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Necroptosis-elicited host immunity:GOx-loaded MoS_(2) nanocatalysts for self-amplified chemodynamic immunotherapy

Nano Research 2022年第3期15卷 2244-2253页

作者： Wensheng Xie Jingsong Lu Zhenhu Guo Xiaoxiao Guo Yongjiu Chi Jieling Ye Junxin Zhang Wanling Xu Lingyun Zhao Yen Wei The Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology(Ministry of Education) Department of ChemistryTsinghua UniversityBeijing 100084China State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Research Center of Magnetic and Electronic Materials College of Materials Science and EngineeringZhejiang University of TechnologyHangzhou 310014China State Key Laboratory of Powder Metallurgy Powder Metallurgy Research InstituteCentral South UniversityChangsha 410083China Department of Chemistry Tsinghua UniversityBeijing 100084China.

Nanoparticles induced potent antitumor immunotherapy plays a significant role for enhancing conventional therapeutic ***,revealing the pathway of how nanoagents themselves trigger the host immunity or how to maximize the immunotherapy efficacy still needs further ***,rose-like MoS2 nanoflowers modified with 2-deoxy-D-glucose(2-DG)and glucose oxidase(GOx)(MPGGFs)have been successfully fabricated via a one-pot hydrothermal reaction and following one-by-one surface modification as a multifunctional nanocatalyst for photothermal therapy enhanced self-amplified chemodynamic immunotherapy(PTT-co-CDT).By introducing GOx,the obtained MPGGFs exhibited self-amplified chemodynamic therapeutic efficacy under hypoxia tumor microenvironment(TME)because of the raised intracellular H2O2 level via enzyme-catalysis of ***,combined with the intrinsic excellent photothermal conversion efficiency of MoS2 nanoflowers,PTT-co-CDT performances by MPGGFs could effectively induce the necroptosis of tumor cells both in vitro and in *** the induced necroptosis via PTT-co-CDT by MPGGFs could directly trigger host immunity by activating the antigen-specific T-cells(CD4^(+) and CD8^(+)).Finally,the excellent in vivo safety of MPGGFs makes us believe that the successful construction of rose-like multifunctional nanocatalyst not only has great potentials for self-amplified chemodynamic immunotherapy,but also provides a paradigm for exploring necroptosis triggered host immunity for cancer treatment.

关键词： chemodynamic immunotherapy necroptosis nanocatalyst photothermal therapy self-amplified

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3D/4D additive-subtractive manufacturing of heterogeneous ceramics

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Journal of materials Science & technology 2024年第34期201卷 210-221页

作者： Guo Liu Xinya Lu Xiaofeng Zhang Yan Zhao Shenghui Yi Jingjun Xu Yuqi Zhan Jianan Yin Chengcheng Feng Zhifeng Zhou Peiyu Wang Zhou Chen Yunhu He Siyao Chen Pengchao Liu Jun Zuo Yu Dai Jian Wu Sida Liu Jian Lu Centre for Advanced Structural Materials City University of Hong Kong Shenzhen Research InstituteGreater Bay Joint DivisionShenyang National Laboratory for Materials ScienceShenzhen 518057China CityU-Shenzhen Futian Research Institute Shenzhen 518045China Hong Kong Branch of National Precious Metals Material Engineering Research Center City University of Hong KongHong Kong 999077China Department of Mechanical Engineering City University of Hong KongHong Kong 999077China Department of Materials Science and Engineering City University of Hong KongHong Kong 999077China National Engineering Laboratory for Modern Materials Surface Engineering Technology&The Key Lab of Guangdong for Modern Surface Engineering Technology Institute of New MaterialsGuangdong Academy of ScienceGuangzhou 510650China State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body College of Mechanical and Vehicle EngineeringHunan UniversityChangsha 410082China Faculty of Materials Science Shenzhen MSU-BIT UniversityShenzhen 518100China Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Physics and Materials Nanchang UniversityNanchang 330031China

