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Enriched photosensitizer for deep-seated-tumor photodynamic therapy

Photonics Research 2024年第5期12卷 1024-1035页

作者： HONGRUI SHAN XUEQIAN WANG QIHENG WEI HAILANG DAI XIANFENG CHEN State Key Laboratory on Fiber Optic Local Area Communication Networks and Advanced Optical Communication Systems Department of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Metal Matrix Composites Shanghai Key Laboratory for Molecular Engineering of Chiral DrugsSchool of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China Collaborative Innovation Center of Light Manipulations and Applications Shandong Normal UniversityJinan 250358China

Photodynamic therapy(PDT)is an innovative approach that utilizes photochemical reactions for non-invasive disease *** PDT is limited by the low penetration depth of visible light required for ***,we employed upconversion nanoparticles(UCNPs)to extend the activation wavelength of photosensitizers into the infrared range,enabling a treatment depth of over 10 ***,we also used the abundant amino groups of branched polyethyleneimine(PEI)with spatial structure to enhance the loading capacity of protoporphyrin(PPIX),and we ultimately improved skin tumor clearance ***,we achieved tumor-specific treatment by utilizing folic acid(FA)targeting and active enrichment of *** to cellular experimental results,we demonstrated the remarkable reactive oxygen species generation capability of the material and ultra-low dark ***,we investigated the apoptosis mechanism and demonstrated that the synthesized nanoparticle stimulates the up-regulation of apoptosis-associated proteins Bax/Bcl-2 and Cyto *** in vivo experiments involving intravenous injection in mouse tails,we investigated the anticancer efficacy of the nanoparticle,confirming its excellent PDT *** research provides a promising avenue for future non-invasive treatment of deep-seated tumors,offering a method for the treatment and management of specific cancers.

关键词： treatment utilize utilizing

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Propagation dynamics of off-axis noncanonical vortices in a collimated Gaussian beam

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Chinese Physics B 2019年第3期28卷 192-196页

作者： Cheng Yin Xuefen Kan Hailang Dai Minglei Shan Qingbang Han Zhuangqi Cao Jiangsu Key Laboratory of Power Transmission and Distribution Equipment Technology Hohai UniversityChangzhou 213022China The State Key Laboratory on Fiber Optic Local Area Communication Networks and Advanced Optical Communication Systems Shanghai JiaoTong UniversityShanghai 200240China

It is widely accepted that an off-axis noncanonical vortex moves across the free-space diffracting Gaussian beam without rotation. But our analysis shows that the vortex swirls a while before it approaches infinite. By neglecting the divergence of the host beam, we focus on this rotation characteristics of the vortices in linear homogeneous media. For the symmetrical host beam, it is found that the vortex moves along an elliptical trajectory, while the topological charge and the angular momentum of the vortex core relative to the beam axis are conserved. For the asymmetrical host beam, the vortex trajectory is rather complicated, since the noncanonical parameter varies as the light propagates, resulting in topological charge inversion. But we find that the vortices are always confined in a rectangular area, and the rotation direction is determined by the topological charge.

关键词： noncanonical optical vortex topological charge inversion

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Selection of Emission Wavelength of Lasing via a Hybrid Microcavity

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Physical Review Applied 2021年第3期16卷 034015-034015页

作者： Hong Yang Hailang Dai Qiheng Wei Hongrui Shan Zhuangqi Cao Xianfeng Chen The State Key Laboratory on Fiber Optic Local Area Communication Networks and Advanced Optical Communication Systems Department of Physics and Astronomy Shanghai Jiao Tong University Shanghai 200240 China Shanghai Research Center for Quantum Science Shanghai 201315 China Jinan Institute of Quantum Technology Jinan 250101 China Collaborative Innovation Center of Light Manipulations and Applications Shandong Normal University Jinan 250358 China

In the applications of optical communication and light-matter interaction manipulation, the capability of on-demand lasing output with programmable and continuous wavelength tunability over a broad spectral range under low threshold is key functionality. However, the ability to control multiwavelength lasing characteristics within a small mode volume with high reconfigurability remains challenging. The number of dyes and the emission wavelengths of existing materials always restrict the color gamut. In this Letter, we introduce a selection of emission wavelength laser by injecting Rhodamine 6G solution mixed with Au nanoparticles in the metal-cladded slab-capillary hybrid microcavity. A mechanism for tuning laser emission wavelengths is designed by manipulating the diameter of Au nanoparticles in Rhodamine 6G solution. Precision control of distinctive lasing wavelengths and a narrower peak are achieved, along with a stable lasing beam output from both ends of the capillary due to coherent superposition. Our findings offer possibilities for realizing a micro selection of emission wavelength laser from a single overall structure.

