检索结果-内蒙古大学图书馆

Learning Phenotype Associated Signature in Spatial Transcriptomics with PASSAGE (Small Methods 5/2025)

Small Methods 2025年第5期9卷

作者： Chen-Kai Guo Chen-Rui Xia Guangdun Peng Zhi-Jie Cao Ge Gao Center for Cell Lineage and Development CAS Key Laboratory of Regenerative Biology Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine GIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Centre University of Chinese Academy of Sciences Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences Guangzhou 510530 China University of Chinese Academy of Sciences Beijing 100049 China State Key Laboratory of Gene Function and Modulation Research School of Life Sciences Biomedical Pioneering Innovative Center (BIOPIC) and Beijing Advanced Innovation Center for Genomics (ICG) Center for Bioinformatics (CBI) Peking University Beijing 100871 China Changping Laboratory Beijing 102206 China

来源：评论

学校读者我要写书评

暂无评论

Efflux of N1-acetylspermidine from hepatoma fosters macrophage-mediated immune suppression to dampen immunotherapeutic efficacy

引用

Immunity 2025年

作者： Zheng-Yu Liu Cai-Yuan Wu Rui-Qi Wu Jun-Cheng Wang Chun-Xiang Huang Xu-Yan Wang Yaojun Zhang Limin Zheng Yun Chen Xiang-Ming Lao Dong-Ping Chen Dong-Ming Kuang Guangdong Province Key Laboratory of Pharmaceutical Functional Genes MOE Key Laboratory of Gene Function and Regulation School of Life Sciences Sun Yat-sen University Guangzhou 510275 China State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for Cancer Sun Yat-sen University Cancer Center Guangzhou 510060 China. Guangdong Province Key Laboratory of Pharmaceutical Functional Genes MOE Key Laboratory of Gene Function and Regulation School of Life Sciences Sun Yat-sen University Guangzhou 510275 China. Department of Oncology The Affliated Wuxi People's Hospital of Nanjing Medical University Wuxi People's Hospital Wuxi Medical Center Nanjing Medical University Wuxi 211103 China. Electronic address: chenyun@***. State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for Cancer Sun Yat-sen University Cancer Center Guangzhou 510060 China. Electronic address: laoxm@***. Guangdong Province Key Laboratory of Pharmaceutical Functional Genes MOE Key Laboratory of Gene Function and Regulation School of Life Sciences Sun Yat-sen University Guangzhou 510275 China. Electronic address: chendp23@***. State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for Cancer Sun Yat-sen University Cancer Center Guangzhou 510060 China. Electronic address: kdming@***.

Metabolic reprogramming is a hallmark of tumor progression. Here, we examined the metabolic profile of hepatocellular carcinoma (HCC), a disease that responds poorly to immune checkpoint blockade (ICB). Polyamine metabolism increased in HCC samples. Of the polyamine spectrum analyzed, N1-acetylspermidine (N1-Ac-Spd) accumulated in HCC tissue as compared with nontumoral liver tissue and was elevated in paired plasma. Injection of N1-Ac-Spd promoted tumor progression in preclinical models and compromised the efficacy of ICB. Inflammatory macrophages increased expression of the spermidine/spermine N1-acetyltransferase 1, SAT1, in hepatoma cells, leading to increased N1-Ac-Spd efflux via the polyamine transporter protein SLC3A2. Mechanistically, N1-Ac-Spd efflux activated SRC signaling in a charge-dependent manner, which in turn induced CCL1 macrophage polarization, the recruitment of CCR8 regulatory T cells, and an immunosuppressive tumor microenvironment (TME). In vivo interventions targeting SLC3A2, SAT1, or CCL1 enhanced the antitumor effects of ICB therapy. Our findings provide insight into the mechanisms whereby metabolic reprogramming fosters an immunosuppressive TME, with implications for the treatment of HCC.

