咨询与建议

限定检索结果

文献类型

  • 221 篇 期刊文献
  • 75 篇 会议

馆藏范围

  • 296 篇 电子文献
  • 0 种 纸本馆藏

日期分布

学科分类号

  • 201 篇 医学
    • 98 篇 药学(可授医学、理...
    • 63 篇 临床医学
    • 54 篇 中西医结合
    • 27 篇 中药学(可授医学、...
    • 18 篇 基础医学(可授医学...
    • 2 篇 公共卫生与预防医...
    • 1 篇 中医学
    • 1 篇 医学技术(可授医学...
  • 42 篇 理学
    • 29 篇 化学
    • 20 篇 生物学
    • 2 篇 生态学
    • 1 篇 物理学
  • 32 篇 工学
    • 24 篇 化学工程与技术
    • 5 篇 生物医学工程(可授...
    • 5 篇 生物工程
    • 2 篇 冶金工程
    • 2 篇 环境科学与工程(可...
    • 1 篇 材料科学与工程(可...
    • 1 篇 动力工程及工程热...
    • 1 篇 水利工程
  • 4 篇 农学
    • 1 篇 作物学
  • 1 篇 管理学
    • 1 篇 工商管理

主题

  • 14 篇 depression
  • 14 篇 apoptosis
  • 14 篇 oxidative stress
  • 13 篇 ginsenoside rg1
  • 11 篇 atherosclerosis
  • 11 篇 inflammation
  • 10 篇 neuroinflammatio...
  • 10 篇 neuroprotection
  • 10 篇 parkinson's dise...
  • 9 篇 α-synuclein
  • 7 篇 ischemia
  • 7 篇 disease
  • 7 篇 nrf2
  • 6 篇 alzheimer's dise...
  • 6 篇 hippocampus
  • 6 篇 cell
  • 5 篇 endothelium
  • 5 篇 cancer
  • 5 篇 vasorelaxation
  • 5 篇 nf-κb

机构

  • 46 篇 state key labora...
  • 25 篇 state key labora...
  • 16 篇 college of pharm...
  • 13 篇 state key labora...
  • 11 篇 state key labora...
  • 10 篇 beijing key labo...
  • 10 篇 state key labora...
  • 9 篇 beijing key labo...
  • 8 篇 state key labora...
  • 8 篇 state key labora...
  • 8 篇 state key labora...
  • 8 篇 hunan university...
  • 8 篇 hunan university...
  • 7 篇 state key labora...
  • 6 篇 state key labora...
  • 6 篇 institute of mat...
  • 5 篇 state key labora...
  • 5 篇 state key labora...
  • 5 篇 tianjin universi...
  • 5 篇 shanxi key labor...

作者

  • 55 篇 nai-hong chen
  • 30 篇 shi-feng chu
  • 30 篇 guan-hua du
  • 30 篇 chen nai-hong
  • 22 篇 yu-he yuan
  • 18 篇 chu shi-feng
  • 16 篇 zhao zhang
  • 15 篇 zhen-zhen wang
  • 12 篇 du guan-hua
  • 12 篇 shifeng chu
  • 12 篇 naihong chen
  • 12 篇 lian-hua fang
  • 11 篇 zhang zhao
  • 11 篇 haibo zhu
  • 10 篇 yan gao
  • 10 篇 xiaoguang chen
  • 10 篇 tian-yi yuan
  • 10 篇 yu yan
  • 9 篇 li li
  • 9 篇 jing jin