关键词： Surface plasmons Dye lasers Microcavity & microdisk lasers Nanoparticles Tunable lasers Finite-difference time-domain method Fluorescence spectroscopy Resonance techniques

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Direct Visualizing the Spin Hall Effect of Light via Ultrahigh-Order Modes

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Physical Review Letters 2020年第5期124卷 053902-053902页

作者： Hailang Dai Luqi Yuan Cheng Yin Zhuangqi Cao Xianfeng Chen The State Key Laboratory on Fiber Optic Local Area Communication Networks and Advanced Optical Communication Systems School of Physics and Astronomy Shanghai Jiao Tong University Shanghai 200240 China Jiangsu Key Laboratory of Power Transmission and Distribution Equipment Technology Hohai University Changzhou 213022 China Collaborative Innovation Center of Light Manipulations and Applications Shandong Normal University Jinan 250358 China

We report an experiment showing the submillimeter Imbert-Fedorov shift from the ultrastrong spin-orbital angular momentum coupling, which is a photonic version of the spin Hall effect, by measuring the reflection of light from the surface of a birefringent symmetrical metal cladding planar waveguide. The light incidents at a near-normal incident angle and excites resonant ultrahigh-order modes inside the waveguide. A 0.16-mm displacement of separated reflected light spots corresponding to two polarization states is distinguishable by human eyes. In our experiment, we demonstrate the control of polarizations of light and the direct observation of the spin Hall effect of light, which opens an important avenue towards potential applications for optical sensing and quantum information processing, where the spin nature of photons exhibits key features.

关键词： Angular momentum of light Quantum states of light Spin Hall effect Spin-orbit coupling Liquid crystal lasers optical microcavities Polarization

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White Beam Lasing from a Hybrid Microcavity with Slab-Capillary Mode Coupling

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Physical Review Applied 2019年第6期11卷 064055-064055页

作者： Hai-Lang Dai Cheng Yin Zhi-yuan Xiao Zhuang-Qi Cao Xian-Feng Chen The State Key Laboratory on Fiber Optic Local Area Communication Networks and Advanced Optical Communication Systems School of Physics and Astronomy Shanghai Jiao Tong University Shanghai 200240 China Collaborative Innovation Center of IFSA (CICIFSA) Shanghai Jiao Tong University Shanghai 200240 China Jiangsu Key Laboratory of Power Transmission and Distribution Equipment Technology Hohai University Changzhou 213022 China

We report a hybrid multichannel metal-cladded slab-capillary microcavity, which supports simultaneous red, green, and blue lasing from an individual microcavity at room temperature. White and tunable lasing over the full range of visible colors is achieved through controlled injection of different dye solutions into the metal-cladded capillaries of the microcavity. The results show that RGB lasing beams with a line width of approximately 1 nm are observed from the metal-cladded slab-capillary microcavity. The experimental observations show the realization of white light and lasing simultaneously in a single hybrid microcavity. Moreover, the improvement in the laser structure enables the elimination of background noise. Our work describes a simplification in fabricating microlasers with dynamically color-controllable emissions and provides an important route toward the potential of realizing a microlaser device generating both white and full color light directly from a single monolithic structure.

关键词： Dye lasers Integrated optics Laser-system design Microcavity & microdisk lasers Optoelectronics Photonics Tunable lasers Waveguides

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Simple Raman scattering sensor integrated with a metallic planar optical waveguide: effective modulation via minor structural adjustment

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Chinese optics Letters 2018年第1期16卷 71-75页

作者：陆炎阚雪芬许田方靖淮王孟殷澄陈险峰 Physics Department Nantong University The State Key Laboratory on Fiber Optic Local Area Communication Networks and Advanced Optical Communication Systems Department of Physics and Astronomy Shanghai Jiao Tong University College of Internet of Things Engineering Hohai University

We report experimental realization of Raman spectra enhancement of copper phthalocyanine, using an on-chip metallic planar waveguide of the sub-millimeter scale. The oscillating ultrahigh order modes excited by the direct coupling method yield high optical intensity at resonance, which is different from the conventional strategy to create localized ＂hot spots.＂ The observed excitation efficiency of the Raman signal is significantly enhanced,owing to the high Q factor of the resonant cavity. Furthermore, effective modulation of the Raman intensity is available by adjusting the polymethyl methacrylate（PMMA） thickness in the guiding layer, i.e., by tuning the light–matter interaction length. A large modulation depth is verified through the fact that 10 times variation in the enhancement factor is observed in the experiment as the PMMA thickness varies from 7 to 23 μm.