关键词： N1-acetylspermidine hepatocellular carcinoma immune privilege immunotherapy inflammatory macrophages polyamine metabolism regulatory T cells

来源：评论

学校读者我要写书评

暂无评论

RNA m 6 A dynamics promote transcription and RNA stability of bivalent genes during iPSC-induced generation of human lung progenitors

引用

Cell Reports 2025年第6期44卷

作者： Shenghua Dong Junjie Pang Yushuai Wang Le Han Xiaoxiao Zhou Feng Huang Subo Zhang Ning Ma Huilin Huang Hengyou Weng State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for Cancer Sun Yat-sen University Cancer Center Guangzhou China MOE Key Laboratory of Gene Function and Regulation State Key Laboratory of Biocontrol School of Life Sciences Sun Yat-sen University Guangzhou China Guangzhou National Laboratory Guangzhou China The Key Laboratory for Stem Cells and Tissue Engineering Ministry of Education Zhongshan School of Medicine Sun Yat-sen University Guangzhou China School of Basic Medical Sciences Guangzhou Medical University Guangzhou China The First Affiliated Hospital The Fifth Affiliated Hospital State Key Laboratory of Respiratory Diseases Guangzhou Medical University Guangzhou China

RNA N 6 -methyladenosine (m 6 A) modifications play a crucial role in the control of RNA synthesis and metabolism during embryonic development. However, the m 6 A landscape and its impact on early embryonic lung development remain elusive. In this study, we uncover the dynamic and stage-specific patterns of the m 6 A methylome that correlate with gene expression changes during the differentiation of human induced pluripotent stem cells (iPSCs) into lung progenitors (LPs). Mechanistically, RNA binding motif protein 15B (RBM15B) is upregulated and enhances m 6 A modification in differentiated cells. Concurrently, the loss of the m 6 A reader YTH domain-containing protein 1 (YTHDC1) alleviates Polycomb repressive complex 2 (PRC2)-mediated transcriptional silencing of bivalent genes such as GATA4 , GATA6 , and EOMES . Moreover, the upregulation of another m 6 A reader, insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2), further stabilizes these messenger RNA (mRNA) transcripts. The switch of m 6 A readers coordinates chromatin remodeling and post-transcriptional regulation to drive lung endoderm specification. This study highlights the delicate m 6 A-centered regulatory mechanisms and the indispensable role of m 6 A modification in the early stages of embryonic lung development.

关键词： N 6 -methyladenosine modifications m 6 A modifications YTH domain-containing protein 1 YTHDC1 insulin like growth factor 2 mRNA-binding protein 2 IGF2BP2 Polycomb repressive complex 2 PRC2 bivalent genes lung endoderm specification CP: Molecular biology CP: Stem cell research

来源：评论

学校读者我要写书评

暂无评论

Characterization of a trypanosome from large yellow croaker ( Larimichthys crocea ), cage-cultured in seawater, in China

引用

Aquaculture Reports 2025年 43卷

作者： Ju-Feng Wang Xin-Tao Li Peng Zhang Li-Wen Xu Jin-Yong Zhang Geoff Hide De-Hua Lai Zhao-Rong Lun Guangdong Provincial Key Laboratory of Aquatic Economic Animals MOE Key Laboratory of Gene Function and Regulation State Key Laboratory of Biocontrol School of Life Sciences Sun Yat-Sen University Guangzhou 510275 PR China Key Laboratory of South China Sea Fishery Resources Exploitation & Utilization Ministry of Agriculture and Rural Affairs South China Sea Fisheries Research Institute Chinese Academy of Fishery Sciences Guangzhou 510300 PR China School of Marine Science and Engineering Qingdao Agricultural University Qingdao 266109 PR China Environmental Research and Innovation Centre and Biomedical Research and Innovation Centre School of Science Engineering and Environment University of Salford Salford M5 4WT UK

A significant outbreak of trypanosomosis occurred in farmed large yellow croaker ( Larimichthys crocea ) in Southeast China resulting in daily mortality rates, over 70 days, of up to 1 % with cumulative losses nearing 60 %. Despite the severity of the outbreak, details of the specific trypanosomes infecting large yellow croaker remain unclear. In this study, samples of fish were collected from the fish farmer during the outbreak. A high prevalence of trypanosomes, confirmed by microscopy and PCR analysis, was associated with pathology. Sequence identification and phylogenetic analysis indicated that the isolated trypanosome had 99.27 % sequence identity with Trypanosoma carassii MARV, a typical freshwater fish trypanosome, and clustered within the T. carassii complex C group. Morphological characterization, using Giemsa staining, further supported the similarity between the trypanosomes infecting large yellow croaker and the T. carassii complex C group. Additionally, a broader host range was established as it also infected Nile tilapia ( Oreochromis niloticus ), koi ( Cyprinus carpio ) and largemouth bass ( Micropterus salmoides ), leading to its designation as a subspecies within the T. carassii complex, named T. carassii spectrum . This represents the first documented instance of T. carassii , a typical freshwater fish trypanosome, infecting a marine fish whilst highlighting its severe pathogenicity and the urgent need for effective control measures. Furthermore, in vitro cultivation was successfully established, providing a foundation for future research on prevention and management strategies.