The manufacturing of heterogeneous high-temperature material components is challenging for use in practical ***-dimensional(3D)printing provides solutions to programmable constructing ceramic ***,the development of heterogeneous ceramics is limited by low flexibil-ity of heterogeneity,geometrical complexity,structural resolution,manufacturing efficiency,and mate-rial *** this study,we demonstrated flexible and rapid approaches for fabricating complicated and precise heterogeneous ceramics by shape-changing(4D)or shape-keeping(3D)additive-subtractive manufacturing(ASM)*** shape-changing strategy for heterogeneous ceramics was achieved by global ceramization of heterogeneous precursors,while the shape-keeping strategy for heterogeneous ceramics was achieved by local receramization of homogeneous *** element analysis(FEA)simulations of the influence of the thermal shrinkage dominant in the shape-changing strategy on the shape deformation of heterogeneous ceramics could be valuable predictions of the experimental *** 3D/4D ASM methods are generic for high-temperature materials and extendable to metallic and dia-mond materials.

关键词： 3D/4D printing Additive-subtractive manufacturing Heterogeneous ceramics Elastomer-derived ceramics Local receramization

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Cu@Cu2s Core-Shell Heterostructure Nanowires Electrocatalysts for Highly Efficient Sulfion Oxidation-Assisted Hydrogen Production

SSRN

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SSRN 2025年

作者： Zhou, Ming Zhang, Hongling Guo, Jiangna Yang, Mengqi Li, Xingyu Luo, Sen Liu, Guanyu Weng, Ruixue Xiao, Peng Cui, Xun Ma, Chaowei Dong, Xiaoyu Yang, Wenjing Zhang, Yunhuai College of Chemistry and Chemical Engineering Chongqing University Chongqing400031 China College of Physics Chongqing University Chongqing400031 China State Key Laboratory of New Textile Materials and Advanced Processing Wuhan Textile University Wuhan430200 China Xinjiang Key Laboratory of New Energy Materials and Green Chemical Engineering Xinjiang Institute of Engineering Xinjiang830023 China

Electrocatalytic sulfur oxidation-assisted hydrogen evolution is a promising method that can efficiently degrade sulfur ions in recovered waste water while cost-effectively producing hydrogen. However, it still remains a great challenge to develop efficient and stable electrocatalysts with a well-defined heterointerface and high sulfur tolerance. Herein, we present a facile and liquid-phase approach to synthesis Cu@Cu2S core-shell heterostructure nanowires derived from copper nanowires at room temperature for robust sulfide oxidation reaction (SOR)-assisted H2 generation. The Cu@Cu2S core-shell heterostructure nanowires exhibit superior SOR activity with an ultralow potential of 0.3 V (vs. RHE) at a current density of 100 mA cm−2. More importantly, the assembled hybrid system with Cu@Cu2S displays remarkable durability over 216 h with negligible activity decay. Combined with the experimental characterizations and theoretical calculations, it was demonstrated that Cu@Cu2S core-shell heterostructure nanowires possessed reduced transition energy barriers in the rate-determining *S3 to *S4 oxidation step and a higher integrated density of states, significantly optimizing adsorption/desorption energy of sulfur intermediates, thereby greatly boosting the catalytic activity and alleviating the sulfur poisoning. Our findings provide a new strategy to develop core-shell heterostructure electrocatalysts with substantially enhanced activity and stability. © 2025, The Authors. All rights reserved.

关键词： Nanowires

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S-Scheme Homojunction and Activate Site Engineering Over Tio2 for Highly Efficient Photocatalytic Nitrogen Fixation

SSRN

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SSRN 2023年

作者： Wang, Yongchao Li, Zhen Zhu, Huiling Xu, Xiangran Zeng, Zhaowu Liu, Xiaoyi Wang, Huan Gong, Mingxing Liu, Xueqin Wang, Yang Faculty of Materials Science and Chemistry China University of Geosciences Wuhan430074 PR China State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile University Wuhan430200 PR China

The presence of efficient catalytic active sites and an ample supply of electrons are the two indispensable factors for achieving photocatalytic nitrogen fixation. Herein, the Fe-doped TiO2 S-scheme anatase/rutile homojunction (F-T-A/R) was synthesized as a brilliant photocatalyst for photocatalytic nitrogen fixation from N2 to NH3 under ambient atmosphere. The optimized F-T-A/R photocatalyst (A/R = 98:2, Fe-2wt%) exhibits an unprecedented NH3 generation rate of 358 μmol gcat-1 h-1 in water solvent and under simulated solar light irradiation. Experimental and theoretical studies reveal that the constructed S-scheme homojunction in F-A/R-TiO2 is conducive to fluent charge separation and adequate supply of electrons on rutile with higher nitrogen fixing activity, while the tuned local electronic structure of oxygen vacancy with Fe doping is engineered to strengthen active sites, synergistically enhancing the photocatalytic nitrogen fixation. © 2023, The Authors. All rights reserved.