关键词： Simple Raman scattering sensor integrated with a metallic planar optical waveguide effective modulation via minor structural adjustment

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Angular-modulated spatial distribution of ultrahigh-order modes assisted by random scattering

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Chinese Physics B 2017年第11期26卷 254-257页

作者：阚雪芬殷澄许田陈凡李建韩庆邦陈险峰 Jiangsu Key Laboratory of Power Transmission and Distribution Equipment Technology Hohai University The State Key Laboratory on Fiber Optic Local Area Communication Networks and Advanced Optical Communication Systems Department of Physics and Astronomy Shanghai Jiao Tong University Physics Department Nantong University Optoelectronics Devices Laboratory Photonlabs Inc.

In designing an optical waveguide with metallic films on a nanometer scale, the random scattering by the natural roughness of the thin film is always ignored. In this paper, we demonstrate that for the ultrahigh-order modes（UOMs） in the symmetric metal cladding waveguide, such a scattering leads to drastic variations in their spatial distribution at different incident angles. Owing to the high mode density of the UOMs, the random scattering induced coupling can be easily related to different modes with different propagation directions or wavenumbers. At small incident angles, the intra-mode coupling dominates, which results in a spatial distribution in the form of concentric rings. At large incident angles, the inter-mode coupling plays the most important role and leads to an array-like pattern. Experimental evidence via optically trapped nanoparticles support the theoretical hypothesis.

关键词： metallic waveguide random scattering optical trapping

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Experimental demonstration of coherent light emission by a metallic optofluidic cavity exploiting continuous pump

Experimental demonstration of coherent light emission by a m...

引用

Frontiers in optics, FiO 2017

作者： Dai, Hailang Cao, Zhuangqi Chen, Xianfeng The State Key Laboratory on Fiber Optic Local Area Communication Networks Advanced Optical Communication Systems Department of Physics and Astronomy Shanghai JiaoTong University Shanghai200240 China Shanghai Jiao Tong University Shanghai200240 China

ISBN: (纸本)9781943580330

We describe an ultralow-threshold continuous wave microfluidic dye laser based on a hollow-core metal-cladding optical waveguide (HCMW) with cavity dimensions of millimeter scale. The high quality factor Q, spontaneous emission coupling factor β and enhancement ratio η of the HCMW chip strengthen the interaction between gain medium and the ultrahigh order modes (UOMs), hence a room-temperature lasing can be effectively pumped by a continuous laser of very low intensity. Rhodamine B, 6G and Methylene blue are chosen to verify the applicability of the concept, where Methylene blue has not been applied as laser dye before due to the issue of quenching. Lasers are emitted from the chip surface in the form of concentric cones when the pumped laser is well coupled into the UOMs. For Methylene blue with concentration of 2.57*10-13 mol/ml, the operated lasing can be observed with the launched pump threshold as low as 2.1 μW/cm2. © OSA 2017.

关键词： Pumping (laser)

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Fluorescent intensity of single bio-molecule enhancement by optofluidic resonator

Fluorescent intensity of single bio-molecule enhancement by ...

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Bio-optics: Design and Application, BODA 2017

作者： Ye, Xiaona Dai, Hailang Cao, Zhuangqi Chen, Xianfeng The State Key Lab. on Fiber Optic Local Communicaton Networks Advanced Optical Communication Systems Department of Physics and Astronomy Shanghai JiaoTong University Shanghai200240 China Shanghai Jiao Tong University Shanghai200240 China

Single molecular fluorescence enhancement is investigated via a novel method called optofluidic resonator hollow-core metal-cladding waveguide (ORHCMW). The fluorescence intensity of low-concentration solution has bee... 详细信息

ISBN: (纸本)9781943580255

关键词： Resonators

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Tunable rectangular array illuminator in periodically poled LiNbO_3 crystal

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Chinese optics Letters 2014年第5期12卷 15-18页

作者：李秋颖霍娟赵晓辉陈险峰 State Key Laboratory on Fiber Optic Local Area Communication Networks and Advanced Optical Communication Systems Department of Physics Shanghai Jiao Tong University

An electro-optic tunable rectangular array illuminator in one-dimensional periodically poled LiNbO3 （PPLN） crystal is presented experimentally which result is in good agreement with results from simu- lation. The illuminator is formed based on the Talbot self-imaging effect by applying an electric field on PPLN. The intensi~.y distribution of rectangular array could be precisely modulated. Compared with other array illuminators, this tunable illuminator uses a lower voltage and could get a more concentrated intensity distribution. The influence of the incident angle to the self-imaging patterns is studied for the first time.

关键词： PPLN Tunable rectangular array illuminator in periodically poled LiNbO3 crystal

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