Shiwen Ma, Wentao Hu, Die Wang, Xinyu Xu, Haixing Li, Binbin Department of Pharmaceutical Engineering School of Chemistry Chemical Engineering and Life Sciences Wuhan University of Technology Wuhan 430070 China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Wuhan 430070 China Foshan Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong Laboratory Xianhu Hydrogen Valley Foshan 528200 China Hainan Institute Wuhan University of Technology Sanya 572000 China Biomedical Materials and Engineering Research Center of Hubei Province Wuhan University of Technology Wuhan 430070 China

Inflammatory bowel disease (IBD) is an idiopathic, lifelong, and devastating chronic inflammatory disease of the gastrointestinal tract. Berberine, an alkaloid extracted from the Chinese herb Huanglian, is a pharmaceutical ingredient with antibacterial, anti-inflammatory, and antiviral pharmacological effects in Chinese medicine. However, direct administration of berberine requires high doses due to its low bioavailability and high waste in the stomach. In this study, we prepared berberine-loaded pH-responsive Eudragit® FS 30D-attapulgite (FS-ATT) microspheres for the targeted treatment of colitis. The microspheres had pH-responsive release behavior, with minimal berberine release (about 5.97%) in simulated gastric fluid and high berberine release in simulated colonic fluid (about 69.27%). In addition, it was revealed by in vivo biological evaluations that, compared with drugs in an equivalent solution form taken orally, a significant improvement in IBD symptoms was observed after oral administration of drug-loaded FS-ATT microspheres, leading to an increase in the diversity of intestinal microbiota, inhibition of inflammatory cytokines, and enhanced therapeutic effects of berberine. The pH-responsive FS-ATT microspheres could offer a promising drug delivery platform for managing and treating many gastrointestinal diseases. © 2025 Elsevier B.V.

关键词： Attapulgite Berberine Inflammatory bowel disease pH-responsive

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Effect of Magnetic Field Annealing on the Soft Magnetic Properties of Cofesib Ribbon and its Fluxgate Performance

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SSRN 2023年

作者： Xu, Jiahui Kang, Shujie Wang, Jian Xu, Feng Shi, Chao Zhang, Kewei Wang, Jiafu Chen, Zhengxiang He, Jun Sun, Zhigang State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Wuhan430070 China School of Materials Science and Engineering Taiyuan University of Science and Technology Taiyuan030024 China China Shipbuilding Industry Corporation 710th Research Institute Yichang443003 China Division of Functional Material Research Central Iron and Steel Research Institute Beijing100081 China

As a key part of fluxgate, the properties of magnetic core determine the performance of fluxgate sensor. We studied the effects of zero magnetic field annealing (ZFA) and longitudinal magnetic field annealing (LFA) on soft magnetic properties, magnetic anisotropy and magnetic domain structure of the Co70Fe5Si15B10 amorphous ribbon and its fluxgate sensor performance. It is found that LFA can effectively modulate the magnetic domain from irregular shape and size to wide regular strip domains. As a result, pinning effect, magnetic anisotropy and coercivity decrease, while the initial permeability increases. And finally, the sensitivity of the fluxgate become higher, and noise become less. The results show that the optimal soft magnetic properties of the ribbons are obtained after LFA at 440 ℃, with the initial permeability of 21020 and the coercivity of 0.2 A/m. We applied a square wave excitation signal of size 30 mA and frequency 2.4 kHz to test the performance of the fluxgates. It is found that the flux gate sensitivity increases from the original 36.54 to 41.82 mV/μT after magnetic field annealing treatment, and the peak-to-peak noise (Noisep-p) value at 10Hz bandwidth in 250 s decreases from the original 5.22 to 2.14 nT. The results show that the LFA treatment of the core has a significant effect on its magnetic properties and fluxgate performance enhancement, and these results have good implications for the construction of high-performance fluxgate. © 2023, The Authors. All rights reserved.