关键词： Titanium dioxide

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Simultaneously healing cracks and strengthening additively manufactured Co_(34)Cr_(32)Ni_(27)Al_(4)Ti_(3) high-entropy alloy by utilizing Fe-based metallic glasses as a glue

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Journal of materials Science & technology 2024年第12期179卷 125-137页

作者： Hao Kang Kaikai Song Leilei Li Xiaoming Liu Yandong Jia Gang Wang Yaocen Wang Si Lan Xin Lin Lai-Chang Zhang Chongde Cao School of Physical Science and Technology Northwestern Polytechnical UniversityXian 710072China School of Mechanical Electrical&Information EngineeringShandong UniversityWeihai 264209China Institute of Materials Shanghai UniversityShanghai 200444China Herbert Gleiter Institute of Nanoscience School of Materials Science and EngineeringNanjing University of Science and TechnologyNanjing 210094China State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXian 710072China Centre for Advanced Materials and Manufacturing School of EngineeringEdith Cowan University270 Joondalup DriveJoondalupPerthWestern Australia 6027Australia Research and Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518057China

Solidification cracking issues during additive manufacturing(AM)severely prevent the rapid development and broad application of this *** this work,a representative Co_(34)Cr_(32)Ni_(27)Al_(4)Ti_(3) high-entropy al-loy(HEA)susceptible to crack formation was fabricated by selective laser melting(SLM).As expected,many macroscopic cracks *** crack issues were successfully solved after introducing a certain amount of Fe-based metallic glass(MG)powder as a glue during *** effect of MG addition on the formation and distribution of defects in the SLM-processed HEA was quantitatively *** an increasing mass fraction of the MG,the dominant defects transformed from cracks to lack of fusion(LOF)defects and finally ***,the MG preferred to be segregated to the boundaries of the molten ***,the coarse columnar crystals gradually transformed into equiaxed crystals in the molten pool and fine-equiaxed crystals at the edge of the molten pool,inhibiting the initiation of cracks and providing extra grain boundary ***,multiple precipitates are formed at the boundaries of cellular structures,which contribute significantly to *** to the brit-tle SLM-processed Co_(34)Cr_(32)Ni_(27)Al_(4)Ti_(3) HEA,the SLM-processed HEA composite exhibited a high ultimate tensile strength greater than 1.4 Ga and enhanced *** work demonstrates that adding Fe-based MG powders as glues into SLM-processed HEAs may be an attractive method to heal cracks and simultaneously enhance the mechanical properties of additively manufactured products.

关键词： Selective laser melting High-entropy alloys Crack healing Metallic glasses Mechanical properties

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Information Express of Soft Bionic Finger Based on Visual Recognition

Information Express of Soft Bionic Finger Based on Visual Re...

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IEEE International Conference on Cyborg and Bionic Systems (CBS)

作者： Sai Li Jiarun Wang Xinpeng Li Zixin Huang School of Electrical and Information Engineering Wuhan Institute of Technology Wuhan China Hubei Key Laboratory of Digital Textile Equipment Wuhan Textile University Wuhan China Ministry of Education Key Laboratory of Textile Fiber and Products (Wuhan Textile University) Wuhan China State Key Laboratory of New Textile Materials and Advanced Processing Technologies (Wuhan Textile University) Wuhan China

Soft robots have developed rapidly because of their own structure, adaptability and safety, which can be applied in different fields. However, the human robot interaction of soft robots faces enormous challenges. In this paper, we take the soft bionic finger (SBF) as the research object, design a multi chamber SBF, and propose a visual recognition to drive SBF. The bending information of the finger is converted into the information of driving air pressure, and drive the SBF. The SBF can simulate the bending of human finger and replace human finger to express some information. Finally, in the visual bending experiment, it is verified that the error between the bending angle of the human finger and the bending angle of the SBF is within a certain allowable range. It shows the feasibility of driving SBF to express information based on visual recognition, and also reflects strong human robot interaction.