关键词： Trypanosoma carassii Fish trypanosomosis Large yellow croaker Marine fish

来源：评论

学校读者我要写书评

暂无评论

The pigment transporter Redboy confers programmed body colour transition in orchid mantises

引用

Nature ecology & evolution 2025年 2025 May 30页

作者： Xiao-Jin Pei Dong Zhao Jie Luo Pei-Yao Jia Yuan Luo Dong-Wei Yuan Wen-Xin Hou Zhan-Feng Zhang Dan-Yan Huang Jia-Xin Ni Hui-Ze Gao Zhanqi Chen Yun-Xia Luan Xue-Xin Chen Wei Zhang Sheng Li Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology Guangzhou Key Laboratory of Insect Development Regulation and Application Research Institute of Insect Science and Technology School of Life Sciences South China Normal University Guangzhou China. Guangmeiyuan R&D Center Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology South China Normal University Meizhou China. Guangdong Laboratory for Lingnan Modern Agriculture Guangzhou China. State Key Laboratory of Gene Function and Modulation Research School of Life Sciences Peking University Beijing China. Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary Studies Peking University Beijing China. State Key Laboratory of Crop Stress Biology for Arid Areas and Key Laboratory of Integrated Pest Management on Crops in Northwestern Loess Plateau Ministry of Agriculture and Rural Affairs Northwest A&F University Yangling People's Republic of China. Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical Garden Chinese Academy of Sciences Yunnan China. Guangdong Laboratory for Lingnan Modern Agriculture Guangzhou China. xxchen@***. Ministry of Agriculture and Rural Affairs Key Lab of Molecular Biology of Crop Pathogens and Insect Pests Key Laboratory of Biology of Crop Pathogens and Insects of Zhejiang Province Institute of insect Sciences Zhejiang University Hangzhou China. xxchen@***. State Key Laboratory of Gene Function and Modulation Research School of Life Sciences Peking University Beijing China. weizhangvv@***. Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary Studies Peking University Beijing China. weizhangvv@***. Institute of Ecology Peking University Beijing China. weizhangvv@***. Institute for Tibetan Plateau Research Peking University Beijing China. weizhangvv@***. Medog Biodiversity Observation and Research Station of Xizang Autonomous Region Nyingchi China

Programmed phenotypic transition is prevalent throughout the tree of life, yet the concrete mechanisms that underpin this phenomenon are poorly understood. The orchid mantis (Hymenopus coronatus, Mantodea) is a model study system for programmed body colour transitions that displays a prominent black-red body colour in first-instar nymphs, then switches to a flowery white body colour in later-instar nymphs. Here we reveal that this body colour transition is achieved by the simultaneous excretion of decarboxylated-xanthommatin (red pigment) and the accumulation of uric acid (white pigment) in the epidermis during the first moult. This change in pigmentation is associated with a novel subtype of ABCG pigment transporter that we call 'Redboy' in Polyneoptera, which is upregulated by insect steroid hormone (ecdysone) during the first moult of orchid mantises. RNAi assay and pigment analyses show that Redboy functions together with the co-transporter White, exporting red pigments from and concurrently importing white pigments into the epidermal cells. Spectral reflectance analyses and predation experiments reveal that Redboy-conferred programmed body colour transition enhances predator avoidance during the first instar, and both prey attraction and predator avoidance in later instars. Our findings clarify how gene family evolution and hormone regulation coordinate programmed phenotypic transition and promote ecological adaptation in orchid mantises.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Targeting VSIG4⁺ tissue-resident macrophages enhances T cell cytotoxicity and immunotherapy efficacy in cancer