关键词： Magnetic anisotropy

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Rational Design of Air-Stable and Intact Anode-Electrolyte Interface for Garnet-Type Solid-state Batteries

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SSRN 2022年

作者： Zhang, Jiaxu Wang, Changhong Zheng, Matthew Ye, Minghao Zhai, Huiyu Li, Jun Tan, Gangjian Tang, Xinfeng Sun, Xueliang State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Wuhan430070 China Department of Mechanical and Materials Engineering University of Western Ontario 1151 Richmond St. LondonONN6A 3K7 Canada

Garnet-type solid-state electrolytes are a promising fast lithium-ion conductor due to their high room-temperature ion conductivity and inherent stability against lithium metal. However, interfacial lithiophobic Li2CO3 makes garnet/Li interfacial ionic contact challenging. The general approach to physically or chemically eliminating Li2CO3 inevitably leads to a Li-deficiency layer at the garnet surface, significantly retarding interfacial ion transport. Contrary to the aforementioned approach, herein we chemically upcycle the Li2CO3 on the garnet surface via the double replacement reaction between Li2CO3 and SiO2. This approach in-situ constructs an air-stable and lithiophilic LixSiOy (LSO) on the garnet surface and averts the Li-deficiency layer formation. The LSO modified symmetric cell displays a low interfacial impedance of 3 Ω cm2 and a high critical current density of 1.2 mA cm−2 at 30 0C. This work provides a promising strategy to upcycle interfacial Li2CO3 on the garnet electrolyte. © 2022, The Authors. All rights reserved.

关键词： Garnets

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Fabrication of nanoporous Ni and NiO via a dealloying strategy for water oxidation catalysis

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Journal of Energy Chemistry 2020年第11期29卷 125-134页

作者： Xiangrong Ren Yiyue Zhai Qi Zhou Junqing Yan Shengzhong Liu Key Laboratory of Applied Surface and Colloid Chemistry Ministry of EducationShaanxi Engineering Lab for Advanced Energy TechnologySchool of Materials Science and EngineeringShaanxi Normal UniversityXi'an 710119ShaanxiChina State Key Laboratory of Advanced Processing and Recycling of Nonferrous Metals Lanzhou University of TechnologyLanzhou 730050GansuChina Materials Science and Engineering College Lanzhou University of TechnologyLanzhou 730050GansuChina

Nickel oxides and(oxy)hydroxides are promising replacements for noble-metal-based catalysts owing to their high activity and good long-term stability for the oxygen evolution reaction(OER). Herein, we developed nanoporous Ni by a method of combined rapid solidification and chemical dealloying. Subsequently,nanoporous Ni O was obtained via heating treatment, the macropore and skeleton sizes of the NiO originated from Ni10Al90 alloy are 100–300 nm and 80–200 nm, respectively. Benefiting from the multi-stage nanoporous structure and high specific surface area, the nanoporous NiO demonstrates an outstanding OER, reaching 20 mA cm-2 at an overpotential of 356 mV in 1 M KOH. The corresponding Tafel slope and apparent activation energy are measured to be 76.73 mV dec-1 and 29.0 kJ mol-1, respectively. Moreover,kinetic analysis indicates that the Ni O catalyst shows pseudocapacitive characteristics, and the improved current is attributed to the high-rate pseudocapacitive behavior that efficiently maintains increased nickel redox cycling to accelerate the reaction rates. After 1000 cycles of voltammetry, the overpotential of the NiO decreases by 22 mV(j = 10 mA cm-2), exhibiting excellent stability and durability.

关键词： Rapid solidification Dealloying Nanoporous Ni Electrocatalyst OER

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双功能Cu-TiO2/CuO光催化剂用于大规模协同处理含有机污染物和重金属离子的废水

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中国科学：材料科学（英文版） 2023年第1期66卷 179-192页

作者：丁杨 Soumyajit Maitra 王春花郑润田 Tarek Barakat Subhasis Roy 陈丽华苏宝连 Laboratory of Inorganic Materials Chemistry (CMI) University of Namur Namur Belgium Namur Institute of Structured Matter (NISM) University of Namur Namur Belgium Department of Chemical Engineering University of Calcutta Kolkata West Bengal India Department of Chemistry KU Leuven Leuven Belgium State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Wuhan China

大多数所制备的光催化剂通常只用于单一地降解有机污染物或还原Cr(Ⅵ)的光催化.然而,无机和有机污染物通常共存于工业污水中.同时消除混合的无机和有机污染物仍然存在着巨大的挑战.在本文中,我们通过原位掺杂和异质结工程策略,制备出了... 详细信息