关键词： Deformable models Visualization Computational modeling Fingers Human-robot interaction Bending Soft robotics

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In situ reduced MXene/AuNPs composite toward enhanced charging/discharging and specific capacitance

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Journal of advanced Ceramics 2021年第5期10卷 1061-1071页

作者： Zixiang ZHENG Wei WU Tao YANG Enhui WANG Zhentao DU Xinmei HOU Tongxiang LIANG Hailong WANG Beijing Advanced Innovation Center for Materials Genome Engineering Collaborative Innovation Center of Steel TechnologyUniversity of Science and Technology BeijingBeijing 100083China MOE Key Laboratory of New Processing Technology for Non-ferrous Metals and Materials Guangxi Key Laboratory of Processing for Non-ferrous Metals and Featured MaterialsGuangxi UniversityNanning 530004China School of Materials Science and Engineering Jiangxi University of Science and TechnologyGanzhou 341000China School of Materials Science Engineering Zhengzhou UniversityZhengzhou 450001China

In this work,gold nanoparticles(AuNPs)decorated Ti_(3)C_(2)T_(x) nanosheets(MXene/AuNPs composite)are fabricated through a self-reduction reaction of Ti_(3)C_(2)T_(x) nanosheets with HAuCl_(4) aqueous *** obtained composite is characterized as AuNPs with the diameter of about 23 nm uniformly dispersing on nanosheets without *** composite(MXene decorated on 4.8 wt% AuNPs)is further employed to construct supercapacitor for the first time with a higher specific capacitance of 278 F·g^(-1) at 5 mV·s^(-1) than that of pure Ti_(3)C_(2)T_(x) and 95% of cyclic stability after 10,000 ***,MXene/AuNPs composite symmetric supercapacitor with filter paper as separator and H_(2)SO_(4) as electrolyte,is *** supercapacitor exhibits a high volumetric energy density of 8.82 Wh·L^(-1) at a power density of 264.6 W·L^(-1) and ultrafast-charging/discharging *** exhibits as a promising candidate applied in integrated and flexible supercapacitors.

关键词： supercapacitors MXene gold nanoparticles(AuNPs) self-reduction composite

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Engineering heterostructured Ni@Ni(OH)_(2) core-shell nanomaterials for synergistically enhanced water electrolysis

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Green Energy & Environment 2022年第5期7卷 1024-1032页

作者： Jun-Wei Zhang Xian-Wei Lv Tie-Zhen Ren Zheng Wang Teresa J.Bandosz Zhong-Yong Yuan Hebei Provincial Key Laboratory of Green Chemical Technology&High Efficient Energy Saving School of Chemical Engineering and TechnologyHebei University of TechnologyTianjin300130China Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) School of Materials Science and EngineeringNankai UniversityTianjin300350China State Key Laboratory of High-efficiency Utilization of Coal and Green Chemical Engineering Ningxia UniversityYinchuan750021NingxiaChina Department of Chemistry and Biochemistry The City College of New YorkNY10031USA

Heterostructure engineering of electrocatalysts provides a fascinating platform to reasonably manipulate the physicochemical properties of nanomaterials and further improve their catalytic efficiency for water ***,it still remains a huge challenge to construct welldesigned core-shell heterostructured catalysts and identify the key role of components for synergistic ***,a melted polymeric salt tactics was innovatively developed to synthesize heterostructured Ni@Ni(OH)_(2) core-shell nanomaterials supported on porous carbon(named Ni@Ni(OH)_(2)/PC),wherein well-defined Ni(OH)_(2)-Ni heterostructure plays a pivotal role in improving electrocatalytic activity for water reduction and ***,the stable porous carbon support functions as a highway for continuous electron transfer between Ni and Ni(OH)_(2),and simultaneously enables the full exposure of accessible active *** fabricated Ni@Ni(OH)_(2)/PC exhibits outstanding bifunctional electrocatalytic performance for overall water splitting(η_(10)=1.55 V) with a good long-time *** work sheds new light on the design of engineering heterostructure of active bifunctional electrocatalysts for efficient energy conversion system.