引用

Developmental Cell 2025年

作者： Ma, Zikun Wang, Yuzhao Wang, Weikai Wei, Chen Liu, Zhenhua Li, Zhiyong Ye, Yunlin Mao, Yize Yuan, Yunfei Huang, Zhenkun Zhang, Ji Cao, Yun Mao, Xiaopeng Zhang, Yan Jin, Xin Yin, Jianhua Li, Guibo Zheng, Limin Liu, Zhaoyuan Li, Xiangdong Liang, Xiaoyu Liu, Zhuowei Sun Yat-Sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou 510060 China Department of Urology Sun Yat-Sen University Cancer Center Guangzhou 510060 China BGI Research Chongqing 401329 China College of Life Sciences University of Chinese Academy of Sciences Beijing 100049 China Department of Pancreatobiliary Surgery Sun Yat-Sen University Cancer Center Guangzhou 510060 China Department of Liver Surgery Sun Yat-Sen University Cancer Center Guangzhou 510060 China Department of Neurosurgery/Neuro-Oncology Sun Yat-Sen University Cancer Center Guangzhou 510060 China Department of Pathology Sun Yat-Sen University Cancer Center Guangzhou 510060 China Department of Urology the First Affiliated Hospital of Sun Yat-Sen University Guangdong Provincial Key Laboratory of Brain Function and Disease Guangdong Translational Medicine Innovation Platform Guangzhou China BGI Research Shenzhen 518083 China State Key Laboratory of Genome and Multi-omics Technologies BGI Research Shenzhen 518083 China MOE Key Laboratory of Gene Function and Regulation State Key Laboratory of Biocontrol School of Life Sciences Sun Yat-Sen University Guangzhou China Shanghai Institute of Immunology Department of Immunology and Microbiology Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Department of Radiation Oncology Sun Yat-Sen University Cancer Center Guangzhou 510060 China Sun Yat-sen University Cancer Center Gansu Hospital Lanzhou 730050 China

Tissue-resident macrophage (TRM) is crucial for organ development and homeostasis. However, the role of TRM-derived tumor-associated macrophage (TAM) subpopulations in cancer remains unclear. Using single-cell RNA sequencing and lineage tracing, we reported a TRM-derived TAM subpopulation, characterized by VSIG4 overexpression in testicular cancer. Macroscopically, such subpopulation was also found in tumors such as hepatocellular carcinoma, lung cancer, and glioblastoma. It was associated with poor prognosis and the suppression of CD8⁺ T-cell-dependent immunity via VSIG4. Notably, VSIG4 promoted immunosuppressive effects through direct or indirect modes, including interacting with receptors on CD8⁺ T cells or inducing transcription of IL-11 in TAMs. More importantly, MEF2C was identified as a key transcription factor that maintained VSIG4 expression and determined the biological behaviors of VSIG4⁺ TAMs. In preclinical models, targeting VSIG4⁺ TAMs via VSIG4 or MEF2C demonstrated a favorable effect of enhancing the efficacy of immune checkpoint inhibitors. © 2025 Elsevier Inc.

关键词： cancer cell development immunotherapy T cell immunity testicular cancer tissue-resident macrophages tumor immune microenvironment tumor-associated macrophages VSIG4