大多数所制备的光催化剂通常只用于单一地降解有机污染物或还原Cr(Ⅵ)的光催化.然而,无机和有机污染物通常共存于工业污水中.同时消除混合的无机和有机污染物仍然存在着巨大的挑战.在本文中,我们通过原位掺杂和异质结工程策略,制备出了新型的双功能Cu-TiO2/CuO光催化剂用于大规模高效协同光催化消除废水中的有机污染物和过渡金属离子.具体而言,这种双功能光催化剂在RhB和Cr(Ⅵ)共存溶液中的光催化RhB降解率和Cr(Ⅵ)还原率分别是在单一RhB或Cr(Ⅵ)污染物溶液中对应值的2.35和3.84倍.光催化染料分子降解和Cr(Ⅵ)还原之间存在显著增强的协同效应.此外,该双功能光催化剂在大规模光催化消除混合污染物方面也表现出较好的活性和稳定性.理论计算表明,铜掺杂和异质结工程促进了高效的光吸收、增高的载流子密度以及快速的光生载流子转移,从而产生高效的协同光催化作用.这种双功能光催化剂的概念为大规模工业废水处理和净化开辟了新途径.

关键词： bi-functional photocatalysts in-situ Cu doping TiO_2 heterostructure synergistic effect

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Inside Back Cover: Carbon Neutralization, Volume 2, Issue 2, March 2023

Carbon Neutralization

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Carbon Neutralization 2023年第2期2卷

作者： Yonghua Cheng Bowen Jiang Somboon Chaemchuen Francis Verpoort Zongkui Kou State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Wuhan Hubei China

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A novel dopant for spiro-OMeTAD towards efficient and stable perovskite solar cells

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Science China materials 2021年第12期64卷 2915-2925页

作者： Zhipeng Lin Jing Li Hengyi Li Yanping Mo Junye Pan Chao Wang Xiao-Li Zhang Tongle Bu Jie Zhong Yi-Bing Cheng Fuzhi Huang Foshan Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong Laboratory Foshan 528216China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China International School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China Energy Materials and Surface Sciences Unit Okinawa Institute of Science and Technology Graduate UniversityOkinawa 904-0495Japan

2,2’,7,7’-tetrakis-(N,N-di-4-methoxyphenylamino)-9,9’-spirobifluorene(spiro-OMeTAD), as the most commonly used hole transport material(HTM), plays a significant role in the normal structured(n-i-p) high-efficiency perovskite solar cells(PSCs). In general, it is prepared by a halogen solvent(chlorobenzene, CBZ) and needs an ion dopant(lithium bis(trifluoromethanesulfonyl)imide, Li-TFSI) to improve its conductivity and hole mobility. However, such a halogen solvent is not environmentally friendly and the widely used LiTFSI dopant would affect the stability of PSCs. Herein, we develop a non-halogen solvent-tetrahydrofuran(THF)-prepared spiro-OMeTAD solution with a new p-type dopant,potassium bis(fluorosulfonyl)imide(K-FSI), to apply into PSCs. By this strategy, high-hole-mobility spiro-OMeTAD film is achieved. Meanwhile, the potassium ions introduced by diffusion into perovskite surface passivate the interfacial defects. Therefore, a hysteresis-free champion PSC with an efficiency of 21.02% is obtained, along with significantly improved stability against illumination and ambient conditions. This work provides a new strategy for HTMs toward hysteresis-free high-efficiency and stable PSCs by substituting dopants.

关键词： perovskite solar cells spiro-OMeTAD K-FSI hysteresis-free

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Construction of a Sustainably No-Releasing Rgdc Grafted Chitosan Oriented Peripheral Nerve Scaffold

SSRN

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SSRN 2025年

作者： Zhao, Wenxuan Chen, Yuzhe Wu, Xiaopei Dong, Xianzheng Dai, Honglian State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Wuhan430070 China Wuhan University of Technology Advanced Engineering Technology Research Institute of Zhongshan City Zhongshan528400 China State Key Laboratory of New Textile Materials and Advanced Processing Wuhan Textile University Wuhan430200 China