关键词： stability synergistic splitting

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A Short and Highly Efficient Method for Producing Meltblown Nano Yarn with a Helical Structure and High Conductivity

A Short and Highly Efficient Method for Producing Meltblown ...

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作者： Ying-Cun Liu Zi-Yi Su Chen Ze Duo Xu College of Textile and Clothing Engineering Soochow University State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile University

The COVID-19 outbreak has led to the overproduction of meltblown fabrics commonly used in personal protective equipment such as face ***,the yield ofconventional fabrication methods for meltblown fabrics have poor mechanical properties and lack accessional value and functional *** this study,a short and highly efficient process was employed to produce polypropylene/polypyrrole（PPy） meltblown nanoyarn（PPMNY）.The mechanical properties were improved by utilizing a helical structure,and the conductivity was enabled using a combination of PPy *** breaking force of the proposed PPMNY was as high as 10.1cN/tex at 9T/10 cm,nearly 3.3 times more than PPMNY without the helical *** breaking force of the proposed PPMNY was unaffected by the washing process,and the frictional properties and snarling information were similarly maintained by the helical ***,the optimal conductivity of the proposed PPMNY reached 0.044S·***,the novel methods investigated in this study can improve the properties of meltblown fabrics to yield a highly efficient and low-cost technique to produce conductive *** concept can be extended for solving the problems of the single two-dimensional structure with poor mechanical properties and application on Smart Wearable with preferable conductivity.

关键词： Meltblown Nano Yarn Polypyrrole Nanoparticles Helical Structure Mechanical Property Electrical Properties

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Enhanced subacute ischemic stroke treatment via multistage drug delivery system design for combination therapy

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Science China Chemistry 2025年

作者： Xihan Xu Juan-Juan Li Jiamin Li Hui-Yan Zhang Yilin Qi Bing-Sen Shi Tianqi Li Shan-Shan Su Weitao Zhao Chang Chen Zhongying Gong Huiyu Liu Ke-Rang Wang Dong-Sheng Guo Xue Xue State Key Laboratory of Medicinal Chemical Biology College of Pharmacy Nankai University College of Chemistry State Key Laboratory of Elemento-Organic Chemistry Key Laboratory of Functional Polymer Materials (Ministry of Education) Frontiers Science Center for New Organic Matter Collaborative Innovation Center of Chemical Science and EngineeringNankai University College of Chemistry and Materials Science State Key Laboratory of New Pharmaceutical Preparations and Excipients Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education) Key Laboratory of Chemical Biology of Hebei Province Hebei Research Center of the Basic Discipline of Synthetic Chemistry Hebei University Department of Neurology Tianjin First Central Hospital School of Medicine Nankai University Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic-Inorganic Composites Beijing Laboratory of Biomedical Materials Bionanomaterials & Translational Engineering Laboratory Beijing Key Laboratory of BioprocessBeijing University of Chemical Technology

The management of acute ischemic stroke remains challenging due to its abrupt onset and the narrow treatment window,resulting in high rates of disability and *** therapy for neuroprotection and neurorepair strategies provided new hopes for subacute stroke *** we designed a multistage nanodelivery system that matches the unique microenvironment of the subacute phase of stroke,which utilizes calixarene as a building block to effectively load the neuroprotective drug *** calixarene is designed with glycosidic linkages targeting the glucose transporter 1 (GLUT1)on the blood-brain barrier (BBB) and azo bonds that are responsive to hypoxic ***,the decomposed calixarene molecules themselves possess intrinsic bio-activation to modulate inflammatory responses,achieving a multistage therapeutic approach that transitions from targeting to release and finally to *** approach combines anti-inflammation and neuroprotection,providing a multi-level treatment *** system was validated in a rat model of permanent middle cerebral artery occlusion (pMCAO),demonstrating that intravenous administration of the nanodelivery system repairs brain damage and improves motor function 24 h post-pMCAO *** work offers a precise and integrative strategy for stroke patients missing the acute therapy window to improve functional recovery and enhance the effect of comprehensive treatment.

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