来源：评论

学校读者我要写书评

暂无评论

Root microbiota regulates tiller number in rice

引用

Cell 2025年

作者： Zhang, Jingying Wang, Bing Xu, Haoran Liu, Weidong Yu, Jingwei Wang, Qiuxia Yu, Hong Wei, Jin-Wei Dai, Rui Zhou, Jinghang He, Yuhang Zou, Di Yang, Jinhua Ban, Xinwei Hu, Qingliang Meng, Xiangbing Liu, Yong-Xin Wang, Binglei Hu, Bin Wang, Mingyu Xin, Peiyong Chu, Jinfang Li, Changsheng Garrido-Oter, Ruben Yu, Peng van Dijk, Aalt Dirk Jan Dong, Lemeng Bouwmeester, Harro Gao, Song Huang, Ancheng Chu, Chengcai Li, Jiayang Bai, Yang Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China Peking-Tsinghua Center for Life Sciences State Key Laboratory of Gene Function and Modulation Research Peking-Tsinghua-NIBS Graduate Program School of Life Sciences Peking University Beijing 100871 China CAS-JIC Centre of Excellence for Plant and Microbial Science Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China College of Advanced Agricultural Sciences University of Chinese Academy of Sciences Beijing 100101 China Shenzhen Key Laboratory of Plant Genetic Engineering and Molecular Design Institute of Plant and Food Science School of Life Sciences Southern University of Science and Technology Shenzhen 518055 China State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Integrated Traditional Chinese and Western Medicine Research Center Sun Yat-sen University Cancer Center Guangzhou 510060 China Yazhouwan National Laboratory Sanya 572024 China School of Life Sciences Yunnan University Kunming 650504 China Guangdong Basic Research Center of Excellence for Precise Breeding of Future Crops and Guangdong Laboratory for Lingnan Modern Agriculture South China Agricultural University Guangzhou 510642 China Key Laboratory for Enhancing Resource Use Efficiency of Crops in South China Ministry of Agriculture and Rural Affairs South China Agricultural University Guangzhou 510642 China State Key Laboratory of Chemo/Biosensing and Chemometrics College of Biology Hunan University Changsha 410082 China Department of Plant-Microbe Interactions Max Planck Institute for Plant Breeding Research Cologne 50829 Germany Cluster of Excellence on Plant Sciences (CEPLAS) Düsseldorf 40225 Germany Plant Genetics TUM School of Life Sciences Technical University of Munich Freising 85354 Germany Swammerdam Institute for Life Sciences University of Amsterdam Amsterdam 1098 XH Netherlands

Rice tillering is an important agronomic trait regulated by plant genetic and environmental factors. However, the role and mechanism of the root microbiota in modulating rice tillering have not been explored. Here, we examined the root microbiota composition and tiller numbers of 182 genome-sequenced rice varieties grown under field conditions and uncovered a significant correlation between root microbiota composition and rice tiller number. Using cultivated bacterial isolates, we demonstrated that various members of the root microbiota can regulate rice tillering in both laboratory and field conditions. genetic, biochemical, and structural analyses revealed that cyclo(Leu-Pro), produced by the tiller-inhibiting bacterium Exiguobacterium R2567, activates the rice strigolactone (SL) signaling pathway by binding to the SL receptor OsD14, thus regulating tillering. The present work provides insight into how the root microbiota regulates key agronomic traits and offers a promising strategy for optimizing crop growth by harnessing the root microbiota in sustainable agriculture. © 2025 The Authors

关键词： cyclo(Leu-Pro) dipeptide field trial microbial cultivation rice root microbiome root microbiota strigolactone pathway tiller number

来源：评论

学校读者我要写书评

暂无评论

Author Correction: The flying spider-monkey tree fern genome provides insights into fern evolution and arborescence

引用

Nature plants 2024年第2期10卷 344页

作者： Xiong Huang Wenling Wang Ting Gong David Wickell Li-Yaung Kuo Xingtan Zhang Jialong Wen Hoon Kim Fachuang Lu Hansheng Zhao Song Chen Hui Li Wenqi Wu Changjiang Yu Su Chen Wei Fan Shuai Chen Xiuqi Bao Li Li Dan Zhang Longyu Jiang Dipak Khadka Xiaojing Yan Zhenyang Liao Gongke Zhou Yalong Guo John Ralph Ronald R Sederoff Hairong Wei Ping Zhu Fay-Wei Li Ray Ming Quanzi Li State Key Laboratory of Tree Genetics and Breeding Chinese Academy of Forestry Beijing China. Shenzhen Branch Guangdong Laboratory for Lingnan Modern Agriculture Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural Sciences Shenzhen China. State Key Laboratory of Bioactive Substance and Function of Natural Medicines NHC Key Laboratory of Biosynthesis of Natural Products CAMS Key Laboratory of Enzyme and Biocatalysis of Natural Drugs Institute of Materia Medica Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China. Thompson Institute Ithaca NY USA. Plant Biology Section Cornell University Ithaca NY USA. Institute of Molecular & Cellular Biology National Tsing Hua University Hsinchu Taiwan. Beijing Key Laboratory of Lignocellulosic Chemistry Beijing Forestry University Beijing China. Department of Biochemistry and DOE Great Lakes Bioenergy Research Center Wisconsin Energy Institute University of Wisconsin Madison WI USA. State Forestry Administration Key Open Laboratory on the Science and Technology of Bamboo and Rattan Institute of Gene for Bamboo and Rattan Resources International Center for Bamboo and Rattan Beijing China. State Key Laboratory of Tree Genetics and Breeding Northeast Forestry University Harbin China. Beijing Advanced Innovation Center for Tree Breeding by Molecular Design Beijing Forestry University Beijing China. College of Landscape Architecture and Forestry Qingdao Agricultural University Qingdao China. GoldenGate International College Tribhuvan University Battisputali Kathmandu Nepal. State Key Laboratory of Systematic and Evolutionary Botany Institute of Botany Chinese Academy of Science Beijing China. Forest Biotechnology Group Department of Forestry and Environmental Resources North Carolina State University Raleigh NC USA. College of Forest Resources and Environmental Science Michigan Technological Universit