Peripheral nerve regeneration is impeded by an imbalanced microenvironment involving inflammation, oxidative stress, and inadequate vascularization. Traditional drug therapies are limited by poor blood-nerve barrier penetration and lack of multifunctional efficacy. Nitric oxide (NO), a critical gasotransmitter, promotes nerve repair by enhancing axonal growth, synaptic plasticity, and cell survival, while exerting anti-inflammatory, antioxidant, and pro-angiogenic effects. However, uncontrolled NO release risks cytotoxicity. To address this, we engineered a multifunctional hydrogel by grafting RGDC peptides onto chitosan to create an oriented microstructure, incorporating glutathione as a precursor for S-nitrosoglutathione (GSNO), a sustained NO donor. This design combines structural guidance with controlled NO delivery and antioxidant activity. The hydrogel demonstrated excellent biocompatibility and sustained NO release, avoiding cytotoxic levels. The RGDC peptide enhanced cell adhesion and migration, while GSNO effectively reduced intracellular reactive oxygen species (ROS) and promoted human umbilical vein endothelial cell (HUVEC) angiogenesis. The integrated system synergistically modulates the regenerative microenvironment by mitigating oxidative stress, supporting vascularization, and guiding cellular behavior. This strategy overcomes limitations of conventional treatments by combining structural alignment, controlled gasotransmitter release, and multifunctional bioactivity, offering a promising translational solution for peripheral nerve repair. © 2025, The Authors. All rights reserved.

关键词： Scaffolds

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Stoichiometry design in hierarchical CoNiFe phosphide for highly efficient water oxidation

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Science China materials 2022年第10期65卷 2685-2693页

作者： Jiangbo Chen Jie Ying Yuxuan Xiao Yuan Dong Kenneth IOzoemena Silvia Lenaerts Xiaoyu Yang State Key Laboratory of Advanced Technology for Materials Synthesis and Processing School of Materials Science and Engineering&Shenzhen Research Institute&Joint Laboratory for Marine Advanced Materials in Pilot National Laboratory for Marine Science and Technology(Qingdao)Wuhan University of TechnologyWuhan 430070China School of Chemical Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China Molecular Sciences Institute School of ChemistryUniversity of the WitwatersrandPrivate Bag 3Johannesburg 2050South Africa Research Group Sustainable Energy Air and Water TechnologyDepartment of Bioscience EngineeringUniversity of AntwerpAntwerp 2020Belgium School of Engineering and Applied Sciences Harvard UniversityCambridgeMassachusetts 02138USA

Rational composition design of trimetallic phosphide catalysts is of significant importance for enhanced surface reaction and efficient catalytic ***,hierarchical Co_(x)Ni_(y)Fe_(z)P with precise control of stoichiometric metallic elements(x:y:z=(1-10):(1-10):1)has been synthesized,and Co_(1.3)Ni_(0.5)Fe_(0.2)P,as the most optimal composition,exhibits remarkable catalytic activity(η=320 mV at 10 mA cm^(−2))and long-term stability(ignorable decrease after 10 h continuous test at the current density of 10 mA cm^(−2))toward oxygen evolution reaction(OER).It is found that the surface P in Co_(1.3)Ni_(0.5)Fe_(0.2)P was replaced by O under the OER *** density function theory calculations before and after long-term stability tests suggest the clear increasing of the density of states near the Fermi level of Co_(1.3)Ni_(0.5)Fe_(0.2)P/Co_(1.3)Ni_(0.5)Fe_(0.2)O,which could enhance the OH−adsorption of our electrocatalysts and the corresponding OER performance.

关键词： trimetallic phosphides hierarchical structures stoichiometry design charge transfer oxygen evolution reaction

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A facile synthesis of hierarchically porous graphene for high-performance lithium storage

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New Journal of Chemistry 2022年第21期46卷 9999-10003页

作者： Chenming Feng Yi Lu Yixuan Liu Xiaoyu Yang Ge Tian State Key Laboratory of Advanced Technology for Materials Synthesis and Processing & Shenzhen Research Institute & Joint Laboratory for Marine Advanced Materials in Pilot National Laboratory for Marine Science and Technology (Qingdao) Wuhan University of Technology Wuhan China Institut für Anorganische Chemie und Strukturchemie Heinrich-Heine-Universität Düsseldorf Universitätsstraße 1 Düsseldorf 40225 Germany

Hierarchically porous graphene with macro-mesopores is highly desired for enhancing lithium storage. However, it is still not easy to construct such materials with hierarchical porosity. Herein, hierarchical porous graphene was successfully fabricated via two-step calcination. The as-prepared sample exhibits an excellent reversible capacity of 545 mA h g⁻¹ at 5 A g⁻¹ after 700 cycles.

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