语言

  • 276 篇 英文
  • 19 篇 中文
检索条件"机构=State Key Laboratory for Bioactive Substances and Functions of Natural Medicines"
296 条 记 录,以下是1-10 订阅
排序:
Discovery and mechanism verification of first-in-class hydrophobic tagging-based degraders of HBV core protein
收藏 引用
Acta Pharmaceutica Sinica B 2025年 第4期15卷 2170-2196页
作者: Xu, Shujing Wang, Ya Shi, Dazhou Wang, Shuo Qiao, Lijun Yang, Ge Zhou, Yang Liu, Xinyong Wu, Shuo Li, Yuhuan Zhan, Peng Department of Medicinal Chemistry Key Laboratory of Chemical Biology Ministry of Education School of Pharmaceutical Sciences Shandong University Jinan 250012 China Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100050 China State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Beijing Key Laboratory of Antimicrobial Agents NHC Key Laboratory of Biotechnology for Microbial Drugs CAMS Key Laboratory of Antiviral Drug Research Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100050 China
Interfering hepatitis B virus (HBV) capsid assembly holds promise as a therapeutic approach for chronic hepatitis B (CHB). Novel anti-HBV agents are urgently needed to overcome drug resistance challenges, with targete... 详细信息
来源: 评论
Advances in development of antiviral strategies against respiratory syncytial virus
收藏 引用
Acta Pharmaceutica Sinica B 2025年 第4期15卷 1752-1772页
作者: Yang, Ge Jiang, Guangyu Jiang, Jiandong Li, Yuhuan State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050 China CAMS Key Laboratory of Antiviral Drug Research Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050 China Beijing Key Laboratory of Antimicrobial Agents Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050 China NHC Key Laboratory of Biotechnology for Microbial Drugs Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050 China
Human respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infections in infants and young children, as well as an important cause of respiratory tract infections in immunocompromised patients... 详细信息
来源: 评论
Long noncoding RNA GAS5 acts as a competitive endogenous RNA to regulate GSK-3β and PTEN expression by sponging miR-23b-3p in Alzheimer's disease
收藏 引用
Neural Regeneration Research 2026年 第1期21卷 392-405页
作者: Li Zeng Kaiyue Zhao Jianghong Liu Mimin Liu Zhongdi Cai Ting Sun Zhuorong Li Rui Liu Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Medicinal BiotechnologyPeking Union Medical College and Chinese Academy of Medical SciencesBeijingChina Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijingChina
Long noncoding RNA and microRNA are regulatory noncoding RNAs that are implicated in Alzheimer's disease, but the role of long noncoding RNA-associated competitive endogenous RNA has not been fully elucidated. The... 详细信息
来源: 评论
The Combination of a Novel Pleuromutilin Derivative and Polymyxin B Nonapeptide: An Example of Converting Pleuromutilin from Gram-Positive-Only to Broad-Spectrum
SSRN
收藏 引用
SSRN 2025年
作者: Luo, Xinyu Fu, Hengjian Zhang, Jie Han, Zunsheng Pan, Weidong Zhang, Wenxuan Xia, Jie Wu, Song State Key Laboratory of Bioactive Substance and Function of Natural Medicines Department of New Drug Research and Development Institute of Materia Medica Chinese Academy of Medical Sciences Peking Union Medical College Beijing100050 China State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Guiyang550014 China
To alleviate the difficulties in developing antibiotics for Gram-negative bacteria (GNB), our study focuses on expanding the utility of pleuromutilin derivatives, known as Gram-positive-only antibiotics, in battling a...
来源: 评论
miR-486-3p Suppresses Osteosarcoma Proliferation and Migration by Targeting the SPRED1-MAPK/ERK Pathway
收藏 引用
Biochemical Genetics 2025年 1-17页
作者: Zhang, Yu Zhou, Yi Zhang, Sen Zhang, Xiaoying Li, Jiaxin Zhan, Xiao-Kai Department of Orthopaedics The First People’s Hospital of Chengdu Sichuan Province Chengdu China State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100050 China Department of Gastrointestinal Surgery Lishui Hospital Affiliated of Wenzhou Medical University & Lishui City People’s Hospital Zhejiang Province Lishui China Department of Hematology and Oncology Beijing Chao-Yang Hospital Capital Medical University Beijing 100020 China
Osteosarcoma (OS) is a common malignancy of the bone that originates from stromal cell lines. One of the key cellular pathways extensively studied in OS is the mitogen-activated protein kinase (MAPK) pathway, particul... 详细信息
来源: 评论
Evaluating the Neuroprotective Effects of the Novel Kv2.1 Blocker Zj7923 against Ischemic Stroke In Vitro and In Vivo
收藏 引用
Neuropharmacology 2025年 110537页
作者: Tianjiao Yang Weiping Wang Zhuo Li Jie Cai Nan Feng Shaofeng Xu Ling Wang Xiaoliang Wang State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China
The voltage-dependent potassium channel Kv2.1 correlates closely to the regulation of neuronal excitability and cellular apoptosis. Ischemia or oxidative treatment were known to stimulate the surge of Kv2.1-mediated c... 详细信息
来源: 评论
A concise total synthesis of monoterpenoid indole alkaloid (-)-voacafricine A
收藏 引用
Chinese Chemical Letters 2025年
作者: Xuan Pan Tao Sheng Zhanzhu Liu State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia Medica Peking Union Medical College and Chinese Academy of Medical Sciences Beijing 100050 China
A concise total synthesis of novel monoterpenoid indole alkaloid (-)-voacafricine A is described, which proceeded in 14 longest linear steps and 5.2% overall yield. key transformations comprised of (a) an organocataly...
来源: 评论
Potassium 2-(1-hydroxypentyl)-benzoate improves depressive-like behaviors in rat model
收藏 引用
Acta Pharmaceutica Sinica B 2018年 第6期8卷 881-888页
作者: Hao Ma Weiping Wang Shaofeng Xu Ling Wang Xiaoliang Wang State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Sciences & Peking Union Medical College
Potassium 2-(1-hydroxypentyl)-benzoate(PHPB) is a novel drug candidate for acute ischemic stroke. PHPB has been also shown to be beneficial for some neurodegenerative diseases. In this study, we demonstrated that PHPB... 详细信息
来源: 评论
Parishin C's prevention of Aβ_(1–42)-induced inhibition of long-term potentiation is related to NMDA receptors
收藏 引用
Acta Pharmaceutica Sinica B 2016年 第3期6卷 189-197页
作者: Zhihui Liu Weiping Wang Nan Feng Ling Wang Jiangong Shi Xiaoliang Wang State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences & Peking Union Medical College
The rhizome of Gastrodia elata(GE), a herb medicine, has been used for treatment of neuronal disorders in Eastern Asia for hundreds of years. Parishin C is a major ingredient of GE. In this study, the i.c.v. injection... 详细信息
来源: 评论
Conversion and pharmacokinetics profiles of a novel pro-drug of 3-n-butylphthalide, potassium 2-(1-hydroxypentyl)-benzoate, in rats and dogs
收藏 引用
中国药理学报(英文版) 2018年 第2期39卷 275-285页
作者: Jiang LI Shao-feng XU Ying PENG Nan FENG Ling WANG Xiao-liang WANG State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100050 China
Potassium 2-(1-hydroxypentyl)-benzoate (dl-PHPB) is a novel pro-drug of 3-n-butylphthalide (dl-NBP) that is used to treat ischemic ***,dl-PHPB is in phase Ⅱ-Ⅲ clinical trials in *** this study,we investigated the co... 详细信息
来源: 评论