来源：评论

学校读者我要写书评

暂无评论

Correction to: Galectin-9 promotes a suppressive microenvironment in human cancer by enhancing STING degradation

引用

Oncogenesis 2022年第1期11卷 5页

作者： Chuan-Xia Zhang Dai-Jia Huang Valentin Baloche Lin Zhang Jing-Xiao Xu Bo-Wen Li Xin-Rui Zhao Jia He Hai-Qiang Mai Qiu-Yan Chen Xiao-Shi Zhang Pierre Busson Jun Cui Jiang Li Department of Biotherapy State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Sun Yat-sen University Cancer Center and School of Life Sciences Sun Yat-sen University 510060 Guangzhou P. R. China. MOE Key Laboratory of Gene Function and Regulation State Key Laboratory of Biocontrol Sun Yat-sen University 510275 Guangzhou China. Department of Nasopharyngeal Carcinoma Sun Yat-sen University Cancer Center 510060 Guangzhou China. CNRS UMR 9018 Gustave Roussy and Université Paris-Saclay 39 rue Camille Desmoulins F-94805 Villejuif France. Department of Neurosurgery The First People's Hospital of Changzhou Changzhou 213000 Jiangsu China. CNRS UMR 9018 Gustave Roussy and Université Paris-Saclay 39 rue Camille Desmoulins F-94805 Villejuif France. pierre.busson@gustaveroussy.fr. Department of Biotherapy State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Sun Yat-sen University Cancer Center and School of Life Sciences Sun Yat-sen University 510060 Guangzhou P. R. China. cuij5@***. MOE Key Laboratory of Gene Function and Regulation State Key Laboratory of Biocontrol Sun Yat-sen University 510275 Guangzhou China. cuij5@***. Department of Research and Development Shenzhen Institute for Innovation and Translational Medicine Shenzhen International Biological Valley-Life Science Industrial Park Dapeng New District Shenzhen China. cuij5@***. Department of Biotherapy State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Sun Yat-sen University Cancer Center and School of Life Sciences Sun Yat-sen University 510060 Guangzhou P. R. China. lijiang2@mail.sysu.edu.cn.

来源：评论

学校读者我要写书评

暂无评论

Stimuli-responsive Polymers-based Two-dimensional Photonic Crystals Biosensors

引用

Chinese Journal of Analytical Chemistry 2020年第7期48卷 e20069-e20074页

作者： CUI, Chun-Guo YOU, Ai-Mei SHI, Kai-Yao LIU, R.U.I. LU, Yu-Yuan ZHANG, Qiang Department of Breast Surgery the Third Hospital of Jilin University Changchun130033 China State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun130022 China Provincial Key Laboratory for Gene Diagnosis of Cardiovascular Disease Jilin Provincial Engineering Laboratory for Endothelial Function and Genetic Diagnosis Department of Cardiology the Third Hospital of Jilin University Changchun130033 China Drug Engineering Research Center Harbin University of Commerce Harbin150076 China State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun130022 China

Stimuli-responsive polymers-based two-dimensional photonic crystals (2DPCs) are comprised of two main components, stimuli-responsive hydrogels and structured microparticles. Microparticles can self-assemble into ordered structures in two dimensional spacing on the surface of hydrogels. The ordered structure allows structural colors that can be used as indicator phenomena to detect various analytes. The changes in colors are associated with the concentration change of analytes. Therefore, the concentration of the analytes can be determined using a simple colorimetric comparison. 2DPCs have attracted much attention due to their sensing applications. This article covers a brief general introduction of 2DPC and highlights many milestone examples as biosensors to inspire more innovative research work in the near future. © 2020 Changchun Institute of Applied Chemistry, Chinese Academy of Sciences

关键词： Photonic crystals

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：